A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults

Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain

(2021) Veronica M. Piggott et al.   MOLECULES

Cannabinoid modulation of corticolimbic activation to threat in trauma-exposed adults: a preliminary study

(2020) Christine A. Rabinak et al.   PSYCHOPHARMACOLOGY

The effects of FAAH inhibition on the neural basis of anxiety-related processing in healthy male subjects: a randomized clinical trial

(2020) Martin P. Paulus et al.   NEUROPSYCHOPHARMACOLOGY

Estimating the risk of PTSD in recent trauma survivors: results of the International Consortium to Predict PTSD (ICPP)

(2019) Arieh Y. Shalev et al.   World Psychiatry

Distinct hippocampal engrams control extinction and relapse of fear memory

(2019) Anthony F. Lacagnina et al.   NATURE NEUROSCIENCE

Influence of Δ9-tetrahydrocannabinol on long-term neural correlates of threat extinction memory retention in humans

(2019) Mira Z. Hammoud et al.   NEUROPSYCHOPHARMACOLOGY

Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial

(2019) Leah M. Mayo et al.   BIOLOGICAL PSYCHIATRY

Stress-induced modulation of endocannabinoid signaling leads to delayed strengthening of synaptic connectivity in the amygdala

(2019) Farhana Yasmin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fear extinction in the human brain: A meta-analysis of fMRI studies in healthy participants

(2018) Miquel A. Fullana et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice

(2018) Leah M. Mayo et al.   MOLECULAR PSYCHIATRY

Impact of FAAH genetic variation on fronto-amygdala function during emotional processing

(2018) Anne Gärtner et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses

(2018) Tina Zimmermann et al.   NEUROPSYCHOPHARMACOLOGY

GABA Concentrations in the Anterior Cingulate Cortex Are Associated with Fear Network Function and Fear Recovery in Humans

(2017) Nina Levar et al.   Frontiers in Human Neuroscience

Dentate Gyrus Contributes to Retrieval as well as Encoding: Evidence from Context Fear Conditioning, Recall, and Extinction

(2017) Brian E. Bernier et al.   JOURNAL OF NEUROSCIENCE

Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents

(2017) Tingting Duan et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

The Prevalence of Posttraumatic Stress Disorder in Primary Care

(2017) Margaret Spottswood et al.   HARVARD REVIEW OF PSYCHIATRY

FAAHGene Variation Moderates Stress Response and Symptom Severity in Patients with Posttraumatic Stress Disorder and Comorbid Alcohol Dependence

(2016) Primavera A. Spagnolo et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Genetically reduced FAAH activity may be a risk for the development of anxiety and depression in persons with repetitive childhood trauma

(2016) Judit Lazary et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species

(2016) Dylan G. Gee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Fatty Acid Amide Hydrolase C385A Variant Affects Brain Binding of the Positron Emission Tomography Tracer [11C]CURB

(2015) Isabelle Boileau et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Corticotropin-Releasing Hormone Drives Anandamide Hydrolysis in the Amygdala to Promote Anxiety

(2015) J. M. Gray et al.   JOURNAL OF NEUROSCIENCE

FAAH genetic variation enhances fronto-amygdala function in mouse and human

(2015) Iva Dincheva et al.   Nature Communications

Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation

(2014) R J Bluett et al.   Translational Psychiatry

Quantification of anandamide and 2-arachidonoylglycerol plasma levels to examine potential influences of tetrahydrocannabinol application on the endocannabinoid system in humans

(2013) Ulrike Thieme et al.   Drug Testing and Analysis

Cannabinoid modulation of prefrontal–limbic activation during fear extinction learning and recall in humans

(2013) Christine A. Rabinak et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Amygdala FAAH and anandamide: mediating protection and recovery from stress

(2013) Ozge Gunduz-Cinar et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure

(2012) M N Hill et al.   MOLECULAR PSYCHIATRY

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

(2012) O Gunduz-Cinar et al.   MOLECULAR PSYCHIATRY

Optogenetic stimulation of a hippocampal engram activates fear memory recall

(2012) Xu Liu et al.   NATURE

Clarifying the Role of the Rostral dmPFC/dACC in Fear/Anxiety: Learning, Appraisal or Expression?

(2012) Simon Maier et al.   PLoS One

A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity

(2012) Annette Conzelmann et al.   PSYCHOPHARMACOLOGY

The Study of Fear Extinction: Implications for Anxiety Disorders

(2011) Bronwyn M. Graham et al.   AMERICAN JOURNAL OF PSYCHIATRY

The endocannabinoid system in anxiety, fear memory and habituation

(2011) S Ruehle et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Task-Induced Deactivation from Rest Extends beyond the Default Mode Brain Network

(2011) Ben J. Harrison et al.   PLoS One

Fear conditioning and extinction: emotional states encoded by distinct signaling pathways

(2011) Natalie C. Tronson et al.   TRENDS IN NEUROSCIENCES

Emotional processing in anterior cingulate and medial prefrontal cortex

(2010) Amit Etkin et al.   TRENDS IN COGNITIVE SCIENCES

Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder

(2009) Mohammed R. Milad et al.   BIOLOGICAL PSYCHIATRY

Trauma exposure and stress-related disorders in inner city primary care patients

(2009) Charles F. Gillespie et al.   GENERAL HOSPITAL PSYCHIATRY

Segregated Populations of Hippocampal Principal CA1 Neurons Mediating Conditioning and Extinction of Contextual Fear

(2009) N. C. Tronson et al.   JOURNAL OF NEUROSCIENCE

Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids

(2009) Matthew N. Hill et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Interactions between environmental aversiveness and the anxiolytic effects of enhanced cannabinoid signaling by FAAH inhibition in rats

(2009) J. Haller et al.   PSYCHOPHARMACOLOGY

Divergent Effects of Genetic Variation in Endocannabinoid Signaling on Human Threat- and Reward-Related Brain Function

(2008) Ahmad R. Hariri et al.   BIOLOGICAL PSYCHIATRY

Consistency and functional specialization in the default mode brain network

(2008) B. J. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice

(2007) David J. Rademacher et al.   NEUROPHARMACOLOGY