Screening and Validation of Molecular Targeted Radiosensitizers

Radioresistance of KRAS/TP53‐Mutated Lung Cancer can be overcome by Radiation Dose Escalation or EGFR Tyrosine Kinase Inhibition In Vivo

(2019) Kristin Gurtner et al.   INTERNATIONAL JOURNAL OF CANCER

Lung tumorspheres reveal cancer stem cell-like properties and a score with prognostic impact in resected non-small-cell lung cancer

(2019) Alejandro Herreros-Pomares et al.   Cell Death & Disease

The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients

(2019) Jill Hallin et al.   Cancer Discovery

Combining precision radiotherapy with molecular targeting and immunomodulatory agents: a guideline by the American Society for Radiation Oncology

(2018) Robert G Bristow et al.   LANCET ONCOLOGY

Pre-clinical imaging for establishment and comparison of orthotopic non-small cell lung carcinoma: in search for models reflecting clinical scenarios

(2018) Rozina Aktar et al.   BRITISH JOURNAL OF RADIOLOGY

Phase Ib study of neoadjuvant chemoradiation (CRT) with midostaurin, 5-fluorouracil (5-FU) and radiation (XRT) for locally advanced rectal cancer: Sensitization of RAS mutant tumors.

(2018) Theodore S. Hong et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical Development of Novel Drug–Radiotherapy Combinations

(2018) Saif S. Ahmad et al.   CLINICAL CANCER RESEARCH

A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study

(2017) Jacob G Scott et al.   LANCET ONCOLOGY

Short-Term Screening Assays for the Identification of Therapeutics for Cancer

(2016) D. E. Citrin   CANCER RESEARCH

A Landscape of Pharmacogenomic Interactions in Cancer

(2016) Francesco Iorio et al.   CELL

Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials

(2016) C. N. Coleman et al.   CLINICAL CANCER RESEARCH

Preclinical Data on Efficacy of 10 Drug-Radiation Combinations: Evaluations, Concerns, and Recommendations

(2016) Helen B. Stone et al.   Translational Oncology

Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways

(2015) M. A. Morgan et al.   CLINICAL CANCER RESEARCH

3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation

(2015) IRIS EKE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Simultaneous β1 integrin-EGFR Targeting and Radiosensitization of Human Head and Neck Cancer

(2015) Iris Eke et al.   JNCI-Journal of the National Cancer Institute

Towards an Integrated Understanding of Epidermal Growth Factor Receptor Biology for Radiation Therapy: Integrins Enter

(2015) H. Willers et al.   JNCI-Journal of the National Cancer Institute

Adapting a Drug Screening Platform to Discover Associations of Molecular Targeted Radiosensitizers with Genomic Biomarkers

(2015) Qi Liu et al.   MOLECULAR CANCER RESEARCH

Small Molecule Inhibition of MDM2-p53 Interaction Augments Radiation Response in Human Tumors

(2015) L. R. Werner et al.   MOLECULAR CANCER THERAPEUTICS

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer

(2015) Anthony C. Faber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumorsphere as an effective in vitro platform for screening anti-cancer stem cell drugs

(2015) Che-Hsin Lee et al.   Oncotarget

Simultaneous β1 integrin-EGFR Targeting and Radiosensitization of Human Head and Neck Cancer

(2015) Iris Eke et al.   JNCI-Journal of the National Cancer Institute

Towards an Integrated Understanding of Epidermal Growth Factor Receptor Biology for Radiation Therapy: Integrins Enter

(2015) H. Willers et al.   JNCI-Journal of the National Cancer Institute

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation

(2014) M. Wang et al.   CANCER RESEARCH

Interaction of Radiation Therapy With Molecular Targeted Agents

(2014) Zachary S. Morris et al.   JOURNAL OF CLINICAL ONCOLOGY

A High Content Clonogenic Survival Drug Screen Identifies MEK Inhibitors as Potent Radiation Sensitizers for KRAS Mutant Non–Small-Cell Lung Cancer

(2014) Steven H. Lin et al.   Journal of Thoracic Oncology

Effect of combined irradiation and EGFR/Erb-B inhibition with BIBW 2992 on proliferation and tumour cure in cell lines and xenografts

(2014) Kristin Gurtner et al.   Radiation Oncology

Patient-derived models of acquired resistance can identify effective drug combinations for cancer

(2014) Adam S. Crystal et al.   SCIENCE

Improving the Efficacy of Chemoradiation with Targeted Agents

(2014) M. A. Morgan et al.   Cancer Discovery

Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway

(2013) Xiao-Fang Dai et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Opportunities and Challenges in the Era of Molecularly Targeted Agents and Radiation Therapy

(2013) Steven H. Lin et al.   JNCI-Journal of the National Cancer Institute

Combination Therapy with the Histone Deacetylase Inhibitor LBH589 and Radiation Is an Effective Regimen for Prostate Cancer Cells

(2013) Weiwei Xiao et al.   PLoS One

EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells

(2012) I. Eke et al.   CANCER RESEARCH

Three-dimensional cell culture: the missing link in drug discovery

(2012) Susan Breslin et al.   DRUG DISCOVERY TODAY

NCI–RTOG Translational Program Strategic Guidelines for the Early-Stage Development of Radiosensitizers

(2012) Yaacov Richard Lawrence et al.   JNCI-Journal of the National Cancer Institute

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Preclinical models in radiation oncology

(2012) Jenna Kahn et al.   Radiation Oncology

Radiation-Induced Reprogramming of Breast Cancer Cells

(2012) Chann Lagadec et al.   STEM CELLS

Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression

(2011) Kristin Gurtner et al.   RADIOTHERAPY AND ONCOLOGY

Radiobiology goes 3D: How ECM and cell morphology impact on cell survival after irradiation

(2011) Iris Eke et al.   RADIOTHERAPY AND ONCOLOGY

Integrating complex genomic datasets and tumour cell sensitivity profiles to address a 'simple' question: which patients should get this drug?

(2009) Cyril Benes et al.   BMC Medicine

A Gene Expression Model of Intrinsic Tumor Radiosensitivity: Prediction of Response and Prognosis After Chemoradiation

(2009) Steven A. Eschrich et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Increased efficiency for performing colony formation assays in 96-well plates: novel applications to combination therapies and high-throughput screening

(2008) David Katz et al.   BIOTECHNIQUES