Article
Pharmacology & Pharmacy
Zhen Zhang, Xia Lim, You Huang, Jingwei Zhou, Shasha Yang, Xinyi Wei, Wenjing Lai, Xin Zhang, Chaomei Fu
Summary: Fuzi-Lizhong pill (FLZP) is a traditional Chinese medicine with good clinical effect on diarrhea-predominant irritable bowel syndrome (IBS-D). It mainly treats IBS-D by regulating gut microbiota, influencing inflammation, and immune system.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Claudia Di Rosa, Annamaria Altomare, Vittoria Terrigno, Florencia Carbone, Jan Tack, Michele Cicala, Michele Pier Luca Guarino
Summary: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and altered bowel habits. The exact cause of IBS is not fully understood, but it is believed to involve a combination of factors such as abnormal gut motility, inflammation, increased intestinal permeability, and sensitivity. Diet and gut microbiota have also been identified as important contributors to IBS. This review examines the effects of dietary components, functional foods, prebiotics, probiotics, and symbiotics on symptoms and gut microbiota in individuals with IBS-C.
Review
Microbiology
Jun-Jie Hou, Xin Wang, Yu-Ming Wang, Bang-Mao Wang
Summary: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disease that is closely associated with abnormal changes in gut microbiota and bile acids (BAs) metabolism. Recent research progress supports the potential of new therapeutic strategies targeting the microbiota-BAs axis for the treatment of IBS-D and other related diseases.
CRITICAL REVIEWS IN MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Annamaria Altomare, Claudia Di Rosa, Elena Imperia, Sara Emerenziani, Michele Cicala, Michele Pier Luca Guarino
Summary: The study explores the effects of different nutritional protocols on IBS-D symptoms and intestinal microbiota variations. An ideal nutritional protocol does not yet exist for IBS-D patients, but it is crucial to consider the impact of different nutritional approaches on the composition of the intestinal microbiota for better management of this functional disorder.
Article
Medicine, Research & Experimental
Haomeng Wu, Kai Zhan, Kehan Rao, Huan Zheng, Shumin Qin, Xudong Tang, Shaogang Huang
Summary: The effects of different rat models of diarrhea-predominant irritable bowel syndrome (IBS-D) on the brain-gut-microbiota (BGM) axis were evaluated in this study. The results showed that these models caused changes in brain gut peptides, cytokine levels, spinal cord neuronal activity, intestinal mucosal barrier function, and gut microbiota composition and structure.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Karolina S. Jabbar, Brendan Dolan, Lisbeth Eklund, Catharina Wising, Anna Ermund, Asa Johansson, Hans Tornblom, Magnus Simren, Gunnar C. Hansson
Summary: The study found potentially pathogenic Brachyspira species in a subset of patients with IBS, with a significantly higher prevalence of Brachyspira colonization in IBS patients compared to healthy volunteers, especially in IBS-D patients. Brachyspira colonization was associated with accelerated oro-anal transit, mild mucosal inflammation, mast cell activation, and alterations of molecular pathways linked to bacterial uptake and ion-fluid homeostasis.
Article
Public, Environmental & Occupational Health
Gabriella Yazbeck, Diana Malaeb, Hamid Shaaban, Abir Sarray El Dine, Souheil Hallit, Rabih Hallit
Summary: This study aimed to assess the rate of unidentified IBS among Lebanese adults and investigate the role of socio-demographic factors, anxiety, depression, insomnia, and eating attitudes on IBS diagnosis. A cross-sectional study was conducted using a self-reporting questionnaire distributed via social media. The study found that higher psychological distress and insomnia severity were significantly associated with higher odds of having possible unidentified IBS.
Article
Biotechnology & Applied Microbiology
Hao Lin, Qingqing Guo, Zhiyong Wen, Songlin Tan, Jie Chen, Lijian Lin, Pengcheng Chen, Jianquan He, Jianbo Wen, Ye Chen
Summary: Fecal microbiota transplantation (FMT) treatment effectively alleviates anxiety and depression behaviors in IBS-D patients, improves symptoms, and enhances quality of life. Additionally, FMT reduces the content of certain short-chain fatty acids (SCFAs) and decreases the abundance of specific microorganisms.
MICROBIAL CELL FACTORIES
(2021)
Article
Microbiology
Jingze Yang, Peng Wang, Tong Liu, Lin Lin, Lixiang Li, Guanjun Kou, Ruchen Zhou, Pan Li, Yanqing Li
Summary: This study found differences in the microbial composition of the caecum and descending colon in IBS-D patients, with increased numbers of EC cells and higher TPL1 expression levels compared to controls. The Ruminococcus torques group and Dorea appear to be promising targets for future research in treating IBS-D patients.
Article
Oncology
Cong Chen, Shanmin Yuan, Xiaohong Chen, Jiangping Xie, Zheng Wei
Summary: The molecular mechanism of Xihuang pill (XHP) in breast cancer (BC) was investigated using murine mammary carcinoma 4T1 cell xenografts. XHP inhibited BC cell proliferation, migration, and invasion, induced pyroptosis, and activated the cAMP/PKA signalling pathway. Inhibiting the cAMP/PKA signalling pathway reversed the anti-cancer activity of XHP.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Emily V. Wechsler, Eric D. Shah
Summary: A review summarized important determinants of choosing IBS treatment, including clinical profiles and cost-effectiveness of prescription drugs; the shared decision-making model helps guide informed discussions for patients to select the appropriate treatment.
Editorial Material
Gastroenterology & Hepatology
Eric D. Shah
Summary: This article is linked to papers by Gunn et al. To view these articles, please visit the provided link.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Michael Camilleri, Paula Carlson, Joelle BouSaba, Sanna McKinzie, Priya Vijayvargiya, Yorick Magnus, Wassel Sannaa, Xiao Jing Wang, Victor Chedid, Ting Zheng, Daniel Maselli, Jessica Atieh, Ann Taylor, Asha A. Nair, Nagaswaroop Kengunte Nagaraj, Stephen Johnson, Jun Chen, Duane Burton, Irene Busciglio
Summary: Compared with IBS-D patients without ABAM, those with BAD show significant differences in colonic transit, microbial diversity, gene expression, and bacterial composition. These differences are associated with barrier dysfunction, inflammation, and microbial changes.
Review
Medicine, General & Internal
Giusi Desire Sciume, Ginevra Berti, Christian Lambiase, Italia Paglianiti, Vincenzo Villanacci, Francesco Rettura, Antonio Grosso, Angelo Ricchiuti, Nicola de Bortoli, Paolo Usai Satta, Gabrio Bassotti, Massimo Bellini
Summary: Irritable bowel syndrome with predominant diarrhea (IBS-D) and functional diarrhea (FD) are disorders of gut-brain interaction that have a significant impact on the patient's quality of life. Bile acid malabsorption (BAM) and microscopic colitis (MC) are often responsible for the lack of response to conventional treatments in these patients. Therefore, considering these factors and finding appropriate treatments should be part of the diagnostic process.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Yuk Kam Yau, Qi Su, Zhilu Xu, Whitney Tang, Jessica Y. L. Ching, Joyce Wing Yan Mak, Chun Pan Cheung, Matthew Fung, Margaret Ip, Paul Kay Sheung Chan, Justin Che Yuen Wu, Francis Ka Leung Chan, Siew C. Ng
Summary: This study found that performing two FMT treatments at a four-week interval did not significantly reduce IBS severity scoring system (IBS-SSS) score in patients with diarrhea-predominant IBS. However, more patients experienced improvement in abdominal bloating, which was associated with a reduction in hydrogen sulphide-producing bacteria.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Neurosciences
Ruiwei Gao, Minjie Wang, Jie Lin, Lan Hu, Zhihua Li, Chao Chen, Lin Yuan
Article
Obstetrics & Gynecology
Cheng-Qiu Lu, Jie Lin, Lin Yuan, Jian-Guo Zhou, Kun Liang, Qing-Hua Zhong, Jin-Hua Huan, Li-Ping Xu, Hui Wu, Zhi Zheng, Li-Li Ping, Yi Sun, Zhan-Kui Li, Ling Liu, Qin Lyu, Chao Chen
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2018)
Article
Neurosciences
Jie Lin, Yusuke Niimi, Mariano Guardia Clausi, Hur Dolunay Kanal, Steven W. Levison
EXPERIMENTAL NEUROLOGY
(2020)
Article
Allergy
Hao-cheng Zheng, Yong-an Wang, Zi-rui Liu, Ya-lan Li, Jing-wei Kong, Dong-yu Ge, Gui-ying Peng
JOURNAL OF ASTHMA AND ALLERGY
(2020)
Article
Plant Sciences
Yuan Li, Fuhao Chu, Ping Li, Nadia Johnson, Tao Li, Yan Wang, Rongxian An, Dantong Wu, Jiena Chen, Zeqi Su, Xiaohong Gu, Xia Ding
Summary: This study explored the therapeutic mechanism of Maxing Shigan decoction (MXSGD) against COVID-19 through network pharmacology and in vitro experiments, identifying potential components that could target key proteins of the coronavirus. Results showed positive characteristics of multi-component, multi-target intervention with MXSGD in combatting COVID-19, revealing its antiviral and anti-inflammatory pharmacodynamic substances and mechanism. This suggests the important role of traditional Chinese medicine in the prevention and treatment of COVID-19.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Yan Wang, Fuhao Chu, Jie Lin, Yuan Li, Nadia Johnson, Jianglan Zhang, Cong Gai, Zeqi Su, Hongjie Cheng, Linheng Wang, Xia Ding
Summary: Dendrobium chrysotoxum Lindl, a traditional Chinese medicinal herb, has shown promising clinical effects in treating chronic gastritis and precancerous lesions of gastric cancer. This study used network pharmacology to identify active ingredients and pharmacological mechanisms of Dendrobium chrysotoxum Lindl in the prevention and treatment of PLGC. The main active ingredient Erianin was found to regulate cancer-related signaling pathways and inhibit cell viability, migration, and induce apoptosis in PLGC, suggesting its potential as a candidate for PLGC treatment methods.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Physiology
Fuhao Chu, Yicong Li, Xiangmei Meng, Yuan Li, Tao Li, Mengyin Zhai, Haocheng Zheng, Tianxi Xin, Zeqi Su, Jie Lin, Ping Zhang, Xia Ding
Summary: This study found that the activation of inflammatory response, disturbance of gut microbiota, and changes in fecal metabolic phenotype could be closely related to the occurrence of PLGC in rats. The study provides new insights into the mechanisms of risk factors for chronic gastritis and GC from the perspective of inflammation-immune homeostasis, gut microbiota, and metabolic balance.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jie Lin, Shi-Wei Li, Jing Zhang, Fu-Hao Chu, Cheng-Ze Li, Zhi-Xu Bie, Han-Lu Tang, Shan Gao, Ping Li, Meng-Ting Liao, Tian-Xi Xin, Fu Zhao, Pi-Nan Liu, Xia Ding
Summary: This study evaluated the antitumor efficacy of Qu-Du-San-Jie (QDSJ) decoction, a traditional Chinese medicine formula, on neurofibromatosis type 2 (NF2)-associated vestibular schwannomas (VSs). The study identified the components of QDSJ and their targets using ultra high-performance liquid chromatography-mass spectroscopy (UHPLC-MS) analysis. It also investigated the potential mechanisms of QDSJ in treating NF2-associated VS through network pharmacology. The results showed that QDSJ induced cell death and apoptosis of schwannoma cells in vitro and suppressed tumor growth in vivo. QDSJ was found to regulate necroptosis, apoptosis, cell cycle, angiogenesis, adherens junction, and neuroactive ligand-receptor interaction. Overall, QDSJ decoction showed significant antitumor activity against NF2-associated schwannoma and has the potential to be tested in future clinical trials.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Simiao Yu, Jingxiao Wang, Haocheng Zheng, Ruilin Wang, Nadia Johnson, Tao Li, Ping Li, Jie Lin, Yuan Li, Jin Yan, Ying Zhang, Zhenyu Zhu, Xia Ding
Summary: This review describes the pathogenesis and underlying mechanisms of the transition from inflammation to cancer in NASH. NASH is a liver disease characterized by metabolic dysregulation, chronic inflammation, and cell death, with approximately 20-30% of cases developing into HCC, or liver cancer.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Biochemistry & Molecular Biology
Yunze Liu, Haocheng Zheng, Anna Meilin Gu, Yuan Li, Tieshan Wang, Chengze Li, Yixiao Gu, Jie Lin, Xia Ding
Summary: Through the TCGA and GEO databases, we identified 173 metabolism-related genes (MRGs) associated with M2 macrophage infiltration in gastric cancer. Twelve MRGs were adopted as a prognostic signature and used to develop a risk model. Patients in the high-risk group had poorer survival outcomes and were less sensitive to certain drugs. Risk scores were correlated with immune cell infiltration, including CD8+ T cells and M2 macrophages. Single-cell sequencing analysis revealed differences in the expression and distribution of the 12 signature genes in the tumor microenvironment. In vitro experiments confirmed that Sorcin-knockdown gastric cancer cells suppressed M2 polarization of macrophages, inhibiting the proliferation and migration of gastric cancer cells. These findings provide a valuable prognostic signature for evaluating clinical outcomes, treatment options, and potential targets for gastric cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)