COVID‐19 and the liver: A 2021 update

Multi-organ proteomic landscape of COVID-19 autopsies

(2021) Xiu Nie et al.   CELL

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19

(2021) Yun Kit Yeoh et al.   GUT

SARS-CoV-2 infection in patients with autoimmune hepatitis

(2021) Thomas Marjot et al.   JOURNAL OF HEPATOLOGY

SARS-CoV-2 vaccination in patients with liver disease: responding to the next big question

(2021) Thomas Marjot et al.   Lancet Gastroenterology & Hepatology

AASLD Expert Panel Consensus Statement: Vaccines to Prevent COVID‐19 Infection in Patients with Liver Disease

(2021) Oren K. Fix et al.   HEPATOLOGY

EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients

(2021) Markus Cornberg et al.   JOURNAL OF HEPATOLOGY

Age and comorbidity are central to the risk of death from COVID-19 in liver transplant recipients.

(2021) Gwilym J. Webb et al.   JOURNAL OF HEPATOLOGY

SARS-CoV-2 variants and ending the COVID-19 pandemic

(2021) Arnaud Fontanet et al.   LANCET

Sixteen novel lineages of SARS-CoV-2 in South Africa

(2021) Houriiyah Tegally et al.   NATURE MEDICINE

COVID-19 and liver disease: mechanistic and clinical perspectives

(2021) Thomas Marjot et al.   Nature Reviews Gastroenterology & Hepatology

Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

(2021) Robert Challen et al.   BMJ-British Medical Journal

Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity

(2021) Janie F. Shelton et al.   NATURE GENETICS

Hepatocellular carcinoma demonstrates heterogeneous growth patterns in a multi‐center cohort of patients with cirrhosis

(2020) Nicole E. Rich et al.   HEPATOLOGY

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

COVID-19 Presenting as Acute Hepatitis

(2020) Praneet Wander et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses

(2020) Furong Qi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Clinical Characteristics and Outcomes of COVID-19 Among Patients with Pre-Existing Liver Disease in United States: A Multi-Center Research Network Study

(2020) Shailendra Singh et al.   GASTROENTEROLOGY

Considerations in performing endoscopy during the COVID-19 pandemic

(2020) Roy Soetikno et al.   GASTROINTESTINAL ENDOSCOPY

Liver Biochemistries in Hospitalized Patients With COVID‐19

(2020) Patricia P. Bloom et al.   HEPATOLOGY

Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID‐19 Pandemic: AASLD Expert Panel Consensus Statement

(2020) Oren K. Fix et al.   HEPATOLOGY

Longitudinal association between markers of liver injury and mortality in COVID‐19 in China

(2020) Fang Lei et al.   HEPATOLOGY

Acute Liver Injury in COVID‐19: Prevalence and Association with Clinical Outcomes in a Large US Cohort

(2020) Meaghan M. Phipps et al.   HEPATOLOGY

Clinical practice guidance for hepatology and liver transplant providers during the COVID-19 pandemic: APASL expert panel consensus recommendations

(2020) George Lau et al.   Hepatology International

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

(2020) Safiya Richardson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19

(2020) Yijin Wang et al.   JOURNAL OF HEPATOLOGY

COVID-19: Abnormal liver function tests

(2020) Qingxian Cai et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study

(2020) Dong Ji et al.   JOURNAL OF HEPATOLOGY

Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19

(2020) Ishan Paranjpe et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up

(2020) Behnood Bikdeli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

SARS‐CoV‐2 virus and liver expression of host receptors: Putative mechanisms of liver involvement in COVID‐19

(2020) Carlos J Pirola et al.   LIVER INTERNATIONAL

COVID‐19 and liver disease

(2020) Jian Sun et al.   LIVER INTERNATIONAL

Coronaviruses and Immunosuppressed Patients: The Facts During the Third Epidemic

(2020) Lorenzo D’Antiga   LIVER TRANSPLANTATION

Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies

(2020) Sufang Tian et al.   MODERN PATHOLOGY

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver diseases in COVID-19: Etiology, treatment and prognosis

(2020) Jian Wu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

(2020) Tao Chen et al.   BMJ-British Medical Journal

Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 — United States, February 12–March 28, 2020

(2020) et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID-19: a systematic review and meta-analysis

(2020) Ren Mao et al.   Lancet Gastroenterology & Hepatology

Liver injury in COVID-19: management and challenges

(2020) Chao Zhang et al.   Lancet Gastroenterology & Hepatology

SARS‐CoV‐2 infection and early mortality of wait‐listed and solid organ transplant recipients in England: a national cohort study

(2020) Rommel Ravanan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort

(2020) Jasmohan S Bajaj et al.   GUT

Abnormal Liver Tests in COVID‐19: A Retrospective Observational Cohort Study of 1827 Patients in a Major U.S. Hospital Network

(2020) Melanie A. Hundt et al.   HEPATOLOGY

Prevalence of chronic liver disease in patients with COVID-19 and their clinical outcomes: a systematic review and meta-analysis

(2020) Alexander J. Kovalic et al.   Hepatology International

Is the increased risk for MAFLD patients to develop severe COVID-19 linked to perturbation of the gut-liver axis?

(2020) Gabriella Assante et al.   JOURNAL OF HEPATOLOGY

Epidemiological pattern, incidence and outcomes of COVID-19 in liver transplant patients.

(2020) Jordi Colmenero et al.   JOURNAL OF HEPATOLOGY

High rates of 30-day mortality in patients with cirrhosis and COVID-19

(2020) Massimo Iavarone et al.   JOURNAL OF HEPATOLOGY

Abnormal liver function tests predict transfer to intensive care unit and death in COVID‐19

(2020) Salvatore Piano et al.   LIVER INTERNATIONAL

Impact of chronic liver disease on outcomes of hospitalized patients with COVID‐19: A multicentre United States experience

(2020) Nikroo Hashemi et al.   LIVER INTERNATIONAL

Liver histopathology in severe COVID 19 respiratory failure is suggestive of vascular alterations

(2020) Aurelio Sonzogni et al.   LIVER INTERNATIONAL

Metabolic‐associated fatty liver disease is associated with severity of COVID‐19

(2020) Yu‐Jie Zhou et al.   LIVER INTERNATIONAL

Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data

(2020) Stephen M. Lagana et al.   MODERN PATHOLOGY

Factors associated with COVID-19-related death using OpenSAFELY

(2020) Elizabeth J. Williamson et al.   NATURE

Extrapulmonary manifestations of COVID-19

(2020) Aakriti Gupta et al.   NATURE MEDICINE

Pharmacologic Treatment of Transplant Recipients Infected With SARS-CoV-2

(2020) Laure Elens et al.   THERAPEUTIC DRUG MONITORING

COVID-19 and the liver: little cause for concern

(2020) Mansoor N Bangash et al.   Lancet Gastroenterology & Hepatology

Clinical Characteristics of COVID-19 Patients With Pre-existing Hepatitis B Virus Infection

(2020) Qing He et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Predictors of Outcomes of COVID-19 in Patients with Chronic Liver Disease: US Multi-center Study

(2020) Donghee Kim et al.   Clinical Gastroenterology and Hepatology

Liver Injury in Liver Transplant Recipients with Coronavirus Disease 2019 (COVID‐19): US Multicenter Experience

(2020) Atoosa Rabiee et al.   HEPATOLOGY

Sofosbuvir/daclatasvir regimens for the treatment of COVID-19: an individual patient data meta-analysis

(2020) Bryony Simmons et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study

(2020) Thomas Marjot et al.   JOURNAL OF HEPATOLOGY

Rates and characteristics of SARS‐CoV‐2 infection in persons with hepatitis C virus infection

(2020) Adeel A. Butt et al.   LIVER INTERNATIONAL

Risk Factors for Hospitalization, Mechanical Ventilation, or Death Among 10 131 US Veterans With SARS-CoV-2 Infection

(2020) George N. Ioannou et al.   JAMA Network Open

Little to no expression of angiotensin‐converting enzyme‐2 on most human peripheral blood immune cells but highly expressed on tissue macrophages

(2020) Xiang Song et al.   CYTOMETRY PART A

Protective role of tacrolimus, deleterious role of age and comorbidities in liver transplant recipients with Covid-19: results from the ELITA/ELTR multi-center European study

(2020) Luca S. Belli et al.   GASTROENTEROLOGY

WGO Guidance for the Care of Patients With COVID-19 and Liver Disease

(2020) Saeed Hamid et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

(2020) Merryn Voysey et al.   LANCET

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data

(2020) Luis Antonio Díaz et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effectiveness of influenza vaccines in adults with chronic liver disease: a systematic review and meta-analysis

(2019) Suvi Härmälä et al.   BMJ Open

Response to hepatitis B vaccination in patients with liver cirrhosis

(2017) Ioanna Aggeletopoulou et al.   REVIEWS IN MEDICAL VIROLOGY

Evolution of the immune system in humans from infancy to old age

(2015) A. Katharina Simon et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Management of infections pre- and post-liver transplantation: Report of an AISF consensus conference

(2014) Stefano Fagiuoli et al.   JOURNAL OF HEPATOLOGY

Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma

(2014) Alessandro Cucchetti et al.   JOURNAL OF HEPATOLOGY

Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis

(2012) Erica Villa et al.   GASTROENTEROLOGY

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY