Editorial Material
Multidisciplinary Sciences
Tikvah K. K. Hayes, Matthew Meyerson
Summary: Assessing genetic and cellular changes in human lung cancer during its progression can contribute to the development of treatments, as reported by the TRACERx project.
Article
Medicine, General & Internal
Yun Fan, Yang Liu, Liuchun Wang, Yiran Cai, Wen Cao, Wenjie Sun, Xiao Zou, Bing Li, Zhou Zhang, Shangli Cai, Shannon Chuai, Yusheng Han, Xiaojie Pan, Dingzhi Huang
Summary: This study developed a blood-based intratumor heterogeneity (ITH) index for predicting the response to immune checkpoint blockade (ICB) therapy. The results showed that low blood-based ITH index is associated with better overall survival (OS) and progression-free survival (PFS) in patients receiving immunotherapy.
Article
Multidisciplinary Sciences
Ming Chen, Runzhe Chen, Ying Jin, Jun Li, Xin Hu, Jiexin Zhang, Junya Fujimoto, Shawna M. Hubert, Carl M. Gay, Bo Zhu, Yanhua Tian, Nicholas McGranahan, Won-Chul Lee, Julie George, Xiao Hu, Yamei Chen, Meijuan Wu, Carmen Behrens, Chi-Wan Chow, Hoa H. N. Pham, Junya Fukuoka, Jia Wu, Edwin Roger Parra, Latasha D. Little, Curtis Gumbs, Xingzhi Song, Chang-Jiun Wu, Lixia Diao, Qi Wang, Robert Cardnell, Jianhua Zhang, Jing Wang, Xiuning Le, Don L. Gibbons, John Heymach, J. Jack Lee, William N. William, Chao Cheng, Bonnie Glisson, Ignacio Wistuba, P. Andrew Futreal, Roman K. Thomas, Alexandre Reuben, Lauren A. Byers, Jianjun Zhang
Summary: In this study, researchers found that limited-stage small-cell lung cancer (LS-SCLC) tumors have a relatively homogeneous mutational landscape but a cold and heterogeneous TCR repertoire. Higher mutational burden, higher T cell infiltration, and positive PD-L1 expression are associated with longer overall survival, while higher chromosomal copy number aberration (CNA) burden is associated with shorter overall survival in patients with LS-SCLC.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Nathan Farrokhian, Jeff Maltas, Mina Dinh, Arda Durmaz, Patrick Ellsworth, Masahiro Hitomi, Erin McClure, Andriy Marusyk, Artem Kaznatcheev, Jacob G. Scott
Summary: In this study, the frequency-dependent interactions between a gefitinib-resistant non-small cell lung cancer population and its sensitive ancestor were measured experimentally. The cost of resistance was found to be insufficient in predicting competitive exclusion, and frequency-dependent growth rate measurements were necessary. Simulations showed that ecological growth effects can influence the predicted extinction time.
Review
Pharmacology & Pharmacy
Ana Cristina Goncalves, Elena Richiardone, Joana Jorge, Barbara Polonia, Cristina P. R. Xavier, Iris Chiara Salaroglio, Chiara Riganti, M. Helena Vasconcelos, Cyril Corbet, Ana Bela Sarmento-Ribeiro
Summary: Despite advancements in cancer therapies, treatment failures and tumor relapses still result in poor outcomes for many patients. Resistance mechanisms, including mutation-driven and tumor microenvironment-induced phenotypic heterogeneity, play a crucial role in limiting the effectiveness of anticancer treatments. Tumor cell metabolism is a key factor in adaptive resistance, allowing cancer cells to survive, metastasize, and develop resistance to therapies.
DRUG RESISTANCE UPDATES
(2021)
Review
Oncology
Kit Yee Wong, Alvin Ho-Kwan Cheung, Bonan Chen, Wai Nok Chan, Jun Yu, Kwok Wai Lo, Wei Kang, Ka Fai To
Summary: Lung cancer is a common and deadly disease, with the tumor microenvironment playing a crucial role. Cancer-associated fibroblasts (CAFs) have gained attention in the study of nonsmall cell lung carcinoma (NSCLC), as their heterogeneity and functions are closely associated with tumor development.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Mengxue Jiao, Hui Liu, Xuejun Liu
Summary: Tumoral heterogeneity is a leading cause of difference in prognosis and drug resistance in lung adenocarcinoma. This study explored the molecular mechanisms of tumor heterogeneity and established a predictive model based on transcriptional patterns to accurately distinguish histologic subtypes. A tumor heterogeneous scoring model (L2SITH) was created using two crucial genes, which could stratify patients and predict prognosis and response to anti-PD-1 immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Walter Z. Wang, Alyssa Shulman, Joseph M. Amann, David P. Carbone, Philip N. Tsichlis
Summary: Small cell lung cancer (SCLC) is an aggressive tumor with poor understanding of its biology. Recent studies identified four distinct subsets of SCLC and revealed the importance of intratumoral heterogeneity in SCLC development and progression. These findings will inform the design of new therapeutic strategies.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
John H. Lockhart, Hayley D. Ackerman, Kyubum Lee, Mahmoud Abdalah, Andrew John Davis, Nicole Hackel, Theresa A. Boyle, James Saller, Aysenur Keske, Kay Hanggi, Brian Ruffell, Olya Stringfield, W. Douglas Cress, Aik Choon Tan, Elsa R. Flores
Summary: Preclinical genetically engineered mouse models (GEMMs) of lung adenocarcinoma are valuable for studying tumor formation, progression, and therapeutic resistance. To improve histological analysis in these models, researchers developed GLASS-AI, a machine learning tool for grading, segmenting, and analyzing tumors. GLASS-AI showed agreement with expert raters and revealed previously unreported intratumor heterogeneity. Integration of immunohistochemical staining with GLASS-AI analysis identified dysregulation of Mapk/Erk signaling in high-grade lung adenocarcinomas. This study demonstrates the usefulness of GLASS-AI and the power of combining machine learning and molecular biology techniques for cancer research.
NPJ PRECISION ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Runmin Wei, Siyuan He, Shanshan Bai, Emi Sei, Min Hu, Alastair Thompson, Ken Chen, Savitri Krishnamurthy, Nicholas E. Navin
Summary: CellTrek is a computational method that combines single-cell RNA sequencing and spatial transcriptomics to achieve single-cell spatial mapping. It has demonstrated accuracy and robustness through simulation and experimental validation, and has been successfully applied to tumor tissues.
NATURE BIOTECHNOLOGY
(2022)
Article
Oncology
Zoi Kanaki, Alexandra Voutsina, Athina Markou, Ioannis S. Pateras, Konstantinos Potaris, Margaritis Avgeris, Periklis Makrythanasis, Emmanouil I. Athanasiadis, Ioannis Vamvakaris, Eleni Patsea, Konstantinos Vachlas, Evi Lianidou, Vassilis Georgoulias, Athanasios Kotsakis, Apostolos Klinakis
Summary: By transplanting human tumors into mice, this study identified clinical factors and molecular characteristics of tumor cells that affect the success of transplantation. Squamous cell carcinomas showed higher efficiency in growth in mice, and the presence of specific markers in circulating tumor cells from patients' blood correlated with transplantation success.
Article
Biochemical Research Methods
Leonardo Pellegrina, Fabio Vandin
Summary: The study presents a new algorithm, MASTRO, for discovering significantly conserved evolutionary trajectories in cancer. The algorithm is applied to lung cancer and acute myeloid leukemia data, confirming and extending previous findings.
Review
Oncology
Laila C. Roisman, Waleed Kian, Alaa Anoze, Vered Fuchs, Maria Spector, Roee Steiner, Levi Kassel, Gilad Rechnitzer, Iris Fried, Nir Peled, Naama R. Bogot
Summary: Personalized medicine has revolutionized lung cancer treatment by tailoring therapies to individual patients. However, the complexity of clinical aspects such as tumor molecular profile and treatment resistance poses challenges for physicians. The integration of innovative technologies, such as deep learning and radiomics, has the potential to support clinical decision making and precision therapies in lung cancer treatment.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Patricia Neuperger, Jozsef a. Balog, Laszlo Tiszlavicz, Jozsef Furak, Nikolett Gemes, Edit Kotogany, Klara Szalontai, Laszlo G. Puskas, Gabor J. Szebeni
Summary: Non-small cell lung cancer (NSCLC) is a major cause of cancer-related deaths globally. Intratumoral heterogeneity (ITH) poses challenges in the treatment of lung cancer patients. In this study, the heterogeneity of NSCLC cell lines and primary lung adenocarcinoma was investigated using single-cell mass cytometry (CyTOF). The study analyzed the expression pattern of 13 markers in NSCLC adenocarcinoma cells and demonstrated intra- and inter-cell-line heterogeneity. Hypoxic modeling revealed the influence of hypoxic microenvironment and altered metabolism on cell-line heterogeneity. CyTOF analysis of human primary lung adenocarcinoma confirmed the ITH and identified markers associated with lung tumor tissue. Additionally, TMEM45A expression in human lung adenocarcinoma was demonstrated for the first time.
Article
Pathology
Alejandro Francisco-Cruz, Pedro Rocha, Alexandre Reuben, Santhoshi N. Krishnan, Priyam Das, Runzhe Chen, Kelly Quek, Jun Li, Edwin R. Parra, Luisa M. Solis, Souptik Barua, Mei Jiang, Rossana Lazcano, Chi-Wan Chow, Carmen Behrens, Curtis Gumb, Latasha Little, Junya Fukuoka, Neda Kalhor, Annikka Weissferdt, Humam Kadara, John V. Heymach, Stephen Swisher, Boris Sepesi, Arvind Rao, Cesar Moran, Jianhua Zhang, J. Jack Lee, Junya Fujimoto, P. Andrew Futreal, Ignacio I. Wistuba, Christine B. Peterson, Jianjun Zhang
Summary: Our understanding of the molecular mechanisms underlying postsurgical recurrence of non-small cell lung cancer (NSCLC) is limited. In this study, we investigated the impact of intratumor heterogeneity (ITH) at the cellular level on survival in patients with stage I NSCLC. We found that relapsed tumors displayed different immune biology compared with nonrecurrent tumors, with a higher percentage of immune cells expressing PD-L1 and an increase in regulatory T cells and antigen-experienced T cells. Spatial analysis revealed that a higher level of infiltration of certain immune cell subtypes in the tumor was associated with poor overall survival. Furthermore, Treg ITH was found to be associated with inferior recurrence-free survival, regardless of tumor mutational burden, neoantigen burden, genomic ITH, and T cell repertoire ITH.
Article
Oncology
Jiwei Bai, Jianxin Shi, Yazhuo Zhang, Chuzhong Li, Yujia Xiong, Hela Koka, Difei Wang, Tongwu Zhang, Lei Song, Wen Luo, Bin Zhu, Belynda Hicks, Amy Hutchinson, Erin Kirk, Melissa A. Troester, Mingxuan Li, Yutao Shen, Tianshun Ma, Junmei Wang, Xing Liu, Shuai Wang, Songbai Gui, Mary L. McMaster, Stephen J. Chanock, Dilys M. Parry, Alisa M. Goldstein, Xiaohong R. Yang
Summary: This study identified two molecular subtypes of skull-base chordoma and found that one subtype is associated with somatic mutations and reduced expression in chromatin remodeling genes, while the other subtype is characterized by the upregulation of genes in epithelial-mesenchymal transition and Sonic Hedgehog pathways. Immunohistochemical staining showed that the expression of certain markers is significantly associated with survival outcomes. These findings contribute to a better understanding of chordoma tumorigenesis and provide potential targets for clinical prognostication and treatment.
CLINICAL CANCER RESEARCH
(2023)
Article
Substance Abuse
Raimondo Maria Pavarin, Dario Consonni, Fabio Lucchi, Paolo Pandolfi, Silvia Marani, Francesco Palmese, Marco Domenicali
Summary: This study aims to investigate whether patients with AUD and SUD have a higher mortality rate for COVID-19-related mortality. The results of the study show that these patients have excess mortality for all causes of death and for COVID-19-related mortality.
EUROPEAN ADDICTION RESEARCH
(2023)
Article
Environmental Sciences
Corrado Magnani, Carolina Mensi, Alessandra Binazzi, Daniela Marsili, Federica Grosso, Juan Pablo Ramos-Bonilla, Daniela Ferrante, Enrica Migliore, Dario Mirabelli, Benedetto Terracini, Dario Consonni, Daniela Degiovanni, Michela Lia, Maria Fernanda Cely-Garcia, Margarita Giraldo, Benjamin Lysaniuk, Pietro Comba, Alessandro Marinaccio
Summary: Asbestos is a carcinogenic substance associated with mesothelioma, lung cancer, laryngeal cancer, and ovarian cancer. It remains one of the most widespread carcinogens in the world, causing a significant global cancer burden. While many high-income countries have banned its use, asbestos is still prevalent in low- and middle-income countries, making it a common occupational and environmental carcinogen worldwide. This report highlights the mesothelioma epidemic in two Italian communities, discusses the activities of the Italian mesothelioma registry, and assesses the potential application of Italian solutions in a high-incidence city in Colombia. International cooperation is emphasized.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Silvia Fustinoni, Dario Consonni
Summary: This study summarizes the occupational exposure to perfluoroalkyl acid surfactants in an Italian fluoropolymer plant and research center from 2004 to 2021. The results show a reduction in the concentration of these chemicals in the serum of workers, indicating the effectiveness of mitigation measures.
ANNALS OF WORK EXPOSURES AND HEALTH
(2023)
Letter
Hematology
Massimo Cugno, Ilaria Mancini, Dario Consonni, Valentina De Zan, Gianluigi Ardissino, Samantha Grifini, Elena Grovetti, Luigi Porcaro, Barbara Ferrari, Andrea Artoni, Flora Peyvandi
Article
Medicine, General & Internal
Deborah Blanca, Giorgio Parrella, Dario Consonni, Stefania Villa, Giuliana Ceriani, Annalisa Cespiati, Giovanni Figini, Gabriele Ghigliazza, Diletta Maira, Giovanna Oberti, Natalia Scaramellini, Giuseppina Luisa Schinco, Francesco Tafuri, Nicola Montano, Maria Domenica Cappellini, Irene Motta
Summary: Blood transfusion is often overused in elderly patients, but an educational program can improve anemia management and transfusion strategy, leading to reduced need for blood transfusion.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Riccardo Asero, Silvia Mariel Ferrucci, Paolo Calzari, Dario Consonni, Massimo Cugno
Summary: The response to omalizumab in severe chronic spontaneous urticaria (CSU) depends on the autoimmune or autoallergic endotype, but the role of thyroid autoimmunity in predicting the response is unclear. In this study, 385 patients with CSU were investigated, and it was found that thyroid autoimmunity was not associated with omalizumab response. However, total IgE levels showed a strong positive association with response, particularly in early responders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Teresa Surace, Cecilia Quitadamo, Alice Caldiroli, Enrico Capuzzi, Fabrizia Colmegna, Guido Nosari, Elisa Borroni, Luca Fedrizzi, Valentina Bollati, Angela Cecilia Pesatori, Michele Carugno, Massimo Clerici, Massimiliano Buoli
Summary: The aim of this study was to summarize available data on the link between air pollution exposure and the onset and severity of psychiatric disorders in pregnant women during the perinatal period. Nine studies were included in the analysis, with most focusing on the association between air pollutant exposure and postpartum depression (PPD) onset. The results showed a significant association between PM2.5 and NO2 exposure and PPD onset, as well as an association between PBDE blood levels and more severe depressive symptoms. One study also observed a link between exposure to PM2.5, PM10 during pregnancy and stressful symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Carolina Mensi, Simona Stella, Barbara Dallari, Sabrina Rugarli, Angela Cecilia Pesatori, Giovanni Luca Ceresoli, Dario Consonni
Summary: This study investigated the occurrence of second primary cancers (SPCs) in pleural mesothelioma (PM) patients and assessed its prognostic implications. The presence of an SPC did not significantly impact survival in the overall PM population, but patients with non-epithelioid PM had a worse prognosis when an SPC was diagnosed. Further studies are needed to clarify the role of SPCs as markers of genetic susceptibility in mesothelioma.
Article
Environmental Sciences
Silvia Fustinoni, Rosa Mercadante, Giorgia Lainati, Simone Cafagna, Dario Consonni
Summary: This study aimed to investigate the kinetics of elimination of cC(6)O(4) in exposed workers. The results showed that the half-life of cC(6)O(4) in human blood is about 8 days, indicating its shorter biopersistence compared to legacy PFAS. The good correlation between urine and serum cC(6)O(4) suggests urine as a possible non-invasive matrix for biomonitoring.
Article
Environmental Sciences
Luca Fedrizzi, Michele Carugno, Dario Consonni, Andrea Lombardi, Alessandra Bandera, Patrizia Bono, Ferruccio Ceriotti, Andrea Gori, Angela Cecilia Pesatori
Summary: This study aims to assess the association between air pollutants and the risk of COVID-19 infection. The findings suggest that long-term exposure to PM10 and nitrogen dioxide (NO2) increases the risk of COVID-19 infection, while the effects of ozone (O3) and short-term exposure to PM10 are uncertain. This study adds to the evidence of the impact of air pollution on COVID-19 infection and highlights the importance of implementing pollution reduction policies to improve public health.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Clara Bodelon, Gretchen L. Gierach, Elizabeth E. Hatch, Emily Riseberg, Amy Hutchinson, Meredith Yeager, Dale P. Sandler, Jack A. Taylor, Robert N. Hoover, Zongli Xu, Linda Titus, Julie R. Palmer, Rebecca Troisi
Summary: This study explored blood DNA methylation in women exposed and unexposed to prenatal diethylstilbestrol (DES). The results showed that DNA methylation levels at 10 CpG sites in six candidate genes were significantly associated with prenatal DES exposure. These findings suggest that in utero DES exposure may be associated with differential blood DNA methylation levels, which could mediate the increased risk of several adverse health outcomes observed in exposed women.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Stefano Faiola, Maria Mandalari, Chiara Coco, Daniela Casati, Arianna Laoreti, Savina Mannarino, Carla Corti, Dario Consonni, Irene Cetin, Mariano Lanna
Summary: This study aimed to evaluate the long-term cardiological outcomes of prenatal RVOTAs in monochorionic diamniotic twin pregnancies complicated by TTTS and treated with FLS. The majority of these pregnancies still had CHD at long-term follow-up. The risk of major CHD increased with prenatal evidence of PS and decreased with the gestational age at the time of TTTS and with the prenatal normalization of blood flow across the pulmonary valve.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
H. Matthew Berns, Dawn E. Watkins-Chow, Sizhu Lu, Pakavarin Louphrasitthiphol, Tongwu Zhang, Kevin M. Brown, Pedro Moura-Alves, Colin R. Goding, William J. Pavan
Summary: This study used single-cell RNA sequencing to define a MC1R-inhibited Gene Signature in red-haired mouse models, which includes previously unidentified genes related to melanogenesis and oncogenic transformation. The results identified TBX3 as a potential gene involved in regulating melanogenesis and senescence bypass.
PIGMENT CELL & MELANOMA RESEARCH
(2023)