Chains of evidence from correlations to causal molecules in microbiome-linked diseases

Microbial Regulation of Host Physiology by Short-chain Fatty Acids

(2021) Bart van der Hee et al.   TRENDS IN MICROBIOLOGY

Promising Treatment for Type 2 Diabetes: Fecal Microbiota Transplantation Reverses Insulin Resistance and Impaired Islets

(2020) Hui Wang et al.   Frontiers in Cellular and Infection Microbiology

Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study

(2020) Theresia M. Schnurr et al.   DIABETOLOGIA

Engineered butyrate-producing bacteria prevents high fat diet-induced obesity in mice

(2020) Liang Bai et al.   Microbial Cell Factories

Fecal microbiota transplantation for the improvement of metabolism in obesity: The FMT-TRIM double-blind placebo-controlled pilot trial

(2020) Elaine W. Yu et al.   PLOS MEDICINE

Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism

(2020) Fabio Takeo Sato et al.   Cells

Gut microbiota and hypertension

(2019) Jun-ichi Oyama et al.   HYPERTENSION RESEARCH

Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets

(2019) Thao Nguyen et al.   Nutrients

The human gut Firmicute Roseburia intestinalis is a primary degrader of dietary β-mannans

(2019) Sabina Leanti La Rosa et al.   Nature Communications

Bile Acids as Metabolic Regulators and Nutrient Sensors

(2019) John Y. L. Chiang et al.   Annual Review of Nutrition

Akkermansia muciniphila abundance is lower in severe obesity but its increased level after bariatric surgery is not associated with metabolic health improvement

(2019) Maria Carlota Dao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice

(2019) Gil Sharon et al.   CELL

Donor metabolic characteristics drive effects of faecal microbiota transplantation on recipient insulin sensitivity, energy expenditure and intestinal transit time

(2019) Pieter de Groot et al.   GUT

Taming the beast: Interplay between gut small molecules and enteric pathogens

(2019) Aman Kumar et al.   INFECTION AND IMMUNITY

Potential roles of gut microbiome and metabolites in modulating ALS in mice

(2019) Eran Blacher et al.   NATURE

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

Deciphering the Chemical Lexicon of Host–Gut Microbiota Interactions

(2019) Gael R. Nicolas et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fecal microbiota transplantation beyond Clostridioides difficile infections

(2019) Koen Wortelboer et al.   EBioMedicine

Antibiotics can cause weight loss by impairing gut microbiota in mice and the potent benefits of lactobacilli

(2019) Zhonghua Miao et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

(2019) Yan Liu et al.   Cell Metabolism

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

The microbiota regulate neuronal function and fear extinction learning

(2019) Coco Chu et al.   NATURE

The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL

(2019) Berk Aykut et al.   NATURE

Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

(2019) Zachariah DeFilipp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Short Chain Fatty Acids and Fecal Microbiota Abundance in Humans with Obesity: A Systematic Review and Meta-Analysis

(2019) Kyu Nam Kim et al.   Nutrients

Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome—A Systematic Review

(2019) Zhang et al.   Nutrients

Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans

(2019) Mattea Müller et al.   Scientific Reports

The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet

(2018) Christine A. Olson et al.   CELL

Clostridium difficile infection and antibiotic-associated diarrhoea

(2018) Benjamin H Mullish et al.   CLINICAL MEDICINE

Translocation of a gut pathobiont drives autoimmunity in mice and humans

(2018) S. Manfredo Vieira et al.   SCIENCE

A selective gut bacterial bile salt hydrolase alters host metabolism

(2018) Lina Yao et al.   eLife

Altered composition of the gut microbiome in patients with drug-resistant epilepsy

(2018) Anjiao Peng et al.   EPILEPSY RESEARCH

Disparate Effects of Antibiotics on Hypertension

(2018) Sarah Galla et al.   PHYSIOLOGICAL GENOMICS

Gut microbiota mediates the anti-obesity effect of calorie restriction in mice

(2018) Shuo Wang et al.   Scientific Reports

Fecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice

(2018) Zi-Lun Lai et al.   Scientific Reports

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

(2018) Lulu Sun et al.   NATURE MEDICINE

Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria

(2018) Elizabeth A. Kennedy et al.   Frontiers in Physiology

GABA-modulating bacteria of the human gut microbiota

(2018) Philip Strandwitz et al.   Nature Microbiology

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring

(2017) Sangdoo Kim et al.   NATURE

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Alterations in the gut microbiota can elicit hypertension in rats

(2017) Sareema Adnan et al.   PHYSIOLOGICAL GENOMICS

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

(2017) Kerstin Berer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fecal microbiota transplantation cured epilepsy in a case with Crohn’s disease: The first report

(2017) Zhi He et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy

(2017) Gan Xie et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Alterations of the Gut Microbiome in Hypertension

(2017) Qiulong Yan et al.   Frontiers in Cellular and Infection Microbiology

Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study

(2017) Dae-Wook Kang et al.   Microbiome

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota

(2016) A. Sloan Devlin et al.   Cell Host & Microbe

Administration of Antibiotics to Children Before Age 2 Years Increases Risk for Childhood Obesity

(2016) Frank I. Scott et al.   GASTROENTEROLOGY

Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior

(2016) Pauline Luczynski et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A Decade Analysis of Trends and Outcomes of Male vs Female Patients Who Underwent Bariatric Surgery

(2016) Monica T. Young et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model

(2016) HONG-MEI ZHANG et al.   Molecular Medicine Reports

Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

(2016) P Zheng et al.   MOLECULAR PSYCHIATRY

Obesity and hypertension

(2016) Shu-Zhong Jiang et al.   Experimental and Therapeutic Medicine

Intestinal Microbiota Is Influenced by Gender and Body Mass Index

(2016) Carmen Haro et al.   PLoS One

Altered fecal microbiota composition in patients with major depressive disorder

(2015) Haiyin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Frenemies: Signaling and Nutritional Integration in Pathogen-Microbiota-Host Interactions

(2015) Elizabeth A. Cameron et al.   Cell Host & Microbe

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

Role of FXR in β-Cells of Lean and Obese Mice

(2015) Björn Schittenhelm et al.   ENDOCRINOLOGY

Correlations of Gut Microbial Community Shift with Hepatic Damage and Growth Inhibition of Carassius auratus Induced by Pentachlorophenol Exposure

(2015) Haifeng Kan et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity

(2015) Injae Hwang et al.   FASEB JOURNAL

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension

(2015) David J. Durgan et al.   HYPERTENSION

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

(2014) Charlie G. Buffie et al.   NATURE

Correlation between the human fecal microbiota and depression

(2014) A. Naseribafrouei et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children

(2013) Dae-Wook Kang et al.   PLoS One

Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified

(2013) Maria De Angelis et al.   PLoS One

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Molecular analysis of gut microbiota in obesity among Indian individuals

(2012) Deepak P Patil et al.   JOURNAL OF BIOSCIENCES

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

(2011) Kerstin Berer et al.   NATURE

Altering Host Resistance to Infections through Microbial Transplantation

(2011) Benjamin P. Willing et al.   PLoS One

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

The GABAergic deficit hypothesis of major depressive disorder

(2010) B Luscher et al.   MOLECULAR PSYCHIATRY

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One