Cytokine responses in nonlesional psoriatic skin as clinical predictor to anti-TNF agents

Atopic dermatitis is an IL-13 dominant disease with greater molecular heterogeneity compared to psoriasis

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2D Visualization of the Psoriasis Transcriptome Fails to Support the Existence of Dual-Secreting IL-17A/IL-22 Th17 T Cells

(2019) Stephanie T. Le et al.   Frontiers in Immunology

Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses

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Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa

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Biologic treatment sequences for plaque psoriasis: a cost-utility analysis based on 10 years of Dutch real-world evidence from BioCAPTURE

(2018) S.L. Klijn et al.   BRITISH JOURNAL OF DERMATOLOGY

Transcriptional determinants of individualized inflammatory responses at anatomically separate sites

(2018) Lam C. Tsoi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Comparison of the cost-effectiveness of biologic drugs used for moderate-to-severe psoriasis treatment in the United States

(2018) Jashin J. Wu et al.   JOURNAL OF DERMATOLOGICAL TREATMENT

CME Part I Psoriasis: Which Therapy for Which Patient Psoriasis comorbidities and preferred systemic agents

(2018) Shivani B. Kaushik et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

CME Part II Psoriasis: Which Therapy for Which Patient Focus on special populations and chronic infections

(2018) Shivani B. Kaushik et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Comparative effectiveness of targeted immunomodulators for the treatment of moderate-to-severe plaque psoriasis: A systematic review and network meta-analysis

(2018) Anne M. Loos et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis

(2018) Curdin Conrad et al.   Nature Communications

Inflammatory bowel disease: towards a personalized medicine

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Certolizumab Pegol for the Treatment of Patients with Moderate-to-Severe Chronic Plaque Psoriasis: Pooled Analysis of Week 16 Data from 3 Randomized Controlled Trials

(2018) A. Blauvelt et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Towards personalized medicine for patients with autoimmune diseases: Opportunities and challenges

(2017) Soheil Tavakolpour   IMMUNOLOGY LETTERS

Novel Strategies on Personalized Medicine for Breast Cancer Treatment: An Update

(2017) Carmen Chan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

(2017) Kei-ichiro Arimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

(2017) Sarah Kim-Hellmuth et al.   Nature Communications

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants

(2017) Lam C. Tsoi et al.   Nature Communications

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

(2017) Kei-ichiro Arimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TNFα and its Receptors in Psoriatic Skin, before and after Treatment with Etanercept

(2017) G. Caldarola et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Cross-Disease Transcriptomics: Unique IL-17A Signaling in Psoriasis Lesions and an Autoimmune PBMC Signature

(2016) William R. Swindell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci

(2015) Lam C. Tsoi et al.   Nature Communications

Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin

(2015) Lam C Tsoi et al.   GENOME BIOLOGY

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Early tissue responses in psoriasis to the antitumour necrosis factor-α biologic etanercept suggest reduced interleukin-17 receptor expression and signalling

(2014) A. Johnston et al.   BRITISH JOURNAL OF DERMATOLOGY

Abnormal Epidermal Barrier Recovery in Uninvolved Skin Supports the Notion of an Epidermal Pathogenesis of Psoriasis

(2014) Li Ye et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcriptome Analysis of Psoriasis in a Large Case–Control Sample: RNA-Seq Provides Insights into Disease Mechanisms

(2014) Bingshan Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

(2014) Richard G. Langley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Markers of systemic inflammation in psoriasis: a systematic review and meta-analysis

(2013) E.A. Dowlatshahi et al.   BRITISH JOURNAL OF DERMATOLOGY

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(2012) Alexander Dobin et al.   BIOINFORMATICS

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

Comparative safety of infliximab and etanercept on the risk of serious infections: does the association vary by patient characteristics?

(2012) Sengwee Toh et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Heterogeneity of Inflammatory and Cytokine Networks in Chronic Plaque Psoriasis

(2012) William R. Swindell et al.   PLoS One

TNF-α Downregulates Filaggrin and Loricrin through c-Jun N-terminal Kinase: Role for TNF-α Antagonists to Improve Skin Barrier

(2011) Byung Eui Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TNFAIP3 Gene Polymorphisms Are Associated with Response to TNF Blockade in Psoriasis

(2011) Trilokraj Tejasvi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Assessment of the Psoriatic Transcriptome in a Large Sample: Additional Regulated Genes and Comparisons with In Vitro Models

(2010) Johann E. Gudjonsson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis

(2010) Andrea Chiricozzi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Long-term etanercept in pediatric patients with plaque psoriasis

(2010) Amy S. Paller et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Golimumab, a new human tumor necrosis factor α antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: Twenty-four-week efficacy and safety results of a randomized, placebo-controlled study

(2009) Arthur Kavanaugh et al.   ARTHRITIS AND RHEUMATISM

Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes

(2009) Lisa C. Zaba et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin

(2009) Johann E. Gudjonsson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY