Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

Exploring the binding mechanism between human profilin (PFN1) and polyproline-10 through binding mode screening

(2019) Leili Zhang et al.   JOURNAL OF CHEMICAL PHYSICS

Acute Effects of Riluzole and Retigabine on Axonal Excitability in Patients With Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

(2018) Maria O. Kovalchuk et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Revealing the architecture of protein complexes by an orthogonal approach combining HDXMS, CXMS, and disulfide trapping

(2018) Kunhong Xiao et al.   Nature Protocols

Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis

(2018) Mina Nekouei et al.   METABOLIC BRAIN DISEASE

ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation

(2018) Mahmoud Kiaei et al.   Scientific Reports

PubChem 2019 update: improved access to chemical data

(2018) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Profilin1 biology and its mutation, actin(g) in disease

(2016) Duah Alkam et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Getting to the core of protein pharmaceuticals – Comprehensive structure analysis by mass spectrometry

(2015) Ulrike Leurs et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Improved Peptide and Protein Torsional Energetics with the OPLS-AA Force Field

(2015) Michael J. Robertson et al.   Journal of Chemical Theory and Computation

Hydrogen-Deuterium Exchange Mass Spectrometry as an Emerging Analytical Tool for Stabilization and Formulation Development of Therapeutic Monoclonal Antibodies

(2015) Ranajoy Majumdar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The power of mass spectrometry in structural characterization of GPCR signaling

(2015) Kunhong Xiao et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

A revision of the El Escorial criteria - 2015

(2015) Albert Ludolph et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?

(2015) Shynrye Lee et al.   Experimental Neurobiology

Flexible membrane proteins: functional dynamics captured by mass spectrometry

(2014) Min Zhou et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

(2013) Hui Wei et al.   DRUG DISCOVERY TODAY

PFN1 mutations are rare in Han Chinese populations with amyotrophic lateral sclerosis

(2013) YongPing Chen et al.   NEUROBIOLOGY OF AGING

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

(2013) Nikolai Hentze et al.   Jove-Journal of Visualized Experiments

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

FTMAP: extended protein mapping with user-selected probe molecules

(2012) C. H. Ngan et al.   NUCLEIC ACIDS RESEARCH

Chemical Cross-Linking and H/D Exchange for Fast Refinement of Protein Crystal Structure

(2011) Daniel Rozbesky et al.   ANALYTICAL CHEMISTRY

Ligand-Dependent Perturbation of the Conformational Ensemble for the GPCR β2 Adrenergic Receptor Revealed by HDX

(2011) Graham M. West et al.   STRUCTURE

Conformational Changes in the G Protein-Coupled Receptor Rhodopsin Revealed by Histidine Hydrogen−Deuterium Exchange

(2010) David T. Lodowski et al.   BIOCHEMISTRY

Refined solution structure of human profilin I

(2010) William J. Metzler et al.   PROTEIN SCIENCE

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Profilin Interaction with Phosphatidylinositol (4,5)-Bisphosphate Destabilizes the Membrane of Giant Unilamellar Vesicles

(2009) Kannan Krishnan et al.   BIOPHYSICAL JOURNAL

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structure Determination of Protein−Protein Complexes Using NMR Chemical Shifts: Case of an Endonuclease Colicin−Immunity Protein Complex

(2008) Rinaldo W. Montalvao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY