Potential therapeutic action of natural products from traditional Chinese medicine on Alzheimer's disease animal models targeting neurotrophic factors

Ginsenoside Rg1 Attenuates Amyloid-β Content, Regulates PKA/CREB Activity, and Improves Cognitive Performance in SAMP8 Mice

(2017) Yan-Qing Shi et al.   JOURNAL OF ALZHEIMERS DISEASE

The involvement of protein kinase G inhibitor in regulation of apoptosis and autophagy markers in spatial memory deficit induced by Aβ

(2016) Marjan Shariatpanahi et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease

(2016) Tingting Zhou et al.   NEUROPHARMACOLOGY

The effects of Ginkgo biloba extract on cognitive functions in aged female rats: The role of oxidative stress and brain-derived neurotrophic factor

(2015) Muaz Belviranlı et al.   BEHAVIOURAL BRAIN RESEARCH

Osthole Upregulates BDNF to Enhance Adult Hippocampal Neurogenesis in APP/PS1 Transgenic Mice

(2015) Hong Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia

(2015) Sung Min Ahn et al.   BMC Complementary and Alternative Medicine

The NGF Metabolic Pathway in the CNS and its Dysregulation in Down Syndrome and Alzheimer's Disease

(2015) M. Florencia Iulita et al.   Current Alzheimer Research

Therapeutic Effects of Herbal Chemicals in Traditional Chinese Medicine on Alzheimer’s Disease

(2015) T.S. Cheung et al.   CURRENT MEDICINAL CHEMISTRY

Multi-Target Strategy and Experimental Studies of Traditional Chinese Medicine for Alzheimer's Disease Therapy

(2015) Lin Li et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Effects of chronic administration of adipokinetic and hypertrehalosemic hormone on animal behavior, BDNF, and CREB expression in the hippocampus and neurogenesis in mice

(2015) Oguz Mutlu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Nonpeptide neurotrophic agents useful in the treatment of neurodegenerative diseases such as Alzheimer's disease

(2015) Masaaki Akagi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Panax notoginseng saponins improve recovery after spinal cord transection by upregulating neurotrophic factors

(2015) Yu Li et al.   Neural Regeneration Research

Harpagoside ameliorates the amyloid-β-induced cognitive impairment in rats via up-regulating BDNF expression and MAPK/PI3K pathways

(2015) J. Li et al.   NEUROSCIENCE

Icariin decreases both APP and Aβ levels and increases neurogenesis in the brain of Tg2576 mice

(2015) F. Li et al.   NEUROSCIENCE

A novel brain-derived neurotrophic factor-modulating peptide attenuates Aβ1-42-induced neurotoxicity in vitro

(2015) Min-Kyoo Shin et al.   NEUROSCIENCE LETTERS

The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s Disease

(2015) Zhenzhen Liu et al.   Oxidative Medicine and Cellular Longevity

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

(2015) Jun-Ming Wang et al.   PHYSIOLOGY & BEHAVIOR

Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model

(2015) Laura Psotta et al.   Frontiers in Behavioral Neuroscience

Nerve Growth Factor Gene Therapy

(2015) Mark H. Tuszynski et al.   JAMA Neurology

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

(2015) Josiane Budni et al.   Aging and Disease

Curcumin Improves Amyloid β-Peptide (1-42) Induced Spatial Memory Deficits through BDNF-ERK Signaling Pathway

(2015) Lu Zhang et al.   PLoS One

Compound danshen tablet ameliorated aβ25-35-induced spatial memory impairment in mice via rescuing imbalance between cytokines and neurotrophins

(2014) Yan Teng et al.   BMC Complementary and Alternative Medicine

Effects of 5-hydroxymethyl furfural extracted from Rehmannia glutinosa Libosch on the expression of signaling molecules relevant to learning and memory among hippocampal neurons exposed to high concentration of corticosterone

(2014) Li-na Zhang et al.   Chinese Journal of Integrative Medicine

Lenti-GDNF Gene Therapy Protects Against Alzheimer's Disease-Like Neuropathology in 3xTg-AD Mice and MC65 Cells

(2014) Susana Revilla et al.   CNS Neuroscience & Therapeutics

History and Experience: A Survey of Traditional Chinese Medicine Treatment for Alzheimer's Disease

(2014) Ping Liu et al.   Evidence-based Complementary and Alternative Medicine

Ginsenoside Rg5 improves cognitive dysfunction and beta-amyloid deposition in STZ-induced memory impaired rats via attenuating neuroinflammatory responses

(2014) Shenghui Chu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Maternal micronutrient imbalance alters gene expression of BDNF, NGF, TrkB and CREB in the offspring brain at an adult age

(2014) Pratiksha Sable et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Neuroprotective Effects of 3,6′-Disinapoyl Sucrose Through Increased BDNF Levels and CREB Phosphorylation via the CaMKII and ERK1/2 Pathway

(2014) Yuan Hu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Deficiency of GDNF Receptor GFR 1 in Alzheimer's Neurons Results in Neuronal Death

(2014) Y. Konishi et al.   JOURNAL OF NEUROSCIENCE

Increased plasma levels of BDNF and inflammatory markers in Alzheimer's disease

(2014) Mayara Chaves Faria et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Possible protective action of neurotrophic factors and natural compounds against common neurodegenerative diseases

(2014) Tadahiro Numakawa   Neural Regeneration Research

Enhancement of the nonamyloidogenic pathway by exogenous NGF in an Alzheimer transgenic mouse model

(2014) Chang Yang et al.   NEUROPEPTIDES

Elevation of Peripheral BDNF Promoter Methylation Links to the Risk of Alzheimer's Disease

(2014) Lan Chang et al.   PLoS One

Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome

(2014) M. Florencia Iulita et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Icaritin opposes the development of social aversion after defeat stress via increases of GR mRNA and BDNF mRNA in mice

(2013) Xiao Wu et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective effects of salvianolic acid B on an Aβ25–35 peptide-induced mouse model of Alzheimer's disease

(2013) Young Woo Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotective effect of hydroxysafflor yellow A on 6-hydroxydopamine-induced Parkinson's disease in rats

(2013) Bing Han et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF

(2013) Dong Wan et al.   Evidence-based Complementary and Alternative Medicine

Neuroprotective effect of Liuwei Dihuang decoction on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat

(2013) Ji-ping Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ginsenosides Rg5 and Rh3 protect scopolamine-induced memory deficits in mice

(2013) Eun-Jin Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

Icariin promotes histone acetylation and attenuates post-stroke cognitive impairment in the central cholinergic circuits of mice

(2013) X. Wang et al.   NEUROSCIENCE

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

(2013) Shelley J. Allen et al.   PHARMACOLOGY & THERAPEUTICS

GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression

(2013) Jan Pláteník et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Memory defect induced by beta-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms

(2012) Zhiming Xia et al.   BRAIN RESEARCH

Antidepressant-like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus

(2012) Bo Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sendai virus vector-mediated brain-derived neurotrophic factor expression ameliorates memory deficits and synaptic degeneration in a transgenic mouse model of Alzheimer's disease

(2012) Yuki Iwasaki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Epimedium flavonoids ameliorate experimental autoimmune encephalomyelitis in rats by modulating neuroinflammatory and neurotrophic responses

(2012) Lin-Lin Yin et al.   NEUROPHARMACOLOGY

Long-term ginsenoside administration prevents memory loss in aged female C57BL/6J mice by modulating the redox status and up-regulating the plasticity-related proteins in hippocampus

(2011) H.F. Zhao et al.   NEUROSCIENCE

Protective effects of catalpol on oligodendrocyte death and myelin breakdown in a rat model of chronic cerebral hypoperfusion

(2011) Qi-Yan Cai et al.   NEUROSCIENCE LETTERS

Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain

(2011) Qi Zhao et al.   Chinese Medicine

Synergistic Increase of BDNF Release from Rat Primary Cortical Neuron by Combination of Several Medicinal Plant-Derived Compounds

(2010) Se-Jin Jeon et al.   Biomolecules & Therapeutics

Ginsenoside Rb1 regulates the expressions of brain-derived neurotrophic factor and caspase-3 and induces neurogenesis in rats with experimental cerebral ischemia

(2010) Xiao-Qing Gao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum

(2010) G. Xu et al.   NEUROSCIENCE

Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats

(2010) Fei Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory

(2009) Wei Xue et al.   ACTA PHARMACOLOGICA SINICA

Liquiritin potentiate neurite outgrowth induced by nerve growth factor in PC12 cells

(2009) Zheng-ai Chen et al.   CYTOTECHNOLOGY

Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax

(2009) Lingai Hu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Five out of 16 plasma signaling proteins are enhanced in plasma of patients with mild cognitive impairment and Alzheimer's disease

(2009) Josef Marksteiner et al.   NEUROBIOLOGY OF AGING

Catalpol ameliorates beta amyloid–induced degeneration of cholinergic neurons by elevating brain-derived neurotrophic factors

(2009) Z. Wang et al.   NEUROSCIENCE

Neuroprotective effects of an alkaloid-free ethyl acetate extract from the root of Sophora flavescens Ait. Against focal cerebral ischemia in rats

(2009) S.J. Park et al.   PHYTOMEDICINE

Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression

(2009) Haixia Dang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Panax Notoginseng Burk Attenuates Impairment of Learning and Memory Functions and Increases ED1, BDNF and β-Secretase Immunoreactive Cells in Chronic Stage Ischemia-Reperfusion Injured Rats

(2008) Chin-Min Chuang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Neurotrophin p75 Receptor (p75 NTR ) Promotes Endothelial Cell Apoptosis and Inhibits Angiogenesis

(2008) Andrea Caporali et al.   CIRCULATION RESEARCH