Molecular mechanisms of early plant pattern-triggered immune signaling

A mis‐regulated cyclic nucleotide‐gated channel mediates cytosolic calcium elevation and activates immunity in Arabidopsis

(2021) Chunhui Zhao et al.   NEW PHYTOLOGIST

Spatially Restricted Immune Responses Are Required for Maintaining Root Meristematic Activity upon Detection of Bacteria

(2021) Aurélia Emonet et al.   CURRENT BIOLOGY

Coding of plant immune signals by surface receptors

(2021) Du-Hwa Lee et al.   CURRENT OPINION IN PLANT BIOLOGY

The receptor-like cytoplasmic kinase RIPK regulates broad-spectrum ROS signaling in multiple layers of plant immune system

(2021) Ping Li et al.   Molecular Plant

Effects of Arabidopsis wall associated kinase mutations on ESMERALDA1 and elicitor induced ROS

(2021) Bruce D. Kohorn et al.   PLoS One

Tyrosine phosphorylation of the lectin receptor‐like kinase LORE regulates plant immunity

(2020) Xuming Luo et al.   EMBO JOURNAL

Origin and Diversity of Plant Receptor-Like Kinases

(2020) Anne Dievart et al.   Annual Review of Plant Biology

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

SCHENGEN receptor module drives localized ROS production and lignification in plant roots

(2020) Satoshi Fujita et al.   EMBO JOURNAL

Mass-spectrometry-based draft of the Arabidopsis proteome

(2020) Julia Mergner et al.   NATURE

Ligand-induced monoubiquitination of BIK1 regulates plant immunity

(2020) Xiyu Ma et al.   NATURE

Tomato wall-associated kinase SlWak1 depends on Fls2/Fls3 to promote apoplastic immune responses to Pseudomonas syringae

(2020) Ning Zhang et al.   PLANT PHYSIOLOGY

Regulation of reactive oxygen species during plant immunity through phosphorylation and ubiquitination of RBOHD

(2020) DongHyuk Lee et al.   Nature Communications

Constitutive Activation of Leucine-Rich Repeat Receptor Kinase Signaling Pathways by BAK1-Interacting Receptor-Like Kinase 3 Chimera

(2020) Ulrich Hohmann et al.   PLANT CELL

The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity

(2020) Kathrin Thor et al.   NATURE

The Cotton Wall-associated Kinase GhWAK7A Mediates Responses to Fungal Wilt Pathogens by Complexing with the Chitin Sensory Receptors

(2020) Ping Wang et al.   PLANT CELL

Illuminating the dark phosphoproteome

(2019) Elise J. Needham et al.   Science Signaling

BRASSINOSTEROID-SIGNALING KINASE 3, a plasma membrane-associated scaffold protein involved in early brassinosteroid signaling

(2019) Hong Ren et al.   PLoS Genetics

AtCERK1 phosphorylation site S493 contributes to the transphosphorylation of downstream components for chitin-induced immune signaling

(2019) Maruya Suzuki et al.   PLANT AND CELL PHYSIOLOGY

The Ca2+ Channel CNGC19 Regulates Arabidopsis defense against Spodoptera Herbivory

(2019) Mukesh Kumar Meena et al.   PLANT CELL

BRASSINOSTEROID-SIGNALING KINASE5 associates with immune receptors and is required for immune responses

(2019) Bharat Bhusan Majhi et al.   PLANT PHYSIOLOGY

Apoplastic invasion patterns triggering plant immunity: plasma membrane sensing at the frontline

(2019) Romain Schellenberger et al.   MOLECULAR PLANT PATHOLOGY

A calmodulin-gated calcium channel links pathogen patterns to plant immunity

(2019) Wang Tian et al.   NATURE

Mechanisms of RALF peptide perception by a heterotypic receptor complex

(2019) Yu Xiao et al.   NATURE

ALotus japonicuscytoplasmic kinase connects Nod factor perception by the NFR5 LysM receptor to nodulation

(2019) Jaslyn E. M. M. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice

(2019) Jiachang Wang et al.   CELL RESEARCH

MAP 4K4 associates with BIK 1 to regulate plant innate immunity

(2019) Yunhe Jiang et al.   EMBO REPORTS

Anion channel SLAH3 is a regulatory target of chitin receptor-associated kinase PBL27 in microbial stomatal closure

(2019) Yi Liu et al.   eLife

The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment

(2019) Xiao Yu et al.   CURRENT BIOLOGY

The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity

(2019) Bo Li et al.   Nature Communications

Cross-Microbial Protection via Priming a Conserved Immune Co-Receptor through Juxtamembrane Phosphorylation in Plants

(2019) Ben-Qiang Gong et al.   Cell Host & Microbe

Surface sensor systems in plant immunity

(2019) Isabell Albert et al.   PLANT PHYSIOLOGY

Receptor-Like Cytoplasmic Kinases: Central Players in Plant Receptor Kinase–Mediated Signaling

(2018) Xiangxiu Liang et al.   Annual Review of Plant Biology

A Tyrosine Phosphorylation Cycle Regulates Fungal Activation of a Plant Receptor Ser/Thr Kinase

(2018) Jun Liu et al.   Cell Host & Microbe

The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity

(2018) Neeraj K. Lal et al.   Cell Host & Microbe

Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases

(2018) Xiangxiu Liang et al.   CELL RESEARCH

Differential requirement of BAK1 C-terminal tail in development and immunity

(2018) Di Wu et al.   Journal of Integrative Plant Biology

A Regulatory Module Controlling Homeostasis of a Plant Immune Kinase

(2018) Jinlong Wang et al.   MOLECULAR CELL

Receptor-like Cytoplasmic Kinases Directly Link Diverse Pattern Recognition Receptors to the Activation of Mitogen-activated Protein Kinase Cascades in Arabidopsis

(2018) Guozhi Bi et al.   PLANT CELL

BRASSINOSTEROID-SIGNALING KINASE1 Phosphorylates MAPKKK5 to Regulate Immunity in Arabidopsis

(2018) Haojie Yan et al.   PLANT PHYSIOLOGY

Activation of Toll-like receptors nucleates assembly of the MyDDosome signaling hub

(2018) Sarah Louise Latty et al.   eLife

The MAP4 Kinase SIK1 Ensures Robust Extracellular ROS Burst and Antibacterial Immunity in Plants

(2018) Meixiang Zhang et al.   Cell Host & Microbe

Understanding early TLR signaling through the Myddosome

(2018) Katherine R. Balka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

An extracellular network of Arabidopsis leucine-rich repeat receptor kinases

(2018) Elwira Smakowska-Luzan et al.   NATURE

Phosphocode-dependent functional dichotomy of a common co-receptor in plant signalling

(2018) Artemis Perraki et al.   NATURE

Comparing Arabidopsis receptor kinase and receptor protein-mediated immune signaling reveals BIK1-dependent differences

(2018) Wei-Lin Wan et al.   NEW PHYTOLOGIST

RECEPTOR-LIKE KINASE 902 Associates with and Phosphorylates BRASSINOSTEROID-SIGNALING KINASE1 to Regulate Plant Immunity

(2018) Yaofei Zhao et al.   Molecular Plant

Quantitative phosphoproteomic analysis reveals common regulatory mechanisms between effector- and PAMP-triggered immunity in plants

(2018) Yasuhiro Kadota et al.   NEW PHYTOLOGIST

OsCERK1-Mediated Chitin Perception and Immune Signaling Requires Receptor-like Cytoplasmic Kinase 185 to Activate an MAPK Cascade in Rice

(2017) Chao Wang et al.   Molecular Plant

Rice Chitin Receptor OsCEBiP Is Not a Transmembrane Protein but Targets the Plasma Membrane via a GPI Anchor

(2017) Ben-Qiang Gong et al.   Molecular Plant

The Tomato Kinase Pti1 Contributes to Production of Reactive Oxygen Species in Response to Two Flagellin-Derived Peptides and Promotes Resistance to Pseudomonas syringae Infection

(2017) Simon Schwizer et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Chitin-induced and CHITIN ELICITOR RECEPTOR KINASE1 (CERK1) phosphorylation-dependent endocytosis of Arabidopsis thaliana LYSIN MOTIF-CONTAINING RECEPTOR-LIKE KINASE5 (LYK5)

(2017) Jan Erwig et al.   NEW PHYTOLOGIST

Conservation of Chitin-Induced MAPK Signaling Pathways in Rice and Arabidopsis

(2017) Kenta Yamada et al.   PLANT AND CELL PHYSIOLOGY

The Arabidopsis Leucine-Rich Repeat Receptor Kinase BIR3 Negatively Regulates BAK1 Receptor Complex Formation and Stabilizes BAK1

(2017) Julia Imkampe et al.   PLANT CELL

Differential Regulation of Two-Tiered Plant Immunity and Sexual Reproduction by ANXUR Receptor-Like Kinases

(2017) Hyunggon Mang et al.   PLANT CELL

Arabidopsisglycosylphosphatidylinositol-anchored protein LLG1 associates with and modulates FLS2 to regulate innate immunity

(2017) Qiujing Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling

(2017) Martin Stegmann et al.   SCIENCE

Sensing Danger: Key to Activating Plant Immunity

(2017) Andrea A. Gust et al.   TRENDS IN PLANT SCIENCE

OsRLCK 57, OsRLCK107 and OsRLCK118 Positively Regulate Chitin- and PGN-Induced Immunity in Rice

(2017) Zhangqun Li et al.   Rice

Extracellular ATP elicits DORN1-mediated RBOHD phosphorylation to regulate stomatal aperture

(2017) Dongqin Chen et al.   Nature Communications

OsCNGC13 promotes seed-setting rate by facilitating pollen tube growth in stylar tissues

(2017) Yang Xu et al.   PLoS Genetics

A lectin receptor kinase as a potential sensor for extracellular nicotinamide adenine dinucleotide in Arabidopsis thaliana

(2017) Chenggang Wang et al.   eLife

Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains

(2017) Christoph A Bücherl et al.   eLife

OsBSK1-2, an Orthologous of AtBSK1, Is Involved in Rice Immunity

(2017) Jing Wang et al.   Frontiers in Plant Science

Activation-Dependent Destruction of a Co-receptor by a Pseudomonas syringae Effector Dampens Plant Immunity

(2016) Lei Li et al.   Cell Host & Microbe

The Arabidopsis CERK1‐associated kinase PBL27 connects chitin perception to MAPK activation

(2016) Kenta Yamada et al.   EMBO JOURNAL

Avr4 promotes Cf-4 receptor-like protein association with the BAK1/SERK3 receptor-like kinase to initiate receptor endocytosis and plant immunity

(2016) Jelle Postma et al.   NEW PHYTOLOGIST

Autophosphorylation of Specific Threonine and Tyrosine Residues in Arabidopsis CERK1 is Essential for the Activation of Chitin-Induced Immune Signaling

(2016) Maruya Suzuki et al.   PLANT AND CELL PHYSIOLOGY

Four receptor-like cytoplasmic kinases regulate development and immunity in rice

(2016) Xiaogang Zhou et al.   PLANT CELL AND ENVIRONMENT

CNGC2 Is a Ca 2+ Influx Channel That Prevents Accumulation of Apoplastic Ca 2+ in the Leaf

(2016) Yan Wang et al.   PLANT PHYSIOLOGY

Receptor kinase complex transmits RALF peptide signal to inhibit root growth inArabidopsis

(2016) Changqing Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of sugar transporter activity for antibacterial defense in Arabidopsis

(2016) Kohji Yamada et al.   SCIENCE

Opening the Gates: Insights into Cyclic Nucleotide-Gated Channel-Mediated Signaling

(2016) Thomas A. DeFalco et al.   TRENDS IN PLANT SCIENCE

SERKing Coreceptors for Receptors

(2016) Xiyu Ma et al.   TRENDS IN PLANT SCIENCE

The Arabidopsis Protein Phosphatase PP2C38 Negatively Regulates the Central Immune Kinase BIK1

(2016) Daniel Couto et al.   PLoS Pathogens

Arabidopsis heterotrimeric G proteins regulate immunity by directly coupling to the FLS2 receptor

(2016) Xiangxiu Liang et al.   eLife

Mechanistic insights into EGFR membrane clustering revealed by super-resolution imaging

(2015) Jing Gao et al.   Nanoscale

A lectin S-domain receptor kinase mediates lipopolysaccharide sensing in Arabidopsis thaliana

(2015) Stefanie Ranf et al.   NATURE IMMUNOLOGY

The receptor-like cytoplasmic kinase PCRK1 contributes to pattern-triggered immunity againstPseudomonas syringaeinArabidopsis thaliana

(2015) Suma Sreekanta et al.   NEW PHYTOLOGIST

Guard cell SLAC1-type anion channels mediate flagellin-induced stomatal closure

(2015) Aysin Guzel Deger et al.   NEW PHYTOLOGIST

Regulation of the NADPH Oxidase RBOHD During Plant Immunity

(2015) Yasuhiro Kadota et al.   PLANT AND CELL PHYSIOLOGY

The Receptor-Like Cytoplasmic Kinase OsRLCK102 Regulates XA21-Mediated Immunity and Plant Development in Rice

(2015) Jing Wang et al.   PLANT MOLECULAR BIOLOGY REPORTER

Importance of tyrosine phosphorylation in receptor kinase complexes

(2015) Alberto P. Macho et al.   TRENDS IN PLANT SCIENCE

The Phylogenetically-Related Pattern Recognition Receptors EFR and XA21 Recruit Similar Immune Signaling Components in Monocots and Dicots

(2015) Nicholas Holton et al.   PLoS Pathogens

An RLP23–SOBIR1–BAK1 complex mediates NLP-triggered immunity

(2015) Isabell Albert et al.   Nature Plants

Microbe-associated molecular pattern-induced calcium signaling requires the receptor-like cytoplasmic kinases, PBL1 and BIK1

(2014) Stefanie Ranf et al.   BMC PLANT BIOLOGY

The FLS2-Associated Kinase BIK1 Directly Phosphorylates the NADPH Oxidase RbohD to Control Plant Immunity

(2014) Lei Li et al.   Cell Host & Microbe

A Plant Phosphoswitch Platform Repeatedly Targeted by Type III Effector Proteins Regulates the Output of Both Tiers of Plant Immune Receptors

(2014) Eui-Hwan Chung et al.   Cell Host & Microbe

The Calcium-Dependent Protein Kinase CPK28 Buffers Plant Immunity and Regulates BIK1 Turnover

(2014) Jacqueline Monaghan et al.   Cell Host & Microbe

Receptor like proteins associate with SOBIR1-type of adaptors to form bimolecular receptor kinases

(2014) Andrea A Gust et al.   CURRENT OPINION IN PLANT BIOLOGY

Negative control of BAK1 by protein phosphatase 2A during plant innate immunity

(2014) C. Segonzac et al.   EMBO JOURNAL

Plant PRRs and the Activation of Innate Immune Signaling

(2014) Alberto P. Macho et al.   MOLECULAR CELL

Direct Regulation of the NADPH Oxidase RBOHD by the PRR-Associated Kinase BIK1 during Plant Immunity

(2014) Yasuhiro Kadota et al.   MOLECULAR CELL

Selective regulation of the chitin-induced defense response by the Arabidopsis receptor-like cytoplasmic kinase PBL27

(2014) Tomonori Shinya et al.   PLANT JOURNAL

OsCERK1 and OsRLCK176 play important roles in peptidoglycan and chitin signaling in rice innate immunity

(2014) Ying Ao et al.   PLANT JOURNAL

A Bacterial Tyrosine Phosphatase Inhibits Plant Pattern Recognition Receptor Activation

(2014) A. P. Macho et al.   SCIENCE

Identification of a Plant Receptor for Extracellular ATP

(2014) J. Choi et al.   SCIENCE

The kinase LYK5 is a major chitin receptor in Arabidopsis and forms a chitin-induced complex with related kinase CERK1

(2014) Yangrong Cao et al.   eLife

MAPK Cascades in Plant Disease Resistance Signaling

(2013) Xiangzong Meng et al.   Annual Review of Phytopathology

A Receptor-like Cytoplasmic Kinase Targeted by a Plant Pathogen Effector Is Directly Phosphorylated by the Chitin Receptor and Mediates Rice Immunity

(2013) Koji Yamaguchi et al.   Cell Host & Microbe

Structural Characterization of the RLCK Family Member BSK8: A Pseudokinase with an Unprecedented Architecture

(2013) Christian Grütter et al.   JOURNAL OF MOLECULAR BIOLOGY

BR-SIGNALING KINASE1 Physically Associates with FLAGELLIN SENSING2 and Regulates Plant Innate Immunity in Arabidopsis

(2013) H. Shi et al.   PLANT CELL

Receptor-like kinase SOBIR1/EVR interacts with receptor-like proteins in plant immunity against fungal infection

(2013) T. W. H. Liebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BIK1 interacts with PEPRs to mediate ethylene-induced immunity

(2013) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in FLS2 Ser-938 Dissect Signaling Activation in FLS2-Mediated Arabidopsis Immunity

(2013) Yangrong Cao et al.   PLoS Pathogens

Non-arginine-aspartate (non-RD) kinases are associated with innate immune receptors that recognize conserved microbial signatures

(2012) Chris Dardick et al.   CURRENT OPINION IN PLANT BIOLOGY

A Xanthomonas uridine 5′-monophosphate transferase inhibits plant immune kinases

(2012) Feng Feng et al.   NATURE

The cell wall-associated kinases, WAKs, as pectin receptors

(2012) Bruce D. Kohorn et al.   Frontiers in Plant Science

A Receptor-like Cytoplasmic Kinase Phosphorylates the Host Target RIN4, Leading to the Activation of a Plant Innate Immune Receptor

(2011) Jun Liu et al.   Cell Host & Microbe

Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling

(2011) M. B. Fessler et al.   JOURNAL OF IMMUNOLOGY

The CDG1 Kinase Mediates Brassinosteroid Signal Transduction from BRI1 Receptor Kinase to BSU1 Phosphatase and GSK3-like Kinase BIN2

(2011) Tae-Wuk Kim et al.   MOLECULAR CELL

TheArabidopsisLeucine-Rich Repeat Receptor–Like Kinases BAK1/SERK3 and BKK1/SERK4 Are Required for Innate Immunity to Hemibiotrophic and Biotrophic Pathogens

(2011) Milena Roux et al.   PLANT CELL

Brassinosteroids inhibit pathogen-associated molecular pattern-triggered immune signaling independent of the receptor kinase BAK1

(2011) C. Albrecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brassinosteroids modulate the efficiency of plant immune responses to microbe-associated molecular patterns

(2011) Y. Belkhadir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Ubiquitination of Pattern Recognition Receptor FLS2 Attenuates Plant Innate Immunity

(2011) D. Lu et al.   SCIENCE

Phosphorylation-Dependent Differential Regulation of Plant Growth, Cell Death, and Innate Immunity by the Regulatory Receptor-Like Kinase BAK1

(2011) Benjamin Schwessinger et al.   PLoS Genetics

Phosphotyrosine Signaling: Evolving a New Cellular Communication System

(2010) Wendell A. Lim et al.   CELL

Receptor-like Cytoplasmic Kinases Integrate Signaling from Multiple Plant Immune Receptors and Are Targeted by a Pseudomonas syringae Effector

(2010) Jie Zhang et al.   Cell Host & Microbe

A Conserved Threonine Residue in the Juxtamembrane Domain of the XA21 Pattern Recognition Receptor Is Critical for Kinase Autophosphorylation and XA21-mediated Immunity

(2010) Xuewei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Lysin Motif Receptor-like Kinase (LysM-RLK) CERK1 Is a Major Chitin-binding Protein inArabidopsis thalianaand Subject to Chitin-induced Phosphorylation

(2010) Elena K. Petutschnig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early signaling through the Arabidopsis pattern recognition receptors FLS2 and EFR involves Ca2+-associated opening of plasma membrane anion channels

(2010) Elena Jeworutzki et al.   PLANT JOURNAL

A domain swap approach reveals a role of the plant wall-associated kinase 1 (WAK1) as a receptor of oligogalacturonides

(2010) A. Brutus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Renaissance of Elicitors: Perception of Microbe-Associated Molecular Patterns and Danger Signals by Pattern-Recognition Receptors

(2009) Thomas Boller et al.   Annual Review of Plant Biology

A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity

(2009) D. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4

(2009) H. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide Functional Investigation into the Roles of Receptor-Like Proteins in Arabidopsis

(2008) G. Wang et al.   PLANT PHYSIOLOGY

BSKs Mediate Signal Transduction from the Receptor Kinase BRI1 in Arabidopsis

(2008) W. Tang et al.   SCIENCE

Rice XB15, a Protein Phosphatase 2C, Negatively Regulates Cell Death and XA21-Mediated Innate Immunity

(2008) Chang-Jin Park et al.   PLOS BIOLOGY