Article
Nanoscience & Nanotechnology
Jing Li, Hong Gao, Yue Xiong, Ling Wang, Haojie Zhang, Fumei He, Jingxin Zhao, Shuna Liu, Liqian Gao, Ying Guo, Wenbin Deng
Summary: This study found that exosomes derived from neural stem cells may enhance wound healing through neurotrophic factors and immunomodulation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Nanoscience & Nanotechnology
Ming Zhao, Jihong Shi, Weixia Cai, Kaituo Liu, Kuo Shen, Zichao Li, Yunchuan Wang, Dahai Hu
Summary: Graphene and its derivatives, along with mesenchymal stem cell-exosomes, show promise in the development of novel wound dressings and cell-free treatment for wound healing. Further studies are needed to understand the mechanisms of action and to promote their clinical transformation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Armin Zakeri, Sanaz Khaseb, Mahshid Akhavan Rahnama, Akram Hajaliaskari, Mina Soufi Zomorrod
Summary: Skin wound healing involves molecular and cellular procedures in four phases: hemostasis, inflammation, proliferation, and tissue remodeling. Mesenchymal stem cells (MSCs) accelerate wound healing through their secretion of exosomes, which mimic the effects of parent MSCs. Exosomes are small vesicles that carry various biomolecules and can modulate the activity of recipient cells. MSC-derived exosomes reduce inflammation, promote proliferation, inhibit apoptosis, and enhance angiogenesis in skin wound healing. Exosomes are emerging as novel mediators for cell-cell communication and potential cell-free therapies.
Article
Biochemistry & Molecular Biology
Jun Ho Lee, Yu Jin Won, Hail Kim, Minji Choi, Esther Lee, Bumsik Ryoou, Seok-Geun Lee, Byong Seung Cho
Summary: Exosomes derived from adipose tissue-derived stem cells (ASCs) have shown beneficial effects on cell proliferation, migration, and gene expression related to wound healing. Combining these ASC-derived exosomes (ASC-EXOs) with hyaluronic acid (HA) can enhance wound closure rates, tissue regeneration, and collagen production in animal models. This suggests the potential for their use in clinical and regenerative aesthetic applications for skin repair and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Nan Hu, Zhengwei Cai, Xudong Jiang, Chuang Wang, Tao Tang, Tianze Xu, Hong Chen, Xiaoqiang Li, Xiaolong Du, Wenguo Cui
Summary: Adipose-derived stem cell (ADSC)-originating exosomes (ADSC-Exos) have potential in diabetic wound repair, but their disadvantages limit their clinical application. This study developed hypoxia-pretreated ADSC-Exo (ADSC-HExo)-embedded GelMA hydrogels (GelMA-HExo) and demonstrated their therapeutic effects in promoting diabetic wound healing. These findings suggest a new therapeutic strategy for diabetic ulcers.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Yanling Song, Yuchan You, Xinyi Xu, Jingyi Lu, Xiajie Huang, Jucong Zhang, Luwen Zhu, Jiahao Hu, Xiaochuan Wu, Xiaoling Xu, Weiqiang Tan, Yongzhong Du
Summary: The ECM@exo treatment, which incorporates ADSC-exos into an ECM hydrogel, shows great potential in promoting wound healing by reducing inflammation, enhancing cell proliferation and migration, as well as promoting angiogenesis and collagen deposition.
Review
Biochemistry & Molecular Biology
Guang Yang, Saquib Waheed, Cong Wang, Mehdihasan Shekh, Zhibin Li, Jun Wu
Summary: Exosomes, as therapeutically relevant cell-secreted extracellular vesicles, have garnered immense interest for their role in intercellular communication and wound healing. Stem cell-derived exosomes exhibit similar biological effects to their source cells but with low immunogenicity and no tumorigenicity. They have shown superior efficacy in promoting wound healing by promoting angiogenesis, cell proliferation, and balancing inflammatory responses. Additionally, engineered exosomes and their potential use in combination with materials provide better therapeutic properties not available in traditional single products.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Cell Biology
Yang An, Shuyan Lin, Xiaojie Tan, Shiou Zhu, Fangfei Nie, Yonghuan Zhen, Luosha Gu, Chunlei Zhang, Baicheng Wang, Wei Wei, Dong Li, Junhao Wu
Summary: ADSCs-EXOs modulate immune responses and inflammation, promote angiogenesis, accelerate proliferation and re-epithelization of skin cells, and regulate collagen remodelling to inhibit scar hyperplasia in wounds. Compared with ADSCs therapeutics, ADSCs-EXOs have high stability, easy storage, immune system non-rejection, homing effect, and easily controlled dosage. In patients with diabetes mellitus, ADSCs-EXOs can improve fat grafting and promote wound healing.
CELL PROLIFERATION
(2021)
Review
Cell & Tissue Engineering
Chuchao Zhou, Boyu Zhang, Yanqing Yang, Qiong Jiang, Tianyu Li, Jun Gong, Hongbo Tang, Qi Zhang
Summary: Wound healing is a complex process involving hemostasis, inflammation, proliferation, and tissue remodeling. Mesenchymal stem cell-derived exosomes (MSC-exos) have lower immunogenicity and high biological activity, and play a role in regulating the behavior of various skin cells. This study focuses on exploring the specific roles and mechanisms of different MSC-exos in wound healing, as well as their limitations and potential applications. Understanding the biological properties of MSC-exos is crucial for developing cell-free therapies for wound healing and cutaneous regeneration.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Dermatology
Daniel Bormann, Alfred Gugerell, Hendrik Jan Ankersmit, Michael Mildner
Summary: Cell secretomes play an important role in wound healing by promoting regeneration. This study reviews the mechanisms of action of cell secretomes in wound healing, important preconditioning strategies to enhance therapeutic efficacy, and clinical trials on secretome-based wound healing.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Immunology
Min Jiang, Xupin Jiang, Hongmei Li, Can Zhang, Ze Zhang, Chao Wu, Junhui Zhang, Jiongyu Hu, Jiaping Zhang
Summary: Diabetic foot is a common complication of diabetes and often leads to amputation. Previous studies have shown that stem cell transplantation can promote the healing of chronic diabetic wounds, but safety concerns have limited its clinical application. Recently, it has been discovered that mesenchymal stem cell-derived extracellular vesicles (EVs) have similar therapeutic effects and offer advantages such as safety and reduced immune response. This paper summarizes the current understanding of mesenchymal stem cell-derived EVs in accelerating the healing of diabetic wounds and their potential clinical applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Anatomy & Morphology
Huldani Huldani, Iuliia A. Kozlitina, Mesfer Alshahrani, Hamid Mahmood Abdullah Daabo, Sami G. Almalki, Khulood H. Oudaha, Ahmed Hussien Alawadi, Ali Alsalamy, S. K. Joshi, Yasser Fakri Mustafa
Summary: This study investigated the therapeutic benefits of adipose stem cell-derived exosomes loaded on hyaluronic acid (HA) for diabetic wound healing in rats. The results showed that treatment with HA and exosomes promoted wound closure, increased the volumes of new epidermis and dermis, enhanced fibroblast density, blood vessel length density, collagen density, and improved tensiometrical parameters of the healed wounds. Additionally, the expression of TGF-beta and VEGF genes was upregulated, while TNF-alpha and IL-1 beta expression and neutrophil density were decreased. The combination of HA and exosomes had a greater effect on diabetic wound healing.
Review
Biotechnology & Applied Microbiology
Ming Hao, MengNa Duan, Zhijing Yang, Hengzong Zhou, Shuangji Li, Jingcheng Xiang, Han Wu, Huimin Liu, Lu Chang, Dongxu Wang, Weiwei Liu
Summary: Wound healing in the oral and maxillofacial area has a significant impact on the patient's quality of life and mental health. Traditional treatment methods are limited in their efficacy, but exosomes secreted by stem cells have shown promising results. However, natural stem cell exosomes have limitations, and engineered stem cell exosomes have been developed to overcome these limitations and provide targeted promotion of efficient soft tissue repair. These engineered exosomes have anti-inflammatory and cell proliferation regulatory abilities, which make them effective treatments for oral and maxillofacial wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yunchuan Wang, Yue Zhang, Ting Li, Kuo Shen, Ke Jia Wang, Chenyang Tian, Dahai Hu
Summary: Engineered skin substitutes derived from human skin reduce inflammatory reactions and are easier to use in clinics. Type I collagen and platelet-rich plasma are mixed to form a stable scaffold, while adipose mesenchymal stem cell derived exosomes improve the performance of the engineered skin. This method provides a new therapeutic strategy and theoretical basis for tissue regeneration and wound repair.
ADVANCED MATERIALS
(2023)
Article
Cell & Tissue Engineering
Yang Zhou, Bo Zhao, Xin-Liao Zhang, Yi-jun Lu, Shou-Tao Lu, Jian Cheng, Yu Fu, Lin Lin, Ning-Yan Zhang, Pei-Xin Li, Jing Zhang, Jun Zhang
Summary: This study investigated the potential clinical application roles of human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes (hADSC-Exo) in cutaneous wound healing. The combined administration of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration showed additional benefits in promoting wound healing, accelerating re-epithelialization, reducing scar widths, and enhancing angiogenesis and collagen synthesis.
STEM CELL RESEARCH & THERAPY
(2021)
Editorial Material
Surgery
Nabil Mopuri, Quentin Frew, Charles Yuen Yung Loh, Peter Dziewulski
ARCHIVES OF PLASTIC SURGERY-APS
(2021)
Article
Orthopedics
Yu-Te Lin, Charles Yuen Yung Loh, Shih-Heng Chen
Summary: Arterialized venous flap is a cutaneous flap relying on subcutaneous veins, but its nonphysiologic blood flow and postoperative complications make it an unpopular choice for reconstruction. We describe an approach to designing arterialized venous flap that eliminates direct arteriovenous shunting and restricts venous congestion.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2022)
Article
Surgery
Woo Sik Pae, Yu-Te Lin, Charles Yuen Yung Loh, Che-Hsiung Lee, Chung-Chen Hsu, Shih-Heng Chen, Cheng-Hung Lin
Summary: This study investigated the impact of articular inclination on outcomes after toe joint transfers for finger proximal interphalangeal joint reconstruction, and found that the articular surface inclination of the toe did not affect the functional range of motion after joint transfer.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Medicine, General & Internal
Ashwin Pai, Richard Baker, Aparna Udyavar Pai, Quillan Young Sing
Article
Pharmacology & Pharmacy
Aline Yen Ling Wang, Kuan-Hung Chen, Hsiu-Chao Lin, Charles Yuen Yung Loh, Yun-Ching Chang, Ana Elena Avina, Chin-Ming Lee, I-Ming Chu, Fu-Chan Wei
Summary: Vascularized composite allotransplantation is a strategy for reconstructing unique defects like amputated limbs. To ensure the function of transplanted limbs, the recovery of the anastomosed nerves is crucial. Tacrolimus has been shown to promote nerve recovery but has risks of systemic complications. A mixed thermosensitive hydrogel was developed for sustained release of tacrolimus, which improved functional recovery of injured nerves without adverse effects.
Article
Surgery
Ashwin Alke Pai, Kavish Maheshwari, Sandip Hindocha
Summary: Communication through a color-coded traffic light system in healthcare improves treatment quality and guides patients through their treatment process.
JOURNAL OF HAND SURGERY-ASIAN-PACIFIC VOLUME
(2022)
Review
Surgery
Ashwin Alke Pai, Quillan Young-Sing, Sudipta Bera, Kavish Maheshwari, Alok Misra
Summary: This study retrospectively analyzed the clinical outcomes and quality-of-life parameters of 27 patients who underwent ELAPE and immediate IGAP flap reconstruction for low rectal cancer. The results showed that this reconstruction method had good patient satisfaction and clinical outcomes.
Article
Medicine, Research & Experimental
Ana Elena Avina, Dante De Paz, Shu-Chun Huang, Kuan-Hung Chen, Yun-Ching Chang, Chin-Ming Lee, Chia-Hsien Lin, Fu-Chan Wei, Aline Yen Ling Wang
Summary: Vascularized composite allotransplantation has potential in face transplantation, but lifelong administration of immunosuppressive drugs limits its use. Modified mRNA (modRNA) technology can produce protein in vivo, and IL-10 modRNA was found to produce functional IL-10 protein in vitro, inhibiting pro-inflammatory cytokines and creating an anti-inflammatory environment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Surgery
Soo Min Cha, Ashwin Pai, Hyun Jong Lee, Hyun Dae Shin
Summary: In this retrospective case series, we found that non-vascularized iliac bone graft longer than 3 cm had satisfactory clinical outcomes in the treatment of non-union of the upper extremities.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2024)
Article
Cell & Tissue Engineering
Aline Yen Ling Wang
Summary: The COVID-19 pandemic has presented a significant challenge to global healthcare and economic systems. The development of modRNA vaccines has allowed for a rapid response to the virus, with promising effectiveness against infection. However, long-term safety and protective immunity still require further investigation.
CELL TRANSPLANTATION
(2022)
Review
Surgery
Aswin Appukuttan, Charles Yuen Yung Loh, Marta Marti Puente, Fortune Iwuagwu
Summary: The reverse SUPBRA flap is a versatile flap for reconstructing defects of the thumb, index, palm and first webspace. It is quick to raise, has a low donor site morbidity and complication rate, and achieves very reasonable functional and aesthetic outcomes.
Article
Surgery
Yu-Te Lin, Charles Yuen Yung Loh
Summary: This article describes a new technique of using a reversed inset of toe PIPJ to repair composite defects of finger joints, with a successful case demonstrating improved hand function. The reverse inset of toe PIPJs shows promise in simultaneous reconstruction of damaged finger PIPJs and building up of bony length distally.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2021)
