Molnupiravir: coding for catastrophe

SARS-CoV-2 RNA dependent RNA polymerase as a therapeutic target for COVID-19

(2021) Ilaria Vicenti et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

(2021) Angela Wahl et al.   NATURE

Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

(2021) Calvin J. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit

(2021) Matthew D Hall et al.   JOURNAL OF INFECTIOUS DISEASES

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

(2021) Florian Kabinger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

(2020) Calvin J. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

(2020) Timothy P. Sheahan et al.   Science Translational Medicine

Analysis of the Potential for N4-Hydroxycytidine to Inhibit Mitochondrial Replication and Function

(2019) Zachary M. Sticher et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small-Molecule Antiviral β-D-N4-Hydroxycytidine Inhibits a Proofreading-Intact Coronavirus with a High Genetic Barrier to Resistance

(2019) Maria L. Agostini et al.   JOURNAL OF VIROLOGY

Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

(2019) Mart Toots et al.   Science Translational Medicine

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

(2018) Jeong-Joong Yoon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

β-D- N 4 -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome

(2017) Nadya Urakova et al.   JOURNAL OF VIROLOGY

Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics

(2013) Everett Clinton Smith et al.   PLoS Pathogens

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

(2012) M. Bouvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA