Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficientin VivoIncorporation of Structurally Divergent Non-native Amino Acids

(2011) Jeffrey K. Takimoto et al.   ACS Chemical Biology

A Fluorescent Reporter of the Phosphorylation Status of the Substrate Protein STAT3

(2011) Vanessa K. Lacey et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photo-Cross-Linkers Incorporated into G-Protein-Coupled Receptors in Mammalian Cells: A Ligand Comparison

(2011) Irene Coin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Production of disulfide-bonded proteins in Escherichia coli

(2011) Mehmet Berkmen   PROTEIN EXPRESSION AND PURIFICATION

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

Intramolecular isopeptide bonds: protein crosslinks built for stress?

(2010) Hae Joo Kang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Far-red fluorescent tags for protein imaging in living tissues

(2009) Dmitry Shcherbo et al.   BIOCHEMICAL JOURNAL

Electrophilic Affibodies Forming Covalent Bonds to Protein Targets

(2009) Lotta Holm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving orthogonal tRNA-synthetase recognition for efficient unnatural amino acid incorporation and application in mammalian cells

(2009) Jeffrey K. Takimoto et al.   Molecular BioSystems

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

(2009) Bryson D Bennett et al.   Nature Chemical Biology

Unique interactions between the chromophore and glutamate 16 lead to far-red emission in a red fluorescent protein

(2009) Xiaokun Shu et al.   PROTEIN SCIENCE

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry