Article
Biochemistry & Molecular Biology
Na Young Kim, Gautam Sethi, Jae-Young Um, Kwang Seok Ahn
Summary: EPBS can potentially function as an anti-cancer agent by inducing apoptosis and autophagy when targeting the SHP-1/STAT3 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Chakrabhavi Dhananjaya Mohan, Min Hee Yang, Shobith Rangappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Amudha Deivasigamani, Kam Man Hui, Gautam Sethi, Kanchugarakoppal S. Rangappa, Kwang Seok Ahn
Summary: This study demonstrates that 3-formylchromone inhibits the activated STAT3 signaling in hepatocellular carcinoma cells and effectively reduces tumor growth and metastasis in a mouse model. The researchers also found that 3-formylchromone does not cause substantial toxicity. Therefore, it has the potential to be a powerful agent for targeting STAT3 signaling in hepatocellular carcinoma.
Article
Pharmacology & Pharmacy
Xue Hu, Fangzhou Jiao, Lan Zhang, Yingan Jiang
Summary: Liver cancer is a common malignancy with drug resistance being a major challenge in treatment. This study demonstrates that Dihydrotanshinone (DHTS) can inhibit the growth of hepatocellular carcinoma by suppressing the JAK2/STAT3 signaling pathway, suggesting its potential as a chemotherapeutic agent.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
QinLei Gu, Kenneth S. Tung, Ulrike M. Lorenz
Summary: To achieve a healthy and functional immune system, there is a delicate balance between the activation of Tcon cells and the suppression by Treg cells. SHP-1 plays a role in modulating this balance by regulating Tcon cell resistance to Treg-mediated suppression. However, the role of SHP-1 in Treg function is still not fully understood.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Rajaghatta N. Suresh, Young Y. Jung, Chakrabhavi D. Mohan, Shalini V. Gowda, Kachigere B. Harsha, Kempegowda Mantelingu, Gautam Sethi, Kwang S. Ahn, Kanchugarakoppal S. Rangappa
Summary: In this study, new compounds called DTI were synthesized and found to exhibit selective cytotoxicity against gastric cancer cells. The cytotoxic effect was achieved by inhibiting the phosphorylation of STAT3 and STAT5, which are transcription factors involved in cancer development. Further investigation revealed that the inhibition of STAT proteins was mediated through the suppression of upstream kinases such as JAK1, JAK2, and Src. The involvement of tyrosine phosphatase and negative regulator PTP & epsilon;C in the DTI-induced STATs inhibition was also demonstrated. Overall, triazolyl-indolo-quinoxaline compounds like DTI show promise as inhibitors of the STAT3/STAT5 pathway in gastric cancer cells.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Adrienn Markovics, Sydney Lupo, Niyati Patel, Katalin Mikecz, D. Rick Sumner, Ryan D. Ross
Summary: This study found that Shp1 overexpression leads to increased bone mass and improved mechanical properties in mice, but only in 28-day-old mice. Female SHP1-Tg mice showed higher trabecular bone volume, trabecular number, and connectivity density compared to wildtype mice.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Oncology
Fang Yuan, Qian Gao, Hailin Tang, Jun Shi, Yiqun Zhou
Summary: This study revealed the inhibitory effect of OP-B on hepatocellular carcinoma (HCC) and its mechanism. OP-B inhibited HCC progression by downregulating PTP1B expression, thus inactivating the PI3K/AKT pathway and activating the AMPK pathway, leading to the suppression of HCC growth, proliferation, invasion, and angiogenesis.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Hanna Mannell, Petra Kameritsch, Heike Beck, Alexander Pfeifer, Ulrich Pohl, Kristin Pogoda
Summary: The gap junction protein Cx43 is involved in endothelial cell migration and angiogenesis through its interaction with the phosphatase SHP-2, enhancing its activity and regulating migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sulafa Ibrahim, Badriya Baig, Soleiman Hisaindee, Hussein Darwish, Ashraf Abdel-Ghany, Hesham El-Maghraby, Amr Amin, Yaser Greish
Summary: Liver cancer remains a major cause of cancer-related deaths, partly due to limitations of available drugs and late diagnosis. Targeted drug delivery systems using nanoparticles, especially magnetic nanoparticles (MNPs), show promise in improving therapeutic value by reducing drug resistance. In this study, PEG-coated MNPs were successfully synthesized and coated with crocetin at different concentrations. The crocetin-coated pegylated MNPs demonstrated good release kinetics under acidic and neutral conditions and showed potential in reducing the proliferation of HepG2 cells in vitro.
Article
Medicine, Research & Experimental
Chen Sun, Ming Bai, Weiwei Ke, Xiaoxun Wang, Xiangxuan Zhao, Zaiming Lu
Summary: The study demonstrated that XL888 can promote apoptosis of HCC cells induced by heat both in vitro and in vivo by affecting the expression of relevant proteins. This suggests a potential new combination strategy to enhance the efficiency of RFA.
Article
Oncology
Jingru Zhang, Yang Liu, Xiaojie Wang, Zhiyi Wang, Enjia Xing, Jingmin Li, Dong Wang
Summary: The antitumor mechanism of curcumin in hepatocellular carcinoma (HCC) cells remains unclear. This study screened and validated the targets of curcumin to understand its mechanism of action in HCC treatment. Through analysis of databases and experimental models, it was demonstrated that curcumin inhibits HCC cell proliferation by inhibiting the expression of PTPN1 and PTPN11.
Article
Microbiology
Huimin Huang, Yongtao Li, Dongliang Li, Li Wang, Wenqiang Jiao, Yilin Bai, Gaiping Zhang
Summary: This study reveals the role of PTPN14 in PEDV infection. PTPN14 overexpression inhibits PEDV infection, while PTPN14 knockdown or phosphatase inhibitor treatment promotes PEDV proliferation. Furthermore, PTPN14 may regulate PEDV infection by dephosphorylating STAT3 in the cytoplasm.
VETERINARY MICROBIOLOGY
(2022)
Article
Oncology
Shusil K. Pandit, Giada Sandrini, Jessica Merulla, Valentina Nobili, Xin Wang, Alessia Zangari, Andrea Rinaldi, Dheeraj Shinde, Giuseppina M. Carbone, Carlo V. Catapano
Summary: Enhanced expression of mitochondrial ribosomal proteins and significant reprogramming of the mitochondrial network are associated with sorafenib resistance in human cell lines and hepatocarcinoma patients. This suggests potential actionable targets for improving therapeutic efficacy.
Article
Biochemistry & Molecular Biology
Yan Ma, Haibo Zhang, Cheng Chen, Lixin Liu, Ting Ding, Ying Wang, Dachang Ma, Xiaoling Ling, Xiaohua Chen, Jianping Li, Guansheng Zhong, Guoqing Ru, Lei Zhang, Jianming Tang
Summary: This study reveals that TRIM32 is upregulated and negatively associated with survival of TNBC patients. Radiotherapy enhances the expression of TRIM32, while depletion of TRIM32 reduces TNBC radioresistance. Mechanistically, radiotherapy promotes the association between TRIM32 and nuclear STAT3, which suppresses TC45-induced dephosphorylation of STAT3, resulting in increased STAT3 transcriptional activation and TNBC radioresistance. TRIM32 and STAT3 phosphorylation are co-expressed in TNBC tissues and correlated with poor prognosis of TNBC patients.
Article
Biochemistry & Molecular Biology
Rukang Zhang, Dong Chen, Hao Fan, Rong Wu, Jiayi Tu, Freya Q. Zhang, Mei Wang, Hong Zheng, Cheng-Kui Qu, Shannon E. Elf, Brandon Faubert, Yu-Ying He, Marc B. Bissonnette, Xue Gao, Ralph J. DeBerardinis, Jing Chen
Summary: Environmental stresses induce reductive carboxylation in cancer cells, which is involved in maintaining redox homeostasis and lipid biosynthesis. Different cellular signals induce reductive carboxylation by regulating the tyrosine phosphorylation and activation of IDH1, achieved through inhibition of the protein phosphatase SHP-2.
CELL CHEMICAL BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Milad Ashrafizadeh, Ali Zarrabi, Hassan Karimi-Maleh, Afshin Taheriazam, Sepideh Mirzaei, Mehrdad Hashemi, Kiavash Hushmandi, Pooyan Makvandi, Ehsan Nazarzadeh Zare, Esmaeel Sharifi, Arul Goel, Lingzhi Wang, Jun Ren, Yavuz Nuri Ertas, Alan Prem Kumar, Yuzhuo Wang, Navid Rabiee, Gautam Sethi, Zhaowu Ma
Summary: Nanomedicine has great potential in the treatment of bladder cancer, including improving drug efficacy, regulating gene expression, providing photodynamic and photothermal therapy, remodeling tumor microenvironment and infiltration of immune cells, timely diagnosis, and targeted therapy for bladder cancer.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Environmental Sciences
Haiying Lu, Changlei Xia, Arunachalam Chinnathambi, Omaima Nasif, Mathiyazhagan Narayanan, Sabarathinam Shanmugam, Nguyen Thuy Lan Chi, Arivalagan Pugazhendhi, Ruangwong On-Uma, Kumchai Jutamas, Wongchai Anupong
Summary: The current study investigated the plant growth promoting (PGP) characteristics of multi-metal-tolerant Bacillus cereus and their positive effect on the physiology, biomolecule substance, and phytoremediation ability of Chrysopogon zizanioides in metal-contaminated soil.
Article
Environmental Sciences
Haiying Lu, Changlei Xia, Arunachalam Chinnathambi, Omaima Nasif, Mathiyazhagan Narayanan, Sabarathinam Shanmugam, Nguyen Thuy Lan Chi, Arivalagan Pugazhendhi, Ruangwong On-Uma, Kumchai Jutamas, Wongchai Anupong
Summary: The aim of this study was to find a bacteria isolate that is tolerant to cadmium (Cd2+) and has the ability to remediate contaminated soil from a KNO3 processing unit. Out of 19 isolates, one isolate, identified as Enterobacter hormaechei SFC3 through molecular characterization, showed superior tolerance to Cd2+ compared to others. The identified strain contained 55% GC content and 45% AT content. The wild and acridine orange mutated E. hormaechei SFC3 exhibited excellent resistance to Cd2+ up to a concentration of 1500 μg mL(-1). Furthermore, both the wild and mutated strains showed significant Cd2+ remediation capability. The findings suggest that E. hormaechei SFC3 is a promising candidate for microbial remediation of Cd2+ contamination.
Article
Biochemistry & Molecular Biology
Young Yun Jung, Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Jae-Young Um, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Kwang Seok Ahn
Summary: The study demonstrates that Brucein D (BD) inhibits Akt-driven signaling events in multiple myeloma (MM) cells, leading to decreased cell viability and proliferation. BD induces apoptosis and reduces the expression of antiapoptotic proteins in MM cells. Additionally, BD reverses the activation of kinases, including Akt, and regulates chemoresistance through the modulation of Akt phosphorylation.
Review
Biotechnology & Applied Microbiology
Milad Ashrafizadeh, Kiavash Hushmandi, Sepideh Mirzaei, Saied Bokaie, Ashkan Bigham, Pooyan Makvandi, Navid Rabiee, Vijay Kumar Thakur, Alan Prem Kumar, Esmaeel Sharifi, Rajender S. Varma, Amir Reza Aref, Marcin Wojnilowicz, Ali Zarrabi, Hassan Karimi-Maleh, Nicolas H. Voelcker, Ebrahim Mostafavi, Gorka Orive
Summary: Green chemistry has shown great promise in biomedical applications, particularly in cancer therapy. Chitosan-based nanoparticles (CS-NPs) serve as a promising carrier for anti-cancer drugs, overcoming drug resistance and enabling synergistic therapy. Various types of nanostructures can be modified with chitosan for efficient delivery of chemotherapeutic agents such as doxorubicin (DOX). The functionalization of CS-NPs with ligands and their pH-sensitive and redox-responsive characteristics further enhance their selectivity and drug release. Considering their high encapsulation efficiency and biocompatibility, significant progress is expected in the clinical translation of CS-NPs.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Environmental Sciences
Lin Yi-Chia, Manigandan Sekar, Arunachalam Chinnathambi, Omaima Nasif, Beata Gavurova, G. K. Jhanani, Kathirvel Brindhadevi, Nguyen Thuy Lan Chi
Summary: The study focused on the effects of chicken waste-based biodiesel blends and constant hydrogen injection on a modified diesel engine. The study also examined the effects of multiwall carbon nanotubes (MWCNT) on engine efficiency. Tests were conducted with different fuel blends and constant hydrogen injection. The findings showed that the addition of chicken waste biodiesel could be a sustainable substitute for fossil fuels while reducing pollutant emissions and improving engine performance with the inclusion of MWCNT.
ENVIRONMENTAL RESEARCH
(2023)
Article
Energy & Fuels
Bingchao Zhao, Xiaoyong Song, Han Wang, Sabariswaran Kandasamy, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Govindasamy Sathiyan, Nguyen Thuy Lan Chi, Rajasree Shanmuganathan
Summary: This study examines the influence of biohydrogen gas on the emissions and performance of a diesel engine. The results show that adding biohydrogen gas can reduce the concentrations of CO, CO2, and NOx in the exhaust, while increasing the brake thermal efficiency and heat release rate of the engine. However, the brake specific fuel consumption is higher due to energy discrepancy.
Article
Energy & Fuels
Rajasree Shanmuganathan, Nguyen Thuy Lan Chi, Arunachalam Chinnathambi, Saleh H. Salmen, G. K. Jhanani, Beata Gavurova, Manigandan Sekar, Arivalagan Pugazhendhi, T. R. Praveenkumar
Summary: Extensive use of fossil fuels is the main cause of global warming. Biodiesel, as a promising alternative, can improve engine performance and reduce emissions when combined with nanoparticles and hydrogen. Among the blends tested, B20CH showed the lowest emissions.
Review
Biochemistry & Molecular Biology
Hardeep Singh Tuli, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Manoj Kumar, Kuldeep Dhama, E. Hui Clarissa Lee, Kenneth Chun-Yong Yap, Sharah Mae Capinpin, Alan Prem Kumar
Summary: Cucurbitacins, a group of highly oxidized tetracyclic triterpenoids found in cucumbers, have potential medical uses. They interact with various cellular targets to inhibit cancer cell growth through induction of apoptosis, cell-cycle arrest, anti-metastasis, and anti-angiogenesis. They may also be used in combination with other drugs to overcome treatment resistance in cancer cells. This study focuses on finding molecular targets for cucurbitacins in suppressing malignant processes.
Article
Biochemistry & Molecular Biology
Basappa Basappa, Lisha K. Poonacha, Zhang Xi, Divakar Vishwanath, Ji-Rui Yang, Omantheswara Nagaraja, Ananda Swamynayaka, Mahendra Madegowda, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Doddahosuru Mahadevappa Gurudatt, Vijay Pandey, Nanjundaswamy Shivananju, Kwang Seok Ahn, Gautam Sethi, Peter E. Lobie, Priya Babu Shubha
Summary: Small molecules are used to inhibit CDK enzymes in cancer treatment. Pyranopyrazoles were identified as CDK inhibitors synthesized by nano-zirconium dioxide via multicomponent reaction. The bioactive pyranopyrazoles target CDK1 in human breast cancer cells.
Article
Biotechnology & Applied Microbiology
Akshay Ravish, Rashmi Shivakumar, Zhang Xi, Min Hee Yang, Ji-Rui Yang, Ananda Swamynayaka, Omantheswara Nagaraja, Mahendra Madegowda, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Vijay Pandey, Gautam Sethi, Kwang Seok Ahn, Peter E. E. Lobie, Basappa Basappa
Summary: This study explored the design of imidazopyridine-tethered pyrazolines as a de novo drug strategy for inhibiting STAT3 phosphorylation in human BC cells. Compound 3f with 2,3-dichlorophenyl substitution was recognized among the tested series as a lead structure that inhibited the viability of MCF-7 cells. It effectively inhibited STAT3 phosphorylation in MCF-7 and T47D cells, indicating that these structures may be an alternative synthon to target STAT3 signaling in BC.
BIOENGINEERING-BASEL
(2023)
Article
Environmental Sciences
Sushmitha Shankar, Anusha Narayana Murthy, P. Rachitha, Vinay B. Raghavendra, N. Sunayana, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Nagaraj Basavegowda, Kathirvel Brindhadevi, Arivalagan Pugazhendhi
Summary: The study focused on the conjugation of silk sericin protein with magnesium oxide nanoparticles to form SS-MgO-NPs. Various techniques, such as UV, XRD, FTIR, SEM, DLS, and EDX, were used to confirm the formation of SS-MgO-NPs. The SS-MgO-NPs showed promising properties, including antioxidant, antibacterial, anti-biofilm, anti-aging, and anticancer activities. Further in vivo research is necessary to validate the therapeutic applications of SS-MgO-NPs.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Na Young Kim, In Jin Ha, Jae-Young Um, Alan Prem Kumar, Gautam Sethi, Kwang Seok Ahn
Summary: This study found that LGA can effectively inhibit the proliferation, invasive ability, and migration of hepatocellular carcinoma cells, and reduce the occurrence of EMT by suppressing MnSOD expression. This has important implications for the development of novel anti-metastatic agents.
Review
Chemistry, Medicinal
Hui Li Ang, Chakrabhavi Dhananjaya Mohan, Muthu K. Shanmugam, Hin Chong Leong, Pooyan Makvandi, Kanchugarakoppal S. Rangappa, Anupam Bishyaee, Alan Prem Kumar, Gautam Sethi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into mesenchymal cells, playing a significant role in tumor progression and resistance to therapy. Various factors, such as signaling pathways, transcriptional regulators, noncoding RNAs, and epigenetic alterations, are involved in the regulation of EMT. However, despite preclinical data, there is a lack of clinical translation in targeting EMT therapeutically. This review discusses the role of these factors in EMT regulation, the contribution of EMT to drug resistance, and potential therapeutic interventions using natural products and nano-formulations as EMT blockers.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Biotechnology & Applied Microbiology
Xin Yuan Lim, Sharah Mae Capinpin, Nagarjun Bolem, Aaron Song Chuan Foo, Wai-Cheong George Yip, Alan Prem Kumar, Daniel Boon Loong Teh
Summary: Glioblastoma multiforme (GBM) is an aggressive brain tumor with limited treatment options due to the difficulty of drugs crossing the blood-brain barrier (BBB) and tumor heterogeneity. Nanoparticle (NP) drug carriers have shown promise in targeting cells beyond the BBB. This review focuses on biomimetic NPs in GBM therapy and their potential in overcoming physiological and anatomical challenges.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
