Efficient killing of tumor cells by CAR-T cells requires greater number of engaged CARs than TCRs

Inefficient CAR-proximal signaling blunts antigen sensitivity

(2020) Venugopal Gudipati et al.   NATURE IMMUNOLOGY

An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer

(2019) Steven Feins et al.   AMERICAN JOURNAL OF HEMATOLOGY

Low Avidity T Cells Do Not Hinder High Avidity T Cell Responses Against Melanoma

(2019) Kalliopi Ioannidou et al.   Frontiers in Immunology

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

(2018) A. J. Davenport et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

The Five Immune Forces Impacting DNA-Based Cancer Immunotherapeutic Strategy

(2017) Suneetha Amara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains

(2017) Daniel T. Harris et al.   JOURNAL OF IMMUNOLOGY

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

(2017) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

(2017) Irene Scarfò et al.   Journal for ImmunoTherapy of Cancer

TCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicity

(2015) Jennifer D Stone et al.   CURRENT OPINION IN IMMUNOLOGY

Integrins Influence the Size and Dynamics of Signaling Microclusters in a Pyk2-dependent Manner

(2015) Maria Steblyanko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C  Regulates Stability of the Peripheral Adhesion Ring Junction and Contributes to the Sensitivity of Target Cell Lysis by CTL

(2014) A. M. Beal et al.   JOURNAL OF IMMUNOLOGY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy

(2013) Matthew D. Vesely et al.   Annals of the New York Academy of Sciences

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

HLA-B7-Restricted Islet Epitopes Are Differentially Recognized in Type 1 Diabetic Children and Adults and Form Weak Peptide-HLA Complexes

(2012) M. Scotto et al.   DIABETES

Long-term Persistence of CD4+ but Rapid Disappearance of CD8+ T Cells Expressing an MHC Class I-restricted TCR of Nanomolar Affinity

(2012) Boris Engels et al.   MOLECULAR THERAPY

Evidence that the Density of Self Peptide-MHC Ligands Regulates T-Cell Receptor Signaling

(2012) Nadia Anikeeva et al.   PLoS One

Functional Characterization of an scFv-Fc Antibody that Immunotherapeutically Targets the Common Cancer Cell Surface Proteoglycan CSPG4

(2011) X. Wang et al.   CANCER RESEARCH

Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes

(2011) Nadia Anikeeva et al.   IMMUNOLOGIC RESEARCH

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

T Cell Receptor Signaling Kinetics Takes the Stage

(2010) Y. Sykulev   Science Signaling

Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain

(2009) Allison M. Beal et al.   IMMUNITY

Visualizing CTL/melanoma cell interactions: multiple hits must be delivered for tumour cell annihilation

(2008) Íris Caramalho et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE