mGluR1 signaling in cerebellar Purkinje cells: Subcellular organization and involvement in cerebellar function and disease

Phospholipase C β3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum

(2020) Yurie Rai et al.   NEUROSCIENCE

Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution

(2019) Samuel G. Rodriques et al.   SCIENCE

TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells

(2019) Bin Wu et al.   eLife

Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum

(2018) Masanobu Kano et al.   CEREBELLUM

Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders

(2018) Hirokazu Hirai et al.   CURRENT OPINION IN PHARMACOLOGY

Metabotropic glutamate receptor trafficking

(2018) Young Ho Suh et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Functional organization of postsynaptic glutamate receptors

(2018) Nicky Scheefhals et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The cerebellum and cognition

(2018) Jeremy D. Schmahmann   NEUROSCIENCE LETTERS

SK2 Channels Associate With mGlu1α Receptors and CaV2.1 Channels in Purkinje Cells

(2018) Rafael Luján et al.   Frontiers in Cellular Neuroscience

Spinocerebellar ataxia: an update

(2018) Roisin Sullivan et al.   JOURNAL OF NEUROLOGY

New Features on the Expression and Trafficking of mGluR1 Splice Variants Exposed by Two Novel Mutant Mouse Lines

(2018) Rika Naito et al.   Frontiers in Molecular Neuroscience

Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells

(2017) Nobutaka Takahashi et al.   JOURNAL OF NEUROCHEMISTRY

IP3 receptor mutations and brain diseases in human and rodents

(2017) Chihiro Hisatsune et al.   JOURNAL OF NEUROCHEMISTRY

Polyglutamine spinocerebellar ataxias — from genes to potential treatments

(2017) Henry L. Paulson et al.   NATURE REVIEWS NEUROSCIENCE

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins

(2017) Ingo H. Greger et al.   NEURON

Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice

(2017) Elisabetta Aloisi et al.   Nature Communications

Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

(2017) Myeongjeong Choo et al.   Nature Communications

Prolonged Type 1 Metabotropic Glutamate Receptor Dependent Synaptic Signaling Contributes to Spino-Cerebellar Ataxia Type 1

(2016) Emmet M. Power et al.   JOURNAL OF NEUROSCIENCE

Are Type 1 metabotropic glutamate receptors a viable therapeutic target for the treatment of cerebellar ataxia?

(2016) Emmet M. Power et al.   JOURNAL OF PHYSIOLOGY-LONDON

Progressive impairment of cerebellar mGluR signalling and its therapeutic potential for cerebellar ataxia in spinocerebellar ataxia type 1 model mice

(2016) Anton N. Shuvaev et al.   JOURNAL OF PHYSIOLOGY-LONDON

Organization and functions of mGlu and GABAB receptor complexes

(2016) Jean-Philippe Pin et al.   NATURE

Timing Rules for Synaptic Plasticity Matched to Behavioral Function

(2016) Aparna Suvrathan et al.   NEURON

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors

(2016) Joshua Levitz et al.   NEURON

Dopamine synapse is a neuroligin-2–mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures

(2016) Motokazu Uchigashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DAG tales: the multiple faces of diacylglycerol—stereochemistry, metabolism, and signaling

(2015) Thomas Oliver Eichmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook

(2015) S. Jarius et al.   Journal of Neuroinflammation

Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits

(2015) Nadia L. Cerminara et al.   NATURE REVIEWS NEUROSCIENCE

Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains

(2015) Karen Perez de Arce et al.   NEURON

Nanoscopic spine localization of Norbin, an mGluR5 accessory protein

(2014) Linda Westin et al.   BMC NEUROSCIENCE

Distinct subsynaptic localization of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar cortex

(2014) Mahnaz Mansouri et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Synaptic Targeting of mGluR1 by Its Carboxyl-Terminal Domain Is Crucial for Cerebellar Function

(2014) Y. Ohtani et al.   JOURNAL OF NEUROSCIENCE

Mutant  -III Spectrin Causes mGluR1  Mislocalization and Functional Deficits in a Mouse Model of Spinocerebellar Ataxia Type 5

(2014) K. R. Armbrust et al.   JOURNAL OF NEUROSCIENCE

Do mutations in the murine ataxia geneTRPC3cause cerebellar ataxia in humans?

(2014) Brent L. Fogel et al.   MOVEMENT DISORDERS

Activity-Dependent Gating of Calcium Spikes by A-type K+ Channels Controls Climbing Fiber Signaling in Purkinje Cell Dendrites

(2014) Yo Otsu et al.   NEURON

STIM1 Controls Neuronal Ca2+ Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior

(2014) Jana Hartmann et al.   NEURON

Metabotropic glutamate receptor 1 splice variants mGluR1a and mGluR1b combine in mGluR1a/b dimers in vivo

(2014) Šárka Techlovská et al.   NEUROPHARMACOLOGY

Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation

(2014) J.-H. Tao-Cheng et al.   NEUROSCIENCE

Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain

(2014) N. Uesaka et al.   SCIENCE

Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells

(2013) Ayumu Konno et al.   CEREBELLUM

Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors

(2013) Visou Ady et al.   EMBO REPORTS

Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system

(2013) Marco Gymnopoulos et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Quantitative Localization of Cav2.1 (P/Q-Type) Voltage-Dependent Calcium Channels in Purkinje Cells: Somatodendritic Gradient and Distinct Somatic Coclustering with Calcium-Activated Potassium Channels

(2013) D. W. Indriati et al.   JOURNAL OF NEUROSCIENCE

Functional Cooperation of Metabotropic Adenosine and Glutamate Receptors Regulates Postsynaptic Plasticity in the Cerebellum

(2013) Y. Kamikubo et al.   JOURNAL OF NEUROSCIENCE

Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1

(2013) Serena Notartomaso et al.   Molecular Brain

Glutamate Receptor  2 Associates with Metabotropic Glutamate Receptor 1 (mGluR1), Protein Kinase C , and Canonical Transient Receptor Potential 3 and Regulates mGluR1-Mediated Synaptic Transmission in Cerebellar Purkinje Neurons

(2012) A. S. Kato et al.   JOURNAL OF NEUROSCIENCE

Chronic Suppression of Inositol 1,4,5-Triphosphate Receptor-Mediated Calcium Signaling in Cerebellar Purkinje Cells Alleviates Pathological Phenotype in Spinocerebellar Ataxia 2 Mice

(2012) A. W. Kasumu et al.   JOURNAL OF NEUROSCIENCE

Cav2.1 in Cerebellar Purkinje Cells Regulates Competitive Excitatory Synaptic Wiring, Cell Survival, and Cerebellar Biochemical Compartmentalization

(2012) T. Miyazaki et al.   JOURNAL OF NEUROSCIENCE

Dynamic Organizing Principles of the Plasma Membrane that Regulate Signal Transduction: Commemorating the Fortieth Anniversary of Singer and Nicolson's Fluid-Mosaic Model

(2011) Akihiro Kusumi et al.   Annual Review of Cell and Developmental Biology

Metabotropic Glutamate Receptors and Interacting Proteins: Evolving Drug Targets

(2011) Ralf Enz   CURRENT DRUG TARGETS

Climbing fiber synapse elimination in cerebellar Purkinje cells

(2011) Masahiko Watanabe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

 -III Spectrin Is Critical for Development of Purkinje Cell Dendritic Tree and Spine Morphogenesis

(2011) Y. Gao et al.   JOURNAL OF NEUROSCIENCE

Mutant PKC  in Spinocerebellar Ataxia Type 14 Disrupts Synapse Elimination and Long-Term Depression in Purkinje Cells In Vivo

(2011) A. N. Shuvaev et al.   JOURNAL OF NEUROSCIENCE

Glutamate Receptor  2 Is Essential for Input Pathway-Dependent Regulation of Synaptic AMPAR Contents in Cerebellar Purkinje Cells

(2011) M. Yamasaki et al.   JOURNAL OF NEUROSCIENCE

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Trans-Synaptic Interaction of GluRδ2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum

(2010) Takeshi Uemura et al.   CELL

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors

(2010) Etienne Doumazane et al.   FASEB JOURNAL

Loss of  -III Spectrin Leads to Purkinje Cell Dysfunction Recapitulating the Behavior and Neuropathology of Spinocerebellar Ataxia Type 5 in Humans

(2010) E. M. Perkins et al.   JOURNAL OF NEUROSCIENCE

Preferential Localization of Muscarinic M1 Receptor on Dendritic Shaft and Spine of Cortical Pyramidal Cells and Its Anatomical Evidence for Volume Transmission

(2010) M. Yamasaki et al.   JOURNAL OF NEUROSCIENCE

Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice

(2010) Y. Gao et al.   JOURNAL OF NEUROSCIENCE

PKC and the control of localized signal dynamics

(2010) Carine Rosse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission

(2010) Asami Tanimura et al.   NEURON

Superresolution Imaging of Chemical Synapses in the Brain

(2010) Adish Dani et al.   NEURON

Single-Molecule Discrimination of Discrete Perisynaptic and Distributed Sites of Actin Filament Assembly within Dendritic Spines

(2010) Nicholas A. Frost et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cbln1 Is a Ligand for an Orphan Glutamate Receptor  2, a Bidirectional Synapse Organizer

(2010) K. Matsuda et al.   SCIENCE

Quantifying the Effects of Elastic Collisions and Non-Covalent Binding on Glutamate Receptor Trafficking in the Post-Synaptic Density

(2010) Fidel Santamaria et al.   PLoS Computational Biology

The Postsynaptic Density Proteins Homer and Shank Form a Polymeric Network Structure

(2009) Mariko Kato Hayashi et al.   CELL

Large-conductance calcium-activated potassium channels in purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains

(2009) Walter A. Kaufmann et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 2

(2009) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Functional Coupling between mGluR1 and Cav3.1 T-Type Calcium Channels Contributes to Parallel Fiber-Induced Fast Calcium Signaling within Purkinje Cell Dendritic Spines

(2009) M. E. Hildebrand et al.   JOURNAL OF NEUROSCIENCE

Translocation of a “Winner” Climbing Fiber to the Purkinje Cell Dendrite and Subsequent Elimination of “Losers” from the Soma in Developing Cerebellum

(2009) Kouichi Hashimoto et al.   NEURON

Influence of parallel fiber–Purkinje cell synapse formation on postnatal development of climbing fiber–Purkinje cell synapses in the cerebellum

(2009) K. Hashimoto et al.   NEUROSCIENCE

A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice

(2009) E. B. E. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia

(2008) Takashi Torashima et al.   EMBO REPORTS

Predominant expression of phospholipase Cβ1 in telencephalic principal neurons and cerebellar interneurons, and its close association with related signaling molecules in somatodendritic neuronal elements

(2008) Masahiro Fukaya et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Enzymological Analysis of Mutant Protein Kinase Cγ Causing Spinocerebellar Ataxia Type 14 and Dysfunction in Ca2+Homeostasis

(2008) Naoko Adachi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic Mechanisms of a Polyglutamine-mediated Neurodegenerative Disease, Spinocerebellar Ataxia Type 1

(2008) Huda Y. Zoghbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Origin of the Complex Spike in Cerebellar Purkinje Cells

(2008) J. T. Davie et al.   JOURNAL OF NEUROSCIENCE

STIM1 Gates TRPC Channels, but Not Orai1, by Electrostatic Interaction

(2008) Weizhong Zeng et al.   MOLECULAR CELL

Control of mental activities by internal models in the cerebellum

(2008) Masao Ito   NATURE REVIEWS NEUROSCIENCE

Mutant γPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells

(2008) Takahiro Seki et al.   NEUROBIOLOGY OF DISEASE

Glutamate Receptor Dynamics in Dendritic Microdomains

(2008) Thomas M. Newpher et al.   NEURON

Control of KCa Channels by Calcium Nano/Microdomains

(2008) Bernd Fakler et al.   NEURON

TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination

(2008) Jana Hartmann et al.   NEURON

Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells

(2008) Jiri Kumpost et al.   NEUROPHARMACOLOGY

Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives

(2008) F. Ferraguti et al.   PHARMACOLOGICAL REVIEWS

PICK1: A multi-talented modulator of AMPA receptor trafficking

(2008) Jonathan G. Hanley   PHARMACOLOGY & THERAPEUTICS

Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination

(2008) M. Kano et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Organization of the core structure of the postsynaptic density

(2008) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mGluR1 agonists elicit a Ca2+ signal and membrane hyperpolarization mediated by apamin-sensitive potassium channels in immature rat purkinje neurons

(2007) Jeffrey G. Netzeband et al.   JOURNAL OF NEUROSCIENCE RESEARCH