Neurobiology of loneliness: a systematic review

Cognitive and Neural Correlates of Loneliness and Wisdom during Emotional Bias

(2021) Gillian Grennan et al.   CEREBRAL CORTEX

Default Mode Network Connectivity and Social Dysfunction in Major Depressive Disorder

(2020) Ilja M. J. Saris et al.   Scientific Reports

10,000 social brains: Sex differentiation in human brain anatomy

(2020) Hannah Kiesow et al.   Science Advances

Self-Other Representation in the Social Brain Reflects Social Connection

(2020) Andrea L. Courtney et al.   JOURNAL OF NEUROSCIENCE

Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA

(2020) Dilip V. Jeste et al.   AGING & MENTAL HEALTH

The relationship between loneliness and working-memory-related frontoparietal network connectivity in people with major depressive disorder

(2020) Mengxia Gao et al.   BEHAVIOURAL BRAIN RESEARCH

Is spirituality a component of wisdom? Study of 1,786 adults using expanded San Diego Wisdom Scale (Jeste-Thomas Wisdom Index)

(2020) Dilip V. Jeste et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Acute social isolation evokes midbrain craving responses similar to hunger

(2020) Livia Tomova et al.   NATURE NEUROSCIENCE

The default network of the human brain is associated with perceived social isolation

(2020) R. Nathan Spreng et al.   Nature Communications

Experimentally induced nostalgia reduces the amplitude of the event-related negativity

(2019) Andrea Bocincova et al.   Social Neuroscience

Loneliness and meaning in life are reflected in the intrinsic network architecture of the brain

(2019) Laetitia Mwilambwe-Tshilobo et al.   Social Cognitive and Affective Neuroscience

Connectome-based individualized prediction of loneliness

(2019) Chunliang Feng et al.   Social Cognitive and Affective Neuroscience

Does loneliness contribute to mild cognitive impairment and dementia? A systematic review and meta-analysis of longitudinal studies

(2019) Elvira Lara et al.   AGEING RESEARCH REVIEWS

Resting brain dynamics at different timescales capture distinct aspects of human behavior

(2019) Raphaël Liégeois et al.   Nature Communications

Cerebellar neural markers of susceptibility to social isolation and positive affective processing

(2019) Nichol M. L. Wong et al.   Brain Structure & Function

Negative Affect Shared with Siblings is Associated with Structural Brain Network Efficiency and Loneliness in Adolescents

(2019) Nichol M.L. Wong et al.   NEUROSCIENCE

The neuroscience of unmet social needs

(2019) Livia Tomova et al.   Social Neuroscience

Structural Brain Correlates of Loneliness among Older Adults

(2019) Sandra Düzel et al.   Scientific Reports

Neurobiology and consequences of social isolation stress in animal model—A comprehensive review

(2018) Faiza Mumtaz et al.   BIOMEDICINE & PHARMACOTHERAPY

Association of loneliness with all-cause mortality: A meta-analysis

(2018) Laura Alejandra Rico-Uribe et al.   PLoS One

An fMRI study of loneliness in younger and older adults

(2018) Alexandra E. D’Agostino et al.   Social Neuroscience

Loneliness 5 years ante-mortem is associated with disease-related differential gene expression in postmortem dorsolateral prefrontal cortex

(2018) Turhan Canli et al.   Translational Psychiatry

Brain activity mediates the relation between emotional but not instrumental support and trait loneliness

(2018) Yangyang Yi et al.   Social Cognitive and Affective Neuroscience

High prevalence and adverse health effects of loneliness in community-dwelling adults across the lifespan: role of wisdom as a protective factor

(2018) Ellen E. Lee et al.   INTERNATIONAL PSYCHOGERIATRICS

The lonely brain: evidence from studying patients with penetrating brain injury

(2018) Irene Cristofori et al.   Social Neuroscience

Regional tau pathology and loneliness in cognitively normal older adults

(2018) Federico d’Oleire Uquillas et al.   Translational Psychiatry

The relationships between brain structural changes and perceived loneliness in older adults suffering from late-life depression

(2017) Emily L.L. Sin et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Perceived social isolation is associated with altered functional connectivity in neural networks associated with tonic alertness and executive control

(2017) Elliot A. Layden et al.   NEUROIMAGE

Neural correlates of social exclusion across ages: A coordinate-based meta-analysis of functional MRI studies

(2017) Nandita Vijayakumar et al.   NEUROIMAGE

Causal interactions in resting-state networks predict perceived loneliness

(2017) Yin Tian et al.   PLoS One

Regional Brain Volumes Moderate, but Do Not Mediate, the Effects of Group-Based Exercise Training on Reductions in Loneliness in Older Adults

(2017) Diane K. Ehlers et al.   Frontiers in Aging Neuroscience

Empty-nest-related psychological distress is associated with progression of brain white matter lesions and cognitive impairment in the elderly

(2017) Dandan Duan et al.   Scientific Reports

Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies

(2016) Nicole K Valtorta et al.   HEART

Differential transcriptome expression in human nucleus accumbens as a function of loneliness

(2016) T Canli et al.   MOLECULAR PSYCHIATRY

Neuroanatomical correlates of attitudes toward suicide in a large healthy sample: A voxel-based morphometric analysis

(2016) Huijuan Liu et al.   NEUROPSYCHOLOGIA

Loneliness in late-life depression: structural and functional connectivity during affective processing

(2016) N. M. L. Wong et al.   PSYCHOLOGICAL MEDICINE

Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults

(2016) Nancy J. Donovan et al.   JAMA Psychiatry

Social relationships and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies

(2015) Jisca S. Kuiper et al.   AGEING RESEARCH REVIEWS

Implicit attention to negative social, in contrast to nonsocial, words in the Stroop task differs between individuals high and low in loneliness: Evidence from event-related brain microstates

(2015) Stephanie Cacioppo et al.   CORTEX

Yearning for connection? Loneliness is associated with increased ventral striatum activity to close others

(2015) Tristen K. Inagaki et al.   Social Cognitive and Affective Neuroscience

Neuroanatomical correlates of individual differences in social anxiety in a non-clinical population

(2015) Xue Tian et al.   Social Neuroscience

Loneliness and implicit attention to social threat: A high-performance electrical neuroimaging study

(2015) Stephanie Cacioppo et al.   Cognitive Neuroscience

White matter structures associated with loneliness in young adults

(2015) Seishu Nakagawa et al.   Scientific Reports

The default network and self-generated thought: component processes, dynamic control, and clinical relevance

(2014) Jessica R. Andrews-Hanna et al.   Annals of the New York Academy of Sciences

Dynamic spatiotemporal brain analyses using high performance electrical neuroimaging: Theoretical framework and validation

(2014) Stephanie Cacioppo et al.   JOURNAL OF NEUROSCIENCE METHODS

White matter structure in loneliness

(2014) Yin Tian et al.   NEUROREPORT

Social Alienation in Schizophrenia Patients: Association with Insula Responsiveness to Facial Expressions of Disgust

(2014) Christian Lindner et al.   PLoS One

Toward a neurology of loneliness.

(2014) Stephanie Cacioppo et al.   PSYCHOLOGICAL BULLETIN

Neuroticism and extraversion mediate the association between loneliness and the dorsolateral prefrontal cortex

(2014) Xia Kong et al.   EXPERIMENTAL BRAIN RESEARCH

Increased Release of Dopamine in the Striata of Young Adults With Hearing Impairment and Its Relevance for the Social Defeat Hypothesis of Schizophrenia

(2014) Martin Gevonden et al.   JAMA Psychiatry

Three dimensional anatomy of the human nucleus accumbens

(2013) L. Lucas-Neto et al.   ACTA NEUROCHIRURGICA

The cerebellum: Its role in language and related cognitive and affective functions

(2013) Hyo Jung De Smet et al.   BRAIN AND LANGUAGE

Social isolation, loneliness, and all-cause mortality in older men and women

(2013) A. Steptoe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Quantitative Meta-Analysis of Functional Imaging Studies of Social Rejection

(2013) Stephanie Cacioppo et al.   Scientific Reports

The Attention System of the Human Brain: 20 Years After

(2012) Steven E. Petersen et al.   Annual Review of Neuroscience

Dorsolateral prefrontal contributions to human working memory

(2012) Aron K. Barbey et al.   CORTEX

Brain Structure Links Loneliness to Social Perception

(2012) Ryota Kanai et al.   CURRENT BIOLOGY

The pain of social disconnection: examining the shared neural underpinnings of physical and social pain

(2012) Naomi I. Eisenberger   NATURE REVIEWS NEUROSCIENCE

The What and How of prefrontal cortical organization

(2010) Randall C. O’Reilly   TRENDS IN NEUROSCIENCES

Neurobiology of Wisdom

(2009) Thomas W. Meeks et al.   ARCHIVES OF GENERAL PSYCHIATRY

Perceived social isolation and cognition

(2009) John T. Cacioppo et al.   TRENDS IN COGNITIVE SCIENCES

How do you feel — now? The anterior insula and human awareness

(2008) A. D. (Bud) Craig   NATURE REVIEWS NEUROSCIENCE

Ecological Momentary Assessment

(2007) Saul Shiffman et al.   Annual Review of Clinical Psychology