Erythropoietin and derivatives: Potential beneficial effects on the brain

CEPO (carbamylated erythropoietin)-Fc protects hippocampal cells in culture against beta amyloid-induced apoptosis: considering Akt/GSK-3β and ERK signaling pathways

(2020) Etrat Hooshmandi et al.   MOLECULAR BIOLOGY REPORTS

A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants

(2020) Sandra E. Juul et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) on learning and memory impairment and hippocampal apoptosis induced by intracerebroventricular administration of streptozotocin in rats

(2020) Maryam Moosavi et al.   BEHAVIOURAL BRAIN RESEARCH

Impact of pretreatment interhemispheric hippocampal asymmetry on improvement in verbal learning following erythropoietin treatment in mood disorders: a randomized controlled trial

(2020) Kamilla W. Miskowiak et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

(2020) Debia Wakhloo et al.   Nature Communications

Erythropoietin-Induced Autophagy Protects Against Spinal Cord Injury and Improves Neurological Function via the Extracellular-Regulated Protein Kinase Signaling Pathway

(2020) Lin Zhong et al.   MOLECULAR NEUROBIOLOGY

Dual Switch Mechanism of Erythropoietin as an Antiapoptotic and Pro-Angiogenic Determinant in the Retina

(2020) Faith Pwaniyibo Samson et al.   ACS Omega

Detection of a nonerythropoietic erythropoietin, Neuro‐EPO, in blood after intranasal administration in rat

(2020) Laurent Martin et al.   Drug Testing and Analysis

Erythropoietin modulates striatal antioxidant signalling to reduce neurodegeneration in a toxicant model of Parkinson's disease

(2020) A.M. Thompson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Potentiation of cord blood cell therapy with erythropoietin for children with CP: a 2 × 2 factorial randomized placebo-controlled trial

(2020) Kyunghoon Min et al.   Stem Cell Research & Therapy

The Promises and Challenges of Erythropoietin for Treatment of Alzheimer’s Disease

(2019) Jiahong Sun et al.   NEUROMOLECULAR MEDICINE

Short erythropoietin-derived peptide enhances memory, improves long-term potentiation, and counteracts amyloid beta-induced pathology

(2019) Oksana Dmytriyeva et al.   NEUROBIOLOGY OF AGING

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

(2019) Strowitzki et al.   Cells

Placental pathology and neonatal brain MRI in a randomized trial of erythropoietin for hypoxic–ischemic encephalopathy

(2019) Yvonne W. Wu et al.   PEDIATRIC RESEARCH

Erythropoietin protects propofol induced neuronal injury in developing rats by regulating TLR4/NF-κB signaling pathway abstract

(2019) Chunyan Zhang et al.   NEUROSCIENCE LETTERS

Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression

(2019) Ilaria M.C. Orlando et al.   HAEMATOLOGICA

Carbamoylated erythropoietin modulates cognitive outcomes of social defeat and differentially regulates gene expression in the dorsal and ventral hippocampus

(2018) Monica Sathyanesan et al.   Translational Psychiatry

Alternative Erythropoietin Receptors in the Nervous System

(2018) Daniela Ostrowski et al.   Journal of Clinical Medicine

NeuroEPO Preserves Neurons from Glutamate-Induced Excitotoxicity

(2018) Fernando Garzón et al.   JOURNAL OF ALZHEIMERS DISEASE

A Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer’s Disease

(2018) Rudy Chang et al.   MOLECULAR PHARMACEUTICS

CEPO-Fc (An EPO Derivative) Protects Hippocampus Against Aβ-induced Memory Deterioration: A Behavioral and Molecular Study in a Rat Model of Aβ Toxicity

(2018) Etrat Hooshmandi et al.   NEUROSCIENCE

Carbamoylated erythropoietin induces a neurotrophic gene profile in neuronal cells

(2018) Neeraj K. Tiwari et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Differential effect of erythropoietin and carbamylated erythropoietin on endothelial cell migration

(2017) Romina E. Maltaneri et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

EphA4 Regulates Neuroblast and Astrocyte Organization in a Neurogenic Niche

(2017) Krysti L. Todd et al.   JOURNAL OF NEUROSCIENCE

Impact of Erythropoiesis-Stimulating Agents on Behavioral Measures in Children Born Preterm

(2017) Jean R. Lowe et al.   JOURNAL OF PEDIATRICS

Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

(2017) Sarah B. Mulkey et al.   JOURNAL OF PEDIATRICS

Erythropoietin Rescues Memory Impairment in a Rat Model of Chronic Cerebral Hypoperfusion via the EPO-R/JAK2/STAT5/PI3K/Akt/GSK-3β Pathway

(2017) Shengli Ma et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effects of erythropoietin on neurodegenerative and ischemic brain diseases: the role of erythropoietin receptor

(2017) Jorge Fuentealba et al.   Neural Regeneration Research

Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants: A Meta-analysis

(2017) Hendrik S. Fischer et al.   PEDIATRICS

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?

(2017) Marcelo N. N. Vieira et al.   Frontiers in Aging Neuroscience

Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders

(2016) K. W. Miskowiak et al.   ACTA PSYCHIATRICA SCANDINAVICA

Recombinant human erythropoietin improves neurological outcomes in very preterm infants

(2016) Juan Song et al.   ANNALS OF NEUROLOGY

Prolyl-4-hydroxylase 2 and 3 coregulate murine erythropoietin in brain pericytes

(2016) Andres A. Urrutia et al.   BLOOD

Recombinant human erythropoietin improves functional recovery in patients with severe traumatic brain injury: A randomized, double blind and controlled clinical trial

(2016) Zhong-min Li et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Downstream modulation of extrinsic apoptotic pathway in streptozotocin-induced Alzheimer's dementia in rats: Erythropoietin versus curcumin

(2016) Doaa M. Samy et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of Early Prophylactic High-Dose Recombinant Human Erythropoietin in Very Preterm Infants on Neurodevelopmental Outcome at 2 Years

(2016) Giancarlo Natalucci et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

An Intranasal Formulation of Erythropoietin (Neuro-EPO) Prevents Memory Deficits and Amyloid Toxicity in the APPSwe Transgenic Mouse Model of Alzheimer’s Disease

(2016) Yamila Rodríguez Cruz et al.   JOURNAL OF ALZHEIMERS DISEASE

Clinical Trial of Erythropoietin in Young Children With Cerebral Palsy

(2016) Kye Hee Cho et al.   JOURNAL OF CHILD NEUROLOGY

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

(2016) Abdel A. Belaidi et al.   JOURNAL OF NEUROCHEMISTRY

Epobis is a Nonerythropoietic and Neuroprotective Agonist of the Erythropoietin Receptor with Anti-Inflammatory and Memory Enhancing Effects

(2016) Oksana Dmytriyeva et al.   MEDIATORS OF INFLAMMATION

Neuroprotection and CD131/GDNF/AKT Pathway of Carbamylated Erythropoietin in Hypoxic Neurons

(2016) Jing Ding et al.   MOLECULAR NEUROBIOLOGY

Long-term effect of epoetin alfa on clinical and biochemical markers in friedreich ataxia

(2016) Francesco Saccà et al.   MOVEMENT DISORDERS

High-dose erythropoietin in patients with progressive multiple sclerosis: A randomized, placebo-controlled, phase 2 trial

(2016) Karen Schreiber et al.   Multiple Sclerosis Journal

High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial

(2016) Y. W. Wu et al.   PEDIATRICS

Preschool Assessment of Preterm Infants Treated With Darbepoetin and Erythropoietin

(2016) Robin K. Ohls et al.   PEDIATRICS

ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception

(2016) Wenjia Zhang et al.   PEPTIDES

Neural correlates of improved executive function following erythropoietin treatment in mood disorders

(2016) K. W. Miskowiak et al.   PSYCHOLOGICAL MEDICINE

High-dose erythropoietin in patients with progressive multiple sclerosis: A randomized, placebo-controlled, phase 2 trial

(2016) Karen Schreiber et al.   Multiple Sclerosis Journal

Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL

(2016) Yan Chen Shang et al.   Aging-US

Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders

(2015) Kamilla W. Miskowiak et al.   BIOLOGICAL PSYCHIATRY

Erythropoietin attenuates Alzheimer-like memory impairments and pathological changes induced by amyloid β42 in mice

(2015) Yi-pei Li et al.   BRAIN RESEARCH

Erythropoietin Stimulates Tumor Growth via EphB4

(2015) Sunila Pradeep et al.   CANCER CELL

Protein tyrosine phosphatase 1B (PTP1B) is involved in the defective erythropoietic function of carbamylated erythropoietin

(2015) María Eugenia Chamorro et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Safety of Early High-Dose Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants

(2015) Jean-Claude Fauchère et al.   JOURNAL OF PEDIATRICS

Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial

(2015) Alistair Nichol et al.   LANCET

The roles of Eph receptors in contextual fear conditioning memory formation

(2015) Monica Dines et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Enhanced brain release of erythropoietin, cytokines and NO during carotid clamping

(2015) Stephana Carelli et al.   NEUROLOGICAL SCIENCES

Erythropoietin improves synaptic plasticity and memory deficits by decrease of the neurotransmitter release probability in the rat model of Alzheimer's disease

(2015) Parisa Esmaeili Tazangi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The Effect of Recombinant Erythropoietin on Plasma Brain Derived Neurotrophic Factor Levels in Patients with Affective Disorders: A Randomised Controlled Study

(2015) Maj Vinberg et al.   PLoS One

Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300

(2014) Miyeon Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

JAK2/STAT5/Bcl-xL signalling is essential for erythropoietin-mediated protection against apoptosis induced in PC12 cells by the amyloid β−peptide Aβ25-35

(2014) Rong Ma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of Erythropoietin and Transfusion Threshold on Neurological Recovery After Traumatic Brain Injury

(2014) Claudia S. Robertson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association Between Early Administration of High-Dose Erythropoietin in Preterm Infants and Brain MRI Abnormality at Term-Equivalent Age

(2014) Russia Ha-Vinh Leuchter et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

EPO-Dependent Activation of PI3K/Akt/FoxO3a Signalling Mediates Neuroprotection in In Vitro and In Vivo Models of Parkinson’s Disease

(2014) Yu Jia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Therapeutic effects of nonerythropoietic erythropoietin analog ARA290 in experimental autoimmune encephalomyelitis rat

(2014) Hong Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

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(2014) Albert Dahan et al.   MOLECULAR MEDICINE

ARA 290, a Peptide Derived from the Tertiary Structure of Erythropoietin, Produces Long-Term Relief of Neuropathic Pain Coupled with Suppression of the Spinal Microglia Response

(2014) Maarten Swartjes et al.   Molecular Pain

Safety and tolerability of carbamylated erythropoietin in Friedreich's ataxia

(2014) Sylvia Boesch et al.   MOVEMENT DISORDERS

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Signaling pathways of cell proliferation are involved in the differential effect of erythropoietin and its carbamylated derivative

(2013) María Eugenia Chamorro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Short-term effects of erythropoietin on neurodevelopment in infants with cerebral palsy: A pilot study

(2013) Hee Song Lee et al.   BRAIN & DEVELOPMENT

The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson’s disease

(2013) Judith Thomas Tayra et al.   BRAIN RESEARCH

Protective action of erythropoietin on neuronal damage induced by activated microglia

(2013) Shirley D. Wenker et al.   FEBS Journal

Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Aβ25-35 non-transgenic mouse model of Alzheimer’s disease

(2013) Tangui Maurice et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Safety and efficacy of recombinant human erythropoietin treatment of non-motor symptoms in Parkinson's disease

(2013) Wooyoung Jang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The AKT/mTOR pathway mediates neuronal protective effects of erythropoietin in sepsis

(2013) Guo-Bin Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

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(2013) Lara Heij et al.   MOLECULAR MEDICINE

A new agonist of the erythropoietin receptor, Epobis, induces neurite outgrowth and promotes neuronal survival

(2012) Stanislava Pankratova et al.   JOURNAL OF NEUROCHEMISTRY

Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemia

(2012) Ting-Fa Zhou et al.   JOURNAL OF SURGICAL RESEARCH

Erythropoietin neuroprotection in neonatal cardiac surgery: A phase I/II safety and efficacy trial

(2012) Dean B. Andropoulos et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Ephrin regulation of synapse formation, function and plasticity

(2012) Martin Hruska et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling

(2012) Randolph S Ashton et al.   NATURE NEUROSCIENCE

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

(2012) Mark A. Greenough et al.   NEUROCHEMISTRY INTERNATIONAL

A Pilot Study of Darbepoetin Alfa for Prophylactic Neuroprotection in Aortic Surgery

(2012) Steven R. Messé et al.   Neurocritical Care

Erythropoietin for Neuroprotection in Neonatal Encephalopathy: Safety and Pharmacokinetics

(2012) Y. W. Wu et al.   PEDIATRICS

Subventricular Zone-Derived Oligodendrogenesis in Injured Neonatal White Matter in Mice Enhanced by a Nonerythropoietic Erythropoietin Derivative

(2012) Eisuke Kako et al.   STEM CELLS

ARA290, a Peptide Derived from the Tertiary Structure of Erythropoietin, Produces Long-term Relief of Neuropathic Pain

(2011) Maarten Swartjes et al.   ANESTHESIOLOGY

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

(2011) Rommy von Bernhardi et al.   ANTIOXIDANTS & REDOX SIGNALING

Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice

(2011) Derya Sargin et al.   BMC BIOLOGY

Neuroprotective effects of recombinant human erythropoietin in the developing brain of rat after lithium-pilocarpine induced status epilepticus

(2011) Şule Çağlayan Sözmen et al.   BRAIN & DEVELOPMENT

Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson's disease in the mouse

(2011) Qing-Hui Zhou et al.   BRAIN RESEARCH

Carbamylation-Derived Products: Bioactive Compounds and Potential Biomarkers in Chronic Renal Failure and Atherosclerosis

(2011) S. Jaisson et al.   CLINICAL CHEMISTRY

Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia

(2011) Yan Chen Shang et al.   CURRENT NEUROVASCULAR RESEARCH

Strategies for extended serum half-life of protein therapeutics

(2011) Roland E Kontermann   CURRENT OPINION IN BIOTECHNOLOGY

Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus

(2011) Christina Zellinger et al.   EPILEPSY RESEARCH

Effect of insulin and an erythropoietin-derived peptide (ARA290) on established neuritic dystrophy and neuronopathy in Akita (Ins2Akita) diabetic mouse sympathetic ganglia

(2011) Robert E. Schmidt et al.   EXPERIMENTAL NEUROLOGY

Different Expression Patterns of Ngb and EPOR in the Cerebral Cortex and Hippocampus Revealed Distinctive Therapeutic Effects of Intranasal Delivery of Neuro-EPO for Ischemic Insults to the Gerbil Brain

(2011) Yan Gao et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Investigation on positive correlation of increased brain iron deposition with cognitive impairment in Alzheimer disease by using quantitative MR R2′ mapping

(2011) Yuanyuan Qin et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer’s disease models

(2011) Soon-Tae Lee et al.   JOURNAL OF NEUROCHEMISTRY

Adult neural precursors isolated from post mortem brain yield mostly neurons: An erythropoietin-dependent process

(2011) Giovanni Marfia et al.   NEUROBIOLOGY OF DISEASE

The Nasal Route as a Potential Pathway for Delivery of Erythropoietin in the Treatment of Acute Ischemic Stroke in Humans

(2011) Julio Cesar García-Rodríguez et al.   TheScientificWorldJOURNAL

Treatment with Nasal Neuro-EPO Improves the Neurological, Cognitive, and Histological State in a Gerbil Model of Focal Ischemia

(2011) Yamila Rodríguez Cruz et al.   TheScientificWorldJOURNAL

Neuroprotective properties of a novel, non-haematopoietic agonist of the erythropoietin receptor

(2010) Stanislava Pankratova et al.   BRAIN

Neuroprotection in stroke in the mouse with intravenous erythropoietin–Trojan horse fusion protein

(2010) Ailing Fu et al.   BRAIN RESEARCH

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential antiapoptotic effect of erythropoietin on undifferentiated and retinoic acid-differentiated SH-SY5Y cells

(2010) Shirley D. Wenker et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Epoetin alfa increases frataxin production in Friedreich's ataxia without affecting hematocrit

(2010) Francesco Saccà et al.   MOVEMENT DISORDERS

Asialoerythropoietin attenuates neuronal cell death in the hippocampal CA1 region after transient forebrain ischemia in a gerbil model

(2010) Taro Yamashita et al.   NEUROLOGICAL RESEARCH

Human Recombinant Erythropoietin in Asphyxia Neonatorum: Pilot Trial

(2010) H. Elmahdy et al.   PEDIATRICS

The Beta-hCG+Erythropoietin in Acute Stroke (BETAS) Study

(2010) Steven C. Cramer et al.   STROKE

Erythropoietin improves operant conditioning and stability of cognitive performance in mice

(2009) Ahmed El-Kordi et al.   BMC BIOLOGY

Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: a Phase II randomized, double-blind, placebo-controlled trial

(2009) Ming-Yuan Tseng et al.   JOURNAL OF NEUROSURGERY

Erythropoietin protects PC12 cells from β-amyloid25–35-induced apoptosis via PI3K/Akt signaling pathway

(2009) Rong Ma et al.   NEUROPHARMACOLOGY

Erythropoietin Improved Neurologic Outcomes in Newborns With Hypoxic-Ischemic Encephalopathy

(2009) C. Zhu et al.   PEDIATRICS

Recombinant Human Erythropoietin in the Treatment of Acute Ischemic Stroke

(2009) Hannelore Ehrenreich et al.   STROKE

Erythropoietin enhances hippocampal long-term potentiation and memory

(2008) Bartosz Adamcio et al.   BMC BIOLOGY

TNF-alpha-induced apoptosis is prevented by erythropoietin treatment on SH-SY5Y cells

(2008) Nicolás Pregi et al.   EXPERIMENTAL CELL RESEARCH

Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response

(2008) M. Brines et al.   JOURNAL OF INTERNAL MEDICINE

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

'O', erythropoietin carbamoylation versus carbamylation

(2008) W. Jelkmann   NEPHROLOGY DIALYSIS TRANSPLANTATION

Protective effect of erythropoietin on β-amyloid-induced PC12 cell death through antioxidant mechanisms

(2008) Gang Li et al.   NEUROSCIENCE LETTERS

Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin

(2008) M. Brines et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA