Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases

Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV

(2020) Jared S. Morse et al.   CHEMBIOCHEM

Peptidomimetic Vinyl Heterocycle Inhibitors of Cruzain Effect Anti-Trypanosomal Activity

(2020) BALA CHANDRA CHENNA et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Curse or Cure? A Perspective on the Developability of Aldehydes as Active Pharmaceutical Ingredients

(2020) Christian Gampe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease

(2020) Lifeng Fu et al.   Nature Communications

A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors**

(2020) Kai S. Yang et al.   ChemMedChem

Catalytic Mechanism of Cruzain from Trypanosoma cruzi As Determined from Solvent Kinetic Isotope Effects of Steady-State and Pre-Steady-State Kinetics

(2018) Xiang Zhai et al.   BIOCHEMISTRY

Human carboxylesterases: a comprehensive review

(2018) Dandan Wang et al.   Acta Pharmaceutica Sinica B

Targeting biomolecules with reversible covalent chemistry

(2016) Anupam Bandyopadhyay et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cruzipain: An Update on its Potential as Chemotherapy Target against the Human Pathogen Trypanosoma cruzi

(2015) M.H. Branquinha et al.   CURRENT MEDICINAL CHEMISTRY

NMRFAM-SPARKY: enhanced software for biomolecular NMR spectroscopy

(2014) Woonghee Lee et al.   BIOINFORMATICS

Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

(2013) Anaïs F. M. Noisier et al.   CHEMICAL COMMUNICATIONS

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

American Trypanosomiasis (Chagas Disease)

(2012) Anis Rassi et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Synthesis and evaluation of novel prodrugs of caspase inhibitors

(2011) Jean-Damien Charrier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Endoperoxide Carbonyl Falcipain 2/3 Inhibitor Hybrids: Toward Combination Chemotherapy of Malaria through a Single Chemical Entity

(2010) Peter Gibbons et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exploitation of the Ubiquitin System by Invading Bacteria

(2010) Olivia Steele-Mortimer   TRAFFIC

In Vitro and In Vivo Studies of the Trypanocidal Properties of WRR-483 against Trypanosoma cruzi

(2010) Yen Ting Chen et al.   PLoS Neglected Tropical Diseases

Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

(2009) Iain D. Kerr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MestRe Nova MestRe Nova . Mestrelab Research S.L. Feliciano Barrera 9B, Bajo, 15706 Santiago de Compostela, Spain. http://www.mestrelab.com . See Web site for pricing information.

(2009) Mark Robert Willcott   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model

(2008) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases