Article
Geriatrics & Gerontology
Nazaneen Saleh, Caglar Cosarderelioglu, Ramya Vajapey, Jeremy Walston, Peter M. Abadir
Summary: Chronic inflammation, oxidative stress, and dysregulation of the renin-angiotensin system commonly contribute to age-related decline. Oral Losartan treatment has a positive impact on brain-specific angiotensin system and reduces protein levels and oxidative stress damage in a frailty mouse model.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Himangshu Sonowal, Hongying Zhang, William Rice, Stephen B. Howell
Summary: The multikinase inhibitor Luxeptinib demonstrates the ability to inhibit the release of IL-1 beta, IL-6, and TNF alpha from monocytes and macrophages, making it a potential treatment for inflammatory diseases and inflammation-associated resistance in cancer. The mechanism involves disabling caspase-1 and inhibiting multiple kinases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Jinfeng Xie, Bingtian Bi, Yunyun Qin, Wenli Dong, Jiahong Zhong, Mengfan Li, Yufang Cheng, Jiangping Xu, Haitao Wang
Summary: Inhibition of phosphodiesterase-4 (PDE4) can reduce depressive symptoms and inflammation in mice, showing potential as antidepressant drugs. The down-regulation of HMGB1/RAGE signaling pathway and suppression of inflammasome may contribute to the antidepressant-like effects of PDE4 inhibitors.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Genetics & Heredity
Na Liu, Yifan Wu, Xin Wen, Peng Li, Fei Lu, Hong Shang
Summary: Chronic restraint stress promotes acute myeloid leukemia (AML) progression and mediates NLRP3 inflammasome activation in xenograft mice. HMGB1 regulates NLRP3 inflammasome activation in AML cells. Knockdown of HMGB1 inhibits AML progression under chronic stress in vivo.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Biochemistry & Molecular Biology
Michal Tomaszewski, Paulina Mertowska, Martyna Janczewska, Agnieszka Styczen, Sebastian Mertowski, Kamil Jonas, Ewelina Grywalska, Grzegorz Kopec
Summary: Pulmonary arterial hypertension (PAH) is a complex disorder where cytokines play a crucial role in deregulation of the immune system. This study found that PAH patients have abnormal immune function with decreased percentages of immune cell subpopulations and changes in cytokine concentration. Furthermore, significant differences were observed between PAH subtypes and immunological parameters, suggesting the important role of the immune system in the pathogenesis of PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Li Zhou, Chuangang Tang, Xiaoxin Li, Fang Feng
Summary: There is growing evidence that inflammatory responses play significant roles in malignancies. This study investigated the impact of the pro-inflammatory-to-anti-inflammatory factor ratio in tumor tissues on overall survival in gastric cancer patients. The results showed that the IL-6/IL-10 mRNA expression ratio in tumor tissues was an independent prognostic factor for overall survival and disease-specific survival in gastric cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Gehad M. Elnagar, Mohamed M. Elseweidy, Nesreen M. I. M. Elkomy, Mohammed M. Keshawy, Ola M. Fathy, Mohammed S. Sobh, Yasmin K. Mahmoud
Summary: This study found that policosanol can alleviate renal inflammation and pyroptosis caused by a high cholesterol diet, improve renal dysfunction and dyslipidemia. Policosanol modulates multiple signaling pathways, reduces oxidative stress and inhibits inflammatory response, thereby reducing renal injury.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Zhanyou Cao, Fan Yang, Yiqun Lin, Jiyi Shan, Huabin Cao, Caiying Zhang, Yu Zhuang, Chenghong Xing, Guoliang Hu
Summary: Cadmium is a toxic heavy metal that can accumulate in the liver, causing damage to liver function. Selenium, an antioxidant, can alleviate the detrimental effects of cadmium on the liver. This study found that selenium can mitigate cadmium-induced oxidative stress and inflammation in hepatocytes, possibly through the NLRP3 inflammasome and HMGB1/NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Sultan Tousif, Anand P. P. Singh, Prachi Umbarkar, Cristi Galindo, Nicholas Wheeler, Angelica Toro Cora, Qinkun Zhang, Sumanth D. D. Prabhu, Hind Lal
Summary: The tyrosine kinase inhibitor ponatinib is found to be the most cardiotoxic agent among all approved tyrosine kinase inhibitors. Through the use of various models, the study reveals that ponatinib induces cardiac inflammation and dysfunction through the activation of the S100A8/A9-TLR4-NLRP3-IL-1beta signaling pathway. These findings provide important preclinical data and rationale for managing ponatinib-induced cardiotoxicity.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Andrea Nieto-Veloza, Shan Hong, Matthew Reeder, Mee-Ja Sula, Doris H. D'Souza, Qixin Zhong, Vermont P. Dia
Summary: This study investigated the protective effect of the soy peptide lunasin in an in vivo model of susceptibility to inflammatory bowel disease (IBD) and identified its potential mechanism of action in vitro. The results showed that lunasin could reduce susceptibility to inflammation and levels of proinflammatory cytokines. Lunasin exhibited anti-inflammatory properties and decreased susceptibility to IBD in genetically susceptible mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Kenta Fujimura, Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Yoshiko Mizushina, Chintogtokh Baatarjav, Takayoshi Matsumura, Kinya Otsu, Norihiko Takeda, Hiroaki Mizukami, Kazuomi Kario, Masafumi Takahashi
Summary: Sepsis is a life-threatening syndrome, and its associated mortality is increased when cardiac dysfunction and damage (septic cardiomyopathy [SCM]) occur. The NLRP3 inflammasome plays a critical role in the pathophysiology of SCM, with the activation of IL-1 beta and IL-18 contributing to the development of SCM.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Microbiology
Katherine C. Barnett, Yuying Xie, Takanori Asakura, Dingka Song, Kaixin Liang, Sharon A. Taft-Benz, Haitao Guo, Shuangshuang Yang, Kenichi Okuda, Rodney C. Gilmore, Jennifer F. Loome, Thomas H. Oguin III, Gregory D. Sempowski, Scott H. Randell, Mark T. Heise, Yu Leo Lei, Richard C. Boucher, Jenny P. -Y. Ting
Summary: Elevated levels of cytokines IL-1(3 and IL-6 are associated with severe COVID-19. Investigating the underlying mechanisms, it was found that primary human airway epithelia (HAE) are not the source of IL-1(3 released upon SARS-CoV-2 infection. The SARS-CoV-2 E protein upregulates inflammasome gene transcription via TLR2 in leukocytes, while infected HAE supply a second signal, including genomic and mitochondrial DNA, to stimulate leukocyte IL-1(3 release.
CELL HOST & MICROBE
(2023)
Article
Immunology
Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Nourin Shakeeb, Prashanth Varkey, Aimy Hynse, Amita Ajit
Summary: This study investigates the expression of inflammatory genes in saliva of COVID-19 patients and compares it with blood samples. The results show that IL-6, TNF-alpha, and IL-10 can be detected in both saliva and blood, and their expression levels are similar. Therefore, saliva may be used as an alternative specimen for monitoring inflammation in COVID-19 patients.
Article
Clinical Neurology
Helge Toft, Jorgen G. Bramness, Lars Lien
Summary: This study investigated the development of cytokines and depression symptoms in patients with comorbid depression and post-traumatic stress disorder (PTSD) over a one-year follow-up period. The results showed that certain inflammatory biomarkers in PTSD patients were similar to those in non-PTSD patients after one year, despite the level of depression remaining unchanged in the PTSD patients.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Ayse Nur Ozdag Acarli, Ayse Deniz Elmali, Nermin Gorkem Sirin, Betul Baykan, Nerses Bebek
Summary: Ictal blinking is a useful lateralizing sign in focal seizures, especially when it is unilateral or asymmetrical. It often appears early in the seizures and is associated with fronto-temporal seizure onset. However, symmetrical blinking does not seem to be valuable in lateralization and localization of focal seizures. Further studies using invasive recordings and periocular electrodes are needed to evaluate the value of blinking in lateralization and localization.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Serkan Aksu, Tuba Cerrahoglu Sirin, Buse Rahime Hasirci Bayir, Cagri Ulukan, Ahmet Zihni Soyata, Adnan Kurt, Sacit Karamursel, Betul Baykan
Summary: This study found that long-term extended transcranial direct current stimulation (tDCS) can effectively alleviate allodynia symptoms in migraine patients and meet the goals of prophylactic treatment.
Article
Clinical Neurology
Emel Oguz-Akarsu, Baris Salman, Sibel Ugur-Iseri, Betul Baykan
Summary: This article reports a case of a 20-year-old woman with long-lasting bilateral paroxysmal high-voltage slow waves on EEG, which were interrupted by sudden verbal stimuli. Whole exome sequencing revealed potential genetic etiology. This rare manifestation of subclinical periodic discharges terminated by verbal stimuli deserves particular attention.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Clinical Neurology
Emanuele Cerulli Irelli, Enrico Cocchi, Georgia Ramantani, Antonella Riva, Roberto Horacio Caraballo, Alessandra Morano, Loretta Giuliano, Tulay Yilmaz, Eleni Panagiotakaki, Francesca F. Operto, Beatriz Gonzalez Giraldez, Simona Balestrini, Katri Silvennoinen, Sara Casciato, Marion Comajuan, Francesco Fortunato, Anna Teresa Giallonardo, Rimma Gamirova, Antonietta Coppola, Giancarlo Di Gennaro, Angelo Labate, Vito Sofia, Gerhard Josef Kluger, Antonio Gambardella, Dorothee G. A. Kasteleijn-NolstTrenite, Betul Baykan, Sanjay M. Sisodiya, Alexis Arzimanoglou, Pasquale Striano, Carlo Di Bonaventura
Summary: Based on age at epilepsy onset (AEO), this study identified three subtypes of objective epilepsy with eyelid myoclonia (EEM) and analyzed their distinct clinical features. Early onset EEM was associated with higher rates of intellectual disability, antiseizure medication refractoriness, and psychiatric comorbidities, while late onset EEM had the highest proportion of myoclonia involving body regions other than eyelids and generalized tonic-clonic seizures. Intermediate onset EEM had the lowest observed rate of additional findings. Family history of EEM was more frequent in the subtypes with intermediate and late onset. Patients with body-MYO showed higher rates of migraine and generalized tonic-clonic seizures.
Article
Clinical Neurology
Betul Baykan, Silvana Franceschetti, Laura Canafoglia, Gianpiero L. Cavalleri, Roberto Michelucci, Ingrid E. Scheffer
Summary: Familial adult myoclonic epilepsy (FAME) is a under-recognized disorder characterized by cortical myoclonus, generalized tonic-clonic seizures, and additional clinical symptoms, which vary depending on the FAME subtype. FAME is caused by pentanucleotide repeat expansions of intronic TTTCA/TTTTA in different genes.
Article
Otorhinolaryngology
Ercan Karababa, Ali Riza Sonkaya, Bulent Satar, Hanifi Korkmaz
Summary: This study aimed to assess VOR function in patients with Parkinson's disease using fHIT. The results showed that PD patients had lower fHIT %CA in the right lateral, left lateral, and left posterior SCC planes compared to the control group. However, there was no statistical difference in VOR abnormality between different PD severity groups. These findings suggest that impaired VOR and reduced dynamic visual acuity should be taken into consideration for vestibular rehabilitation exercises in individuals with PD.
CLINICAL OTOLARYNGOLOGY
(2023)
Article
Clinical Neurology
Yasemin Baranoglu Kilinc, Erkan Kilinc, Aysegul Danis, Fatma Hanci, Sevim Turay, Aynur Ozge, Hayrunnisa Bolay
Summary: The study aimed to investigate serum levels of mitochondrial metabolism/reactive oxygen species (ROS) -related peptides and key migraine-related neuropeptides during migraine attacks in pediatric patients. The findings suggest that elevated levels of these peptides may indicate mitochondrial stress and have potential diagnostic value in monitoring disease progression and treatment response in children with migraines.
Article
Neurosciences
Mustafa Ertugrul Yasa, Ali Riza Sonkaya, Buse Korkmaz, Ozge Coban, Necmiye Un Yildirim
Summary: This study aimed to determine trunk position sense in patients with Parkinson's disease (PD) and investigate its relationship with spinal posture and spinal mobility. The study found that trunk position sense was significantly decreased in patients with PD, but it was not correlated with spinal posture and spinal mobility.
Article
Clinical Neurology
Reza Ghouri, Nevra Oksuz, Bahar Tasdelen, Aynur Ozge
Summary: This study provides valuable insights into the temporal course and prognostic factors of non-Alzheimer's dementias. The findings underscore the importance of considering functional, neuropsychological, and comorbid medical conditions in understanding disease progression. The significant associations between hippocampal atrophy, white matter intensities, and prognosis highlight potential avenues for further research and therapeutic interventions.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Ozge Coban, Necmiye Un Yildirim, Mustafa Ertugrul Yasa, Ali Riza Sonkaya
Summary: This study aimed to examine the effects of aerobic exercise and stretching exercise programs on symptom severity, sleep, and quality of life in patients with primary restless legs syndrome (RLS). The results showed that aerobic exercise and stretching exercise were both effective in decreasing RLS symptoms and improving sleep and quality of life. The choice of exercise approach can be based on available facilities, patient and clinician preference, and the advantages of each method.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Ulas Degirmenci, Metin Yildirim, Merih Akkapulu, Ali Erdinc Yalin, Dilek Cicek Yilmaz, Ragip Onur Oztornaci, Bahar Tasdelen, Serap Yalin
Summary: This study aimed to clarify the relationship between coronary artery disease and Kruppel-like factor 2 protein levels and C1239A polymorphisms. The results showed that men had a 3.8-fold higher risk of CAD than women, but Kruppel-like factor 2 protein levels and C1239A polymorphisms were not associated with coronary artery disease.
CUKUROVA MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Irem Ilgezdi Kaya, Betuel Baykan
Summary: The ILAE Task Force on Classification released a report in 2015 to clarify the classification of status epilepticus. Non-convulsive status epilepticus (NCSE) was defined as SE without prominent motor symptoms, with or without coma. The increasing evidence in patients, who do not meet the Salzburg Consensus Criteria for NCSE diagnosis of 'NCSE' or 'possible NCSE', but whose clinical and electrophysiological features are still suspicious for NCSE, may pave the way for developing more comprehensive criteria. Therefore, we present here the 'generalized non-reactive alpha activity' in the electroencephalogram (EEG) of an elderly patient with no known epilepsy before, who presented with acute confusional state of unexplained cause, which we suspected as NCSE and managed accordingly with success. Considering that 'time is brain', early and correct NCSE diagnosis is critical and the NCSE EEG criteria should be more inclusive for the patients in the 'grey zone like the one presented here with 'generalized non-reactive alpha activity'.
ARCHIVES OF EPILEPSY
(2023)
Article
Clinical Neurology
Berkay Alpay, Bariscan Cimen, Elif Akaydin, Hayrunnisa Bolay, Yildirim Sara
Summary: This study found that single injection of levcromakalim (LVC) can induce migraine-like phenotype in rats and modulate cortical spreading depolarization (CSD), a rodent model of migraine aura. The rapid onset and recovery of migraine-like symptoms caused by LVC might be related to functional alterations in the trigeminal nociceptive system and the K+ channel opening properties of LVC.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Audiology & Speech-Language Pathology
Ozan Gokdogan, Cagil Gokdogan, Fulya Yalcinkaya, Bulent Cengiz, Hayrunnisa Bolay
Summary: The study aimed to determine the effect of migraine on the auditory system. Results from hearing tests showed a significant difference between migraine patients and healthy volunteers. Although hearing tests were normal, the auditory pathway of migraine patients may be affected. Further audiological tests should be conducted to evaluate hearing or speech perception disorders in migraine patients.
AUDIOLOGY AND NEURO-OTOLOGY
(2023)
Article
Clinical Neurology
Arife Cimen Atalar, Ayse Nur Ozdag Acarli, Betuel Baykan, Paolo Martelletti, Hayrunnisa Bolay, Mustafa Ertas, Esme Ekizoglu, Omer Karadas, Burcu Polat, Isil Yazici Gencdal, David Garcia Azorin, Dimos Mitsikostas, Loukia Apostolakopoulou, Hamit Genc, Pinar Yalinay Dikmen, Esra Aciman Demirel, Elif Ilgaz Aydinlar, Rabia Gokcen Gozubatik-Celik, Javid Shafiyev, Bahar Tasdelen, Aynur Ozge
Summary: This multinational observational study aimed to investigate prolonged or worsened headaches associated with COVID-19 vaccination. Questionnaires were used to assess the vaccination-related headaches at three time points. Repeated K-means cluster analysis identified patient profiles with prolonged or worsened headaches related to COVID-19 vaccination.
JOURNAL OF HEADACHE AND PAIN
(2023)
