Review
Biochemistry & Molecular Biology
Jolita Stabrauskiene, Dalia M. Kopustinskiene, Robertas Lazauskas, Jurga Bernatoniene
Summary: Naringin and naringenin, the main bioactive polyphenols in citrus fruits, have antioxidant and anticancer properties. They can suppress cancer development, modulate cellular signaling pathways, and have the potential to improve the condition of cancer patients.
Article
Food Science & Technology
Lorenzo Flori, Lorenzo Albanese, Vincenzo Calderone, Francesco Meneguzzo, Mario Pagliaro, Rosaria Ciriminna, Federica Zabini, Lara Testai
Summary: Citrus flavonoids have beneficial effects on cardiovascular and cardio-metabolic health, but their limited bioavailability hinders their effectiveness. Hydrodynamic cavitation methods have been used to extract stable phytocomplexes with high levels of bioactive compounds from Citrus fruit waste, improving their bioaccessibility. Grapefruit IntegroPectin, which contains 98% naringin, showed superior cardioprotective activity compared to pure naringenin. The extract was also found to activate mitochondrial potassium channels.
Article
Chemistry, Applied
Brunna D'Onofre Couto, Rayla Novaes da Costa, Wilquer Castro Laurindo, Heriveltom Moraes da Silva, Cinthia Rocha da Silva, Jane Selia dos Reis Coimbra, Aparecida Barbosa Mageste, Sandra de Cassia Dias, Igor Jose Boggione Santos
Summary: This study aimed to optimize the production of beta-lactoglobulin nanostructures, characterize their techno-functional properties and stability, and apply them as carriers for bioactive molecules. The results showed that the beta-lg nanostructures have a great capacity to encapsulate hydrophobic molecules and form stable foam and emulsions.
Article
Horticulture
H. Gomez-Martinez, A. Bermejo, E. Zuriaga, M. L. Badenes
Summary: Apricot is a key fruit in the Mediterranean region, valued in the diets of Asian and Mediterranean countries. Polyphenols, the most abundant antioxidants in apricots, play a crucial role in defining fruit quality. The study identified the PPV resistant cultivar 'Goldrich' as the best for increasing antioxidants in apricot varieties.
SCIENTIA HORTICULTURAE
(2021)
Review
Biochemistry & Molecular Biology
Ivan Kreft, Mateja Germ, Aleksandra Golob, Blanka Vombergar, Alena Vollmannova, Samo Kreft, Zlata Luthar
Summary: Tartary buckwheat is a crop that can survive in high altitudes and strong UV radiation environments. It contains a high content of phenolic substances, which are important for its growth and reproduction. Flavonoids are the main bioactive metabolites in Tartary buckwheat, with antioxidant properties and potential in preventing various diseases. Traditional food products such as bread, groats, and sprouts can be made from Tartary buckwheat.
Article
Biochemistry & Molecular Biology
Caterina Russo, Alessandro Maugeri, Laura De Luca, Rosaria Gitto, Giovanni Enrico Lombardo, Laura Musumeci, Giovambattista De Sarro, Santa Cirmi, Michele Navarra
Summary: This study investigates the anti-leukemic properties of the main flavanones of Citrus spp. and their potential implication in SIRT2 inhibition. The results show that naringenin and hesperetin can inhibit SIRT2 activity and induce antiproliferative effects through modulation of the SIRT2/p53/p21/cyclin E1 pathway.
Review
Multidisciplinary Sciences
Joy A. Adetunji, Kehinde D. Fasae, Ayobami I. Awe, Oluwatomiwa K. Paimo, Ayodeji M. Adegoke, Jacob K. Akintunde, Mamello P. Sekhoacha
Summary: Endothelial cells (ECs) play a vital role in maintaining the integrity and functionality of blood vessels. Flavonoids found in citrus fruits, such as naringenin and naringin, have been shown to improve the health of the endothelium by reducing inflammation, oxidative stress, atherosclerosis, and angiogenesis. This review provides a comprehensive summary of the mechanisms through which these citrus flavonoids modulate biomarkers of vascular dysfunction and suggests further studies to assess their therapeutic efficacy in human vascular diseases.
Review
Agronomy
Ivan Kreft, Aleksandra Golob, Mateja Germ
Summary: Tartary buckwheat, originated in the Himalayan area, is rich in flavonoid metabolites rutin and quercetin. The flavonoids can pass the blood-brain barrier and improve brain function by enhancing blood flow to the brain. Breeding efforts for Tartary buckwheat focus on maintaining high nutritional quality and improving growth habits.
Article
Food Science & Technology
Veronica Conti, Marco Romi, Massimo Guarnieri, Claudio Cantini, Giampiero Cai
Summary: This study evaluates the performance of different tomato cultivars in terms of antioxidant accumulation under drought stress. The results show that some local cultivars can produce higher amounts of bioactive compounds under drought conditions, leading to improved fruit quality.
Article
Biochemistry & Molecular Biology
Ezgi Gercek, Hatayi Zengin, Figen Erdem Erisir, Okkes Yilmaz
Summary: The study found that citrus flavonoid naringin demonstrated higher antioxidant activity against the stable free radical DPPH compared to naringenin and can be used as an effective protective agent against oxidative stress.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Hyeon-Jun Seong, Ae Eun Im, Hayeong Kim, Namhyeon Park, Kwang-Yeol Yang, Doman Kim, Seung-Hee Nam
Summary: Naringin, a flavanone glycoside found in citrus fruits, has various biological functions but its bitterness affects the quality and consumer acceptability of citrus products. This study isolated eight microbial strains with naringinase activity from yuzu-based fermented foods and used naringinase from Aspergillus oryzae NYO-2 to produce prunin and naringenin. The bitterness of prunin and naringenin was significantly decreased compared to naringin, and their neuroprotective effects on human neuroblastoma cells were greater. These findings expand the potential applications of naringin deglycosylation to improve sensory and functional properties.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemical Research Methods
Xiao Yu, Wanxiang Yu, Xiaohui Zhang, Yongjie Wang, Shumei Wang, Haiyun Zhai
Summary: A new solid-phase extraction (SPE) coupled with capillary electrophoresis (CE) method was developed for preconcentration and determination of anthraquinones and flavonoids in honey. By optimizing extraction parameters and using chitin as adsorbent, the method achieved enrichment and detection of target compounds with high sensitivity.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Shimaa S. Khaled, Mohammed A. Abdel-Gabbar, Hanan Soliman, Noha A. Ahmed, El-Shaymaa El-Nahass, Osama M. Ahmed
Summary: This study aimed to evaluate the preventive effects of naringin, naringenin, and their combination on liver injury induced by Taxol in Wistar rats. Treatment with naringin and/or naringenin reduced the abnormal levels of liver function markers and improved liver histological changes in Taxol-treated rats. The treatments also decreased hepatic lipid peroxidation and increased antioxidant enzyme activities. The naringin and naringenin mixture appeared to be more effective in improving organ function and structural integrity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Yang Yang, Myah Trevethan, Shu Wang, Ling Zhao
Summary: Naringin and naringenin are subclass of flavonoids that have been shown to have lipid-lowering effects and diverse effects in populations with different health conditions. Recent studies have revealed new mechanisms underlying the hypolipidemic effects of these compounds, as well as their effects on lipid metabolism. In addition, citrus fruits enriched with naringin and naringenin have been studied for their lipid-lowering effects in animal models and human clinical trials. Furthermore, pharmacokinetics studies and the interplays between these flavonoids and gut microbiota have also been summarized.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Zahra Memariani, Syed Qamar Abbas, Syed Shams Ul Hassan, Amirhossein Ahmadi, Aroona Chabra
Summary: Cancer rates are increasing in many low- and middle-income countries due to various factors, including lifestyle changes and societal problems. Different treatment approaches like chemotherapy, surgery, and radiation therapy are used, but can have various short- and long-term side effects. Recent studies show that compounds like naringin and naringenin from citrus fruits have anti-cancer properties through different signaling pathways, and when combined with current anti-cancer agents, can show synergistic effects and help overcome multidrug resistance in cancer treatment.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Aijaz Ali Otho, Rabia Asma Memon, Saeed Akhter Abro, Ayaz Ali Memon
Summary: The study found that the elemental composition of rhizospheric soil was significantly affected by geography, while elements in Fagonia indica biomass were significantly influenced by both seasons and geography. The plant accumulates high concentration of heavy metals during summer and higher concentration of essential nutrients during spring, suggesting that it is recommended to collect the plant for oral use during spring.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Chemistry, Organic
Nilgun Yenil, Fadim Yemies, Israfil Sabikoglu, Najma Memon, Ali Guler
Summary: This study investigated the amounts of phenolic compounds in the peels of four different pomegranate varieties grown in ozdere-Izmir, Turkey for the first time. It was found that refluxing extraction in MeOH yielded the best results for ellagic acid, hesperidin, and quercetin. The amounts of ellagic acid were higher in dry samples compared to fresh samples. Hesperidin and quercetin were detected in significant amounts in most samples.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Anwar Ali Chandio, Shahabuddin Memon, Ayaz Ali Memon, Aamna Balouch, Roomia Memon, Khalid Hussain Thebo, Fakhar N. Memon, Muhammad Hassan Agheem, Safia Sanam Memon, Aijaz Ali Otho
Summary: The CuO nanoparticles functionalized with the diamide derivative of calix[4] arene were used as a catalyst for the synthesis of p-aminophenol. The catalyst showed high efficiency in the conversion process.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Engineering, Chemical
Farooque Ahmed Janjhi, Dahar Janwery, Imamdin Chandio, Sami Ullah, Faisal Rehman, Ayaz Ali Memon, Jabir Hakami, Firoz Khan, Grzegorz Boczkaj, Khalid Hussain Thebo
Summary: This review summarizes different fabrication methods of graphene oxide (GO)-based membranes and discusses the influence of functionalization and cross-linking on membrane properties. It also provides a detailed discussion on the application of GO-based membranes for separation and removal of heavy metal ions. Recommendations and future directions are suggested.
CHEMBIOENG REVIEWS
(2022)
Article
Materials Science, Multidisciplinary
Meher-Un-Nisa Khilji, Noor Ahmed Nahyoon, Mujahid Mehdi, Khalid Hussain Thebo, Nasrullah Mahar, Ayaz Ali Memon, Najma Memon, Nadir Hussain
Summary: A novel nanocomposite of magnesium oxide doped graphene oxide (MgO@GO) was synthesized and used as a visible-light driven photocatalyst for the degradation of Rhodamine 6G (Rh6G). The morphology, structure, functional groups, and chemical composition of the photocatalyst were characterized. By combining tungsten light (50 W), stirring, and aeration, a degradation efficiency of 98% for Rh6G (30 mL, 1 ppm) was achieved within 15 minutes.
Article
Biochemistry & Molecular Biology
Faheeda Soomro, Fida Hussain Memon, Muhammad Ali Khan, Muzaffar Iqbal, Aliya Ibrar, Ayaz Ali Memon, Jong Hwan Lim, Kyung Hyon Choi, Khalid Hussain Thebo
Summary: An easy and efficient method was used to fabricate MoO2@GO and WO3@GO nanocomposite membranes with controlled structure and interlayer spacing. These membranes showed good separation for salt and heavy metal ions due to intensive stacking interaction and electrostatic attraction. They exhibited high rejection rates (>70%) for small metal ions such as sodium (Na+) and magnesium (Mg2+) ions, as well as >99% rejection rates for nickel (Ni2+) and lead (Pb2+) ions, with good water permeability of 275 +/- 10 L m(-2) h(-1) bar(-1). We believe that these fabricated membranes have a bright future in next generation desalination and water purification membranes.
Article
Chemistry, Multidisciplinary
Fayyaz Salih Hussain, Najma Memon, Zeeshan Khatri
Summary: Metallic or metal oxide-based nanoparticles, particularly copper, have the potential to inactivate viruses. In this study, antiviral-coated fabrics were designed using copper oxide nanoparticles synthesized through sonochemistry and deposited using the dip-coating technique. The coated fabrics exhibited small, agglomerated rugby ball structures made of copper oxide nanoparticles, resulting in a hydrophobic surface. The CuO-coated fabric showed maximum antibacterial activity and significant virucidal activity against human adenovirus-B.
Review
Engineering, Chemical
Farooque Ahmed Janjhi, Imamdin Chandio, Dahar Janwery, Ayaz Ali Memon, Khalid Hussain Thebo, Grzegorz Boczkaj, Vahid Vatanpour, Roberto Castro-Munoz
Summary: This review summarizes the latest research progress on MoS2-based membranes in the past three years, including their physiochemical properties, fabrication procedures, molecular separation mechanisms, and separation and stability mechanisms. These membranes have great potential for improving efficiency and reducing energy consumption in water treatment and purification processes.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Article
Materials Science, Multidisciplinary
Ali Hyder, Jamil Ahmed Buledi, Roomia Memon, Anjum Qureshi, Javed H. Niazi, Amber Rehana Solangi, Shahabuddin Memon, Ayaz Ali Memon, Khalid Hussain Thebo
Summary: This study presents a cost-effective and highly sensitive electrochemical sensor based on a nanocomposite material for the detection of gallic acid (GA). The sensor exhibits exceptional electrochemical response towards GA and demonstrates good recovery results when applied to wine and green tea samples.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Geochemistry & Geophysics
Tayyab A. Qureshi, Tanveer A. Gadhi, Danish A. Khokhar, Imran Ali, Najma Memon, Najeebullah Channa, Sikandar Bakhat, Tahir Rafique, Rasool Bux Mahar
Summary: This study evaluated the use of pumice in a novel combined adsorption distillation method for treating reverse osmosis membrane reject water. Results showed that pumice had a high adsorption capacity for dissolved solids, but its efficiency declined over time and required backwashing to maintain its adsorption capacity.
Article
Multidisciplinary Sciences
Ali Hyder, Muzamil Thebo, Dahar Janwery, Jamil Ahmed Buledi, Imamdin Chandio, Awais Khalid, Bader S. Al-Anzi, Hanadi A. Almukhlifi, Khalid Hussain Thebo, Fakhar N. Memon, Ayaz Ali Memon, Amber Rehana Solangi, Shahabuddin Memon
Summary: Water pollution caused by organic pollutants is a global concern. A new composite material has been synthesized and found to effectively remove 2,4,6-trichlorophenol from wastewater.
Article
Chemistry, Multidisciplinary
Shahbaz Ali Mallah, Huma Shaikh, Najma Memon, Sehrish Qazi
Summary: This research work focuses on the fabrication of a graphene oxide-based composite (GOBC) for the removal of contaminants from industrial effluents. GOBC was successfully prepared using intercalation/microwave method. Fixed-bed column tests and Jar-tests were conducted to evaluate the adsorption efficiency of GOBC for harmful compounds and toxic metal ions. The results showed excellent adsorption capacity and kinetics of GOBC, confirming its potential use in wastewater treatment.
Article
Chemistry, Analytical
Meher-Un-Nisa Khilji, Aijaz Ali Otho, Roomia Memon, Awais Khalid, Mohsin Kazi, Ali Hyder, Dahar Janwery, Noor Ahmed Nahyoon, Ayaz Ali Memon, Najma Memon, Khalid Hussain Thebo
Summary: Environmental pollution poses significant challenges to human health, ecosystems, and the sustainability of the planet. This study presents the design of a novel composite membrane that filters pollutants effectively, achieves high water permeance, and demonstrates excellent rejection efficiency for pathogens and harmful substances.
ANALYTICAL LETTERS
(2023)
Article
Zoology
Ranjhan Junejo, Shahabuddin Memon, Muhammad Usman Shar, Ayaz Ali Memon, Fakhar-un-Nisa Memon
Summary: This study optimized the parameters for trapping the red palm weevil using pheromone traps, such as the addition of date fodder, specific doses of aggregation pheromone and kairomone, trap density, and trap color. The results showed that traps baited with date fodder, higher doses of pheromone and kairomone, appropriate trap density, and darker trap color were more effective in capturing the weevils.
PAKISTAN JOURNAL OF ZOOLOGY
(2022)
