LncAY controls BMI1 expression and activates BMI1/Wnt/β-catenin signaling axis in hepatocellular carcinoma

METTL3/YTHDF2 m 6 A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer

(2020) Haiyun Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

(2020) Bo Tang et al.   Molecular Cancer

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network

(2019) Maosheng Cheng et al.   ONCOGENE

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

(2019) Jasmin Paris et al.   Cell Stem Cell

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

(2019) Ting Li et al.   Molecular Cancer

YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma

(2019) Jiajie Hou et al.   Molecular Cancer

Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis

(2019) Bin Li et al.   ONCOGENE

Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

(2018) Tanmoy Mondal et al.   CANCER CELL

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

Molecular therapies and precision medicine for hepatocellular carcinoma

(2018) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

Unique features of long non-coding RNA biogenesis and function

(2016) Jeffrey J. Quinn et al.   NATURE REVIEWS GENETICS

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibiting initiation — targeting BMI1 is effective

(2016) Louise Stone   Nature Reviews Urology

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical significance of OCT4 and SOX2 protein expression in cervical cancer

(2015) Bo Wook Kim et al.   BMC CANCER

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

(2015) Xiao Wang et al.   CELL

A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma

(2014) Ji-hang Yuan et al.   CANCER CELL

Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

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Validation of Bmi1 as a Therapeutic Target of Hepatocellular Carcinoma in Mice

(2014) Shibo Qi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Internal mRNA Methylation Finally Finds Functions

(2014) T. W. Nilsen   SCIENCE

Co-delivery of Doxorubicin and Bmi1 siRNA by Folate Receptor Targeted Liposomes Exhibits Enhanced Anti-Tumor Effects in vitro and in vivo

(2014) Tan Yang et al.   Theranostics

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer

(2012) Karim Nacerddine et al.   JOURNAL OF CLINICAL INVESTIGATION

BMI1 as a novel target for drug discovery in cancer

(2011) Liangxian Cao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Bmi-1 Is a Crucial Regulator of Prostate Stem Cell Self-Renewal and Malignant Transformation

(2010) Rita U. Lukacs et al.   Cell Stem Cell

Current status of molecularly targeted therapy for hepatocellular carcinoma: basic science

(2010) Shinji Tanaka et al.   International Journal of Clinical Oncology

gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis

(2009) Julia Bollrath et al.   CANCER CELL

Targeted depletion of BMI1 sensitizes tumor cells to P53-mediated apoptosis in response to radiation therapy

(2009) N M Alajez et al.   CELL DEATH AND DIFFERENTIATION

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics

(2009) Isabelle Bisson et al.   CELL RESEARCH

The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

(2009) Li-Bing Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Bmi1 Functions as an Oncogene Independent of Ink4A/Arf Repression in Hepatic Carcinogenesis

(2009) C.-R. Xu et al.   MOLECULAR CANCER RESEARCH

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma

(2008) T. Chiba et al.   CANCER RESEARCH

Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene

(2008) Benjamin Cieply et al.   HEPATOLOGY

Expression and clinical significance of the stem cell marker CD133 in hepatocellular carcinoma

(2008) W. Song et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE