Article
Ecology
Moriah Sandy, Tina I. Bui, Kenia Segura Aba, Nestor Ruiz, John Paszalek, Elise W. Connor, Christine V. Hawkes
Summary: The chemical interactions between fungal endophytes and plant leaves are likely to be the key mechanism affecting plant phenotypic traits. This study found that multiple fungal strains share functional similarities in their effects on plant growth and physiology under unstressed conditions. Plant metabolomics profiles were correlated with fungal treatments, and specific metabolites were associated with plant trait variation. These findings have implications for the development of metabolites as crop management tools.
Review
Plant Sciences
Neveen Atta Elhamouly, Omar A. Hewedy, Amr Zaitoon, Angelica Miraples, Omnia T. Elshorbagy, Suzan Hussien, Amira El-Tahan, Deliang Peng
Summary: The global environment is influenced by various secondary metabolites, produced by plants and microorganisms, which have diverse chemical properties and play significant roles in plant disease control and growth promotion. Fungal secondary metabolites are particularly important in this regard.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Medicinal
Si -Si Liu, Rong Huang, Shou-Peng Zhang, Tang-Chang Xu, Kun Hu, Shao-Hua Wu
Summary: Two new nucleoside derivatives, kipukasins O (1) and P (2), one new cyclohexenone derivative, arthropsadiol D (5), and one new natural product, (+)-2,5-dimethyl-3(2H)-benzofuranone (6), were isolated from the culture broth of the endophytic fungus Aspergillus polyporicola R2. The absolute configuration of compound 5 was determined and the antimicrobial activities of these compounds were evaluated.
Review
Biochemistry & Molecular Biology
Manu Kumar, Sandeep Kumar Singh, Prem Pratap Singh, Vipin Kumar Singh, Avinash Chandra Rai, Akhileshwar Kumar Srivastava, Livleen Shukla, Mahipal Singh Kesawat, Atul Kumar Jaiswal, Sang-Min Chung, Ajay Kumar
Summary: Tuberculosis is a progressive disease with high mortality rates, hindered by drug resistance of Mycobacterium tuberculosis. Plant-derived secondary metabolites are being explored for their potential in developing anti-TB drugs targeting the action site of the bacteria. Computational approaches can play a significant role in screening these plant metabolites against tuberculosis virulence for drug design.
Article
Microbiology
Chuan You, Dan Qin, Yumeng Wang, Wenyi Lan, Yehong Li, Baohong Yu, Yajun Peng, Jieru Xu, Jinyan Dong
Summary: Beneficial interactions between endophytes and plants are crucial for plant growth and metabolite accumulation. Plant-derived triterpenoids were found to promote the growth of endophytic bacteria and fungi, which in turn enhanced host plant growth and secondary metabolite productions. This study suggests a strategy for constructing synthetic communities (SynComs) based on the screening of secondary metabolites, where bacteria and fungi work together to promote plant health.
Review
Microbiology
Johannes Mapuranga, Jiaying Chang, Lirong Zhang, Na Zhang, Wenxiang Yang
Summary: Fungal plant pathogens employ proteinaceous and non-proteinaceous effectors, including secondary metabolites (SMs) and small non-coding RNAs (sRNAs), to manipulate the host plant's defense system. While much research has focused on secreted effector proteins, the roles of fungal SMs and sRNAs have been largely overlooked. Fungal SMs are generated during plant colonization, especially in early infection stages, while fungal sRNAs target plant genes involved in resistance and defense responses. Understanding the functions of these effectors can provide insights into the infection process and host genes targeted. This review discusses the roles of fungal SMs and sRNAs in plant-fungal interactions, translocation of sRNA effectors across kingdoms, and the application of cross-kingdom RNA interference in managing plant diseases.
Review
Biochemistry & Molecular Biology
Ali Movahedi, Amir Almasi Zadeh Yaghuti, Hui Wei, Paul Rutland, Weibo Sun, Mohaddeseh Mousavi, Dawei Li, Zhuge Qiang
Summary: Populus trees face continuous environmental challenges throughout their life cycle, exhibiting various defenses including the production of secondary metabolites. While many of these metabolites have been functionally described, their overall functions are still not fully understood. Research indicates therapeutic effects and leads to further study of secondary metabolites and their biosynthesis in Populus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Shiv Shanker Pandey, Rahul Jain, Priyanka Bhardwaj, Ankita Thakur, Manju Kumari, Shashi Bhushan, Sanjay Kumar
Summary: Endophytes play a crucial role in regulating plant metabolism and have various beneficial effects such as improving nutrient absorption, nitrogen fixation, and stress tolerance in plants. They have the potential to be used in developing microbial formulations and elicitors to enhance plant health and produce therapeutic secondary metabolites. This review focuses on the tissue specificity of endophytes, the importance of seed-associated endophytes, their interactions with host plants, and their applications in plant in-vitro systems and as microbial consortia.
MICROBIOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Nai-Qian Dong, Hong-Xuan Lin
Summary: Phenylpropanoid metabolism is crucial for plant development and interaction with the environment. Plants have evolved multiple branches of this pathway, generating a variety of metabolites. Various factors regulate phenylpropanoid metabolism to maintain homeostasis during plant development and in response to environmental stresses.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2021)
Article
Plant Sciences
Tan Anh Nhi Nguyen, Takeshi Higa, Akito Shiina, Yuniar Devi Utami, Kei Hiruma
Summary: Fungi produce secondary metabolites (SMs) that play important roles in their stress responses and can regulate relationships with plants. However, many questions remain regarding fungal SM clusters, their expressions, and influences on host plants.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2023)
Article
Ecology
Jakob Joachin, Camryn Kritzell, Elliot Lagueux, Noah C. Luecke, Kerri M. Crawford
Summary: Pathogens play a crucial role in shaping plant communities through their species-specific effects on plants. Changes in water availability can alter plant communities by affecting the specificity of plant-pathogen interactions. This study found that under high water availability, a pathogenic soil fungus had stronger negative effects on plant biomass and exhibited species-specific effects.
Review
Plant Sciences
Xue-liang Chen, Mei-chen Sun, Sun-li Chong, Jin-ping Si, Ling-shang Wu
Summary: In natural systems, plant-symbiont-pathogen interactions have important effects on mitigating stresses in plants. Multi-omics technologies can be used to study plant-microbe interactions, particularly plant-endophyte interactions. Endophytes are naturally occurring microbes in plants that do not cause symptoms but provide benefits to their host plants. Understanding the complex mechanisms between plants and endophytes can be achieved through multi-omics approaches.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ilaria Chiocchio, Manuela Mandrone, Paola Tomasi, Lorenzo Marincich, Ferruccio Poli
Summary: Plant wastes contain valuable secondary metabolites that have wide applications in healthcare and food industries; however, the potential of plant secondary metabolites for other uses requires further research and exploration.
Review
Engineering, Chemical
Yaxuan Wang, Zhaogao Li, Mengwei Xu, Zhihao Xiao, Chaobo Liu, Bing Du, Delin Xu, Lin Li
Summary: Signaling molecules play a crucial role in connecting endophytes and host plants. They are involved in the recognition of endophytes, regulation of host plant growth and development, and synthesis of secondary metabolites. This review provides an overview of the types and characteristics of signaling molecules in medicinal plants, as well as the intracellular conduction and multi-molecular crosstalk of signaling molecules during interactions between endophytic bacteria and medicinal plants. It also summarizes the molecular mechanisms of signal molecules in the accumulation and regulation of medical metabolites. This work serves as a reference for utilizing endophytic bacteria and medicinal plants to synthesize pharmaceutical active ingredients in a bioreactor.
Review
Plant Sciences
Anna Koprivova, Stanislav Kopriva
Summary: Plants communicate with microorganisms through metabolites exuded from roots, which play a crucial role in modulating the functions of plant associated microbiota. Recent research has identified various metabolites involved in this communication network, but there are still significant knowledge gaps to be filled in future studies.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Chemistry, Applied
Drielli Rhiane P. Colhado Areas, Marcia R. P. Cabral, Anderson V. G. Ramos, Juliana L. B. Peixoto, Marta R. Barrotto do Carmo, Debora C. Baldoqui, Carla Porto, Maria Helena Sarragiotto
Summary: Chemical investigation of Lessingianthus brevifolius aerial parts led to the discovery of new flavonoids and hirsutinolide-type sesquiterpene lactones. Dereplication study using UHPLC-HRMS and molecular networking identified several known compounds, some of which were reported for the first time in L. brevifolius and the Lessingianthus genus.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Claudio Roberto Novello, Elisangela Dusman, Rodolfo Bento Balbinot, Jessica Carreira de Paula, Celso Vataru Nakamura, Joao Carlos Palazzo de Mello, Maria Helena Sarragiotto
Summary: This study isolated two novel active compounds from the stem bark of Croton echioides, highlighting their potential as therapeutic agents for combating leishmaniasis.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Angela Aparecida da Silva, Julio Cesar Polonio, Aline Maria Bulla, Andressa Domingos Polli, Juliana Cristina Castro, Lilian Capelari Soares, Verci Alves de Oliveira-Junior, Veronica Elisa Pimenta Vicentini, Arildo Jose Braz de Oliveira, Jose Eduardo Goncalves, Regina Aparecida Correia Goncalves, Joao Lucio Azevedo, Benicio Alves de Abreu-Filho, Joao Alencar Pamphile
Summary: This study evaluated the biological activity of the extract of Botryosphaeria fabicerciana isolated from leaves of Morus nigra, showing potential as an antibacterial and antioxidant agent. Major compounds included mellein and beta-orcinaldehyde, with best MIC and MBC observed against Gram-positive bacteria. Antioxidant activity was also demonstrated by the extract.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Mariana R. Passos de Souza, Anderson V. G. Ramos, Josiane A. Monteiro de Oliveira, Marcia R. P. Cabral, Eloisa G. Sampiron, Regiane B. de Lima Scodro, Mary Ann Foglio, Ana Lucia T. G. Ruiz, Marta R. B. do Carmo, Maria H. Sarragiotto, Debora C. Baldoqui
Summary: The chemical investigation of Chromolaena palmaris expanded the phytochemical composition knowledge of the genus by discovering 25 compounds, including a phytoprostane, flavonoids, phenolic acids, and a caffeoyl-glucoside derivative. The plant showed cytotoxicity towards human cancer cell lines and antimicrobial activity against Mycobacterium tuberculosis, with some compounds exhibiting potential for further drug development.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemical Research Methods
Debora L. O. Araujo, Anderson V. G. Ramos, Joao Daufemback, Maria E. de Souza, Beatriz Pereira Moreno, Cleverton S. Fernandes, Ana Paula Lopes, Alana C. Battistella, Ernani A. Basso, Jesui V. Visentainer, Tatiana S. Tiuman, Solange M. Cottica, Marta R. B. Carmo, Maria H. Sarragiotto, Debora C. Baldoqui
Summary: The phytochemical investigation of the Brazilian native plant Praxelis sanctopaulensis led to the identification of 47 compounds, including diastereomers, known compounds, and fatty acids. These compounds exhibit potential antioxidant and antimicrobial activities. Principal component analysis revealed similarities between flavonoids identified in P. sanctopaulensis and Chromolaena species.
PHYTOCHEMICAL ANALYSIS
(2022)
Article
Microbiology
Jessica C. Paula, Nilma S. Fernandes, Thaysa K. Karam, Paula Barea, Maria H. Sarragiotto, Tania Ueda-Nakamura, Sueli O. Silva, Celso Nakamura
Summary: The study demonstrated that RCC and C5 are effective against intracellular amastigotes of L. amazonensis by inducing oxidative stress and ultrastructural changes such as accumulation of lipid bodies and autophagic vacuoles, leading to parasite death.
FUTURE MICROBIOLOGY
(2022)
Article
Plant Sciences
Anelise Samara Nazari Formagio, Wagner Vilegas, Carla Roberta Ferreira Volobuff, Candida Aparecida Leite Kassuya, Valter Paes de Almeida, Jane Manfron, Zefa Valdevina Pereira, Marcia Regina Pereira Cabral, Maria Helena Sarragiotto
Summary: This study investigated the potential antioxidant, anti-acetylcholinesterase, antihyperalgesic, anti-nociceptive and anti-inflammatory properties of the methanolic extract of Palicourea tomentosa leaves. The results showed significant inhibition of pain and inflammatory parameters by the extract, supporting its traditional analgesic use.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Anderson Valdiney Gomes Ramos, Nathalia de Sa, Debora Larissa Oliveira Araujo, Marcia Regina Pereira Cabral, Giovana Ferreira Costacurta, Beatriz Cardoso de Freitas, Lenisa Vieira Vilegas, Regiane Bertin de Lima Scodro, Vera Lucia Dias Siqueira, Erika Seki Kioshima Cotica, Marta Regina Barrotto do Carmo, Maria Helena Sarragiotto, Debora Cristina Baldoqui
Summary: Twenty-one known specialised metabolites and potentially 28 other compounds were isolated from Vernonanthura nudiflora flowers. The structures of the compounds were established using NMR spectroscopic experiments and dereplication technique. The compounds showed promising antimycobacterial and cytotoxic activities.
NATURAL PRODUCT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
iris Carolina dos Santos Lacerda, Julio Cesar Polonio, Halison Correia Golias
Summary: Endophytic fungi are a rich source of secondary metabolites with antiviral effects, making research on developing novel antiviral substances important.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Mycology
Shalene da Silva da Silva Santos, Angela Aparecida da da Silva, Julio Cesar Polonio, Andressa Domingos Polli, Ravely Casarotti Orlandelli, Joao Arthur Dos Santos dos Santos Oliveira, Jose Usan Torres Brandao Filho, Joao Lucio Azevedo, Joao Alencar Pamphile
Summary: The protective and growth-promoting activities of Colletrotrichum and Diaporthe endophytes on tomato plants were explored and evaluated in this study. In vitro dual culture assays and greenhouse experiments confirmed the effectiveness of these endophytes in inhibiting Fusarium oxysporum and promoting the growth of tomato plants.
MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY
(2022)
Article
Chemistry, Physical
Paula Barea, Diego Alberto dos Santos Yamazaki, Diego de Souza Lima, Flavio Augusto Vicente Seixas, Willian Ferreira da Costa, Gisele de Freitas Gauze, Maria Helena Sarragiotto
Summary: A set of novel /3-carboline derivatives were designed and subjected to virtual screening studies by molecular docking in AChE. Among them, derivatives 1a-c, 2a, 3d-f, and 4d,e showed promising inhibition of AChE and BuChE. The results suggest that the design and selection strategies used in this study were efficient in the development of new dual-targeted AChE/BuChE inhibitors.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Integrative & Complementary Medicine
Rosangela Rumi Sugauara, Wanessa de Campos Bortolucci, Carla Maria Mariano Fernandez, Marcia Regina Pereira Cabral, Regina Aparecida Correia Goncalves, Maria Helena Sarragiotto, Jose Eduardo Goncalves, Nelson Barros Colauto, Giani Andrea Linde, Maria Graciela Iecher Faria Nunes, Suelen Pereira Ruiz, Zilda Cristiani Gazim
Summary: This study used UHPLC-ESI/qTOF and different in vitro antioxidant methods to identify the antioxidant compounds in C. xanthocarpa leaves. The results showed that the leaves of this plant contain a high concentration of antioxidant compounds, which have potential applications in the food, cosmetic, and pharmaceutical fields.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2023)
Article
Biochemistry & Molecular Biology
Caroline Pinto Zani, Aline Pinto Zani, Cristiane Melissa Thomazini, Karina Miyuki Retamiro, Aline Rufino de Oliveira, Debora Lais Goncalves, Maria Helena Sarragiotto, Francielle Pelegrin Garcia, Sueli de Oliveira Silva, Celso Vataru Nakamura, Tania Ueda-Nakamura
Summary: In this study, the cytotoxic potential and mechanism of action of a compound called BCP-1 were analyzed in breast cancer cells and non-tumor breast cells. The results showed that BCP-1 inhibited cancer cell proliferation, induced cell cycle arrest and oxidative stress, and activated apoptosis and autophagy pathways. BCP-1 also demonstrated antimetastatic potential.
Article
Microbiology
Bruno Cesar do Espirito Santo, Joao Arthur dos Santos Oliveira, Marcos Alessandro dos Santos Ribeiro, Rodrigo Pawloski Schoffen, Andressa Domingos Polli, Julio Cesar Polonio, Angela Aparecida da Silva, Benicio Alves de Abreu Filho, Michele Cristina Heck, Eduardo Cesar Meurer, Paola Pereira Constantin, Marcos Pileggi, Veronica Elisa Pimenta Vicentini, Halison Correia Golias, Joao Alencar Pamphile
Summary: This study investigates the chemical profile and potential antibacterial activity of specialized metabolites in the endophytic fungus Colletotrichum siamense associated with coffee plants. Several compounds with pharmacological potential were found, suggesting the potential of this fungus in biotechnological applications.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Paula Barea, Valeria Aquilino Barbosa, Diego Alberto dos Santos Yamazaki, Carla Maria Beraldi Gomes, Claudio R. Novello, Willian Ferreira da Costa, Gisele de Freitas Gauze, Maria Helena Sarragiotto
Summary: The activity of new compounds against acetylcholinesterase and butyrylcholinesterase was evaluated. The results showed that these compounds exhibited selectivity towards butyrylcholinesterase and demonstrated strong inhibitory activity. Among them, compound 12 showed the highest inhibitory activity and competed with butyrylthiocholine for the same binding site.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
