Sialic acid conjugate-modified liposomal platform modulates immunosuppressive tumor microenvironment in multiple ways for improved immune checkpoint blockade therapy

A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells

(2021) Shiyang Shen et al.   Nature Nanotechnology

Codelivery of Anti‐PD‐1 Antibody and Paclitaxel with Matrix Metalloproteinase and pH Dual‐Sensitive Micelles for Enhanced Tumor Chemoimmunotherapy

(2020) Zhenwei Su et al.   Small

Cancer Stem Cells: Devil or Savior—Looking behind the Scenes of Immunotherapy Failure

(2020) Lorenzo Castagnoli et al.   Cells

Immune checkpoints in tumor microenvironment and their relevance to the development of cancer stem cells

(2020) Neda Khosravi et al.   LIFE SCIENCES

Harnessing the bioresponsive adhesion of immuno-bioglue for enhanced local immune checkpoint blockade therapy

(2020) Kye Il Joo et al.   BIOMATERIALS

Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells

(2019) Yu Yi et al.   JOURNAL OF CONTROLLED RELEASE

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets

(2019) Luca Cassetta et al.   CANCER CELL

Dual-Ligand Modification of PEGylated Liposomes Used for Targeted Doxorubicin Delivery to Enhance Anticancer Efficacy

(2019) Cong Li et al.   AAPS PHARMSCITECH

Targeted delivery of ibrutinib to tumor-associated macrophages by sialic acid-stearic acid conjugate modified nanocomplexes for cancer immunotherapy

(2019) Qiujun Qiu et al.   Acta Biomaterialia

Nucleus-targeted nano delivery system eradicates cancer stem cells by combined thermotherapy and hypoxia-activated chemotherapy

(2019) Hongjuan Li et al.   BIOMATERIALS

Interactions between cancer stem cells, immune system and some environmental components: Friends or foes?

(2019) Fatemeh Vahidian et al.   IMMUNOLOGY LETTERS

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

(2019) Alex Miranda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of tumor-associated macrophages and cancer chemotherapy

(2019) Irina Larionova et al.   OncoImmunology

Unraveling triple-negative breast cancer tumor microenvironment heterogeneity: towards an optimized treatment approach

(2019) Yacine Bareche et al.   JNCI-Journal of the National Cancer Institute

Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers

(2019) Chia-Hsueh Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Glycocalyx-Mimicking Nanoparticles Improve Anti-PD-L1 Cancer Immunotherapy through Reversion of Tumor-Associated Macrophages

(2018) Yufei Zhang et al.   BIOMACROMOLECULES

Anti-cancer therapy with TNFα and IFNγ: A comprehensive review

(2018) Jing Shen et al.   CELL PROLIFERATION

Targeted delivery of pixantrone to neutrophils by poly(sialic acid)- p -octadecylamine conjugate modified liposomes with improved antitumor activity

(2018) Xiang Luo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

A Multifunctional Biomimetic Nanoplatform for Relieving Hypoxia to Enhance Chemotherapy and Inhibit the PD-1/PD-L1 Axis

(2018) Mei-Zhen Zou et al.   Small

Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway

(2018) Jianqin Lu et al.   ACS Nano

High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors

(2018) Saman Maleki Vareki   Journal for ImmunoTherapy of Cancer

Targeted delivery of epirubicin to tumor-associated macrophages by sialic acid-cholesterol conjugate modified liposomes with improved antitumor activity

(2017) Songlei Zhou et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

(2017) Peiguo Shi et al.   Cell Discovery

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Overcoming barriers to effective immunotherapy: MDSCs, TAMs, and Tregs as mediators of the immunosuppressive microenvironment in head and neck cancer

(2016) Ruth J. Davis et al.   ORAL ONCOLOGY

Cancer immunotherapy: harnessing the immune system to battle cancer

(2015) Yiping Yang   JOURNAL OF CLINICAL INVESTIGATION

The interaction of anticancer therapies with tumor-associated macrophages

(2015) Alberto Mantovani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The anticancer efficacy of pixantrone-loaded liposomes decorated with sialic acid–octadecylamine conjugate

(2014) Zhennan She et al.   BIOMATERIALS

Coencapsulation of epirubicin and metformin in PEGylated liposomes inhibits the recurrence of murine sarcoma S180 existing CD133+ cancer stem-like cells

(2014) Qiang Yang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

iTEP Nanoparticle-Delivered Salinomycin Displays an Enhanced Toxicity to Cancer Stem Cells in Orthotopic Breast Tumors

(2014) Peng Zhao et al.   MOLECULAR PHARMACEUTICS

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Liposome: classification, preparation, and applications

(2013) Abolfazl Akbarzadeh et al.   Nanoscale Research Letters

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Trial watch

(2012) Erika Vacchelli et al.   OncoImmunology

Comparison of KRAS and EGFR gene status between primary non-small cell lung cancer and local lymph node metastases: implications for clinical practice

(2011) Leina Sun et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway

(2010) L. Zitvogel et al.   CLINICAL CANCER RESEARCH

In vivo near-infrared fluorescence imaging of cancer with nanoparticle-based probes

(2010) Xiaoxiao He et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-  and IL-6 signaling

(2008) Y. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA