Article
Medicine, General & Internal
Sung Ha Lim, Hyun Jeong Ju, Ju Hee Han, Ji Hae Lee, Won-Soo Lee, Jung Min Bae, Solam Lee
Summary: This retrospective cohort study reveals a significant association between COVID-19 and autoimmune and autoinflammatory connective tissue disorders, suggesting the need for long-term evaluation of such disorders in patients with COVID-19.
Article
Gastroenterology & Hepatology
Richard Hansen, Susanna Meade, R. Mark Beattie, Marcus Kh Auth, Nick Croft, Philip Davies, David Devadason, Conor Doherty, Jenny Epstein, Lucy Howarth, Fevronia Kiparissi, Rafeeq Muhammed, Vinay Shivamurthy, Christine Spray, Michael P. Stanton, Franco Torrente, Arun Urs, David Wilson, Peter M. Irving, Mark Samaan, Jochen Kammermeier
Summary: Pediatric acute severe colitis (ASC) management during the COVID-19 pandemic involves challenges due to the reliance on immunosuppression and potential for surgery. A RAND panel of experts recommended COVID-19-specific adaptations to ASC guidelines, including SARS-CoV-2 testing, expedited biological screening, isolation, and appropriate use of medications such as methylprednisolone and infliximab. The panel also suggested routine prophylactic anticoagulation and avoidance of delaying colectomy in patients with SARS-CoV-2 infection.
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Gastroenterology & Hepatology
Mohammed Deputy, Kapil Sahnan, Guy Worley, Komal Patel, Violeta Balinskaite, Alex Bottle, Paul Aylin, Elaine M. Burns, Ailsa Hart, Omar Faiz
Summary: The Covid-19 pandemic has had a detrimental effect on inflammatory bowel disease (IBD) services, leading to delays in emergency care and access to investigations and surgeries. A study in England found significant decreases in hospital attendances for acute ulcerative colitis (UC) and acute Crohn's disease (CD), as well as a decrease in the volume of IBD procedures and investigations. The study also highlighted the importance of prioritizing care for patients with IBD to prevent clinical harm and a decrease in quality of life.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Raffi Lev-Tzion, Gili Focht, Rona Lujan, Adi Mendelovici, Chagit Friss, Shira Greenfeld, Revital Kariv, Amir Ben-Tov, Eran Matz, Daniel Nevo, Yuval Barak-Corren, Iris Dotan, Dan Turner
Summary: COVID-19 vaccine effectiveness in IBD patients is comparable to non-IBD controls and is not affected by treatment with TNF inhibitors or corticosteroids. The risk of IBD exacerbation did not differ between vaccinated and unvaccinated patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Lev Lichtenstein, Benjamin Koslowsky, Ami Ben Ya'acov, Irit Avni-Biron, Baruch Ovadia, Ofer Ben-Bassat, Timna Naftali, Uri Kopylov, Yael Haberman, Hagar Eran, Rami Eliakim, Adi Lahat-Zok, Ayal Hirsch, Eran Zittan, Nitsan Maharshak, Matti Waterman, Eran Israeli, Idan Goren, Jacob Ollech, Henit Yanai, Bella Ungar, Benjamin Avidan, Dana Ben Hur, Bernardo Melamud, Ori Segol, Zippora Shalem, Iris Dotan, Selwyn Odes, Shomron Ben-Horin, Yf'at Snir, Yael Milgrom, Efrat Broide, Eran Goldin, Shmuel Delgado, Yulia Ron, Nathaniel Cohen, Eran Maoz, Maya Zborovsky, Safwat Odeh, Naim Abu Freha, Eyal Shachar, Yehuda Chowers, Tal Engel, Hila Reiss-Mintz, Arie Segal, Adar Zinger, Ariella Bar-Gil Shitrit
Summary: The use of immunosuppressive therapy in IBD patients does not worsen the severity of COVID-19, and in fact, patients receiving biologics have milder infection course. Treatment can be postponed until recovery from COVID-19.
Article
Development Studies
Olivier Bargain, Ulugbek Aminjonov
Summary: The study found that work-related mobility in high-poverty regions during lockdown period decreased significantly less compared to other regions, and higher poverty levels accelerated the spread of the virus. The research also suggested the complementary role of social protection measures and physical distancing measures in pandemic response.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Business, Finance
Barbara Bedowska-Sojka, Agata Kliber
Summary: This paper examines the impact of changes in pandemic restrictions on the market perception of sovereign risk in selected Latin American and Asian economies. The risk is measured by sovereign bond spreads. Using the Markov switching modeling, the study finds that imposing restrictions in Asian countries, except for China, leads to an increase in bond spreads only in the high volatility regime. The causality approach demonstrates various asymmetric causality patterns between stringency index and bond spreads.
FINANCE RESEARCH LETTERS
(2022)
Article
Medicine, General & Internal
Yu Nishida, Shuhei Hosomi, Koji Fujimoto, Rieko Nakata, Naoko Sugita, Shigehiro Itani, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Noriko Kamata, Toshio Watanabe, Satoko Ohfuji, Yasuhiro Fujiwara
Summary: The study found that 34% of UC patients and 46% of CD patients reported disease exacerbation within 2 months after the lockdown. For UC, age, sleep duration, and stress due to the COVID-19 pandemic were independent factors associated with exacerbation. For CD, age and active disease before the state of emergency were independently associated with exacerbation.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Freddy Caldera, Francis A. Farraye, Brian M. Necela, Davitte Cogen, Sumona Saha, Arnold Wald, Nader D. Daoud, Kelly Chun, Ian Grimes, Megan Lutz, Sean R. Van Helden, Melanie D. Swift, Abinash Virk, Adil E. Bharucha, Tushar C. Patel, Gregory J. Gores, Saranya Chumsri, Mary S. Hayney, Keith L. Knutson
Summary: Most patients with inflammatory bowel disease achieve a cell-mediated immune response (CMIR) to mRNA COVID-19 vaccines, with no difference compared to healthy control subjects. There is no significant difference in CMIR between immunocompetent and immunosuppressed patients. There is no correlation between humoral and cell-mediated immunity after vaccination.
INFLAMMATORY BOWEL DISEASES
(2023)
Editorial Material
Gastroenterology & Hepatology
Freddy Caldera, Sophie Balzora, Mary S. Hayney, Francis A. Farraye, Raymond K. Cross
Summary: The recent emergency use authorization of a third COVID-19 vaccine means that most patients with inflammatory bowel disease (IBD) will soon be eligible to be vaccinated. Gastroenterology clinicians should be prepared to address patients' concerns regarding safety and efficacy of vaccines, strongly recommend vaccination, and educate patients about logistics for successful vaccination. These measures are crucial to ensure high uptake among patients with IBD.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Medicine, General & Internal
Toshikuni Suda, Morio Takahashi, Yasumi Katayama, Koichi Soga, Ikuhiro Kobori, Yumi Kusano, Masaya Tamano
Summary: The first wave of the COVID-19 pandemic worsened the disease activity in UC patients, but it significantly recovered in 2021 and remained stable in 2022.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Letter
Gastroenterology & Hepatology
Karime Lucas Uemura, Natalia Sousa Freitas Queiroz, Charlie W. Lees
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Sport Sciences
Flavio Augustino Back, Adriano Akira Ferreira Hino, Wilynson Gomes Bojarski, Joao Manoel Goncalves Aurelio, Claudia Roberta de Castro Moreno, Fernando Mazzilli Louzada
Summary: Chronotype is another variable that can predict the risk of dropout in physical exercise programs, along with the frequency of exercise in the first week and the duration of membership.
SPORT SCIENCES FOR HEALTH
(2023)
Editorial Material
Gastroenterology & Hepatology
Natalia Sousa Freitas Queiroz, Adam S. Cheifetz, Konstantinos Papamichael
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Biochemistry & Molecular Biology
Karoline Soares Garcia, Matheus Freitas Cardoso de Azevedo, Alexandre de Sousa Carlos, Luisa Leite Barros, Jane Oba, Carlos Walter Sobrado Junior, Aytan Miranda Sipahi, Olivia Duarte de Castro Alves, Tomas Navarro-Rodriguez, Rogerio Serafim Parra, Julio Maria Fonseca Chebli, Liliana Andrade Chebli, Cristina Flores, Andrea Vieira, Christianne Damasceno Arcelino do Ceara, Natalia Sousa Freitas Queiroz, Aderson Omar Mourao Cintra Damiao
Summary: Therapeutic drug monitoring (TDM) is important in optimizing response to anti-tumor necrosis factor drugs and preventing inadequate drug exposure. This study aimed to describe the remission rates of Brazilian inflammatory bowel disease (IBD) patients at six months using a proactive TDM algorithm guided by IFX trough levels (ITL) and antibodies to IFX (ATI) levels. The results showed that proactive TDM was associated with a high persistence rate of 82.9% and favorable remission rates at six months.
Article
Nutrition & Dietetics
Ilanna Marques Gomes da Rocha, Raquel Torrinhas, Danielle Fonseca, Clelia de Oliveira Lyra, Julianna Lys de Sousa Alves Neri, Bianca Depieri Balmant, Leticia Callado, Karen Charlton, Natalia Queiroz, Dan L. Waitzberg
Summary: This study investigated the association between inflammatory diet, gut microbiota profile, inflammation, and permeability in patients with IBD in clinical remission. The results showed a positive correlation between the inflammatory potential of the diet and elevated calprotectin levels, but not with zonulin levels. Specific bacteria sequences were also found to have an exponential behavior across different inflammatory diet groups and correlated with calprotectin or zonulin levels. The study suggests that a pro-inflammatory diet intake may contribute to disease relapse in IBD patients.
Article
Medicine, General & Internal
Ferdinando D'Amico, Virginia Solitano, Fernando Magro, Pablo A. Olivera, Jonas Halfvarson, David Rubin, Axel Dignass, Sameer Al Awadhi, Taku Kobayashi, Natalia Sousa Freitas Queiroz, Marta Calvo, Paulo Gustavo Kotze, Subrata Ghosh, Laurent Peyrin-Biroulet, Silvio Danese
Summary: As the patents for biologic originator drugs expire, biosimilars are emerging as cost-effective alternatives within healthcare systems. A global survey was conducted to shed light on physicians' knowledge, beliefs, practical approaches, and concerns related to biosimilar adoption. Based on the survey results, a consensus was reached on key statements covering biosimilar effectiveness, safety, indications, rationale, multiple switches, therapeutic drug monitoring, non-medical switching, and future perspectives. The consensus affirmed that biosimilars are equally effective and safe compared to originator drugs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Adriana Zanoni Dotti, Daniela Oliveira Magro, Eduardo Garcia Vilela, Julio Maria Fonseca Chebli, Liliana Andrade Chebli, Flavio Steinwurz, Marjorie Argollo, Nayara Salgado Carvalho, Jose Miguel Luz Parente, Murilo Moura Lima, Rogerio Serafim Parra, Ramir Luan Perin, Cristina Flores, Eloa Marussi Morsoletto, Sandro da Costa Ferreira, Juliano Coelho Ludvig, Roberto Luiz Kaiser, Mikaell Alexandre Gouvea Faria, Guilherme Mattioli Nicollelli, Adriana Ribas Andrade, Natalia Sousa Freitas Queiroz, Paulo Gustavo Kotze
Summary: This study demonstrates the effectiveness and safety of vedolizumab as a first-line biological agent in patients with mild-to-moderate Crohn's disease.
CROHNS & COLITIS 360
(2023)
Article
Gastroenterology & Hepatology
Matheus Freitas Cardoso de Azevedo, Luisa Leite Barros, Filipe Fernandes Justus, Jane Oba, Karoline Soares Garcia, Camilla de Almeida Martins, Alexandre de Sousa Carlos, Andre Zonetti Arruda Leite, Aytan Miranda Sipahi, Natalia Sousa Freitas Queiroz, Aderson Omar Mourao Cintra Damiao
Summary: This study aimed to identify risk factors for active tuberculosis (TB) development in inflammatory bowel disease (IBD) patients and describe their clinical characteristics and outcomes in a tertiary referral center in Brazil. Results showed that active TB was significantly associated with IBD diagnosis older than 17 years and anti-TNF therapy. Reintroduction of anti-TNFs after TB treatment appears to be safe.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Lucas Rodrigues Boarini, Carlos Walter Sobrado, Giana Rabello Mota, Luisa Lina Villa, Idblan Carvalho de Albuquerque, Natalia Sousa Freitas Queiroz, Carolina Bortolozzo Graciolli Facanali, Sidney Roberto Nadal, Ivan Cecconello
Summary: The aim of the study was to evaluate the prevalence of HPV and high-risk HPV in patients with perianal Crohn's disease compared to a control group. The results showed that perianal fistulizing Crohn's disease patients had a higher frequency of HPV in the fistulous tract than those without Crohn's disease.
Review
Gastroenterology & Hepatology
Natalia Sousa Freitas Queiroz, Camilla de Almeida Martins, Abel Botelho Quaresma, Pablo A. Olivera A. Sendra, Kenneth Ernest-Suarez, Paulo Gustavo Kotze
Summary: Latin America is a diverse region with 47 countries and territories, each with its own cultural, historical, and healthcare management differences. However, there is a lack of high-quality data on inflammatory bowel diseases (IBD) in this region, including information on the use of biological and advanced therapies. Patients with IBD in Latin America face barriers and inequities in accessing healthcare services. This review examines the obstacles to IBD care in Latin America and gathers data from various sources, including epidemiological studies and surveys of healthcare professionals in the region.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Ramir Luan Perin, Daniela Oliveira Magro, Adriana Ribas Andrade, Marjorie Argollo, Nayara Salgado Carvalho, Aderson Omar Moura Cintra Damiao, Adriana Zanoni Dotti, Sandro da Costa Ferreira, Cristina Flores, Juliano Coelho Ludvig, Rodrigo Bremer Nones, Natalia Sousa Freitas Queiroz, Rogerio Serafim Parra, Flavio Steinwurz, Fabio Vieira Teixeira, Paulo Gustavo Kotze
Summary: The study demonstrated the efficacy and safety of tofacitinib in patients with ulcerative colitis from Latin America, which was consistent with previous studies from other countries and meta-analyses.
CROHNS & COLITIS 360
(2023)
Article
Gastroenterology & Hepatology
Camilla de Almeida Martins, Matheus Freitas Cardoso de Azevedo, Alexandre Sousa Carlos, Aderson Omar Mourao Cintra Damiao, Carlos Walter Sobrado Jr, Sergio Carlos Nahas, Natalia Sousa Freitas Queiroz
Summary: This study has enhanced our understanding of the predictive factors of treatment response to IFX in a well-characterized Brazilian IBD population. The study found that the duration of IFX therapy and higher albumin levels increased the likelihood of clinical remission, while previous surgery decreased its chance. Prior use of adalimumab and higher C-reactive protein levels reduced the likelihood of endoscopic remission.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Health Care Sciences & Services
Abel B. Quaresma, Aderson O. M. C. Damiao, Claudio S. R. Coy, Daniela O. Magro, Adriano A. F. Hino, Douglas A. Valverde, Remo Panaccione, Stephanie B. Coward, Siew C. Ng, Gilaad G. Kaplan, Paulo G. Kotze
Summary: The incidence of Crohn's disease (CD) is decreasing while the incidence of ulcerative colitis (UC) is increasing in Brazil, leading to a stable incidence of inflammatory bowel diseases (IBD) from 2012 to 2020. The prevalence of IBD has been climbing, with 0.1% of Brazilians living with IBD in 2020. Additionally, there is a south-north gradient in the prevalence rates of IBD, CD, and UC in Brazil in 2020.
LANCET REGIONAL HEALTH-AMERICAS
(2022)
