E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non–small cell lung cancer

MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty

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Cancer statistics, 2020

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Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

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MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3

(2020) Chuanyin Li et al.   National Science Review

KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors

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Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions

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MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence GNRH1 Expression

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Next-generation characterization of the Cancer Cell Line Encyclopedia

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Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer

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Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors

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Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

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Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

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Cross-talk between protein synthesis, energy metabolism and autophagy in cancer

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The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168

(2018) Xiaoduo Xie et al.   NATURE CELL BIOLOGY

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo

(2018) Sara Mainardi et al.   NATURE MEDICINE

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

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Development of a stress response therapy targeting aggressive prostate cancer

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Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia

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Best Practices Recommendations for Diagnostic Immunohistochemistry in Lung Cancer

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Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium

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Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

(2017) Felix R Day et al.   NATURE GENETICS

Reproductive endocrinology: Puberty timing and cancer risk

(2017) David Holmes   Nature Reviews Endocrinology

Tracking the Evolution of Non–Small-Cell Lung Cancer

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The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

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Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

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Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome

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Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer

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Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study

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Causes, diagnosis, and treatment of central precocious puberty

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Comprehensive genomic profiles of small cell lung cancer

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The “tale” of poly(A) binding protein: The MLLE domain and PAM2-containing proteins

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Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer

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Dystrophin is a tumor suppressor in human cancers with myogenic programs

(2014) Yuexiang Wang et al.   NATURE GENETICS

Ubiquitination in disease pathogenesis and treatment

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ALKin Lung Cancer: Past, Present, and Future

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Mutations of DEPDC5 cause autosomal dominant focal epilepsies

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Central Precocious Puberty Caused by Mutations in the Imprinted Gene MKRN3

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Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

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The Ubiquitin Code

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Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers

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Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

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Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

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Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

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The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

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Atypical pulmonary carcinoid tumour in a 28-year-old nonsmoker with Prader-Willi syndrome

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Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu

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Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

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Kras regulatory elements and exon 4A determine mutation specificity in lung cancer

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