Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

Mechanisms and therapeutic implications of hypermutation in gliomas

(2020) Mehdi Touat et al.   NATURE

Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases

(2020) Johannes G. Reiter et al.   NATURE GENETICS

Mutational signatures are jointly shaped by DNA damage and repair

(2020) Nadezda V. Volkova et al.   Nature Communications

A Compendium of Mutational Signatures of Environmental Agents

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Quantitative evidence for early metastatic seeding in colorectal cancer

(2019) Zheng Hu et al.   NATURE GENETICS

SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events

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Pan-cancer whole-genome analyses of metastatic solid tumours

(2019) Peter Priestley et al.   NATURE

Longitudinal molecular trajectories of diffuse glioma in adults

(2019) Floris P. Barthel et al.   NATURE

The mutational footprints of cancer therapies

(2019) Oriol Pich et al.   NATURE GENETICS

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

(2019) Frederick W. Goldberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy

(2019) Pamela Munster et al.   Cancer Management and Research

Genomic analysis reveals secondary glioblastoma after radiotherapy in a subset of recurrent medulloblastomas

(2018) Ji Hoon Phi et al.   ACTA NEUROPATHOLOGICA

The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells GrownIn Vitroand as Orthotopic Xenografts

(2018) Cindy R. Timme et al.   MOLECULAR CANCER THERAPEUTICS

Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium

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MutationalPatterns: comprehensive genome-wide analysis of mutational processes

(2018) Francis Blokzijl et al.   Genome Medicine

The genetic landscape of gliomas arising after therapeutic radiation

(2018) Giselle Y. López et al.   ACTA NEUROPATHOLOGICA

Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis

(2018) Ilias Georgakopoulos-Soares et al.   GENOME RESEARCH

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

(2017) Helen Davies et al.   NATURE MEDICINE

Synthetic lethality and cancer

(2017) Nigel J. O'Neil et al.   NATURE REVIEWS GENETICS

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

APOBEC3 induces mutations during repair of CRISPR–Cas9-generated DNA breaks

(2017) Liqun Lei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

APOBEC3 induces mutations during repair of CRISPR–Cas9-generated DNA breaks

(2017) Liqun Lei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia

(2016) R. Thijssen et al.   BLOOD

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

Implementation of a Multicenter Biobanking Collaboration for Next‐Generation Sequencing‐Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies

(2016) Sander Bins et al.   ONCOLOGIST

Mutational signatures of ionizing radiation in second malignancies

(2016) Sam Behjati et al.   Nature Communications

SpeedSeq: ultra-fast personal genome analysis and interpretation

(2015) Colby Chiang et al.   NATURE METHODS

The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline

(2015) Adeolu B. Adewoye et al.   Nature Communications

Numerical chromosomal instability mediates susceptibility to radiation treatment

(2015) Samuel F. Bakhoum et al.   Nature Communications

Role of Radiation Therapy in Palliative Care of the Patient With Cancer

(2014) Stephen T. Lutz et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium report†

(2014) Jack M. Su et al.   NEURO-ONCOLOGY

Estimating the demand for radiotherapy from the evidence: A review of changes from 2003 to 2012

(2014) Michael B. Barton et al.   RADIOTHERAPY AND ONCOLOGY

LUMPY: a probabilistic framework for structural variant discovery

(2014) Ryan M Layer et al.   GENOME BIOLOGY

APOBEC3 Cytidine Deaminases in Double-Strand DNA Break Repair and Cancer Promotion

(2013) R. Nowarski et al.   CANCER RESEARCH

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair

(2012) R. Nowarski et al.   BLOOD

Non-B DB v2.0: a database of predicted non-B DNA-forming motifs and its associated tools

(2012) Regina Z. Cer et al.   NUCLEIC ACIDS RESEARCH

First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G

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CNVnator: An approach to discover, genotype, and characterize typical and atypical CNVs from family and population genome sequencing

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Estimating the Need for Radiotherapy for Patients With Prostate, Breast, and Lung Cancers: Verification of Model Estimates of Need With Radiotherapy Utilization Data From British Columbia

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The Sequence Alignment/Map format and SAMtools

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