Article
Chemistry, Medicinal
Chika I. Chukwuma, Samson S. Mashele, Shasank S. Swain
Summary: The study synthesized a Zn(II) acetate complex of cinnamic acid with improved anti-diabetic and antioxidant pharmacological effects, potentially serving as a safe nutraceutical for glycemic control.
MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Limpho M. Ramorobi, Godfrey R. Matowane, Samson S. Mashele, Shasank S. Swain, Tshepiso J. Makhafola, Polo-Ma-Abiele H. Mfengwana, Chika I. Chukwuma
Summary: The development of a zinc(II)-syringic acid complex shows improved anti-hyperglycemic and antioxidant potential. The complex demonstrates strong antioxidant and anti-hyperglycemic activities, as well as protective effects on liver cells and tissues. It also enhances cellular zinc uptake and glucose utilization efficiency. The complex has potential therapeutic applications for diabetes and oxidative complications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Physical
Moony Na, Vikram Singh, Rak Hyeon Choi, Byung Gon Kim, Hye Ryung Byon
Summary: We developed a pH-sensitive growth mechanism to form in situ protective layers using glutaric acid (GA) and Zn2+ in the electrolyte solution. By deprotonating GA additives and integrating them with Zn2+ coordination, a thin Zn glutarate layer was formed to prevent hydrogen evolution reaction (HER) and Zn hydroxide sulfate hydrate (ZHS) precipitation. The study demonstrated the effective formation of Zn-organic protective layers for long-term cycling.
ENERGY STORAGE MATERIALS
(2023)
Article
Engineering, Environmental
Jozef Kovacik, Slawomir Dresler, Maciej Strzemski, Ireneusz Sowa, Petr Babula, Magdalena Wojciak-Kosior
Summary: The study found that in the medicinal plant Hypericum perforatum L., strontium can be mitigated by organic nitrogen forms, and even have a stimulatory effect. Additionally, the effects of strontium on the plant mainly manifest in changes in primary and secondary metabolites, as well as in mineral elements.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Agronomy
Yanyan Li, Ruzhen Wang, Heyong Liu, Xue Feng, Bin Wang, Zhirui Wang, Jiangping Cai, Lijuan Yang, Yong Jiang
Summary: Mowing can counteract the synergistic effect of nitrogen and zinc addition on plant zinc uptake in nitrogen-fertilized grasslands. This finding suggests the necessity of zinc fertilization in grassland management.
Article
Environmental Sciences
Qian Li, Chunfeng Guan, Yi Zhao, Xiaoye Duan, Zhihui Yang, Jiehua Zhu
Summary: In this study, exogenous salicylic acid (SA) treatment was found to enhance the physiological adaptability and reduce zinc (Zn) toxicity in alfalfa plants. The application of SA improved photosynthesis, stimulated the antioxidant system and glutathione metabolism, and induced the transcription of related genes, thereby increasing tolerance to Zn stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Nutrition & Dietetics
Ting Zhang, Wen-Rong Jiang, Yin-Yin Xia, Toby Mansell, Richard Saffery, Richard D. Cannon, Jamie De Seymour, Zhen Zou, Ge Xu, Ting-Li Han, Hua Zhang, Philip N. Baker
Summary: The study suggests a relationship between maternal serum fatty acid levels and gestational diabetes mellitus (GDM) subtypes, with different fatty acid levels observed in different GDM subtypes during pregnancy. Specifically, higher levels of ALA and DHA in early pregnancy are associated with an increased risk of fasting plasma glucose (FPG) GDM subtype.
CLINICAL NUTRITION
(2021)
Article
Engineering, Environmental
Xin Wang, Yiwei Zhong, Yuzheng Kang, Jintao Gao, Zhancheng Guo
Summary: In this study, selective reduction roasting combined with water leaching was used to pretreat high zinc dust (HZD) in order to enhance the recovery of zinc. The results showed improved efficiency in the acid leaching of zinc, promoting the recycling of HZD.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2022)
Article
Agronomy
Raheela Rehman, Muhammad Asif, Ismail Cakmak, Levent Ozturk
Summary: This study found that wheat is more efficient in uptake and translocation of foliar-applied zinc compared to maize, regardless of the zinc supply level. Therefore, wheat has better agronomic biofortification potential than maize.
Article
Plant Sciences
Maleeha Razzaq, Nudrat Aisha Akram, Shafaqat Ali, Muhammad Ashraf
Summary: The effect of foliar-applied vanillic acid (VA) on biomass, photosynthesis, oxidative stress, antioxidant enzyme activities and uptake of chromium (Cr) in maize plants under varying levels of Cr stress was evaluated. Results showed that Cr stress reduced physiological and morphological characteristics, while foliar-applied VA improved gas exchange attributes and antioxidant defense system, leading to enhanced Cr stress tolerance in maize plants.
PAKISTAN JOURNAL OF BOTANY
(2023)
Article
Agriculture, Dairy & Animal Science
Hidayat Mohd Yusof, Nor'Aini Abdul Rahman, Rosfarizan Mohamad, Uswatun Hasanah Zaidan, Anjas Asmara Samsudin
Summary: Traditionally, higher levels of inorganic zinc (Zn) were added to broiler chicken diets to meet optimal body requirements, but this can lead to heavy metal contamination. Nanomaterial ZnO NPs have unique properties that increase nutrient utilization and improve broiler physiological function and production. This study found that dietary biosynthesized ZnO NPs increased Zn absorption in broiler chickens, improved tibia bone development, and enhanced antioxidative status in serum and liver tissue.
Article
Materials Science, Multidisciplinary
S. R. Kunst, A. C. V. Bianchin, L. T. Mueller, J. A. Santana, T. M. Volkmer, F. D. P. Morisso, C. L. P. Carone, J. Z. Ferreira, I. L. Mueller, C. T. Oliveira
Summary: In this study, anodizing was used to improve the corrosion resistance of Zamak by forming oxide layers on its surface. The research found that anodizing promotes better corrosion resistance by creating oxide layers that fill the cracks generated during the anodizing process.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Chemistry, Multidisciplinary
Haotian Lu, Xuanlin Zhang, Minghe Luo, Keshuang Cao, Yunhao Lu, Ben Bin Xu, Hongge Pan, Kai Tao, Yinzhu Jiang
Summary: This research presents a new strategy of zinc-electrolyte interface charge engineering induced by amino acid additives, leading to highly reversible zinc plating/stripping with improved stability and uniformity of the zinc metal anode. Long-term stable cycling at high and ultra-high current densities has been demonstrated, highlighting the reliable self-adaptive feature of the zinc-electrolyte interface.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Plant Sciences
Ghulam Abbas, Sadia Rehman, Manzer H. Siddiqui, Hayssam M. Ali, Muhammad Ansar Farooq, Yinglong Chen
Summary: The study found that the application of potassium (K) and humic acid (HA) improved plant tolerance to salinity stress in wheat genotypes. The combined application of 10 mM K and HA was most effective in alleviating salt stress and increasing plant biomass. Genotype SARC 1 performed better than SARC 5 for cultivation on saline soils.
Article
Nanoscience & Nanotechnology
Wangsheng Yuan, Ye Yuan, Junwei Wu, Chaolin You, Yishuang He, Xinhai Yuan, Qinghong Huang, Lili Liu, Lijun Fu, Yuping Wu
Summary: By constructing an Al-complexed artificial interfacial layer on the zinc surface, the wettability of the electrolyte is improved, side reactions are inhibited, and zinc-ion flux is regulated, resulting in long cycle life for aqueous zinc-ion batteries.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Plant Sciences
Adeline Lum Nde, Chika I. Chukwuma, Ochuko L. Erukainure, Maria S. Chukwuma, Motlalepula G. Matsabisa
Summary: Senna occidentalis contains various phytochemical constituents that have anti-diabetic, hypoglycemic, anti-hyperlipidemic, and antioxidative effects. Research indicates that different parts of the plant exert anti-diabetic effects by regulating blood glucose, lipid profile, antioxidant status, and islet function.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eunice A. Akuru, Chika Chukwuma, Chika E. Oyeagu, Ochuko L. Erukainure, Boitumelo Mashile, Reaotshepa Setlhodi, Samson S. Mashele, Tshepiso J. Makhafola, Jeremiah O. Unuofin, Taiwo O. Abifarin, Thando C. Mpendulo
Summary: The study evaluates the antioxidant, nutritional, and phytochemical profiles of the Wonderful pomegranate peel, showing its potential as a source of functional nutrients and phenolic antioxidants. The peel exhibits potent antioxidant activities, preventing oxidative stress-induced damage in liver cells and tissues. Additionally, metabolomics analysis reveals beneficial metabolic alterations following treatment with the peel extract, suggesting its potential in improving overall body function and mitigating hepatic oxidative damage.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Correction
Plant Sciences
Ochuko L. Erukainure, Omamuyovwi M. Ijomone, Chika I. Chukwuma, Xin Xiao, Veronica F. Salau, Md Shahidul Islam
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Godfrey R. Matowane, Limpho M. Ramorobi, Samson S. Mashele, Susanna L. Bonnet, Anwar E. M. Noreljaleel, Shasank S. Swain, Tshepiso J. Makhafola, Chika Chukwuma
Summary: Complexation of zinc(II) with ferulic acid improves glycaemic control and antioxidant potential.
Article
Plant Sciences
Ochuko L. Erukainure, Sunelle Rademan, Joseph O. Erhabor, Chika I. Chukwuma, Adeline Lum Nde, Motlalepula G. Matsabisa
Summary: This study investigated the protective effects of Cannabis sativa on the regulation of purinergic and glucogenic enzymes. Results showed that the extracts of Cannabis sativa can reduce cellular damage caused by oxidative stress and help maintain redox balance.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Limpho M. Ramorobi, Godfrey R. Matowane, Samson S. Mashele, Susanna L. Bonnet, Anwar E. M. Noreljaleel, Shasank S. Swain, Tshepiso J. Makhafola, Chika Chukwuma
Summary: This study investigated the complexation-mediated synergistic interaction between zinc(II) and p-coumaric acid in the management of diabetes and oxidative stress. The results showed that the complex formed by zinc(II) and p-coumaric acid was more effective in antioxidant and antihyperglycemic activities compared to p-coumaric acid alone. The complex exhibited strong inhibitory effects on lipid peroxidation and GSH depletion, and enhanced glucose uptake and hexokinase activity. These findings suggest that zinc(II) complexation may be an important approach in improving the application potential of p-coumaric acid in the management of diabetes and oxidative stress.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Godfrey R. Matowane, Limpho M. Ramorobi, Samson S. Mashele, Susanna L. Bonnet, Anwar E. M. Noreljaleel, Shasank S. Swain, Tshepiso J. Makhafola, Chika I. Chukwuma
Summary: This study aimed to synthesize a novel medicinal Zn(II) complex with enhanced antioxidant and anti-hyperglycemic properties. The results showed that the complex exhibited stronger antioxidant and anti-hyperglycemic activity compared to caffeic acid alone and had better interaction with insulin signaling target proteins. This finding has potential medicinal relevance.
MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Limpho M. Ramorobi, Godfrey R. Matowane, Samson S. Mashele, Shasank S. Swain, Tshepiso J. Makhafola, Polo-Ma-Abiele H. Mfengwana, Chika I. Chukwuma
Summary: The development of a zinc(II)-syringic acid complex shows improved anti-hyperglycemic and antioxidant potential. The complex demonstrates strong antioxidant and anti-hyperglycemic activities, as well as protective effects on liver cells and tissues. It also enhances cellular zinc uptake and glucose utilization efficiency. The complex has potential therapeutic applications for diabetes and oxidative complications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Y. Mbakazi, A. P. Kappo, O. S. Soyingbe, N. S. Nety, T. J. Makhafola, C. I. Chukwuma, M. P. Dikhoba, N. G. Mariri, N. I. Mongalo
Summary: This study reports on the antibacterial, cytotoxic, and antioxidant activities of the extract from Sarcophyte sanguinea subsp. piriei (Hutch.) B. The methanol extract showed the highest antibacterial and antioxidant activities, suggesting its potential as an immune booster and preventive agent against infections.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Food Science & Technology
Reaotshepa Setlhodi, Boitumelo Mashile, Gloria O. Izu, Sefater Gbashi, Samson S. Mashele, Susanna L. Bonnet, Tshepiso J. Makhafola, Chika I. Chukwuma
Summary: Ellagitannins are the main bioactive tannins in pomegranate peel. This study used advanced chemometrics models to determine the solvent extraction (methanol, ethanol, acetone, water) that yields the highest antioxidant and ellagitannins profiles. Acetone extraction had the highest total phenol and flavonoid contents, while methanol extraction had the strongest radical scavenging activity. The models adequately characterized and predicted the variation and patterns in the antioxidant and ellagitannins datasets.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Reaotshepa Setlhodi, Boitumelo Mashile, Gloria O. Izu, Sefater Gbashi, Samson S. Mashele, Susanna L. Bonnet, Tshepiso J. Makhafola, Chika I. Chukwuma
Summary: This study used advanced chemometrics models to determine the influence of different extraction temperatures on the antioxidant profile and ellagitannins recovery of pomegranate peel extract. Extraction at 78 degrees Celsius showed the highest antioxidant activity and ellagitannins content. Pearson's bivariate correlation showed a strong positive correlation between ellagitannins and the anti-lipid peroxidative profile of the extract. The PCA and OPLS models adequately characterized and predicted the variation and patterns in the antioxidant and phytochemical datasets. OPLS biplot showed a distinct clustering pattern around 78 degrees Celsius extraction temperature, indicating the influence of ellagitannins on the antioxidant profile at this temperature.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Limpho M. Ramorobi, Godfrey R. Matowane, Samson S. Mashele, Ochuko L. Erukainure, Tshepiso J. Makhafola, Chika I. Chukwuma
Summary: Zinc(II) and syringic acid were investigated for their antidiabetic and antioxidative effects in diabetic rats. The complex of zinc(II) and syringic acid reduced polyphagia, polydipsia, and weight loss in diabetic rats. The complex enhanced the anti-hyperglycemic action of zinc(II) and syringic acid, reduced lipid peroxidation, and increased antioxidant enzyme activity.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Chemistry, Medicinal
Veronica F. Salau, Ochuko L. Erukainure, Gideon Ayeni, Collins U. Ibeji, Tosin A. Olasehinde, Chika I. Chukwuma, Neil A. Koorbanally, Md. Shahidul Islam
Summary: The neuroprotective effect of betulinic acid against oxidative neurotoxicity induced by iron was investigated in isolated rat brains. The induction of oxidative neurotoxicity resulted in suppressed antioxidant levels and increased levels of reactive oxygen species. Treatment with betulinic acid reversed these effects and restored the depleted compounds. Pathway analysis revealed the activation of neuroprotective metabolic pathways upon betulinic acid treatment. Molecular docking showed a strong binding affinity between betulinic acid and ATPase. These findings suggest that betulinic acid confers neuroprotection by restoring redox balance and modulating various metabolic pathways.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Food Science & Technology
Boitumelo Mashile, Reaotshepa Setlhodi, Gloria O. Izu, Ochuko L. Erukainure, Samson S. Mashele, Tshepiso J. Makhafola, Kenneth C. Eze, Chika I. Chukwuma
Summary: This study optimized the extraction of bioactive ellagitannins and punicalagin from pomegranate peel using temperature-dependent extraction. The extract obtained at 78 degrees C had the highest content of phenols, flavonoids, tannins, and punicalagin, showing the strongest antioxidant and glycaemic control properties. The purified tannin from the extract at 78 degrees C exhibited better anti-lipid peroxidation and glucose modulatory effects compared to the crude extract and purified punicalagin.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Veronica F. Salau, Ochuko L. Erukainure, Neil A. Koorbanally, Chika Chukwuma, Md Shahidul Islam
Summary: Cinnamic acid has anti-diabetic properties by enhancing glucose uptake, improving redox imbalance and proteolysis, and modulating glucose-lipid metabolism.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)