MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer

MG53 as a Novel Therapeutic Protein to Treat Acute Lung Injury

(2021) Bryan A Whitson et al.   MILITARY MEDICINE

MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine

(2021) Zhongguang Li et al.   Cells

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration

(2021) Bryan A. Whitson et al.   CURRENT OPINION IN PHARMACOLOGY

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

MG53 does not manifest the development of diabetes in db/db mice

(2020) Qiang Wang et al.   DIABETES

Treatment of cancer cells with Lapatinib negatively regulates general translation and induces stress granules formation

(2020) Pauline Adjibade et al.   PLoS One

MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling

(2020) Matthew Sermersheim et al.   Nature Communications

Recombinant MG53 Protein Protects Mice from Lethal Influenza Virus Infection

(2020) Adam D. Kenney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications

(2020) Noémie Legrand et al.   WORLD JOURNAL OF GASTROENTEROLOGY

In vivo profiling of metastatic double knockouts through CRISPR–Cpf1 screens

(2019) Ryan D. Chow et al.   NATURE METHODS

Elevated expression of G3BP1 associates with YB1 and p‐AKT and predicts poor prognosis in nonsmall cell lung cancer patients after surgical resection

(2019) Hongmei Zheng et al.   Cancer Medicine

Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

(2019) Zehua Bian et al.   Nature Communications

The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury

(2019) Fangxia Guan et al.   Stem Cell Research & Therapy

Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells

(2018) Shikshya Timalsina et al.   JOURNAL OF BIOCHEMISTRY

Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer

(2018) Ken-ichi Takayama et al.   MOLECULAR CANCER RESEARCH

Stress granule-associated protein G3BP2 regulates breast tumor initiation

(2017) Nisha Gupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic insights into mammalian stress granule dynamics

(2016) Marc D. Panas et al.   JOURNAL OF CELL BIOLOGY

Impairment of stress granule assembly via inhibition of the eIF2alpha phosphorylation sensitizes glioma cells to chemotherapeutic agents

(2016) Fabrício de Almeida Souza Vilas-Boas et al.   JOURNAL OF NEURO-ONCOLOGY

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

MG53 permeates through blood-brain barrier to protect ischemic brain injury

(2016) Yonggang Yao et al.   Oncotarget

Vinca alkaloid drugs promote stress-induced translational repression and stress granule formation

(2016) Witold Szaflarski et al.   Oncotarget

Poly(A)-binding proteins and mRNA localization: who rules the roost?

(2015) N. K. Gray et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Stress granules, P-bodies and cancer

(2015) Paul Anderson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

Upregulation of MG53 Induces Diabetic Cardiomyopathy Through Transcriptional Activation of Peroxisome Proliferation-Activated Receptor  

(2015) F. Liu et al.   CIRCULATION

Overexpression of Ras-GTPase-activating protein SH3 domain-binding protein 1 correlates with poor prognosis in gastric cancer patients

(2015) Lingqiang Min et al.   HISTOPATHOLOGY

Modulation of Wound Healing and Scar Formation by MG53 Protein-mediated Cell Membrane Repair

(2015) Haichang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes

(2015) Chuanxi Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

(2015) Syam Prakash Somasekharan et al.   JOURNAL OF CELL BIOLOGY

Cardioprotection of recombinant human MG53 protein in a porcine model of ischemia and reperfusion injury

(2015) Jianxun Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Amelioration of ischemia-reperfusion-induced muscle injury by the recombinant human MG53 protein

(2015) Hua Zhu et al.   MUSCLE & NERVE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

MG53-mediated cell membrane repair protects against acute kidney injury

(2015) Pu Duann et al.   Science Translational Medicine

Sorafenib, a multikinase inhibitor, induces formation of stress granules in hepatocarcinoma cells

(2015) Pauline Adjibade et al.   Oncotarget

Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment

(2015) Gejing De et al.   Oncotarget

GW25-e3518 The Changes of Desmosomal Protein Expression Level in Arrhythmogenic Right Ventricular Cardiomyopathy in Chinese Patients With Pathogenic Desmosome Mutations

(2014) Wang Li et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

5-Fluorouracil affects assembly of stress granules based on RNA incorporation

(2014) Christian Kaehler et al.   NUCLEIC ACIDS RESEARCH

Anoctamin 6 Regulates C2C12 Myoblast Proliferation

(2014) Piming Zhao et al.   PLoS One

Treatment of acute lung injury by targeting MG53-mediated cell membrane repair

(2014) Yanlin Jia et al.   Nature Communications

Mitsugumin 53 (MG53) Ligase Ubiquitinates Focal Adhesion Kinase during Skeletal Myogenesis

(2013) Nga Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

(2013) Ruisheng Song et al.   NATURE

Stress granules and cell signaling: more than just a passing phase?

(2013) Nancy Kedersha et al.   TRENDS IN BIOCHEMICAL SCIENCES

MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling

(2013) Jae-Sung Yi et al.   Nature Communications

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BrafV600E-Driven Lung Tumors

(2013) A. M. Strohecker et al.   Cancer Discovery

GAP161 targets and downregulates G3BP to suppress cell growth and potentiate cisplaitin-mediated cytotoxicity to colon carcinoma HCT116 cells

(2012) Hao Zhang et al.   CANCER SCIENCE

Both G3BP1 and G3BP2 contribute to stress granule formation

(2012) Hideaki Matsuki et al.   GENES TO CELLS

Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules

(2012) Ken Fujimura et al.   NUCLEIC ACIDS RESEARCH

PKCα Binds G3BP2 and Regulates Stress Granule Formation Following Cellular Stress

(2012) Tamae Kobayashi et al.   PLoS One

Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy

(2012) N. Weisleder et al.   Science Translational Medicine

Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair

(2011) Moonsun Hwang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A versatile single-plasmid system for tissue-specific and inducible control of gene expression in transgenic mice

(2011) Jae-Kyun Ko et al.   FASEB JOURNAL

The chemotherapeutic agent bortezomib induces the formation of stress granules

(2010) Marie-Josée Fournier et al.   Cancer Cell International

p53 stabilization: the importance of nuclear import

(2010) J-C Marine   CELL DEATH AND DIFFERENTIATION

Cardioprotection of Ischemia/Reperfusion Injury by Cholesterol-Dependent MG53-Mediated Membrane Repair

(2010) Xianhua Wang et al.   CIRCULATION RESEARCH

Stress granules

(2009) Paul Anderson et al.   CURRENT BIOLOGY

Membrane Repair Defects in Muscular Dystrophy Are Linked to Altered Interaction between MG53, Caveolin-3, and Dysferlin

(2009) Chuanxi Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties

(2008) Marco Sardiello et al.   BMC EVOLUTIONARY BIOLOGY

MG53 Regulates Membrane Budding and Exocytosis in Muscle Cells

(2008) Chuanxi Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

(2008) Kyoko Arimoto et al.   NATURE CELL BIOLOGY

MG53 nucleates assembly of cell membrane repair machinery

(2008) Chuanxi Cai et al.   NATURE CELL BIOLOGY

A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly

(2008) Takbum Ohn et al.   NATURE CELL BIOLOGY

Stress granules: the Tao of RNA triage

(2008) Paul Anderson et al.   TRENDS IN BIOCHEMICAL SCIENCES