Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy

(2020) Alejandro Peña et al.   STRUCTURE

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

Experimental determination of the force of malaria infection reveals a non-linear relationship to mosquito sporozoite loads

(2020) Maya Aleshnick et al.   PLoS Pathogens

Dynamic and asymmetric fluctuations in the microtubule wall captured by high-resolution cryoelectron microscopy

(2020) Garrett E. Debs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodium berghei Kinesin-5 Associates With the Spindle Apparatus During Cell Division and Is Important for Efficient Production of Infectious Sporozoites

(2020) Mohammad Zeeshan et al.   Frontiers in Cellular and Infection Microbiology

4.5 Å Cryo-EM Structure of Yeast Kinesin-5-Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance

(2019) Ottilie von Loeffelholz et al.   JOURNAL OF MOLECULAR BIOLOGY

NetSurfP-2.0: Improved prediction of protein structural features by integrated deep learning

(2019) Michael Schantz Klausen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The antimalarial screening landscape—looking beyond the asexual blood stage

(2019) Sabrina Yahiya et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cryo-EM structure of the Ustilago maydis kinesin-5 motor domain bound to microtubules

(2019) Ottilie von Loeffelholz et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

(2019) Samuel E Lacey et al.   eLife

A microtubule RELION-based pipeline for cryo-EM image processing

(2019) Alexander D. Cook et al.   JOURNAL OF STRUCTURAL BIOLOGY

Taxanes convert regions of perturbed microtubule growth into rescue sites

(2019) Ankit Rai et al.   NATURE MATERIALS

A Completely Reimplemented MPI Bioinformatics Toolkit with a New HHpred Server at its Core

(2018) Lukas Zimmermann et al.   JOURNAL OF MOLECULAR BIOLOGY

Microtubule structure by cryo-EM: snapshots of dynamic instability

(2018) Szymon W. Manka et al.   Essays in Biochemistry

The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner

(2017) Kayla M. Bell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Intraflagellar transport dynein is autoinhibited by trapping of its mechanical and track-binding elements

(2017) Katerina Toropova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Malaria: Biology and Disease

(2016) Alan F. Cowman et al.   CELL

Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy

(2016) Stephanie M Myers et al.   Future Medicinal Chemistry

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Refinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment

(2016) Agnel Praveen Joseph et al.   METHODS

Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta

(2016) Ray Yu-Ruei Wang et al.   eLife

Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins

(2015) Rui Zhang et al.   CELL

Measuring Pushing and Braking Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules

(2015) Yuta Shimamoto et al.   DEVELOPMENTAL CELL

TEMPy: a Python library for assessment of three-dimensional electron microscopy density fits

(2015) Irene Farabella et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Small Molecule Screen for Candidate Antimalarials TargetingPlasmodiumKinesin-5

(2014) Liqiong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prime movers: the mechanochemistry of mitotic kinesins

(2014) Robert A. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family

(2014) Adeline Goulet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement

(2014) Luyan Cao et al.   Nature Communications

High-resolution structures of kinesin on microtubules provide a basis for nucleotide-gated force-generation

(2014) Zhiguo Shang et al.   eLife

Kinesin-5: Cross-bridging mechanism to targeted clinical therapy

(2013) Edward J. Wojcik et al.   GENE

Loop L5 Assumes Three Distinct Orientations during the ATPase Cycle of the Mitotic Kinesin Eg5

(2013) Joseph M. Muretta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

The bipolar assembly domain of the mitotic motor kinesin-5

(2013) Seyda Acar et al.   Nature Communications

A comparative assessment and analysis of 20 representative sequence alignment methods for protein structure prediction

(2013) Renxiang Yan et al.   Scientific Reports

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

The Loop 5 Element Structurally and Kinetically Coordinates Dimers of the Human Kinesin-5, Eg5

(2011) Joshua S. Waitzman et al.   BIOPHYSICAL JOURNAL

Accelerated Profile HMM Searches

(2011) Sean R. Eddy   PLoS Computational Biology

Crystal Structure of Arginase fromPlasmodium falciparumand Implications forl-Arginine Depletion in Malarial Infection,

(2010) Daniel P. Dowling et al.   BIOCHEMISTRY

The Conserved L5 Loop Establishes the Pre-Powerstroke Conformation of the Kinesin-5 Motor, Eg5

(2010) Adam G. Larson et al.   BIOPHYSICAL JOURNAL

Patterns of kinesin evolution reveal a complex ancestral eukaryote with a multifunctional cytoskeleton

(2010) Bill Wickstead et al.   BMC EVOLUTIONARY BIOLOGY

Loop 5-directed Compounds Inhibit Chimeric Kinesin-5 Motors

(2010) Liqiong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loop L5 Acts as a Conformational Latch in the Mitotic Kinesin Eg5

(2010) William M. Behnke-Parks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An atomic-level mechanism for activation of the kinesin molecular motors

(2010) C. V. Sindelar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An allosteric transition trapped in an intermediate state of a new kinesin–inhibitor complex

(2009) Hung Yi Kristal Kaan et al.   BIOCHEMICAL JOURNAL

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism

(2009) Courtney L. Parke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motile microtubule crosslinkers require distinct dynamic properties for correct functioning during spindle organization in Xenopus egg extract

(2009) J. Cahu et al.   JOURNAL OF CELL SCIENCE

Sub-angstrom accuracy in protein loop reconstruction by robotics-inspired conformational sampling

(2009) Daniel J Mandell et al.   NATURE METHODS

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

QMEAN server for protein model quality estimation

(2009) Pascal Benkert et al.   NUCLEIC ACIDS RESEARCH

Single-headed mode of kinesin-5

(2008) Kuniyoshi Kaseda et al.   EMBO REPORTS

Microtubule cross-linking triggers the directional motility of kinesin-5

(2008) Lukas C. Kapitein et al.   JOURNAL OF CELL BIOLOGY

Protein Structure Fitting and Refinement Guided by Cryo-EM Density

(2008) Maya Topf et al.   STRUCTURE

Force Generation in Kinesin Hinges on Cover-Neck Bundle Formation

(2008) Wonmuk Hwang et al.   STRUCTURE