3-Hydroxy-3-methylglutaric and 3-methylglutaric acids impair redox status and energy production and transfer in rat heart: relevance for the pathophysiology of cardiac dysfunction in 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency

Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca2+–XO–ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways

(2016) Ying Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective role of melatonin in mitochondrial dysfunction and related disorders

(2015) Giuseppe Paradies et al.   ARCHIVES OF TOXICOLOGY

Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage

(2015) Carlo Cervellati et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Partial inhibition of the ubiquitin–proteasome system ameliorates cardiac dysfunction following ischemia–reperfusion in the presence of high glucose

(2015) Buin Adams et al.   Cardiovascular Diabetology

Lipoic Acid: Its Antioxidant and Anti-Inflammatory Role and Clinical Applications

(2015) Fabiana Moura et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Antioxidant Properties of Melatonin and its Potential Action in Diseases

(2015) Cigdem Karaaslan et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis

(2015) Mehrajuddin Bhat et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Protective Effect of Lipoic Acid on Selected Cardiovascular Diseases Caused by Age-Related Oxidative Stress

(2015) Beata Skibska et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial Ca2+ in neurodegenerative disorders

(2015) Rosella Abeti et al.   PHARMACOLOGICAL RESEARCH

Hepatocyte growth factor suppresses hypoxia/reoxygenation-induced XO activation in cardiac microvascular endothelial cells

(2014) Yingqian Zhang et al.   HEART AND VESSELS

Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

(2014) Joaquín J. García et al.   JOURNAL OF PINEAL RESEARCH

The selective NADPH oxidase inhibitor apocynin has potential prophylactic effects on melamine-related nephrolithiasis in vitro and in vivo

(2014) Xiaoran Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

α-Lipoic acid protected cardiomyoblasts from the injury induced by sodium nitroprusside through ROS-mediated Akt/Gsk-3β activation

(2014) Surong Jiang et al.   TOXICOLOGY IN VITRO

Redox homeostasis is compromised in vivo by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in rat cerebral cortex and liver

(2013) M. S. da Rosa et al.   FREE RADICAL RESEARCH

Disturbance of brain energy and redox homeostasis provoked by sulfite and thiosulfate: Potential pathomechanisms involved in the neuropathology of sulfite oxidase deficiency

(2013) Mateus Grings et al.   GENE

In vivo experimental evidence that the major metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency induce oxidative stress in striatum of developing rats: A potential pathophysiological mechanism of striatal damage in this disorder

(2013) Carolina Gonçalves Fernandes et al.   MOLECULAR GENETICS AND METABOLISM

In Vitro Stimulation of Oxidative Stress By Hypoxanthine in Blood of Rats: Prevention by Vitamins E Plus C and Allopurinol

(2013) Ana Caroline Mesquita Casagrande et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Complex II of the Mitochondrial Respiratory Chain Is the Key Mediator of Divalent Manganese-Induced Hydrogen Peroxide Production in Microglia

(2013) Yue Liu et al.   TOXICOLOGICAL SCIENCES

Mitochondrial dysfunction in heart failure

(2012) Mariana G. Rosca et al.   HEART FAILURE REVIEWS

Creatine kinase and ATP synthase reaction rates in human frontal lobe measured by 31P magnetization transfer spectroscopy at 4T

(2012) Fei Du et al.   MAGNETIC RESONANCE IMAGING

Oleanolic Acid: A Novel Cardioprotective Agent That Blunts Hyperglycemia-Induced Contractile Dysfunction

(2012) Rudo F. Mapanga et al.   PLoS One

Hydrogen peroxide targets the cysteine at the active site and irreversibly inactivates creatine kinase

(2011) Chang Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria

(2010) Beatriz Puisac et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Melatonin: Action as antioxidant and potential applications in human disease and aging

(2010) Dominique Bonnefont-Rousselot et al.   TOXICOLOGY

Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices

(2009) Caroline Wagner et al.   ARCHIVES OF TOXICOLOGY

Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia

(2009) K. R. Atkuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats

(2008) Guilhian Leipnitz et al.   LIFE SCIENCES

Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex

(2007) Guilhian Leipnitz et al.   JOURNAL OF NEUROSCIENCE RESEARCH