A Primer on the Evolution of Aducanumab: The First Antibody Approved for Treatment of Alzheimer’s Disease

Alzheimer's disease

(2021) Philip Scheltens et al.   LANCET

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of Aducanumab for Alzheimer Disease

(2021) G. Caleb Alexander et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Aducanumab produced a clinically meaningful benefit in association with amyloid lowering

(2021) Jeffrey Cummings et al.   Alzheimers Research & Therapy

Landmark Alzheimer’s drug approval confounds research community

(2021) Asher Mullard   NATURE

A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer’s disease

(2021) Stephen Salloway et al.   NATURE MEDICINE

Three FDA advisory panel members resign over approval of Alzheimer’s drug

(2021) Elisabeth Mahase   BMJ-British Medical Journal

Aducanumab, gantenerumab, BAN2401, and ALZ-801—the first wave of amyloid-targeting drugs for Alzheimer’s disease with potential for near term approval

(2020) Martin Tolar et al.   Alzheimers Research & Therapy

Immune response and endocytosis pathways are associated with the resilience against Alzheimer’s disease

(2020) Niccolò Tesi et al.   Translational Psychiatry

Overview of dominantly inherited AD and top‐line DIAN‐TU results of solanezumab and gantenerumab

(2020) Randall J Bateman et al.   Alzheimers & Dementia

Understanding the Amyloid Hypothesis in Alzheimer’s Disease

(2019) Giulia Paroni et al.   JOURNAL OF ALZHEIMERS DISEASE

What matters to people with memory problems, healthy volunteers and health and social care professionals in the context of developing treatment to prevent Alzheimer's dementia? A qualitative study

(2019) Julie Watson et al.   HEALTH EXPECTATIONS

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals

(2018) Hsin-Yi Wu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β

(2018) Joseph W. Arndt et al.   Scientific Reports

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Emma Nichols et al.   LANCET NEUROLOGY

Glial contributions to neurodegeneration in tauopathies

(2017) Cheryl E. G. Leyns et al.   Molecular Neurodegeneration

Alzheimer amyloid hypothesis lives on

(2017) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Reexamining Alzheimer's Disease: Evidence for a Protective Role for Amyloid-β Protein Precursor and Amyloid-β

(2017) Rudy J. Castellani et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's disease: The amyloid hypothesis on trial

(2016) Judith R. Harrison et al.   BRITISH JOURNAL OF PSYCHIATRY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Novel strategies for Alzheimer's disease treatment: An overview of anti-amyloid beta monoclonal antibodies

(2016) Katarzyna Rygiel   INDIAN JOURNAL OF PHARMACOLOGY

Ten Challenges of the Amyloid Hypothesis of Alzheimer’s Disease

(2016) Kasper Planeta Kepp   JOURNAL OF ALZHEIMERS DISEASE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

Promising Targets for the Treatment of Neurodegenerative Diseases

(2015) SL Budd Haeberlein et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

A critical analysis of the ‘amyloid cascade hypothesis’

(2014) Richard A. Armstrong   FOLIA NEUROPATHOLOGICA

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

(2014) Jeffrey L Cummings et al.   Alzheimers Research & Therapy

Normal cognition in transgenic BRI2-Aβ mice

(2013) Jungsu Kim et al.   Molecular Neurodegeneration

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Cognitive reserve in ageing and Alzheimer's disease

(2012) Yaakov Stern   LANCET NEUROLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

(2011) Todd E. Golde et al.   NEURON

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

(2010) Miranda N. Reed et al.   NEUROBIOLOGY OF AGING

Current Alzheimer's disease clinical trials: Methods and placebo outcomes

(2009) Lon S. Schneider et al.   Alzheimers & Dementia

 -Amyloid Monomers Are Neuroprotective

(2009) M. L. Giuffrida et al.   JOURNAL OF NEUROSCIENCE

Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease

(2009) Joseph L. Price et al.   NEUROBIOLOGY OF AGING

Fibrillar amyloid-  burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

(2009) E. M. Reiman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BETASCAN: Probable β-amyloids Identified by Pairwise Probabilistic Analysis

(2009) Allen W. Bryan et al.   PLoS Computational Biology

Behavioral symptoms and caregiver burden in dementia

(2009) KS Shaji et al.   Indian Journal of Psychiatry