Transcriptomic signatures of psychomotor slowing in peripheral blood of depressed patients: evidence for immunometabolic reprogramming

Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia

(2020) Mandakh Bekhbat et al.   BRAIN BEHAVIOR AND IMMUNITY

Protein and Gene Markers of Metabolic Dysfunction and Inflammation Together Associate with Functional Connectivity in Reward and Motor Circuits in Depression

(2020) David R. Goldsmith et al.   BRAIN BEHAVIOR AND IMMUNITY

Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function

(2019) Ajay Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can’t or Won’t? Immunometabolic Constraints on Dopaminergic Drive

(2019) Michael T. Treadway et al.   TRENDS IN COGNITIVE SCIENCES

Pro‐inflammatory immune cell gene expression during the third trimester of pregnancy is associated with shorter gestational length and lower birthweight

(2019) Kharah M. Ross et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Involvement of inflammatory gene expression pathways in depressed patients with hyperphagia

(2019) Hilde de Kluiver et al.   Translational Psychiatry

Co-Expression Network Analysis Revealed That the ATP5G1 Gene Is Associated With Major Depressive Disorder

(2019) Duan Zeng et al.   Frontiers in Genetics

Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder

(2018) Gwenaël G.R. Leday et al.   BIOLOGICAL PSYCHIATRY

Treatment-resistant depression and peripheral C-reactive protein

(2018) Samuel R. Chamberlain et al.   BRITISH JOURNAL OF PSYCHIATRY

What does plasma CRP tell us about peripheral and central inflammation in depression?

(2018) Jennifer C. Felger et al.   MOLECULAR PSYCHIATRY

Divergent transcriptional profiles in pediatric asthma patients of low and high socioeconomic status

(2018) Gregory E. Miller et al.   PEDIATRIC PULMONOLOGY

Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder

(2018) Ebrahim Haroon et al.   PSYCHONEUROENDOCRINOLOGY

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

(2018) Josh Allen et al.   Frontiers in Neuroscience

Glucose and lipid-related biomarkers and the antidepressant response to infliximab in patients with treatment-resistant depression

(2018) Mandakh Bekhbat et al.   PSYCHONEUROENDOCRINOLOGY

A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder

(2018) David Stacey et al.   Translational Psychiatry

Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides

(2018) Yi Zhou et al.   Translational Psychiatry

Human Plasmacytoid and Monocyte-Derived Dendritic Cells Display Distinct Metabolic Profile Upon RIG-I Activation

(2018) Tünde Fekete et al.   Frontiers in Immunology

Ketamine’s antidepressant effect is mediated by energy metabolism and antioxidant defense system

(2017) Katja Weckmann et al.   Scientific Reports

Fatigue is associated with inflammation in patients with head and neck cancer before and after intensity-modulated radiation therapy

(2016) Canhua Xiao et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory markers are associated with decreased psychomotor speed in patients with major depressive disorder

(2016) David R. Goldsmith et al.   BRAIN BEHAVIOR AND IMMUNITY

Absolute Measurements of Macrophage Migration Inhibitory Factor and Interleukin-1-β mRNA Levels Accurately Predict Treatment Response in Depressed Patients

(2016) Annamaria Cattaneo et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Metabolic Reprogramming Supports IFN-γ Production by CD56brightNK Cells

(2016) Sinéad E. Keating et al.   JOURNAL OF IMMUNOLOGY

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

(2016) D R Goldsmith et al.   MOLECULAR PSYCHIATRY

Transcriptomics in Interferon-α-Treated Patients Identifies Inflammation-, Neuroplasticity- and Oxidative Stress-Related Signatures as Predictors and Correlates of Depression

(2016) Nilay Hepgul et al.   NEUROPSYCHOPHARMACOLOGY

Transcriptional profiling of mitochondria associated genes in prefrontal cortex of subjects with major depressive disorder

(2016) Qingzhong Wang et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Alterations in leukocyte transcriptional control pathway activity associated with major depressive disorder and antidepressant treatment

(2016) S H Mellon et al.   Translational Psychiatry

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes

(2016) Ekta Lachmandas et al.   Nature Microbiology

Age-related increases in basal ganglia glutamate are associated with TNF, reduced motivation and decreased psychomotor speed during IFN-alpha treatment: Preliminary findings

(2015) Ebrahim Haroon et al.   BRAIN BEHAVIOR AND IMMUNITY

Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets

(2015) Andre Carvalho et al.   CNS & Neurological Disorders-Drug Targets

Gene expression in major depressive disorder

(2015) R Jansen et al.   MOLECULAR PSYCHIATRY

Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression

(2015) J C Felger et al.   MOLECULAR PSYCHIATRY

Association of childhood trauma with fatigue, depression, stress, and inflammation in breast cancer patients undergoing radiotherapy

(2015) Tatiana J. Han et al.   PSYCHO-ONCOLOGY

Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression

(2015) A Karabatsiakis et al.   Translational Psychiatry

Neurocognitive predictors of antidepressant clinical response

(2014) Gerard E. Bruder et al.   JOURNAL OF AFFECTIVE DISORDERS

Testing the Predictive Value of Peripheral Gene Expression for Nonremission Following Citalopram Treatment for Major Depression

(2014) Jean-Philippe Guilloux et al.   NEUROPSYCHOPHARMACOLOGY

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Gene co-expression network analysis reveals common system-level properties of prognostic genes across cancer types

(2014) Yang Yang et al.   Nature Communications

Time-dependent metabolomic profiling of Ketamine drug action reveals hippocampal pathway alterations and biomarker candidates

(2014) K Weckmann et al.   Translational Psychiatry

Transcriptional signatures related to glucose and lipid metabolism predict treatment response to the tumor necrosis factor antagonist infliximab in patients with treatment-resistant depression

(2013) Divya Mehta et al.   BRAIN BEHAVIOR AND IMMUNITY

The association between depressive symptoms, cognitive function, and inflammation in major depression

(2013) Jesper Krogh et al.   BRAIN BEHAVIOR AND IMMUNITY

Predictors of depression in breast cancer patients treated with radiation: Role of prior chemotherapy and nuclear factor kappa B

(2013) Mylin A. Torres et al.   CANCER

Type I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing

(2013) S Mostafavi et al.   MOLECULAR PSYCHIATRY

Dopaminergic Mechanisms of Reduced Basal Ganglia Responses to Hedonic Reward During Interferon Alfa Administration

(2012) Lucile Capuron et al.   ARCHIVES OF GENERAL PSYCHIATRY

CpGassoc: an R function for analysis of DNA methylation microarray data

(2012) Richard T. Barfield et al.   BIOINFORMATICS

Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors’ and Longitudinal ‘Targets’

(2012) Annamaria Cattaneo et al.   NEUROPSYCHOPHARMACOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression

(2012) Charles L. Raison et al.   JAMA Psychiatry

Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients

(2012) D Martins-de-Souza et al.   Translational Psychiatry

Plasmacytoid Dendritic Cells: Recent Progress and Open Questions

(2011) Boris Reizis et al.   Annual Review of Immunology

Treatment response and cognitive impairment in major depression: Association with C-reactive protein

(2011) Hui Hua Chang et al.   BRAIN BEHAVIOR AND IMMUNITY

Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes

(2011) S. W. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular signatures of peripheral blood mononuclear cells during chronic interferon-α treatment: relationship with depression and fatigue

(2011) J. C. Felger et al.   PSYCHOLOGICAL MEDICINE

Gene expression biomarkers of response to citalopram treatment in major depressive disorder

(2011) F Mamdani et al.   Translational Psychiatry

Chronic Interferon-Alpha Administration Disrupts Sleep Continuity and Depth in Patients with Hepatitis C: Association with Fatigue, Motor Slowing, and Increased Evening Cortisol

(2010) Charles L. Raison et al.   BIOLOGICAL PSYCHIATRY

Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward

(2010) Naomi I. Eisenberger et al.   BIOLOGICAL PSYCHIATRY

Increased peripheral blood expression of electron transport chain genes in bipolar depression

(2010) Robert D Beech et al.   BIPOLAR DISORDERS

Inflammation Causes Mood Changes Through Alterations in Subgenual Cingulate Activity and Mesolimbic Connectivity

(2009) Neil A. Harrison et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

lumi: a pipeline for processing Illumina microarray

(2008) P. Du et al.   BIOINFORMATICS

Peripheral Inflammation is Associated with Altered Substantia Nigra Activity and Psychomotor Slowing in Humans

(2008) Lena Brydon et al.   BIOLOGICAL PSYCHIATRY

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C

(2008) Matthias Majer et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

(2008) Weiping Cao et al.   NATURE IMMUNOLOGY