Article
Nutrition & Dietetics
Hong Qin, Ziyu Song, Chunyu Zhao, Jinxin Yang, Fan Xia, Lewen Wang, Anwar Ali, Wenya Zheng
Summary: In this study, liquiritigenin (LQG) was found to inhibit lipid accumulation in 3T3-L1 adipocytes via mTOR-mediated autophagy, suggesting its potential as a natural bioactive component in dietary supplements for preventing obesity.
Article
Pharmacology & Pharmacy
Chaiwat Monmai, Jin-Suk Kim, Hyun Bo Sim, Doh-Won Yun, Sung-Dug Oh, Eui-Shik Rha, Jong-Jin Kim, So-Hyeon Baek
Summary: This study evaluated the effects of extracts from transgenic rice on inhibiting adipogenesis and anti-inflammatory activity. The results showed that the extracts significantly reduced lipid accumulation in cells and inhibited the expression of adipogenesis-related mRNA and inflammation-related factors. Therefore, transgenic rice may have potential as an obesity-reducing and/or -preventing agent.
Article
Biochemistry & Molecular Biology
Sung Woo Choi, Heeseung Oh, Seung Yeon Park, Wonjun Cho, A. M. Abd El-Aty, Ahmet Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jung
Summary: Musclin (MUS) can attenuate inflammation, enhance physical endurance, inhibit adipocyte differentiation, and affect related molecular mechanisms, thereby reducing lipid accumulation and altering lipid metabolism protein expression.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Dai Majima, Ryosuke Mitsuhashi, Misaki Yamasaki, Kazuaki Kajimoto, Tatsuya Fukuta, Kentaro Kogure
Summary: The study demonstrated that α-tocopheryl succinate (TS) can suppress lipid accumulation in adipocytes by regulating lipid metabolic cell signaling, promoting lipolysis, and inhibiting lipid synthesis.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Medicine, Research & Experimental
Jeong Won Choi, Hyeok Jin Choi, Gwang Hyeon Ryu, Jae Won Lee, Jueng Kyu Beak, Eun Jeong Koh, Jin Boo Jeong
Summary: This study aimed to investigate the mechanism of action of Paeonia lactiflora root (PLR) in its anti-obesity activity. The results showed that PLR inhibited lipid droplet accumulation and triacylglycerol levels, while increasing lipolytic and thermogenic factors in fat cells. These findings suggest that PLR could be a potential natural agent for obesity control.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hee Jung Kim, Dong Uk Im, Gia Cac Chau, Neeraj Kumar Mishra, In Su Kim, Sung Hee Um
Summary: In this study, a newly synthesized indole derivative, CF3-allylated indole, was found to effectively inhibit adipogenesis by regulating PKA/AMPK signaling in the early stage of adipocyte differentiation. These findings suggest the potential of CF3-allylated indole in controlling initial adipocyte differentiation in metabolic disorders such as obesity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Medicinal
Hyo-Geun Lee, Yu-An Lu, Jun-Geon Je, Thilina U. Jayawardena, Min-Cheol Kang, Seung-Hong Lee, Tae-Hee Kim, Dae-Sung Lee, Jeong-Min Lee, Mi-Jin Yim, Hyun-Soo Kim, You-Jin Jeon
Summary: The study revealed that ethanol extract from Grateloupia elliptica has a significant inhibitory effect on lipid accumulation, and a chlorophyll derivative with lipid accumulation inhibitory activity was successfully isolated.
Article
Nutrition & Dietetics
Beegum Noorjahan Shijina, Achuthan Radhika, Sainulabdeen Sherin, Prabath Gopalakrishnan Biju
Summary: The indole alkaloid vindoline from Catharanthus roseus was found to have significant improvements in insulin resistance, oxidative stress, and inflammatory responses. It enhanced glucose metabolism and increased the expression of insulin receptors, alleviating symptoms of insulin resistance.
Article
Immunology
Veronica Marquez, Grisel Ballesteros, Thomas Dobner, Ramon A. Gonzalez
Summary: Human adenovirus 36 (HAdV-D36) infection can induce obesity in animal models and promote adipocyte differentiation. In this study, the researchers explored the replication cycle of HAdV-D36 in preadipocytes and found that only adipocyte-committed cells supported productive viral replication, leading to a greater impact on adipogenesis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Plant Sciences
Masao Yamasaki, Yusei Kiue, Kento Fujii, Moe Sushida, Yumi Yamasaki, Kazuhiro Sugamoto, Yosuke Suzuki, Yasuko Koga, Hisato Kunitake, Hisahiro Kai, Kenjiro Ogawa, Kazuo Nishiyama, Yo Goto, Takayuki Nakayama
Summary: Blueberry leaf extract (BLEx) has been found to suppress lipid accumulation and uric acid production in adipocytes, mainly due to the highly polymerized proanthocyanidin-rich fraction. Additionally, BLEx can inhibit uric acid production in adipocytes under hypoxic conditions.
Article
Biotechnology & Applied Microbiology
Wanfeng Xu, Ling Hou, Ping Li, Ling Li
Summary: The interference of NNMT expression was found to reduce lipid accumulation and triglyceride content, as well as decrease the expression of certain genes and proteins related to lipid metabolism. This suggests that NNMT plays an important role in the function and metabolism of adipocytes.
Article
Biochemistry & Molecular Biology
Ji Li, Xuedong Wang, Xiangyu Meng, Xin Zhou, Han Huang, Yi Feng, Yujie Fu, Xinxin Liu, Bo Yu
Summary: Obesity is a global burden linked to severe medical complications. Geraniin, a polyphenolic compound, has shown pharmacological effects in reducing lipid accumulation and obesity. This study investigates the mechanism of geraniin in inhibiting lipid accumulation in adipocytes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Hayley C. Jackson, Carmen Pheiffer, Babalwa Jack, Donita Africander
Summary: This study provides an inexpensive model that mimics the characteristics of obesity by manipulating the time of adipocyte differentiation and increasing the glucose concentration. The results show that adipocyte hypertrophy, ROS production, IL-6 gene expression, lipolysis, and MCP1 gene expression are dependent on glucose and time. In addition, the hypertrophic model exhibits significantly higher expression of steroidogenic enzymes and enhanced conversion of cortisone and androstenedione. These characteristics make hypertrophic 3T3-L1 adipocytes an appropriate in vitro model to study adipocyte dysfunction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yu-Kyoung Park, Byeong-Churl Jang
Summary: The study revealed that the receptor tyrosine kinase c-Met plays a crucial role in embryogenesis, morphogenesis, metabolism, cell growth, and differentiation. JNJ38877605 (JNJ), an inhibitor of c-Met, showed anti-tumor activity. In this research, the expression and phosphorylation of c-Met, as well as its effects on fat accumulation, were investigated in murine preadipocyte 3T3-L1 cells. The findings demonstrated that c-Met is a novel mediator of adipogenesis, regulating lipid accumulation in adipocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zexiu Qi, Jie Lin, Ruichang Gao, Weize Wu, Yan Zhang, Xinyuan Wei, Xiang Xiao, Huili Wang, Ye Peng, John M. Clark, Yeonhwa Park, Quancai Sun
Summary: This study investigates the molecular mechanisms of deltamethrin induced fat accumulation in murine adipocytes. The results show that deltamethrin promotes adipogenesis and involves multiple key functional groups regulating adipogenesis.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Won-Chul Lim, Hyunhee Kim, Hyeonseok Ko
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Eun Ju Shin, Seongin Jo, Sungbin Choi, Chang-Won Cho, Won-Chul Lim, Hee-Do Hong, Tae-Gyu Lim, Young Jin Jang, Mi Jang, Sanguine Byun, Youngkyung Rhee
Article
Multidisciplinary Sciences
Won-Chul Lim, Hyunhee Kim, Young-Joo Kim, Bu-Nam Jeon, Hee-Bum Kang, Hyeonseok Ko
SCIENTIFIC REPORTS
(2020)
Article
Plant Sciences
Hyunhee Kim, Pilju Choi, Taejung Kim, Youngseok Kim, Bong Geun Song, Young-Tae Park, Seon-Jun Choi, Cheol Hee Yoon, Won-Chul Lim, Hyeonseok Ko, Jungyeob Ham
Summary: The study found that Rk1 and Rg5 inhibited TGF-beta 1-induced EMT and the development of stem cell properties by regulating the Smad and NF-kB/ERK pathways.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Chemistry, Medicinal
Young-Ran Song, Won-Chul Lim, Ahram Han, Myung-Hee Lee, Eun Ju Shin, Kwang-Min Lee, Tae-Gyu Nam, Tae-Gyu Lim
JOURNAL OF MEDICINAL FOOD
(2020)
Article
Food Science & Technology
Chang-Won Cho, Young-Ran Song, Won-Chul Lim, Youn-Hwan Hwang, Young Kyoung Rhee, Jae Woong Choi, Kyung-Tae Lee, Hee-Do Hong
Article
Biochemistry & Molecular Biology
Won-Chul Lim, Jae Woong Choi, Nho-Eul Song, Chang-Won Cho, Young Kyoung Rhee, Hee-Do Hong
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Wonchul Lim, Bu-Nam Jeon, Young-Joo Kim, Ki-Hwan Kim, Hyeonseok Ko
Summary: The study found that FBI-1 plays a negative role in epithelial-to-mesenchymal transition in lung cancer, suggesting it as a potential therapeutic target and diagnostic indicator for early stage of lung cancer metastasis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Seongin Jo, Young-Sung Jung, Ye-Ryeong Cho, Ji-Won Seo, Won-Chul Lim, Tae-Gyu Nam, Tae-Gyu Lim, Sanguine Byun
Summary: Rosa gallica, a widely used species for medicinal and culinary purposes, has demonstrated antioxidant, anti-inflammatory, and antibacterial activities. It has been shown to prevent skin aging in vivo, primarily through the component gallic acid targeting the c-Raf/MEK/ERK/c-Fos signaling axis to restore collagen levels. This suggests that Rosa gallica could be utilized in nutraceuticals for combating skin aging.
Article
Food Science & Technology
Won-Chul Lim, Eun Ju Shin, Tae-Gyu Lim, Jae Woong Choi, Nho-Eul Song, Hee-Do Hong, Chang-Won Cho, Young Kyoung Rhee
Summary: G-Rf enhances exercise endurance in mice by promoting myoblast differentiation and enhancing mitochondrial biogenesis through the AMPK and p38 MAPK signaling pathways, leading to increased energy production.
Article
Biochemistry & Molecular Biology
Woo-Jin Sim, Jisong Ahn, Wonchul Lim, Dong Ju Son, Eunjung Lee, Tae-Gyu Lim
Summary: Through a study on SKH-1 mice, it was found that oral administration of eggshell membrane (ESM) can improve skin moisture and reduce wrinkles. ESM intake can restore skin moisture, reduce collagen degradation and expression of collagenase induced by UVB irradiation, and restore the expression of antioxidant enzymes. Thus, ESM has anti-wrinkle and skin moisturizing properties.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Chang-Won Cho, Young-Ran Song, Youn-Hwan Hwang, Young Kyoung Rhee, Won-Chul Lim, JaeWoong Choi, Kyung-Tae Lee, Hee-Do Hong
Summary: In this study, the polysaccharide fraction PLEO extracted from persimmon leaves using pectinase showed no toxicity, mutagenicity, or chromosomal aberration in vitro under the experimental conditions.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Biochemistry & Molecular Biology
Won-Chul Lim, Hyo-Kyung Choi, Kyung-Tack Kim, Tae-Gyu Lim
Article
Chemistry, Medicinal
Won-Chul Lim, Hyunhee Kim, Young-Joo Kim, Kyung-Chul Choi, In Ho Lee, Ki Heon Lee, Mi Kyung Kim, Hyeonseok Ko
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2017)
Article
Biochemistry & Molecular Biology
Jae-Woo Choi, Hye Won Kang, Won-Chul Lim, Mi-Kyoung Kim, In-Young Lee, Hong-Yon Cho
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2017)
