Article
Biochemistry & Molecular Biology
Jinglin Zhu, Hongguang Quan
Summary: This study demonstrates that ADSC-Exos-carried XIST accelerate cutaneous wound healing through suppressing miR-96-5p and restoring the DDR2 expression.
Article
Biochemistry & Molecular Biology
Bo Li, Li Qian, Li Pi, Xianxi Meng
Summary: This study aims to investigate the underlying mechanism of ADSCs-derived exosome (ADSCs-exos) mediated wound healing. The results showed that ADSCs-exos carrying H19 promoted macrophage M2 polarization, thereby enhancing fibroblast proliferation, migration, and endothelial cell angiogenesis. MiR-130b-3p was identified as a downstream effector in H19-mediated effects. In conclusion, ADSCs-derived exosomal H19 accelerates cutaneous wound healing via the miR-130b-3p/PPAR gamma/STAT3 axis.
Article
Biotechnology & Applied Microbiology
Jie Wang, Hao Wu, Yixuan Peng, Yue Zhao, Youyou Qin, Yingbo Zhang, Zhibo Xiao
Summary: Research indicates that hypoxic adipose stem cells exosomes (HypADSCs-exo) can promote diabetic wound healing by regulating miRNAs and the PI3K/AKT signaling pathway, inhibiting inflammatory response.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lifeng Ge, Kangyan Wang, Hang Lin, Endong Tao, Weijie Xia, Fulin Wang, Cong Mao, Yongzeng Feng
Summary: The tissue reconstruction of diabetic wounds is challenging due to severe inflammation and other complications caused by diabetes. In this study, engineered exosomes derived from miR-132-overexpressing adipose stem cells were used to promote diabetic wound healing. The miR-132-exo significantly enhanced skin flap survival and improved wound healing by reducing inflammation, promoting angiogenesis, and stimulating M2-macrophage polarization mediated by the NF-kappa B signaling pathway.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hsiang-Hao Hsu, Aline Yen Ling Wang, Charles Yuen Yung Loh, Ashwin Alke Pai, Huang-Kai Kao
Summary: This study found that diabetic ASC-Exo enhance cutaneous wound healing by stimulating dermal cell proliferation, keratinocyte proliferation, and angiogenesis. The diabetic ASC-Exo also stimulate resident monocytes/macrophages to secrete more TGF-beta 1 and activate the TGF-beta/Smad3 signaling pathway.
Review
Cell Biology
Kehinde Ross
Summary: miRNAs play a critical role in wound healing, particularly in influencing the behavior of epidermal keratinocytes. Combining multiple miRNA mimics targeting different but complementary wound healing processes may be more effective in promoting wound repair.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell & Tissue Engineering
Simin Huang, Xueer Wang, Min Zhang, Mianbo Huang, Yuan Yan, Yinghua Chen, Yijia Zhang, Jinfu Xu, Lingwei Bu, Ruyi Fan, Huiyi Tang, Canjun Zeng, Lu Zhang, Lin Zhang
Summary: Our study demonstrates that Cdc42 plays a crucial role in ADSCs-mediated skin wound healing induced by activin B. Cdc42N17-transfected ADSCs inhibited the migration, proliferation, and secretion induced by activin B, and also suppressed the wound closure rate and the expression of CD31 and alpha-SMA.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Armin Zakeri, Sanaz Khaseb, Mahshid Akhavan Rahnama, Akram Hajaliaskari, Mina Soufi Zomorrod
Summary: Skin wound healing involves molecular and cellular procedures in four phases: hemostasis, inflammation, proliferation, and tissue remodeling. Mesenchymal stem cells (MSCs) accelerate wound healing through their secretion of exosomes, which mimic the effects of parent MSCs. Exosomes are small vesicles that carry various biomolecules and can modulate the activity of recipient cells. MSC-derived exosomes reduce inflammation, promote proliferation, inhibit apoptosis, and enhance angiogenesis in skin wound healing. Exosomes are emerging as novel mediators for cell-cell communication and potential cell-free therapies.
Article
Biochemistry & Molecular Biology
Jie Zhou, Tianhong Wei, Zhiyou He
Summary: The study demonstrated that ADSCs accelerate LEC proliferation, migration, and lymphangiogenesis through the METTL3 pathway and regulate VEGF-C expression via the METTL3/IGF2BP2-m6A pathway in DFU mice. These findings suggest that ADSCs may enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m6A modification to promote wound healing in DFUs.
MOLECULAR MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Jing Li, Hong Gao, Yue Xiong, Ling Wang, Haojie Zhang, Fumei He, Jingxin Zhao, Shuna Liu, Liqian Gao, Ying Guo, Wenbin Deng
Summary: This study found that exosomes derived from neural stem cells may enhance wound healing through neurotrophic factors and immunomodulation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Medicine, Research & Experimental
Rongfeng Shi, Yinpeng Jin, Suming Zhao, Hongxin Yuan, Jiahai Shi, Hui Zhao
Summary: Diabetes mellitus is a major cause of blindness and chronic ulcers in the working age population worldwide. Previous studies have found that differentially expressed circular RNAs (circRNAs) are associated with hyperglycemia-induced endothelial cell damage. The transplantation of adipose-derived stem cells (ADSCs) exosomes, which deliver circRNA, has a better therapeutic effect in enhancing wound healing in diabetic mice. This study identified abnormally expressed circRNAs in endothelial progenitor cells (EPCs) under hyperglycemic conditions using high-throughput sequencing. The results showed that circ-Snhg11 expression decreased in EPCs under hyperglycemic conditions, and its overexpression suppressed hyperglycemia-induced endothelial cell damage and M1-like macrophage polarization.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Guang Yang, Saquib Waheed, Cong Wang, Mehdihasan Shekh, Zhibin Li, Jun Wu
Summary: Exosomes, as therapeutically relevant cell-secreted extracellular vesicles, have garnered immense interest for their role in intercellular communication and wound healing. Stem cell-derived exosomes exhibit similar biological effects to their source cells but with low immunogenicity and no tumorigenicity. They have shown superior efficacy in promoting wound healing by promoting angiogenesis, cell proliferation, and balancing inflammatory responses. Additionally, engineered exosomes and their potential use in combination with materials provide better therapeutic properties not available in traditional single products.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Nanoscience & Nanotechnology
Ming Zhao, Jihong Shi, Weixia Cai, Kaituo Liu, Kuo Shen, Zichao Li, Yunchuan Wang, Dahai Hu
Summary: Graphene and its derivatives, along with mesenchymal stem cell-exosomes, show promise in the development of novel wound dressings and cell-free treatment for wound healing. Further studies are needed to understand the mechanisms of action and to promote their clinical transformation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Cell & Tissue Engineering
Wenya Zhang, Jinhua Zhang, Yan Cui, Yongxiang Zhao, Xiaohua Lei
Summary: An increasing number of astronauts in microgravity environments for long-term space missions has led to serious health problems, including accidental injury and trauma. Skin, as the largest organ and outermost layer of the human body, has the ability to withstand harmful influences. Recent studies have looked into the effects of microgravity on skin cells and wound healing, but there is still limited understanding of the mechanisms and intervention measures. Stem cells and their exosomes have shown potential for improving cutaneous wound healing. This review discusses the effects of microgravity on wound healing and summarizes current research on ground-based treatments using stem cells and exosomes. It also proposes promising therapeutic strategies for wound healing in the microgravity environment using stem cells or exosomes.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Zifei Shao, Jinghao Xu, Xiang Wang, Yuxi Zhou, Yujing Wang, Yiyang Li, Jianping Zhao, Kun Li
Summary: This study discovered that Exo-ATs improve skin wound healing by promoting the migration and proliferation of keratinocytes and fibroblasts, as well as collagen production by fibroblasts. miR-92a plays a role in this process by targeting LATS2 and regulating the YAP/TAZ signaling pathway.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Manigandan Nagarajan, Gobichettipalayam Balasubramaniam Maadurshni, Jeganathan Manivannan
Summary: This study found that exposure to BPA exacerbates hypertension-induced pathological changes, including renal fibrosis, oxidative stress, elevated angiotensin-converting enzyme activity, dysfunction of antioxidant and tricarboxylic acid cycle enzymes, tissue lipid abnormalities, and expression of inflammatory factors. In addition, high levels of BPA have dose-dependent effects on kidney cells, including oxidative stress, mitochondrial dysfunction, and lipid peroxidation. Therefore, a precise investigation of BPA exposure in hypertensive populations is highly recommended during risk assessment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Haiping Bao, Qiang Zhang, Yu Li, Chen Nie
Summary: In this study, the role of circDLGAP4 in Parkinson's disease (PD) was investigated. The results showed that circDLGAP4 upregulated HMGA2 by recruiting EIF4A3, thus alleviating neuronal injury in PD.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Lina Yang, Tianwei He, Yanming Yu
Summary: This study found that uric acid induces kidney injury by inducing IL-17 expression, and treatment with anti-IL-17 antibody can alleviate uric acid-induced kidney injury.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ediandra T. Castro, Amalia G. Alves, Daniela de Bittencourt Maia, Larissa S. Magalhaes, Mariana P. Paim, Filipe Penteado, Caroline S. Gomes, Eder J. Lenardao, Cesar A. Bruning, Cristiani F. Bortolatto
Summary: This study investigated the antioxidant activity and toxicity of selenium-containing compounds in liver tissue. The results showed that these compounds have potential antioxidant effects, which can be attributed to their ability to scavenge free radicals and mimic enzyme activity. Additionally, one of the compounds exhibited low toxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)