Review
Cell Biology
Qian Li, Nengxian Shi, Chen Cai, Mingming Zhang, Jing He, Ying Tan, Weijun Fu
Summary: Pyroptosis is a gene-regulated cell death process dependent on Caspase, which leads to the production of proinflammatory mediators. Mitochondria also play a crucial role in cell death, with mitochondrial outer membrane permeabilization being a key mechanism. Investigating the roles of mitochondria in pyroptosis can provide new strategies for regulating cell death with potential clinical benefits.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Apiwan Arinno, Chayodom Maneechote, Titikorn Chunchai, Busarin Arunsak, Sasiwan Kerdphoo, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This study demonstrates the potential therapeutic effects of α7nAChR and mAChR agonists in mitigating trastuzumab-induced cardiotoxicity by improving mitochondrial dysfunction, autophagic deficiency, and excessive myocyte death, thus highlighting their significance in improving cardiac function.
Article
Medicine, Research & Experimental
Tong Li, Houshuai Zeng, Wenjing Xian, Hongxing Cai, Jianbo Zhang, Shiji Zhou, Yingxue Yang, Min Luo, Peng Zhu
Summary: This study found that Maresin1 (MaR1) can reduce liver macrophage pyroptosis by reducing mitochondrial damage, thereby alleviating liver ischemia-reperfusion (I/R) injury. MaR1 inhibits liver macrophage pyroptosis by protecting mitochondria. Finally, it was found that MaR1 exerts mitochondrial protective effects through activation of its nuclear receptor RORa and the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Bingqing Xia, Xiaoyan Pan, Rong-Hua Luo, Xurui Shen, Shuangqu Li, Yi Wang, Xiaoli Zuo, Yan Wu, Yingqi Guo, Gengfu Xiao, Qiguang Li, Xin-Yan Long, Xiao-Yan He, Hong-Yi Zheng, Ying Lu, Wei Pang, Yong-Tang Zheng, Jia Li, Lei-Ke Zhang, Zhaobing Gao
Summary: This research reports a novel mechanism by which SARS-CoV-2 can evade neutralizing antibodies through cell-to-cell transmission. Infected cells release extracellular vesicles (EVs) that contain large amounts of live virus particles. These EVs protect the virus from neutralizing antibodies and are able to reinfect other cells.
Article
Cell Biology
Yaguang Bi, Haixia Xu, Xiang Wang, Hong Zhu, Junbo Ge, Jun Ren, Yingmei Zhang
Summary: Doxorubicin-induced cardiotoxicity is limited by its life-threatening cardiotoxicity, which is mainly caused by mitochondrial damage-induced cardiomyocyte death. FUNDC1 plays a beneficial role in DOX cardiotoxicity by regulating the cytoplasmic release of mitochondrial DNA and the activation of PANoptosome. This study provides new insights into the pathogenesis of DOX-induced cardiotoxicity and suggests potential therapeutic strategies targeting FUNDC1.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Abishai Dominic, Nhat-Tu Le, Masafumi Takahashi
Summary: The inflammasome is a vital multiprotein complex that mediates innate immune pathways. Reactive oxygen species (ROS), especially derived from mitochondria, play a critical role in NLRP3 inflammasome activation and are involved in a feedback loop with the inflammasome. The precise mechanism of how ROS affects inflammasome activation needs further investigation.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Engineering, Biomedical
Yudi Deng, Fuya Jia, Peihang Jiang, Liqiang Chen, Liyun Xing, Xinran Shen, Lian Li, Yuan Huang
Summary: Inducing pyroptosis in cancer cells can be achieved by delivering a drug complex to mitochondria, but the compensatory activation of mitophagy limits its anti-tumor effects. By inhibiting mitophagy, the pyroptosis can be intensified, leading to improved anti-tumor effects.
Article
Pharmacology & Pharmacy
Aarti Singh, Daniela Strobbe, Michelangelo Campanella
Summary: Pyroptosis, a specialized form of cell death involved in fighting pathogens, loses regulation during SARS-CoV-2 infection, leading to damage to the immune system and organs. While molecular pathways downstream of inflammasome formation have been identified and drugs are available for regulation, further research is needed on the pharmacology of upstream events.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
ShiYue Yang, Yang Yang, FeiFei Wang, QinYu Luo, Yan Zhang, Fei Zheng, Qiang Shu, QiXing Chen, XiangMing Fang
Summary: TREM2 plays a crucial role in enhancing host defense against bacterial infection by fine-tuning ROS generation and suppressing pyroptosis in macrophages, as demonstrated in both mouse models and patients with bacterial sepsis. These findings suggest that TREM2 may serve as a promising candidate target for sepsis therapy.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Engineering, Environmental
Zheng Zhang, Xin Zhang, Shuangshuang Zhao, Caihong Dong, Wei Feng, Luodan Yu, Li Ding, Yu Chen, Baoding Chen
Summary: Calcium overload can effectively induce inflammatory regulated cell death (RCD) in Gas-dermin E (GSDME)-expressed tumor cells, providing a distinct and effective pathway for treating refractory carcinomas with a strong inflammatory response.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Le Bich Hang Pham, Khanh Linh Chung, Seoyoung Kim, Jeeyeon Lee
Summary: In this study, we developed a dual-organelle-targeting probe called MPBA14+ with selective photosensitizing activity. Through live-cell imaging analysis, we found that MPBA14+ selectively localized in lipid droplets (LDs) and mitochondria, enabling monitoring of their interactions. Additionally, MPBA14+ was shown to induce a recently identified type of proinflammatory cell death called pyroptosis, mediated by mitochondrial dysfunction. The stable fluorescence emitted by MPBA14+ allowed for live-cell imaging analysis of changes in LDs, mitochondria, and peridroplet mitochondria (PDM) via photodynamic therapy (PDT).
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Biotechnology & Applied Microbiology
Hong Wang, Guoxin Jing, Jintong Niu, Li Yang, Youyuan Li, Yi Gao, Huichao Wang, Xiaorong Xu, Yechang Qian, Shilong Wang
Summary: The study introduces a novel supramolecular photosensitizer LDH@ZnPc, capable of triggering pyroptosis while possessing mitochondria anchoring ability, effectively enhancing the antitumor immunity in photodynamic therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biology
Hongxia Ruan, Xuejuan Li, Lina Zhou, Zihan Zheng, Rulin Hua, Xu Wang, Yuan Wang, Yujie Fan, Shuwen Guo, Lihua Wang, Shafiq Ur Rahman, Ziwei Wang, Yuyuan Wei, Shuangyan Yu, Rongzhi Zhang, Qian Cheng, Jie Sheng, Xue Li, Xiaoyan Liu, Ruqiang Yuan, Xiaoyan Zhang, Lihong Chen, Guowang Xu, Youfei Guan, Jing Nie, Hongqiang Qin, Feng Zheng
Summary: Peritoneal fibrosis and angiogenesis contribute to the failure of peritoneal dialysis. Elevated glucose concentrations cause pyroptosis in mesothelial cells, initiating fibrosis. Treatment with melatonin reduces pyroptosis and angiogenesis, preserving peritoneal function.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Immunology
Ji Zhu, Hang Chen, Jianan Guo, Chen Zha, Dezhao Lu
Summary: This study investigated the protective role of sodium tanshinone IIA sulfonate (STS) in atherosclerosis (AS). The results showed that STS can regulate endothelial cell mitochondrial function and pyroptosis through an AMPK-dependent mitochondrial pathway. The study found that STS treatment enhanced maintenance of mitochondrial homeostasis and inhibited mitochondrial ROS overproduction via AMPK, thereby improving endothelial cell pyroptosis during AS. These findings suggest that STS has potential therapeutic effects in AS through its antioxidant and anti-inflammatory properties.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Lian He, Zixian Huang, Kai Huang, Rui Chen, Nhung T. Nguyen, Rui Wang, Xiaoli Cai, Zhiquan Huang, Stefan Siwko, Joel R. Walker, Gang Han, Yubin Zhou, Ji Jing
Summary: LiPOP is a set of optogenetic tools that can induce photoswitchable necroptosis and pyroptosis in live cells using light. Studies have shown that combining LiPOPs with upconversion nanoparticles or bioluminescence can achieve wireless optogenetic or chemo-optogenetic killing of cancer cells in multiple mouse tumor models. LiPOPs have the potential to trigger necroptotic and pyroptotic cell death in cultured cells and living animals, opening up possibilities for studying non-apoptotic cell death pathways in microbial infection and anti-tumor immunity.
