Anti-cancer therapy with TNFα and IFNγ: A comprehensive review

Vascular-targeted TNFα and IFNγ inhibits orthotopic colorectal tumor growth

(2016) Jing Shen et al.   Journal of Translational Medicine

Self-targeting of TNF-releasing cancer cells in preclinical models of primary and metastatic tumors

(2016) Eleonora Dondossola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular-targeted TNFα improves tumor blood vessel function and enhances antitumor immunity and chemotherapy in colorectal cancer

(2015) Lan Lu et al.   JOURNAL OF CONTROLLED RELEASE

Systemic use of tumor necrosis factor alpha as an anticancer agent

(2015) Nicholas J. Roberts et al.   Oncotarget

Inhibition of Tumor Angiogenesis by Interferon-γ by Suppression of Tumor-Associated Macrophage Differentiation

(2014) Tao Sun et al.   ONCOLOGY RESEARCH

The Dose-Dependent Tumor Targeting of Antibody-IFN  Fusion Proteins Reveals an Unexpected Receptor-Trapping Mechanism In Vivo

(2014) T. Hemmerle et al.   Cancer Immunology Research

Interferon-γ-Induced Necrosis: An Antitumor Biotherapeutic Perspective

(2013) Siddharth Balachandran et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

T-helper-1-cell cytokines drive cancer into senescence

(2013) Heidi Braumüller et al.   NATURE

Targeting TNF-  to Neoangiogenic Vessels Enhances Lymphocyte Infiltration in Tumors and Increases the Therapeutic Potential of Immunotherapy

(2012) A. Calcinotto et al.   JOURNAL OF IMMUNOLOGY

Selective Targeting of Interferon   to Stromal Fibroblasts and Pericytes as a Novel Therapeutic Approach to Inhibit Angiogenesis and Tumor Growth

(2012) R. Bansal et al.   MOLECULAR CANCER THERAPEUTICS

Tumor-targeted TNF  stabilizes tumor vessels and enhances active immunotherapy

(2012) A. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The targeted delivery of IL17 to the mouse tumor neo-vasculature enhances angiogenesis but does not reduce tumor growth rate

(2011) Nadine Pasche et al.   ANGIOGENESIS

The Two Faces of Interferon-  in Cancer

(2011) M. R. Zaidi et al.   CLINICAL CANCER RESEARCH

Cloning and characterization of novel tumor-targeting immunocytokines based on murine IL7

(2011) Nadine Pasche et al.   JOURNAL OF BIOTECHNOLOGY

Natural killer cell-produced IFN-γ and TNF-α induce target cell cytolysis through up-regulation of ICAM-1

(2011) Ruipeng Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tumor rejection by local interferon gamma induction in established tumors is associated with blood vessel destruction and necrosis

(2010) Dana Briesemeister et al.   INTERNATIONAL JOURNAL OF CANCER

Phase II Study of Asparagine-Glycine-Arginine–Human Tumor Necrosis Factor α, a Selective Vascular Targeting Agent, in Previously Treated Patients With Malignant Pleural Mesothelioma

(2010) Vanesa Gregorc et al.   JOURNAL OF CLINICAL ONCOLOGY

A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery

(2010) Zhi Jie Li et al.   JOURNAL OF CONTROLLED RELEASE

Tumor necrosis factor and cancer, buddies or foes?

(2009) Xia Wang et al.   ACTA PHARMACOLOGICA SINICA

Clinical Use of Interferon-γ

(2009) Catriona H.T. Miller et al.   Annals of the New York Academy of Sciences

Phase Ib study of NGR–hTNF, a selective vascular targeting agent, administered at low doses in combination with doxorubicin to patients with advanced solid tumours

(2009) V Gregorc et al.   BRITISH JOURNAL OF CANCER

Tumor vasculature-targeted delivery of tumor necrosis factor-α*

(2008) Anita Tandle et al.   CANCER

TNFR1 Signaling and IFN-γ Signaling Determine whether T Cells Induce Tumor Dormancy or Promote Multistage Carcinogenesis

(2008) Nele Müller-Hermelink et al.   CANCER CELL

Isoaspartate-Glycine-Arginine: A New Tumor Vasculature-Targeting Motif

(2008) F. Curnis et al.   CANCER RESEARCH

The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages

(2008) Paola Allavena et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

IFN-γ– and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers

(2008) Bin Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFN 

(2008) A. M. Gasparri et al.   MOLECULAR CANCER THERAPEUTICS