A conserved strategy for structure change and energy transduction in Hsp104 and other AAA+ protein motors

Processive extrusion of polypeptide loops by a Hsp100 disaggregase

(2020) Mario J. Avellaneda et al.   NATURE

AAA+ proteins

(2020) Thiago V. Seraphim et al.   CURRENT BIOLOGY

Structural and kinetic basis for the regulation and potentiation of Hsp104 function

(2020) Xiang Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for distinct operational modes and protease activation in AAA+ protease Lon

(2020) Mia Shin et al.   Science Advances

Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution

(2019) Xiang Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Hsp104 Function Potentiation Studied by Hydrogen-Deuterium Exchange Detected by Mass Spectrometry (HX-Ms)

(2019) Xiang Ye et al.   BIOPHYSICAL JOURNAL

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate

(2019) Ian Cooney et al.   SCIENCE

Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding

(2019) Edward C. Twomey et al.   SCIENCE

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase

(2019) Alexandrea N. Rizo et al.   Nature Communications

The molecular principles governing the activity and functional diversity of AAA+ proteins

(2019) Cristina Puchades et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stairway to translocation: AAA+ motor structures reveal the mechanisms of ATP‐dependent substrate translocation

(2019) Stephanie N. Gates et al.   PROTEIN SCIENCE

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

Molecular switch-like regulation enables global subunit coordination in a viral ring ATPase

(2018) Sara Tafoya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB

(2018) Hongjun Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

InterPro in 2019: improving coverage, classification and access to protein sequence annotations

(2018) Alex L Mitchell et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM structures of the archaeal PAN-proteasome reveal an around-the-ring ATPase cycle

(2018) Parijat Majumder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

(2018) Andres H. de la Peña et al.   SCIENCE

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

(2017) Stephanie N. Gates et al.   SCIENCE

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing

(2017) Cristina Puchades et al.   SCIENCE

Structure of a AAA+ unfoldase in the process of unfolding substrate

(2017) Zev A Ripstein et al.   eLife

Mechanism of Vps4 hexamer function revealed by cryo-EM

(2017) Min Su et al.   Science Advances

Substrate-translocating loops regulate mechanochemical coupling and power production in AAA+ protease ClpXP

(2016) Piere Rodriguez-Aliaga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

(2016) Adam L Yokom et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate-translocating loops regulate mechanochemical coupling and power production in AAA+ protease ClpXP

(2016) Piere Rodriguez-Aliaga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

(2016) Adam L Yokom et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analytical Aspects of Hydrogen Exchange Mass Spectrometry

(2015) John R. Engen et al.   Annual Review of Analytical Chemistry

Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines

(2015) Adrian O. Olivares et al.   NATURE REVIEWS MICROBIOLOGY

Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover

(2015) J.-K. Ryu et al.   SCIENCE

Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine

(2014) Juan Carlos Cordova et al.   CELL

The ClpXP Protease Unfolds Substrates Using a Constant Rate of Pulling but Different Gears

(2013) Maya Sen et al.   CELL

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor

(2013) J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the Mechanism of Protein Disaggregation Through a ClpB-DnaK Interaction

(2013) R. Rosenzweig et al.   SCIENCE

High Degree of Coordination and Division of Labor among Subunits in a Homomeric Ring ATPase

(2012) Gheorghe Chistol et al.   CELL

Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients

(2012) Morgan E. DeSantis et al.   CELL

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces

(2012) Fabian Seyffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protein dynamics viewed by hydrogen exchange

(2012) John J. Skinner et al.   PROTEIN SCIENCE

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Single-Molecule Protein Unfolding and Translocation by an ATP-Fueled Proteolytic Machine

(2011) Marie-Eve Aubin-Tam et al.   CELL

ClpX(P) Generates Mechanical Force to Unfold and Translocate Its Protein Substrates

(2011) Rodrigo A. Maillard et al.   CELL

The nuts and bolts of ring-translocase structure and mechanism

(2011) Artem Y Lyubimov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Many Overlapping Peptides for Protein Hydrogen Exchange Experiments by the Fragment Separation-Mass Spectrometry Method

(2011) Leland Mayne et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Intersubunit coordination in a homomeric ring ATPase

(2009) Jeffrey R. Moffitt et al.   NATURE