Multiple mechanisms for TRAF3-mediated regulation of the T cell costimulatory receptor GITR

TNF receptor-associated factor 3 restrains B cell receptor signaling in normal and malignant B cells

(2021) Amy L. Whillock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inclusion of Dap10 or 4-1BB costimulation domains in the chPD1 receptor enhances anti-tumor efficacy of T cells in murine models of lymphoma and melanoma

(2020) Hailey Kintz et al.   CELLULAR IMMUNOLOGY

Therapy of Established Tumors with Rationally Designed Multiple Agents Targeting Diverse Immune–Tumor Interactions: Engage, Expand, Enable

(2020) Kellsye P. Fabian et al.   Cancer Immunology Research

GITR domain inside CAR co-stimulates activity of CAR-T cells against cancer

(2018) Vita M Golubovskaya   Frontiers in Bioscience-Landmark

TRAF3 regulation of inhibitory signaling pathways in B and T lymphocytes by kinase and phosphatase localization

(2018) Alicia M. Wallis et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

(2018) Hans D. Brightbill et al.   Nature Communications

TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation

(2018) Gail A. Bishop et al.   Frontiers in Immunology

TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22

(2017) Alicia M. Wallis et al.   Scientific Reports

MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential

(2017) Natalie J. Tigue et al.   OncoImmunology

Development of TRX518, an aglycosyl humanized monoclonal antibody (Mab) agonist of huGITR.

(2017) M. Rosenzweig et al.   JOURNAL OF CLINICAL ONCOLOGY

Ptpn22Modifies Regulatory T Cell Homeostasis via GITR Upregulation

(2016) Dominika J. Nowakowska et al.   JOURNAL OF IMMUNOLOGY

TRAF3 as a powerful and multitalented regulator of lymphocyte functions

(2016) Gail A. Bishop   JOURNAL OF LEUKOCYTE BIOLOGY

Nuclear TRAF3 is a negative regulator of CREB in B cells

(2016) Nurbek Mambetsariev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRAF3, ubiquitination, and B-lymphocyte regulation

(2015) Wai W. Lin et al.   IMMUNOLOGICAL REVIEWS

The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development

(2015) Wai W. Lin et al.   Science Signaling

GITR Intrinsically Sustains Early Type 1 and Late Follicular Helper CD4 T Cell Accumulation to Control a Chronic Viral Infection

(2015) Derek L. Clouthier et al.   PLoS Pathogens

The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development

(2015) Wai W. Lin et al.   Science Signaling

Glucocorticoid-Induced TNF Receptor Expression by T Cells Is Reciprocally Regulated by NF- B and NFAT

(2014) Y. Zhan et al.   JOURNAL OF IMMUNOLOGY

Gene Expression in the Gitr Locus Is Regulated by NF- B and Foxp3 through an Enhancer

(2014) Y. Tone et al.   JOURNAL OF IMMUNOLOGY

The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2

(2014) Zuoan Yi et al.   NATURE IMMUNOLOGY

Modulation of Treg cells/T effector function by GITR signaling is context-dependent

(2013) Amal Ephrem et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TRAF3 regulates the effector function of regulatory T cells and humoral immune responses

(2013) Jae-Hoon Chang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF receptor associated factor 3 plays a key role in development and function of invariant natural killer T cells

(2013) Zuoan Yi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Complex Relationship between TRAF3 and Non-Canonical NF-κB2 Activation in B Lymphocytes

(2013) Wai W. Lin et al.   Frontiers in Immunology

Modulation of GITR for cancer immunotherapy

(2012) David A Schaer et al.   CURRENT OPINION IN IMMUNOLOGY

Pharmacological modulation of GITRL/GITR system: therapeutic perspectives

(2011) Giuseppe Nocentini et al.   BRITISH JOURNAL OF PHARMACOLOGY

T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy

(2011) Laura M. Snell et al.   IMMUNOLOGICAL REVIEWS

TNF Receptor-Associated Factor 3 Is Required for T Cell-Mediated Immunity and TCR/CD28 Signaling

(2010) P. Xie et al.   JOURNAL OF IMMUNOLOGY

CD8 T Cell-Intrinsic GITR Is Required for T Cell Clonal Expansion and Mouse Survival following Severe Influenza Infection

(2010) L. M. Snell et al.   JOURNAL OF IMMUNOLOGY

Agonist Anti-GITR Monoclonal Antibody Induces Melanoma Tumor Immunity in Mice by Altering Regulatory T Cell Stability and Intra-Tumor Accumulation

(2010) Adam D. Cohen et al.   PLoS One

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

TNF superfamily: Costimulation and clinical applications

(2009) Dass S. Vinay et al.   CELL BIOLOGY INTERNATIONAL

Sequence, structure, function, immunity: structural genomics of costimulation

(2009) Kausik Chattopadhyay et al.   IMMUNOLOGICAL REVIEWS

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

(2008) Sandra Gardam et al.   IMMUNITY

Glucocorticoid-induced Tumor Necrosis Factor Receptor Negatively Regulates Activation of Human Primary Natural Killer (NK) Cells by Blocking Proliferative Signals and Increasing NK Cell Apoptosis

(2008) Baoying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reverse signaling initiated from GITRL induces NF-κB activation through ERK in the inflammatory activation of macrophages

(2007) Eun Mi Bae et al.   MOLECULAR IMMUNOLOGY