Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling

Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss

(2021) Tatiana Burrinha et al.   JOURNAL OF CELL SCIENCE

Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model

(2019) Robert J. Andrew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

(2019) Maxime Sartori et al.   ACTA NEUROPATHOLOGICA

Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH

(2019) Tetsuo Cai et al.   JOURNAL OF BIOCHEMISTRY

Updated Meta-Analysis of BIN1, CR1, MS4A6A, CLU, and ABCA7 Variants in Alzheimer’s Disease

(2018) Jucimara Ferreira Figueiredo Almeida et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production

(2018) Wei Hong Toh et al.   MOLECULAR BIOLOGY OF THE CELL

Dysfunctional γ-Secretase in Familial Alzheimer’s Disease

(2018) Michael S. Wolfe   NEUROCHEMICAL RESEARCH

Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle Pathology

(2018) Christopher J. Holler et al.   JOURNAL OF ALZHEIMERS DISEASE

Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models

(2018) Pierre De Rossi et al.   BRAIN PATHOLOGY

Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1

(2017) Na-Young Kim et al.   Alzheimers Research & Therapy

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid

(2016) Florent Ubelmann et al.   EMBO REPORTS

Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts

(2016) Pierre De Rossi et al.   Molecular Neurodegeneration

Loss of Bin1 Promotes the Propagation of Tau Pathology

(2016) Sara Calafate et al.   Cell Reports

Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci

(2015) Badri N. Vardarajan et al.   ANNALS OF NEUROLOGY

Genetic variation in BIN1 gene and Alzheimer's disease risk in Han Chinese individuals

(2014) Meng-Shan Tan et al.   NEUROBIOLOGY OF AGING

α-Taxilin Interacts with Sorting Nexin 4 and Participates in the Recycling Pathway of Transferrin Receptor

(2014) Hiroshi Sakane et al.   PLoS One

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

(2013) J Chapuis et al.   MOLECULAR PSYCHIATRY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

BIN1 Is Decreased in Sporadic but Not Familial Alzheimer’s Disease or in Aging

(2013) Elizabeth B. C. Glennon et al.   PLoS One

Intracellular Itinerary of Internalised β-Secretase, BACE1, and Its Potential Impact on β-Amyloid Peptide Biogenesis

(2013) Pei Zhi Cheryl Chia et al.   TRAFFIC

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease

(2013) Meng-Shan Tan et al.   TRENDS IN MOLECULAR MEDICINE

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

(2013) Etienne Morel et al.   Nature Communications

Critical role of intraneuronal Aβ in Alzheimer's disease: Technical challenges in studying intracellular Aβ

(2012) Gunnar K. Gouras et al.   LIFE SCIENCES

Icy: an open bioimage informatics platform for extended reproducible research

(2012) Fabrice de Chaumont et al.   NATURE METHODS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory

(2012) S. Barral et al.   NEUROLOGY

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

(2012) Celeste M. Karch et al.   PLoS One

Genome-wide association study of Alzheimer's disease

(2012) M I Kamboh et al.   Translational Psychiatry

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE

(2011) Ellen M. Wijsman et al.   PLoS Genetics

Identification of Novel Loci for Alzheimer Disease and Replication of CLU, PICALM, and BIN1 in Caribbean Hispanic Individuals

(2010) Joseph H. Lee et al.   ARCHIVES OF NEUROLOGY

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling

(2009) Saumya Pant et al.   NATURE CELL BIOLOGY

Cellular localization of Nicastrin affects amyloid β species production

(2008) Vanessa A. Morais et al.   FEBS LETTERS

Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo

(2008) John R. Cirrito et al.   NEURON

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE

Gyrating Clathrin: Highly Dynamic Clathrin Structures Involved in Rapid Receptor Recycling

(2008) Yanqiu Zhao et al.   TRAFFIC