Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model

mRNA: A Novel Avenue to Antibody Therapy?

(2019) Thomas Schlake et al.   MOLECULAR THERAPY

Messenger RNA therapy for rare genetic metabolic diseases

(2019) Pedro Berraondo et al.   GUT

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer

(2019) Martin Sebastian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

(2019) Josepmaria Argemi et al.   Nature Communications

Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A-miR-122 Feedback Loop in Liver Fibrosis and Cancer Progression

(2019) Aydin et al.   Cancers

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Identification of TAF1 , HNF4A , and CALM2 as potential therapeutic target genes for liver fibrosis

(2018) Dong Ji et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

(2017) Martin Alberer et al.   LANCET

Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha

(2016) Seema S. Desai et al.   HEPATOLOGY

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis

(2016) Shashi Bala et al.   JOURNAL OF HEPATOLOGY

Primary Sclerosing Cholangitis

(2016) Konstantinos N. Lazaridis et al.   NEW ENGLAND JOURNAL OF MEDICINE

From the RNA world to the clinic

(2016) B. A. Sullenger et al.   SCIENCE

Rb and p53 Liver Functions Are Essential for Xenobiotic Metabolism and Tumor Suppression

(2016) Sathidpak Nantasanti et al.   PLoS One

Regulation of hepatocyte identity and quiescence

(2015) Carmen Berasain et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Resetting the transcription factor network reverses terminal chronic hepatic failure

(2015) Taichiro Nishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

(2015) Andreas Thess et al.   MOLECULAR THERAPY

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference

(2015) Feng Hong et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

(2014) Josef Ehling et al.   GUT

Liver cirrhosis

(2014) Emmanuel A Tsochatzis et al.   LANCET

The stable repression of mesenchymal program is required for hepatocyte identity: A novel role for hepatocyte nuclear factor 4α

(2011) Laura Santangelo et al.   HEPATOLOGY

Hepatocyte nuclear factor 4  attenuates hepatic fibrosis in rats

(2009) H.-Y. Yue et al.   GUT