Effects of heavy metals on reproduction owing to infertility

The reproductive performance of most of the species is adversely affected by hazardous heavy metals like lead, cadmium, mercury, arsenic, zinc, and copper. Heavy metals are liberated in the environment by natural sources like rock weathering, volcanic eruption, and other human activities like industrial discharge, mineral mining, automobile exhaust, and so forth. Heavy metals alter several reproductive functions in both males and females like a decrease in sperm count, motility, viability, spermatogenesis, hormonal imbalance, follicular atresia, and delay in oocyte maturation, and so forth, and thus, forms an important aspect of reproductive toxicology. The present review compiles toxicity aspects of various heavy metals and their efficacy and mechanism of action in mammals.

Automated summary

The reproductive performance of most species is adversely affected by hazardous heavy metals, which are released into the environment through natural and human activities. These metals alter various reproductive functions in both males and females, forming an important aspect of reproductive toxicology. This review summarizes the toxicity aspects of heavy metals on mammals and their mechanisms of action.