Article
Pharmacology & Pharmacy
Fansu Meng, Fengjie Liu, Meng Lan, Tengteng Zou, Lihong Li, Tiange Cai, Yu Cai
Summary: In this study, folate-conjugated bovine serum albumin nanoparticles loaded with baicalin were developed to enhance the bioavailability and targeting ability of the drug, showing promising efficacy in breast cancer therapy by significantly inhibiting tumor growth and reducing side effects compared to free baicalin.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Biophysics
Shalvi Sinai Kunde, Sarika Wairkar
Summary: This review summarizes the development of albumin nanoparticles for chemotherapeutic drug delivery and their targeted approach for breast cancer. The article also introduces the multifunctional therapies available using albumin nanoparticles as a treatment and diagnostic method for breast cancer.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Ferda Ari, Merve Erkisa, Gonca Pekel, Elif Erturk, Gulay Buyukkoroglu, Engin Ulukaya
Summary: Utilizing albumin-based nanoparticle transport systems to enhance the effectiveness of Niclosamide in cancer treatment, the study found that nab-Niclo is more potent than free Niclosamide and albumin, inducing apoptosis through multiple pathways in breast cancer cells. This nanoparticle form of Niclosamide presents a safe and effective treatment strategy for breast cancer patients.
Article
Nanoscience & Nanotechnology
Sendibitiyosi Gandidzanwa, Natasha Beukes, Sinelizwi Joseph, Arno Janse Van Vuuren, Philani Mashazi, Jonathan Britton, Gareth Kilian, Saartjie Roux, Tebello Nyokong, Michael E. Lee, Carminita L. Frost, Zenixole R. Tshentu
Summary: Folate receptor-targeted therapy shows promise in breast cancer treatment. Folate-conjugated palladium-based nanoparticles with non-toxic concentrations were utilized to specifically target breast cancer cells with overexpressed folate receptors. The nanoparticles were found to selectively accumulate in cancer cells relative to normal cells, as demonstrated by qualitative and quantitative analysis using transmission electron microscopy and inductively coupled plasma-optical emission spectroscopy. These findings support the potential use of folate-conjugated palladium nanoparticles in targeting breast cancer cells for radiopharmaceutical applications.
Article
Biochemistry & Molecular Biology
Mei-Yi Lin, Wan-Ting Cheng, Hui-Ching Cheng, Wan-Ching Chou, Hsiu- Chen, Hsiu-Chung Ou, Kun-Ling Tsai
Summary: Baicalin can enhance chemosensitivity to doxorubicin in breast cancer cells through inducing apoptosis via increasing intracellular ROS and Ca2+ concentrations. Pretreatment with ROS inhibitor or Ca2+ chelator can reduce this chemosensitivity.
Review
Pharmacology & Pharmacy
Shilpi Singh, Abha Meena, Suaib Luqman
Summary: Baicalin has shown significant anti-proliferative potential in various cancer cell lines, attracting interest as a potential chemotherapeutic modality. However, its clinical use is limited by low bioavailability, fast metabolism, and other factors. Improving pharmacokinetics and pharmacodynamics, as well as addressing knowledge and technology gaps, are essential for establishing baicalin as an effective and safe compound for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Abdullah Alsrhani, Abozer Y. Elderdery, Badr Alzahrani, Nasser A. N. Alzerwi, Maryam Musleh Althobiti, Musaed Rayzah, Bandar Idrees, Ahmed M. E. Elkhalifa, Suresh K. Subbiah, Pooi Ling Mok
Summary: Breast cancer is a common and increasing malignant disease, and there is a need for better treatment options. Nanotechnology, particularly albumin-based nanoparticles, has potential as a chemotherapy technique for cancer therapy. In this study, albumin visnagin nanoparticles were synthesized and characterized, and their efficacy in suppressing breast cancer cells was examined.
Article
Chemistry, Physical
Marcela Tavares Luiz, Jessyca Aparecida Paes Dutra, Tais de Cassia Ribeiro, Gabriela Correa Carvalho, Rafael Miguel Sabio, Juliana Maldonado Marchetti, Marlus Chorilli
Summary: Breast cancer is a common and lethal cancer in women, and the treatment of which is challenging due to the heterogeneity of tumor cells. This study developed folic acid-modified curcumin-loaded liposomes for breast cancer treatment. The results showed that the modified liposomes exhibited a greater cytotoxicity effect and cellular uptake compared with free curcumin and unmodified liposomes, suggesting the potential of folic acid modification for improving drug internalization in breast cancer cells.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Biotechnology & Applied Microbiology
Susu Xiao, Huan Shi, Yan Zhang, Yu Fan, Li Wang, Li Xiang, Yanlin Liu, Ling Zhao, Shaozhi Fu
Summary: Local hypoxia is a common feature of solid tumors. In this study, a biocompatible bacteria/nanoparticles biohybrid platform was developed to target breast tumors. The results showed that the biohybrid was able to effectively colonize hypoxic tumors, increasing drug accumulation and reducing toxic side-effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Calrin Joseph, Aliscia Daniels, Sooboo Singh, Moganavelli Singh
Summary: This study successfully prepared functionalized gold nanoparticles for targeted gene delivery in breast cancer cells. The nanoparticles exhibited favorable size and negative charge, effectively protecting the gene from degradation and showing good cellular compatibility and enhanced transgene activity. Folate-targeted nanoparticles demonstrated better gene delivery efficiency in specific types of breast cancer cells.
Article
Pharmacology & Pharmacy
Jude Akinyelu, Olakunle Oladimeji, Aliscia Daniels, Moganavelli Singh
Summary: This study reports the synthesis of a gold nanoparticle-based delivery system for doxorubicin (DOX) to cancer cells. The functionalized DOX-nanoparticles showed higher chemotherapeutic activity and potential for clinical application.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Quanyuan Wan, Zihua Zeng, Jianjun Qi, Zhenghu Chen, Xiaohui Liu, Youli Zu
Summary: The study demonstrates the effectiveness of targeted chemotherapy for triple-negative breast cancer using a DNA nanoparticle to deliver doxorubicin to cancer cells, showing promising results in vitro and in animal experiments while potentially reducing side effects for patients.
Article
Medicine, Research & Experimental
Akanksha Behl, Parul Sarwalia, Sushil Kumar, Chittaranjan Behera, Mubashir Javed Mintoo, Tirtha Kumar Datta, Prem N. Gupta, Anil K. Chhillar
Summary: The synergistic potential of MUC1 inhibitors and Gemcitabine-loaded nanoparticles was discussed in this study, aiming to enhance the therapeutic efficacy. Gemcitabine and MUC1 inhibitors were loaded into polymeric nanoparticles using the double emulsion solvent evaporation method. The results showed that the twin-loaded nanoparticles exhibited better anticancer effects.
MOLECULAR PHARMACEUTICS
(2022)
Article
Agriculture, Dairy & Animal Science
Aya M. Al-Rahim, Rawaa AlChalabi, Ali Z. Al-Saffar, Ghassan M. Sulaiman, Salim Albukhaty, Tareg Belali, Elsadig M. Ahmed, Khalil A. A. Khalil
Summary: The study aimed to reduce the expression of inflammatory cytokines by synthesizing FA-MTX-BSA NPs and tested the potential of MTX, MTX-BSA NPs, and FA-MTX-BSA NPs in reducing interleukin and tumor necrosis factor levels.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rohan Ghadi, Pawan Kumar Pandey, Akash Gabhale, Aaradhya Wadikar, M. Dharshini, Kaushik Kuche, Tushar Date, Sanyog Jain
Summary: This study explored a combined therapy using neratinib and silibinin via nanocarriers to target triple negative breast cancer (TNBC). The therapy showed higher cellular uptake and cytotoxicity, and had the ability to promote mixed type cell death.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)