Review
Physiology
Kai Qu, Fang Yan, Xian Qin, Kun Zhang, Wen He, Mingqing Dong, Guicheng Wu
Summary: Mitochondria play a crucial role in generating ATP and their dysfunction can lead to various cellular pathologies, including atherosclerosis. Endothelial mitochondrial dysfunction contributes to abnormal endothelial function and the development of atherosclerosis. Risk factors associated with atherosclerosis, such as high glucose levels, hypertension, and diabetes, can induce mitochondrial dysfunction in endothelial cells.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Hematology
Arada Vinaiphat, Kalailingam Pazhanchamy, Gnanasekaran JebaMercy, SoFong Cam Ngan, Melvin Khee-Shing Leow, Hee Hwa Ho, Yong-Gui Gao, Kah Leong Lim, A. Mark Richards, Dominique P. V. de Kleijn, Christopher P. Chen, Raj N. Kalaria, Jian Liu, Deborah D. O'Leary, Neil E. McCarthy, Siu Kwan Sze
Summary: This study investigates the effects of high salt intake on endothelial cells and vascular structure. It shows that high salt diet decreases the expression of proteins in the endothelial glycocalyx and alters protein mediators in endothelial cells, leading to vascular pathology and increased cardiovascular risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Vadim Z. Z. Lankin, Alla K. K. Tikhaze, Arthur M. M. Melkumyants
Summary: This mini review discusses the role of malondialdehyde (MDA) in the molecular mechanisms of primary atherosclerotic vascular wall lesions. It highlights the important role of chemically modified LDL particles containing MDA in atherogenesis, rather than oxidized LDL. The review also presents experimental evidence of MDA damaging the endothelial glycocalyx, impairing the endothelium's ability to regulate arterial tone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Lawrence Fred Sembajwe, Abdul M. Ssekandi, Agnes Namaganda, Haruna Muwonge, Josephine N. Kasolo, Robert Kalyesubula, Annettee Nakimuli, Mwesigwa Naome, Kaushik P. Patel, Sepiso K. Masenga, Annet Kirabo
Summary: The glycocalyx is involved in cell-surface interactions and plays a crucial role in endothelial cell function. It protects cells from excessive salt exposure and damage to blood vessels. Cardiovascular diseases can be caused by dysfunction or irregular maintenance of the glycocalyx. The components of the glycocalyx can be used as biomarkers or drug targets in managing cardiovascular diseases.
Review
Cell Biology
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu
Summary: The glycocalyx plays a crucial role in inflammation and the development of vascular diseases, with endothelial dysfunction potentially leading to tissue swelling, chronic inflammation, and thrombosis. Eliminating endothelial inflammation may be a key target for treating vascular diseases. Research indicates that by disrupting the cycle of endothelial dysfunction and inflammation, the glycocalyx can help alleviate the progression of inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyun Cao, Yalan Wu, Huiling Hong, Xiao Yu Tian
Summary: Atherosclerosis is linked to endothelial dysfunction and vascular inflammation, and SIRT3 and NAD(+) play critical roles in maintaining normal mitochondrial function and improving endothelial function. The deletion of SIRT3 in endothelial cells accelerates atherosclerosis and amplifies vascular inflammation and oxidative stress. Treatment with NAD(+) attenuates these effects. The study also shows that NAD(+) supplementation improves endothelial function and reduces plaque formation in mouse models of atherosclerosis.
Review
Biochemistry & Molecular Biology
Ghassan Bkaily, Yanick Simon, Ashley Jazzar, Houssein Najibeddine, Alexandre Normand, Danielle Jacques
Summary: Our understanding of essential hypertension is extensive, and while its treatment is well-known, not all individuals with hypertension are salt-sensitive. Even normotensive individuals may face increased cardiovascular risks with a high salt diet. Research on the mechanisms and treatment of hypertension sensitive to high-sodium diets is crucial.
Article
Chemistry, Multidisciplinary
Zhi-chao Dong, Ming-ming Wu, Yun-long Zhang, Qiu-shi Wang, Chen Liang, Xiao Yan, Lei-xin Zou, Chen Chen, Xiao Han, Bo Zhang, Zhi-ren Zhang
Summary: Aflibercept induces vascular dysfunction and hypertension by inhibiting CAT-1/AKT/eNOS/NO signaling, increasing ET-1, and activating NOX1/NOX4-mediated oxidative stress, but these effects can be attenuated by supplementation of L-arginine.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Liujun Jiang, Xiaolei Sun, Jiacheng Deng, Yanhua Hu, Qingbo Xu
Summary: Significant progress has been made in understanding the nature and functions of vascular stem cells, particularly in cardiovascular research. Recent studies using genetic lineage tracing mouse models have shed light on the behaviors of these cells during physiological angiogenesis and in vascular diseases. Further research using new techniques is crucial to fully elucidate the role of vascular stem cells in development and diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Alessandra Puddu, Fabrizio Montecucco, Davide Maggi
Summary: Caveolae are cell surface plasma membrane invaginations observed in terminally differentiated cells, characterized by the presence of caveolin-1. They play a central role in regulating atherosclerosis and can have both pro-atherogenic and anti-atherogenic functions depending on the cell type examined. This study focuses on the role of caveolin-1 in regulating the fate of LDLs in endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Mamali Das, Kasi Pandima Devi, Tarun Belwal, Hari Prasad Devkota, Devesh Tewari, Adeleh Sahebnasagh, Seyed Fazel Nabavi, Hamid Reza Khayat Kashani, Mahsa Rasekhian, Suowen Xu, Mehran Amirizadeh, Kiumarth Amini, Maciej Banach, Jianbo Xiao, Safieh Aghaabdollahian, Seyed Mohammad Nabavi
Summary: Vascular diseases are caused by abnormal endothelial response, resulting in atherosclerosis, hypercholesterolemia, etc. Polyphenols have antioxidative, anti-inflammatory, and anti-hypertensive properties, beneficial for preventing endothelial dysfunction.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Xuesong Li, Xiang Chen, Longbin Zheng, Minghong Chen, Yunjia Zhang, Ruigong Zhu, Jiajing Chen, Jiaming Gu, Quanwen Yin, Hong Jiang, Xuan Wu, Xian Ji, Xin Tang, Mengdie Dong, Qingguo Li, Yuanqing Gao, Hongshan Chen
Summary: This study reveals the activation of the non-canonical STING-PERK pathway in atherosclerosis, which increases BRD4 expression and promotes the transactivation of proinflammatory cytokines. This pathway is triggered by leaked mitochondrial DNA via interaction with oxidized mtDNA. Endothelial STING activation plays a significant role in atherosclerosis.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Medicine, Research & Experimental
Stephani Correia Brazao, Gabriel Ferreira Lima, Lis Jappour Autran, Ana Beatriz Araujo Mendes, Beatriz Alexandre dos Santos, Dangelo Carlo Magliano, Fernanda Carla Ferreira de Brito, Nadia Alice Vieira Motta
Summary: Cilostazol exhibits important anti-inflammatory and vasculoprotective effects on the aortas of hypercholesterolemic rats, possibly through inhibition of the PLC-gamma / PKC-alpha / p38-MAPK / I kappa B-alpha / NF-kB pathway and activation of the PKA / eNOS / PKG pathway.
Review
Biochemistry & Molecular Biology
Michael Poledniczek, Christoph Neumayer, Christoph W. Kopp, Oliver Schlager, Thomas Gremmel, Alicja Jozkowicz, Michael E. Gschwandtner, Renate Koppensteiner, Patricia P. Wadowski
Summary: Inflammation plays a crucial role in the development and progression of atherosclerosis. It negatively affects endothelial barrier properties, glycocalyx, and extracellular matrix composition, leading to vascular remodeling, aneurysm formation, and reduced tissue perfusion. This review discusses the molecular and clinical effects of inflammatory processes on micro- and macrovasculature, with a focus on peripheral artery disease.
Review
Peripheral Vascular Disease
Fabrizio Buffolo, Silvia Monticone, Giovanni Camussi, Elena Aikawa
Summary: Extracellular vesicles (EVs) are membrane-bound structures released by cells that play a pathological role in vascular damage. They facilitate cell-to-cell communication by transferring nucleic acids, protein cargos, and metabolites. EVs promote endothelial dysfunction, vascular inflammation, and contribute to plaque formation and vascular calcification.
Article
Biochemistry & Molecular Biology
Murilo E. Graton, Simone R. Potje, Jessica A. Troiano, Gabriel T. Vale, Ligia A. Perassa, Ana Claudia M. S. Nakamune, Carlos R. Tirapelli, Lusiane M. Bendhack, Cristina Antoniali
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Alice V. Araujo, Fernanda A. Andrade, Michele Paulo, Tiago D. de Paula, Simone R. Potje, Amanda C. Pereira, Lusiane M. Bendhack
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Simone R. Potje, Marcella D. Grando, Andreia Z. Chignalia, Cristina Antoniali, Lusiane M. Bendhack
SCIENTIFIC REPORTS
(2019)
Article
Neurosciences
Barbara Falquetto, Karina Thieme, Marilia B. Malta, Karina C. E. Rocha, Marina Tuppy, Simone R. Potje, Cristina Antoniali, Alice C. Rodrigues, Carolina D. Munhoz, Thiago S. Moreira, Ana C. Takakura
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Medicine, Research & Experimental
Jessica A. Troiano, Simone R. Potje, Murilo E. Graton, Daniela S. Silva, Rafael M. da Costa, Rita C. Tostes, Cristina Antoniali
Summary: Pregnancy decreases the content of vascular O-GlcNAc-modified proteins. Increased OGA activity and decreased O-GlcNAc modification of eNOS boost eNOS activity in arteries of P-Wistar rats. In P-SHR, altered OGA activity may lower the content of O-GlcNAc-modified proteins, but decreased OGT activity seems a potential mechanism to reduce glycosylation.
Article
Medicine, Research & Experimental
Simone R. Potje, Tiago J. Costa, Thais F. C. Fraga-Silva, Ronaldo B. Martins, Maira N. Benatti, Carlos E. L. Almado, Keyla S. G. de Sa, Vania L. D. Bonato, Eurico Arruda, Paulo Louzada-Junior, Rene D. R. Oliveira, Dario S. Zamboni, Christiane Becari, Maria Auxiliadora-Martins, Rita C. Tostes
Summary: Plasma from COVID-19 patients promotes glycocalyx shedding and redox imbalance in endothelial cells, and heparin treatment potentially inhibits glycocalyx disruption.
Review
Biochemistry & Molecular Biology
Marta T. Gomes, Yang Bai, Simone R. Potje, Lu Zhang, Angelia D. Lockett, Roberto F. Machado
Summary: This review discusses the role of bioenergetic and inflammatory impairments in the development of pulmonary arterial hypertension (PAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Simone R. Potje, Ayman Isbatan, Rita C. Tostes, Lusiane M. Bendhack, Randal O. Dull, Joao L. Carvalho-de-Souza, Andreia Z. Chignalia
Summary: The study demonstrated that glypican 1 plays a crucial role in the development of noradrenergic hypertension by acting through IP3R and calcium-dependent signaling pathways. Knockout mice lacking glypican 1 were uniquely protected from a norepinephrine hypertensive challenge, indicating its potential as a target for new therapies for resistant hypertension or conditions with increased norepinephrine levels.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Tiago J. Costa, Simone R. Potje, Thais F. C. Fraga-Silva, Julio A. Da Silva-Neto, Paula R. Barros, Daniel Rodrigues, Mirele R. Machado, Ronaldo B. Martins, Rosangela A. Santos-Eichler, Maira N. Benatti, Keyla S. G. de Sa, Carlos Eduardo L. Almado, Italo A. Castro, Marjorie C. Pontelli, Leonardo La Serra, Fernando S. Carneiro, Christiane Becari, Paulo Louzada-Junior, Rene D. R. Oliveira, Dario S. Zamboni, Eurico Arruda, Maria Auxiliadora-Martins, Fernanda R. C. Giachini, Vania L. D. Bonato, Natasha E. Zachara, Gisele F. Bomfim, Rita C. Tostes
Summary: This study demonstrates that SARS-CoV-2 infection impairs mitochondrial function and activates TLR9 signaling in endothelial cells, leading to inflammatory responses and endothelial dysfunction. Targeting mitochondrial metabolic pathways may offer new therapeutic strategies for COVID-19.
VASCULAR PHARMACOLOGY
(2022)
Article
Physiology
Jessica A. Troiano, Simone R. Potje, Murilo E. Graton, Emily T. Goncalves, Rita C. Tostes, Cristina Antoniali
Summary: Pregnancy increases nitric oxide (NO) generation in arteries without affecting the number of caveolae or the expression of main eNOS regulatory proteins, but decreases Cav-1/eNOS interaction. This decrease seems to be an important mechanism to increase eNOS activity and nitric oxide production in pregnant normotensive and hypertensive rats.
FRONTIERS IN PHYSIOLOGY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Jessica Antonini Troiano, Murilo Eduardo Graton, Simone Regina Potje, Emily Thalia Goncalves, Jessica Luiza de Oliveira Fonseca Zanardo, Priscila Scarpim Benevides, Cristina Antoniali
Meeting Abstract
Biochemistry & Molecular Biology
Murilo Eduardo Graton, Simone Regina Potje, Jessica Antonini Troiano, Gabriel Tavares do Vale, Priscila Scarpim Benevides, Emily Thalia Goncalves, Ana Claudia de Melo Stevanato Nakamune, Carlos Renato Tirapelli, Lusiane Maria Bendhack, Cristina Antoniali
Meeting Abstract
Biochemistry & Molecular Biology
Simone R. Potje, Lusiane Maria Bendhack, Rita de Cassia Tostes, Randal Dull, Joao Carvalho-de-Souza, Andreia Chignalia
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Murilo Graton, Priscila Scarpim Benevides, Jessica Antonini Troiano, Simone Regina Potje, Emily Goncalves, Jessica Zanardo, Ana Claudia Nakamune, Cristina Antoniali
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
