Article
Microbiology
Sebastian G. Wicha, Annabelle Walz, Mohammed H. Cherkaoui-Rbati, Nils Bundgaard, Karsten Kuritz, Christin Gumpp, Nathalie Gobeau, Jorg Mohrle, Matthias Rottmann, Claudia Demarta-Gatsi
Summary: This study developed a novel in vitro-in silico combination approach to predict the pharmacodynamic interactions of antimalarial drug combinations. It successfully predicted the endpoints of clinical trials and provided additional insights into pharmacodynamic drug interactions.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Oncology
Amanda J. Walker
Summary: The article highlights the importance of radiation therapy in cancer treatment, despite the growing number of targeted molecular therapies available. It discusses the regulatory framework for drug development in combination with radiation therapy and emphasizes the need for careful consideration of safety and efficacy in such combinations.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Oncology
Siting Yu, Yang Wang, Ping He, Bianfei Shao, Fang Liu, Zhongzheng Xiang, Tian Yang, Yuanyuan Zeng, Tao He, Jiachun Ma, Xiran Wang, Lei Liu
Summary: While single tumor immunotherapy and radiotherapy have improved survival rates, they have limitations in overcoming metastasis, recurrence, and reducing side effects. Exploring new treatment methods is urgent. The combination of radiotherapy and immunotherapy shows promise in enhancing the immune system's ability to recognize and eradicate tumor cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Virology
Aleksandr Ianevski, Eva Zusinaite, Tanel Tenson, Valentyn Oksenych, Wei Wang, Jan Egil Afset, Magnar Bjoras, Denis E. Kainov
Summary: The study tested several antiviral agents against enterovirus 1 in human cells, confirming the anti-enteroviral activities of some drugs and identifying synergistic effects of drug combinations against enterovirus infection.
Article
Oncology
J. Singh, S. Hatcher, A. A. Ku, Z. Ding, F. Y. Feng, R. A. Sharma, S. X. Pfister
Summary: Radiotherapy is crucial in treating over half of cancer patients, advancements in devices and software have improved its precision and reduced toxicity. Combining drug therapies with radiotherapy could widen the therapeutic window and improve cure rates.
Article
Microbiology
Elizabeth Story-Roller, Christos Galanis, Gyanu Lamichhane
Summary: Mycobacteroides abscessus is a difficult-to-treat environmental pathogen that can cause chronic pulmonary disease in patients with underlying structural lung conditions. Current treatment options are often ineffective and associated with significant toxicities, with the pathogen naturally resistant to many antibiotics.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Jiaqi Li, Hongyan Xu, Richard A. McIndoe
Summary: Drug combination therapies play an important role in cancer treatment, but current methods to identify synergistic drug combinations are limited. This paper presents a computational algorithm that utilizes gene regulatory networks and single drug data to evaluate all possible drug pairs and find potential synergistic drug combinations.
Article
Biochemistry & Molecular Biology
Andreina Henriquez-Figuereo, Esther Moreno, Carmen Sanmartin, Daniel Plano
Summary: This work focuses on the design, synthesis, and biological activities of new selenoester derivatives and thioester homologs with potential as therapeutic candidates for leishmaniasis. These compounds showed structural similarities to antileishmanial drugs and exhibited high sensitivity against Leishmania infantum, the causative agent of visceral leishmaniasis. Four selanylacetic acid derivatives demonstrated significant leishmanicidal characteristics and pharmacological synergism with the oral drug miltefosine.
Article
Chemistry, Medicinal
Manel Ouji, Michel Nguyen, Romain Mustiere, Tony Jimenez, Jean-Michel Augereau, Francoise Benoit-Vical, Celine Deraeve
Summary: Relying on the identification of relevant malaria targets in the context of artemisinin resistance, novel drug combinations and hybrids demonstrated remarkable antimalarial activity against both artemisinin-sensitive and artemisinin-resistant Plasmodium falciparum parasites, highlighting their therapeutic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Cell Biology
Lara M. Schuessele, Julia Koch-Heier, Julian Volk, Markus W. Loeffler, Katharina Hoffmann, Regina M. Bruyns, Oliver Planz
Summary: The Raf/MEK/ERK signaling pathway is crucial for cellular functions and disease development. MEK1/2 inhibitors have potential therapeutic applications, but target engagement assessment is important. The authors developed a method to assess MEK1/2 inhibitor target engagement using PBMCs from healthy volunteers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Claudia Veloso, Romeu A. Videira, Paula B. Andrade, Catarina Cardoso, Carla Vitorino
Summary: The combination of multiple active pharmaceutical ingredients in a fixed-dose combination product for topical administration shows potential in treating various pathologies, including pain. This study presents information on accepted in vitro tests for assessing the safety of topical products and the commonly used methods for evaluating anti-inflammatory activity. Additionally, a new approach for selecting fixed-dose combination products to enhance therapeutic effects is rationalized.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Oncology
Xiaojing Yang, Hanru Ren, Jie Fu
Summary: Immunotherapy, combined with radiotherapy, has shown significant improvement in the effective cure rate for cancer patients, challenging the traditional belief that radiotherapy kills immune cells and has immunosuppressive effects. This article reviews and summarizes the molecular mechanism, clinical treatment, and safety of the combination of radiotherapy and immunotherapy. It also highlights the unanswered questions and future research needs, providing reference for clinicians in guiding subsequent clinical medicine.
Review
Immunology
Xiaojing Yang, Hanru Ren, Zhen Li, Xue Peng, Jie Fu
Summary: This article summarizes the application of immunotherapy in NPC, with a focus on the use of immunotherapy and radiotherapy in the treatment of NPC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Chiranjib Chakraborty, Ashish Ranjan Sharma, Manojit Bhattacharya, Govindasamy Agoramoorthy, Sang-Soo Lee
Summary: The rapid spread of SARS-CoV-2 globally has highlighted the need for effective treatment options. Drug repurposing of existing medications has become a key strategy in managing COVID-19 patients. Clinical trials conducted across multiple countries have shown promising results in antiviral and immunotherapeutic treatments, indicating the importance of further research in this area.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Cheng Cui, Fangrui Cao, Iok Ian Kong, Qinghe Wu, Fangqiong Li, Haiyan Li, Dongyang Liu
Summary: This study aims to use a model-informed drug development approach to facilitate decision making and expedite the clinical progress of cofrogliptin for the treatment of type 2 diabetes. The study successfully achieved waiver approval for the phase 2b dose-finding study, paving the way for the clinical development of cofrogliptin and other DPP-4 inhibitors.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yilin Cao, Daniel Y. Song, Curtiland Deville, Theodore L. DeWeese, Stephen Greco, Phuoc T. Tran, Matthew P. Deek
Summary: This study investigated the rate of prostate bed recurrence in oligometastatic prostate cancer patients after metastasis-directed therapy. The results showed that patients who did not receive prostate bed irradiation had a higher rate of local failure. Prospective studies are needed to determine when prostate bed irradiation should be considered for patients with oligometastatic prostate cancer after radical prostatectomy.
Article
Oncology
Philip Sutera, Kim Van der Eecken, Amar U. Kishan, Anis Hamid, Emily Grist, Gerhardt Attard, Tamara Lotan, Adrianna A. Mendes, Channing J. Paller, Michael A. Carducci, Ashley Ross, Hao Wang, Ken Pienta, Felix Y. Feng, Emmanuel S. Antonarakis, Piet Ost, Daniel Y. Song, Stephen Greco, Curtiland Deville, Theodore DeWeese, Phuoc T. Tran, Matthew P. Deek
Summary: Four different definitions of metastatic volume in mCSPC were compared with similar patient classifications, outcomes, and genetic makeup. High-volume disease was associated with worse overall survival, while low-volume disease with specific mutations may exhibit more aggressive clinical behavior. Incorporating tumor genetics may offer further refinement of current metastatic definitions.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Chalid Assaf, Nathalie Waser, Martine Bagot, Mary He, Tina Li, Mehul Dalal, Francois Gavini, Fabrizio Trinchese, Athanasios Zomas, Meredith Little, Nicola Pimpinelli, Pablo L. Ortiz-Romero, Timothy M. Illidge
Summary: This study provides real-world data on the treatment patterns and outcomes of relapsed or refractory CTCL, highlighting the diverse treatment approaches and the lack of consensus in managing this condition.
Article
Oncology
S. Horwitz, O. A. O'Connor, B. Pro, L. Trumper, S. Iyer, R. Advani, N. L. Bartlett, J. H. Christensen, F. Morschhauser, E. Domingo-Domenech, G. Rossi, W. S. Kim, T. Feldman, T. Menne, D. Belada, A. Illes, K. Tobinai, K. Tsukasaki, S-P Yeh, A. Shustov, A. Huettmann, K. J. Savage, S. Yuen, P. L. Zinzani, H. Miao, V Bunn, K. Fenton, M. Fanale, M. Puhlmann, T. Illidge
Summary: In the 5-year update of ECHELON-2, frontline treatment of PTCL patients with A+CHP continues to show clinically meaningful improvements in PFS and OS compared to CHOP, with continued resolution or improvement of peripheral neuropathy.
ANNALS OF ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Emerson E. Lee, Tanmay Singh, Chen Hu, Misop Han, Curtiland Deville, Aditya Halthore, Stephen Greco, Phuoc Tran, Theodore DeWeese, Daniel Y. Song
Summary: This study found that initiating salvage radiation therapy (SRT) when PSA levels are below 0.5 ng/ml is associated with improved metastasis-free survival (MFS) in patients with biochemical recurrence. Seminal vesicle invasion is also associated with shorter time to biochemical failure and eventual metastasis.
Article
Oncology
Phuoc T. Tran, Kathryn Lowe, Hua-Ling Tsai, Daniel Y. Song, Arthur Y. Hung, Jason W. D. Hearn, Steven Miller, James A. Proudfoot, Matthew P. Deek, Ryan Phillips, Tamara Lotan, Channing J. Paller, Catherine H. Marshall, Mark Markowski, Shirl Dipasquale, Samuel Denmeade, Michael Carducci, Mario Eisenberger, Theodore L. DeWeese, Matthew Orton, Curtiland Deville, Elai Davicioni, Stanley L. Liauw, Elisabeth I. Heath, Stephen Greco, Neil B. Desai, Daniel E. Spratt, Felix Feng, Hao Wang, Tomasz M. Beer, Emmanuel S. Antonarakis
Summary: This study aimed to investigate the effect of enzalutamide on freedom from PSA progression in men with recurrent prostate cancer after radical prostatectomy. The results showed that enzalutamide monotherapy for 6 months in combination with salvage radiation therapy delayed PSA progression and was safe for high-risk patients with postoperative recurrence.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Correction
Multidisciplinary Sciences
R. C. Coombes, P. D. Badman, J. P. Lozano-Kuehne, X. Liu, I. R. Macpherson, I. Zubairi, R. D. Baird, N. Rosenfeld, J. Garcia-Corbacho, N. Cresti, R. Plummer, A. Armstrong, R. Allerton, D. Landers, H. Nicholas, L. McLellan, A. Lim, F. Mouliere, O. E. Pardo, V. Ferguson, M. J. Seckl
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Jennifer Y. Sheng, Claire F. Snyder, Katherine C. Smith, Jennifer DeSanto, Nancy Mayonado, Susan Rall, Sharon White, Amanda L. Blackford, Fabian M. Johnston, Robert L. Joyner, Joan Mischtschuk, Kimberly S. Peairs, Elissa Thorner, Phuoc T. Tran, Antonio C. Wolff, Youngjee Choi
Summary: Survivorship care plans (SCPs) are important for communicating cancer-related information. This study found that some tests conducted after SCP receipt were not consistent with guidelines, indicating overuse. This analysis identifies areas for improvement in guideline-concordant care.
Article
Oncology
Vicky Smith, Debayan Mukherjee, Anna Maria Tsakiroglou, Alexander Baker, Hitesh Mistry, Ananya Choudhury, Peter Hoskin, Timothy Illidge, Catharine M. L. West
Summary: Precision medicine is needed for muscle-invasive bladder cancer to improve survival rates. CD8 T cell counts show promise as a predictive biomarker for immune checkpoint inhibitors (ICIs). However, there is currently no biomarker to stratify patients for hypoxia-targeting or immune-targeting therapies.
Article
Oncology
Thomas Jaki, Abigail Burdon, Xijin Chen, Pavel Mozgunov, Haiyan Zheng, Richard Baird
Summary: The pharmaceutical industry is facing a decline in productivity, especially in the development of oncology drugs. Establishing the potential and optimal dosage of novel treatments is crucial for efficient development. Using novel statistical designs can improve efficiency in dose-finding and accelerate the development of promising interventions. This paper discusses strategies for early oncology development, highlights missed opportunities for improved efficiency, and explores future opportunities in this field.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Vicky Smith, Dave Lee, Mark Reardon, Rekaya Shabbir, Sudhakar Sahoo, Peter Hoskin, Ananya Choudhury, Timothy Illidge, Catharine M. L. West
Summary: Hypoxia and suppressive TME are negative prognostic factors for MIBC. Transcriptomic analyses show that hypoxia increases immune signalling and infiltrates in bladder cancer. This study investigates the relationship between HIF-1 and -2, hypoxia, immune signalling, and infiltrates in MIBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Summary: The PI3K/AKT/mTOR (PAM) signaling pathway plays a crucial role in cell survival, growth, and cell cycle progression. Dysregulation of this pathway is associated with cancer development and resistance to therapy. This review focuses on the major dysregulations in the PAM signaling pathway in cancer and discusses strategies for overcoming treatment resistance. The role of PAM signaling in immunology and immunotherapies is also discussed.
Article
Multidisciplinary Sciences
R. Charles Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O'Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Summary: This study reports the clinical trial results of samuraciclib as an anti-cancer treatment, showing its clinical activity in patients with triple negative breast cancer and HR+/HER2- breast cancer.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Oncology
Alistair E. Ring, Laura Moretti, Angelica Afshari-Mehr, Andrew M. Wardley, Lucy Kilburn, Bora Gurel, Iain R. MacPherson, Richard D. Baird, Sue Martin, Alex Pearson, Rebecca Roylance, Matthew Winter, Kathryn Dunne, Ellen Copson, Tamas Hickish, Peter Stephens, Russell J. Burcombe, Katrina Randle, Judith Bliss, Nicholas C. Turner
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Correction
Oncology
David Tamborero, Rodrigo Dienstmann, Maan Haj Rachid, Jorrit Boekel, Adria Lopez-Fernandez, Markus Jonsson, Ali Razzak, Irene Brana, Luigi De Petris, Jeffrey Yachnin, Richard D. Baird, Yohann Loriot, Christophe Massard, Patricia Martin-Romano, Frans Opdam, Richard F. Schlenk, Claudio Vernieri, Michele Masucci, Xenia Villalobos, Elena Chavarria, Judith Balmana, Giovanni Apolone, Carlos Caldas, Jonas Bergh, Ingemar Ernberg, Stefan Frohling, Elena Garralda, Claes Karlsson, Josep Tabernero, Emile Voest, Jordi Rodon, Janne Lehtio