4.8 Article

The RCSB Protein Data Bank: views of structural biology for basic and applied research and education

Journal

NUCLEIC ACIDS RESEARCH
Volume 43, Issue D1, Pages D345-D356

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/nar/gku1214

Keywords

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Funding

  1. National Science Foundation [NSF] [DBI-0829586, DBI-1338415]
  2. National Institute of General Medical Sciences (NIGMS)
  3. Office of Science, Department of Energy (DOE) [NSF 0753335]
  4. National Library of Medicine (NLM)
  5. National Cancer Institute (NCI)
  6. National Institute of Neurological Disorders and Stroke (NINDS)
  7. National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
  8. Div Of Biological Infrastructure
  9. Direct For Biological Sciences [1338415] Funding Source: National Science Foundation

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The RCSB Protein Data Bank (RCSB PDB, http://www.rcsb.org) provides access to 3D structures of biological macromolecules and is one of the leading resources in biology and biomedicine worldwide. Our efforts over the past 2 years focused on enabling a deeper understanding of structural biology and providing new structural views of biology that support both basic and applied research and education. Herein, we describe recently introduced data annotations including integration with external biological resources, such as gene and drug databases, new visualization tools and improved support for the mobile web. We also describe access to data files, web services and open access software components to enable software developers to more effectively mine the PDB archive and related annotations. Our efforts are aimed at expanding the role of 3D structure in understanding biology and medicine.

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