Article
Chemistry, Multidisciplinary
Tin Tin Manh Nguyen, Van-Hieu Mai, Han Sun Kim, Doyeon Kim, Munjun Seo, Yong Jin An, Sunghyouk Park
Summary: In this study, a fluorine NMR-based method was developed to quantitatively estimate the metabolic interaction between host and gut microbiome. The experimental results revealed the contributions of microbial species with different genetic backgrounds to host drug metabolism, as well as the differential drug metabolism among bacterial substrains and their contributions to host metabolism, which were not observable by conventional sequencing methods. These metabolic contributions were correlated with the developmental toxicity of the drug to the host fed with different substrains.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Microbiology
Megan Taylor, N. M. Vega
Summary: Research suggests that the metabolic state and immune system status of a host can affect the composition of its microbiome, leading to differences in community ecology and stability. This study demonstrates how genetic variations in innate immunity can alter microbiome composition, diversity, and stability in a Caenorhabditis elegans model.
Editorial Material
Biochemistry & Molecular Biology
Kelly A. Speer
Summary: Parasitic and parasitoid organisms rely on chemical cues to locate a host. Recent research suggests that the microbiome can emit volatile organic compounds that attract or repel parasites. This innovative mechanism changes our understanding of host-parasite coevolution and highlights the role of the microbiome as a third actor in this interaction.
Article
Ecology
Nathalia C. Oliveira, Pedro A. P. Rodrigues, Fernando L. Consoli
Summary: The gut bacterial community of fall armyworm larvae, regardless of geographical distribution or host strain, is mainly composed of Enterococcus and Pseudomonas.
Article
Multidisciplinary Sciences
Cheng-Rung Huang, Cheng-Ju Kuo, Chih-Wen Huang, Yu-Ting Chen, Bang-Yu Liu, Chung-Ta Lee, Po-Lin Chen, Wen-Tsan Chang, Yun-Wen Chen, Tzer-Min Lee, Hui-Chen Hsieh, Chang-Shi Chen
Summary: Enterohemorrhagic Escherichia coli (EHEC) induces attaching and effacing lesions in the intestine through a host signaling pathway involving cyclin-dependent kinase CDK1 and formin CYK1, as demonstrated using human intestinal cells and a C. elegans model of infection.
NATURE COMMUNICATIONS
(2021)
Review
Entomology
Christoph Vorburger
Summary: Insect host-parasitoid interactions are common in nature and characterized by host specialization. Many host species rely on heritable bacterial endosymbionts for defense against parasitoids. These symbionts provide strong and specific resistance, potentially due to variation in symbiont-produced toxins. Defensive symbionts are thus important for diversifying selection and may alter host-parasitoid food web structures. Additionally, other defensive mutualisms may also exert diversifying selection on insect parasitoids.
ANNUAL REVIEW OF ENTOMOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Tong Pan, Elizabeth A. Ronan, X. Z. Shawn Xu
Summary: A new study shows that the heat-sensing neuron AFD is responsible for attracting the parasitic nematode Strongyloides stercoralis to human body heat, using unknown neural mechanisms. Interestingly, this same neuron also plays a role in thermotaxis in the nematode C. elegans.
Article
Biotechnology & Applied Microbiology
Christian Roedelsperger
Summary: The reannotation of phylogenomic data using community-curated P. pacificus gene set improves gene annotation quality, but inference of gene models based on homology drops beyond the genus level, suggesting the rapid evolution of nematode lineages. This highlights the need for optimizing gene annotation protocols and the importance of a high quality genome for phylogenomic studies.
Article
Biotechnology & Applied Microbiology
Patrick Lansdon, Maci Carlson, Brian D. Ackley
Summary: The study used the soil-dwelling nematode Caenorhabditis elegans as a model to investigate immune responses against microbial pathogens. The results showed that different isolates of C. elegans exhibited varying susceptibility to different pathogenic bacteria, and their gene expression profiles were also significantly different. This study provides insights into the evolution of immune responses within organisms.
Article
Biochemistry & Molecular Biology
Caroline K. Glidden, Canan Karakoc, Chenyang Duan, Yuan Jiang, Brianna Beechler, Abdul Jabbar, Anna E. Jolles
Summary: Individual animals in natural populations tend to host diverse parasite species concurrently over their lifetimes. In free-living ecological communities, organismal life histories shape interactions with their environment, which ultimately forms the basis of ecological succession. Here, we studied community dynamics of 12 subtypes of protozoan microparasites (Theileria spp.) in a herd of African buffalo.
Article
Developmental Biology
Scott F. Gilbert, Michael G. Hadfield
Summary: This article discusses the contribution of developmental biology to mitigating the consequences of human impacts on the environment and climate change. It emphasizes the need for developmental biology to consider the environment as part of the body and to explore the interactions between developing organisms and their chemical, physical, and biotic environments.
Article
Environmental Sciences
Jagadish Chandra Kumar Mangu, Marios Stylianou, Per-Erik Olsson, Jana Jass
Summary: The exposure to PFAS increases susceptibility to pathogens in Caenorhabditis elegans by reducing host immunity and increasing intestinal membrane permeability, while also increasing bacterial virulence, with potential implications for humans and other animals.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Elena Gimmi, Jesper Wallisch, Christoph Vorburger
Summary: A 2-year field study on black bean aphids revealed that the prevalence of the defensive bacterial endosymbiont Hamiltonella defensa is weakly correlated with parasitism risk but strongly correlated with the number of heat days that previous aphid generations were exposed to. This study provides detailed insights into the dynamics of endosymbiont and parasitoid communities in black bean aphid populations and adds to the growing empirical evidence suggesting multifarious selection shaping the prevalence of H. defensa in the wild.
Article
Ecology
Louis T. Bubrig, Anne N. Janisch, Emily M. Tillet, Amanda Kyle Gibson
Summary: Parasites can have a significant impact on host fitness during the dispersal stage, which is often underestimated. Additionally, the effects of parasites vary depending on host genotype.
Article
Biochemistry & Molecular Biology
Chunlan Hong, Jonathan Lalsiamthara, Jie Ren, Yu Sang, Alejandro Aballay
Summary: The gut-neural axis plays a critical role in physiological processes, and our study shows that intestinal distension caused by Pseudomonas aeruginosa induces histone H4 Lys8 acetylation in the germline of Caenorhabditis elegans, which is essential for both bacterial aversion behavior and its transmission to the next generation. We also found that a 14-3-3 chaperone protein family member, PAR-5, is required for this acetylation process.
Article
Multidisciplinary Sciences
Simon J. O'Hanlon, Adrien Rieux, Rhys A. Farrer, Goncalo M. Rosa, Bruce Waldman, Arnaud Bataille, Tiffany A. Kosch, Kris A. Murray, Balazs Brankovics, Matteo Fumagalli, Michael D. Martin, Nathan Wales, Mario Alvarado-Rybak, Kieran A. Bates, Lee Berger, Susanne Boell, Lola Brookes, Frances Clare, Elodie A. Courtois, Andrew A. Cunningham, Thomas M. Doherty-Bone, Pria Ghosh, David J. Gower, William E. Hintz, Jacob Hoglund, Thomas S. Jenkinson, Chun-Fu Lin, Anssi Laurila, Adeline Loyau, An Martel, Sara Meurling, Claude Miaud, Pete Minting, Frank Pasmans, Dirk S. Schmeller, Benedikt R. Schmidt, Jennifer M. G. Shelton, Lee F. Skerratt, Freya Smith, Claudio Soto-Azat, Matteo Spagnoletti, Giulia Tessa, Luis Felipe Toledo, Andres Valenzuela-Sanchez, Ruhan Verster, Judit Voros, Rebecca J. Webb, Claudia Wierzbicki, Emma Wombwell, Kelly R. Zamudio, David M. Aanensen, Timothy Y. James, M. Thomas P. Gilbert, Che Weldon, Jaime Bosch, Francois Balloux, Trenton W. J. Garner, Matthew C. Fisher
Article
Multidisciplinary Sciences
Kieran A. Bates, Frances C. Clare, Simon O'Hanlon, Jaime Bosch, Lola Brookes, Kevin Hopkins, Emilia J. McLaughlin, Olivia Daniel, Trenton W. J. Garner, Matthew C. Fisher, Xavier A. Harrison
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Matthew C. Fisher, Pria Ghosh, Jennifer M. G. Shelton, Kieran Bates, Lola Brookes, Claudia Wierzbicki, Goncalo M. Rosa, Rhys A. Farrer, David M. Aanensen, Mario Alvarado-Rybak, Arnaud Bataille, Lee Berger, Susanne Boell, Jaime Bosch, Frances C. Clare, Elodie A. Courtois, Angelica Crottini, Andrew A. Cunningham, Thomas M. Doherty-Bone, Fikirte Gebresenbet, David J. Gower, Jacob Hoglund, Timothy Y. James, Thomas S. Jenkinson, Tiffany A. Kosch, Carolina Lambertini, Anssi Laurila, Chun-Fu Lin, Adeline Loyau, An Martel, Sara Meurling, Claude Miaud, Pete Minting, Serge Ndriantsoa, Simon J. O'Hanlon, Frank Pasmans, Tsanta Rakotonanahary, Falitiana C. E. Rabemananjara, Luisa P. Ribeiro, Dirk S. Schmeller, Benedikt R. Schmidt, Lee Skerratt, Freya Smith, Claudio Soto-Azat, Giulia Tessa, Luis Felipe Toledo, Andres Valenzuela-Sanchez, Ruhan Verster, Judit Voeroes, Bruce Waldman, Rebecca J. Webb, Che Weldon, Emma Wombwell, Kelly R. Zamudio, Joyce E. Longcore, Trenton W. J. Garner
SCIENTIFIC REPORTS
(2018)
Article
Microbiology
Kieran A. Bates, Jennifer M. G. Shelton, Victoria L. Mercier, Kevin P. Hopkins, Xavier A. Harrison, Silviu O. Petrovan, Matthew C. Fisher
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Parasitology
David J. Marcogliese, Kayla C. King, Kieran A. Bates
Summary: Parasites can have significant effects on oxidative stress in frogs exposed to atrazine, with certain parasites interacting with the herbicide to affect protein levels, thiol concentrations, and catalase activity in the frogs. Confounding effects of parasitism should be considered in studies of oxidative stress in natural ecosystems, particularly for amphibians in agricultural landscapes.
Review
Microbiology
Emily J. Stevens, Kieran A. Bates, Kayla C. King
Summary: The host microbiota plays a dual role in infectious diseases, either protecting host health or facilitating infections and disease progression. Factors such as microbiota metabolites utilization and depletion of host defenses can impact the invasion and infection process of pathogens.
Editorial Material
Biochemistry & Molecular Biology
Kieran A. Bates, Kayla C. King
TRENDS IN MICROBIOLOGY
(2021)
Article
Marine & Freshwater Biology
Kieran A. Bates, Chelsea Higgins, Maurine Neiman, Kayla C. King
Summary: This opinion piece argues for considering host sex in studying the microbiota of aquatic animals and highlights the advancements that this information could provide in various fields of life sciences.
Article
Microbiology
Kieran A. Bates, Ulf Sommer, Kevin P. Hopkins, Jennifer M. G. Shelton, Claudia Wierzbicki, Christopher Sergeant, Benjamin Tapley, Christopher J. Michaels, Dirk S. Schmeller, Adeline Loyau, Jaime Bosch, Mark R. Viant, Xavier A. Harrison, Trenton W. J. Garner, Matthew C. Fisher
Summary: The skin microbial community structure of amphibians is linked to the clinical outcome of Batrachochytrium dendrobatidis (8d) infections. This study used multi-omics analyses in laboratory and field settings to demonstrate that 8d infection alters microbiome taxonomic and functional profiles.
Article
Biodiversity Conservation
Jingdi Li, Kieran A. Bates, Kim L. Hoang, Tobias E. Hector, Sarah C. L. Knowles, Kayla C. King
Summary: Global climate change has led to more extreme thermal events, and this study found that microbiome diversity and composition change in response to warming and cooling. Host habitat and experimental factors have a greater impact on microbiome diversity and composition than host biological traits. Aquatic organisms, especially in marine habitats, experience a greater depletion in microbiome diversity under cold conditions compared to terrestrial hosts. The findings improve our understanding of the impact of global temperature changes on animal and plant microbiome structures.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Alejandra Wu-Chuang, Kieran A. Bates, Dasiel Obregon, Agustin Estrada-Pena, Kayla C. King, Alejandro Cabezas-Cruz
Summary: This study used a network approach to investigate the effects of a protective microbial symbiont on the structure and function of a model organism's microbiota. The results showed that the presence of the protective symbiont led to significant changes in the community structure and a decrease in the abundance of the antioxidant synthesis pathway. The findings suggest that protective symbionts not only directly combat pathogens but also have a broader impact on the microbial community.
SCIENTIFIC REPORTS
(2022)
Article
Ecology
K. A. Bates, J. Friesen, A. Loyau, H. Butler, V. T. Vredenburg, J. Laufer, A. Chatzinotas, D. S. Schmeller
Summary: The study investigated how the skin microbiome of wild Dhofar toads in Oman is influenced by host environment, pathogen presence, and host biology. The results showed that skin microbiome diversity is mainly influenced by host life stage, water source, and habitat disturbance. The network analysis revealed high site specificity in bacterial co-occurrence patterns.
Review
Environmental Sciences
Dirk S. Schmeller, Davnah Urbach, Kieran Bates, Jordi Catalan, Dan Cogalniceanu, Matthew C. Fisher, Jan Friesen, Leopold Fuereder, Veronika Gaube, Marilen Haver, Dean Jacobsen, Gael Le Roux, Yu-Pin Lin, Adeline Loyau, Oliver Machate, Andreas Mayer, Ignacio Palomo, Christoph Plutzar, Hugo Sentenac, Ruben Sommaruga, Rocco Tiberti, William J. Ripple
Summary: Mountains are an integral part of the global life-support system, but they face threats such as climate change, overexploitation, and water abstraction. These threats result in reduced biodiversity, impaired ecosystem functioning, and ultimately impact the well-being of animals and humans.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Genetics & Heredity
Pria N. Ghosh, Matthew C. Fisher, Kieran A. Bates
FRONTIERS IN GENETICS
(2018)
