Usefulness of cell-penetrating peptides and penetration accelerating sequence for nose-to-brain delivery of glucagon-like peptide-2

Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

(2020) John C. Charpentier et al.   Nature Communications

Toxicity of selected airborne nitrophenols on eukaryotic cell membrane models

(2020) Marta Majewska et al.   CHEMOSPHERE

Energy-dependent endocytosis is responsible for drug transcorneal penetration following the instillation of ophthalmic formulations containing indomethacin nanoparticles

(2019) Noriaki Nagai et al.   International Journal of Nanomedicine

Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro

(2019) Anjana Ajikumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of novel macropinocytosis inhibitors using a rational screen of FDA-approved drugs

(2018) Hui-Ping Lin et al.   BRITISH JOURNAL OF PHARMACOLOGY

An imaging flow cytometry method to assess ricin trafficking in A549 human lung epithelial cells

(2018) Dominic Jenner et al.   METHODS

Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting

(2018) Fabio Sonvico et al.   Pharmaceutics

Hexokinase II–derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells

(2017) Abiy D. Woldetsadik et al.   FASEB JOURNAL

Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis

(2017) Helena Costa Verdera et al.   JOURNAL OF CONTROLLED RELEASE

Influence of paeoniflorin and menthol on puerarin transport across MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model

(2017) Bing Yang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases

(2017) Lila Carniglia et al.   MEDIATORS OF INFLAMMATION

Antidepressant-like effects exerted by the intranasal administration of a glucagon-like peptide-2 derivative containing cell-penetrating peptides and a penetration-accelerating sequence in mice

(2017) Sachie Sasaki-Hamada et al.   PEPTIDES

Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells

(2017) Dipali Patel et al.   Scientific Reports

Intranasal delivery of nanoparticle encapsulated tarenflurbil: A potential brain targeting strategy for Alzheimer's disease

(2016) Eameema Muntimadugu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents

(2016) Jarrad M Scarlett et al.   NATURE MEDICINE

Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery

(2016) Niyanta N. Kumar et al.   Scientific Reports

Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans

(2015) Mitchel J. R. Ruigrok et al.   AAPS Journal

Immunohistochemical determination of the site of antidepressant-like effects of glucagon-like peptide-2 in ACTH-treated mice

(2015) S. Sasaki-Hamada et al.   NEUROSCIENCE

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

Transporters at CNS Barrier Sites: Obstacles or Opportunities for Drug Delivery?

(2014) Lucy Sanchez-Covarrubias et al.   CURRENT PHARMACEUTICAL DESIGN

Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules

(2014) Ana Fortuna et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Oxytocin’s neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial

(2014) Y Aoki et al.   MOLECULAR PSYCHIATRY

Glucagon-like peptide-2 but not imipramine exhibits antidepressant-like effects in ACTH-treated mice

(2013) Takashi Iwai et al.   BEHAVIOURAL BRAIN RESEARCH

Neutral biodegradable lipid-envelope-type nanoparticle using vitamin A-Scaffold for nuclear targeting of plasmid DNA

(2013) Hiroki Tanaka et al.   BIOMATERIALS

Cell-Penetrating Peptide-Mediated Therapeutic Molecule Delivery into the Central Nervous System

(2013) Li-Li Zou et al.   Current Neuropharmacology

Mechanisms of ceramide-induced COX-2-dependent apoptosis in human ovarian cancer OVCAR-3 cells partially overlapped with resveratrol

(2013) Hung-Yun Lin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ghrelin: An emerging new anticonvulsant neuropeptide

(2012) Jeanelle Portelli et al.   EPILEPSIA

Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo

(2012) Ikuhiko Nakase et al.   JOURNAL OF CONTROLLED RELEASE

Effect of the Attachment of a Penetration Accelerating Sequence and the Influence of Hydrophobicity on Octaarginine-Mediated Intracellular Delivery

(2012) Kentaro Takayama et al.   MOLECULAR PHARMACEUTICS

Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using Cell-Penetrating Peptides

(2011) Ikuhiko Nakase et al.   ACCOUNTS OF CHEMICAL RESEARCH

Intranasal delivery of biologics to the central nervous system

(2011) Jeffrey J. Lochhead et al.   ADVANCED DRUG DELIVERY REVIEWS

Prosocial effects of oxytocin and clinical evidence for its therapeutic potential

(2011) Nadine Striepens et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis

(2011) Chung Yeng Looi et al.   PLoS One

Enhanced Target-Specific Accumulation of Radiolabeled Antibodies by Conjugating Arginine-Rich Peptides as Anchoring Molecules

(2010) Rei Miyamoto et al.   BIOCONJUGATE CHEMISTRY

Transduction of Cell-Penetrating Peptides into Induced Pluripotent Stem Cells

(2010) Hiroshi Yukawa et al.   CELL TRANSPLANTATION

Strategy for effective brain drug delivery

(2010) M. Intakhab Alam et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Surface Characteristics of Nanoparticles Determine Their Intracellular Fate in and Processing by Human Blood–Brain Barrier Endothelial Cells In Vitro

(2010) Julia V Georgieva et al.   MOLECULAR THERAPY

Antidepressant-like effects of glucagon-like peptide-2 in mice occur via monoamine pathways

(2009) Takashi Iwai et al.   BEHAVIOURAL BRAIN RESEARCH

Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas)

(2009) Kentaro Takayama et al.   JOURNAL OF CONTROLLED RELEASE

Enhancement of TAT cell membrane penetration efficiency by dimethyl sulphoxide

(2009) Hu Wang et al.   JOURNAL OF CONTROLLED RELEASE

Cell-surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis

(2009) Ikuhiko Nakase et al.   MOLECULAR THERAPY

Neuromedin U inhibits inflammation-mediated memory impairment and neuronal cell-death in rodents

(2008) Takashi Iwai et al.   NEUROSCIENCE RESEARCH