Impact of simulated lung fluid components on the solubility of inhaled drugs and predicted in vivo performance

Understanding Carrier Performance in Low-Dose Dry Powder Inhalation: An In Vitro–In Silico Approach

(2021) Joana T. Pinto et al.   Pharmaceutics

Novel approach for overcoming the stability challenges of lipid-based excipients. Part 1: Screening of solid-state and physical properties of polyglycerol esters of fatty acids as advanced pharmaceutical excipients

(2020) Carolina Corzo et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Pulmonary surfactant and drug delivery: Vehiculization, release and targeting of surfactant/tacrolimus formulations

(2020) Alberto Hidalgo et al.   JOURNAL OF CONTROLLED RELEASE

Use of PBPK modelling to evaluate the performance of DissolvIt, a biorelevant dissolution assay for orally inhaled drug products

(2019) Mireille Hassoun et al.   MOLECULAR PHARMACEUTICS

In vitro dissolution testing of respirable size anti-tubercular drug particles using a small volume dissolution apparatus

(2019) Basanth Babu Eedara et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Insights into DPI sensitivity to humidity: An integrated in-vitro-in-silico risk-assessment

(2019) Snezana Radivojev et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Impact of drug particle shape on permeability and cellular uptake in the lung

(2019) S. Zellnitz et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Physicochemical study of the interactions between Econazole and DL- α -Tocopherol with triblock copolymer aggregates in PBS media.

(2018) María Luisa Rodríguez-Loya et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Density fluctuations in amorphous pharmaceutical solids. Can SAXS help to predict stability?

(2018) Peter Laggner et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs

(2018) Per Bäckman et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

(2018) Elin Boger et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Solubility Determination of Active Pharmaceutical Ingredients Which Have Been Recently Added to the List of Essential Medicines in the Context of the Biopharmaceutics Classification System–Biowaiver

(2018) Gerlinde F. Plöger et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Design and development of a biorelevant simulated human lung fluid

(2018) Mireille Hassoun et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Polysorbate degradation in biotherapeutic formulations: Identification and discussion of current root causes

(2018) Mridula Dwivedi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Searching for physiologically relevant in vitro dissolution techniques for orally inhaled drugs

(2018) Snezana Radivojev et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Prediction of Ketoconazole absorption using an updated in vitro transfer model coupled to physiologically based pharmacokinetic modelling

(2017) Aaron Ruff et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetics of Salbutamol Delivered from the Unit Dose Dry Powder Inhaler: Comparison with the Metered Dose Inhaler and Diskus Dry Powder Inhaler

(2017) Alison Moore et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Efficient Interfacially Driven Vehiculization of Corticosteroids by Pulmonary Surfactant

(2017) Alberto Hidalgo et al.   LANGMUIR

A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition

(2017) Abhinav Kumar et al.   PHARMACEUTICAL RESEARCH

Computer modeling of airway deposition distribution of Foster ® NEXThaler ® and Seretide ® Diskus ® dry powder combination drugs

(2016) Ágnes Jókay et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Numerical simulation of emitted particle characteristics and airway deposition distribution of Symbicort® Turbuhaler® dry powder fixed combination aerosol drug

(2016) Árpád Farkas et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

An in vitro and in silico study of the impact of engineered surface modifications on drug detachment from model carriers

(2016) Shengqian Wu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Efficient approach to enhance drug solubility by particle engineering of bovine serum albumin

(2016) Mouhamad Khoder et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

LC-ESI-MS/MS estimation of loratadine-loaded self-nanoemulsifying drug delivery systems in rat plasma: Pharmacokinetic evaluation and computer simulations by GastroPlus™

(2016) Samridhi Verma et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Inhalation device requirements for patients' inhalation maneuvers

(2016) Peter Haidl et al.   RESPIRATORY MEDICINE

In Vitro Testing for Orally Inhaled Products: Developments in Science-Based Regulatory Approaches

(2015) Ben Forbes et al.   AAPS Journal

Equivalent Lung Dose and Systemic Exposure of Budesonide/Formoterol Combination via Easyhaler and Turbuhaler

(2015) Satu Lähelmä et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Evaluation of the Transwell System for Characterization of Dissolution Behavior of Inhalation Drugs: Effects of Membrane and Surfactant

(2015) Marc Rohrschneider et al.   MOLECULAR PHARMACEUTICS

Integrated in vitro experimental modelling of inhaled drug delivery: deposition, dissolution and absorption

(2015) R.C. Sadler et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

The Acoustic Features of Inhalation can be Used to Quantify Aerosol Delivery from a Diskus™ Dry Powder Inhaler

(2014) Jansen N. Seheult et al.   PHARMACEUTICAL RESEARCH

Albumin–drug interaction and its clinical implication

(2013) Keishi Yamasaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

PBPK models for the prediction of in vivo performance of oral dosage forms

(2013) Edmund S. Kostewicz et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pulmonary drug delivery: from generating aerosols to overcoming biological barriers—therapeutic possibilities and technological challenges

(2013) Christian A Ruge et al.   Lancet Respiratory Medicine

Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology

(2012) A Rostami-Hodjegan   CLINICAL PHARMACOLOGY & THERAPEUTICS

Solubility of salbutamol and salbutamol sulphate in ethanol+water mixtures at 25°C

(2012) Hany S.M. Ali et al.   JOURNAL OF MOLECULAR LIQUIDS

Molecular Nanomedicine Towards Cancer: 111In-Labeled Nanoparticles

(2012) Dimitrios Psimadas et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Interactions of the AT1 antagonist valsartan with dipalmitoyl-phosphatidylcholine bilayers

(2011) C. Potamitis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Prediction of Human Drug Clearance by Multiple Metabolic Pathways: Integration of Hepatic and Intestinal Microsomal and Cytosolic Data

(2011) H. E. Cubitt et al.   DRUG METABOLISM AND DISPOSITION

In Vitro Aqueous Fluid-Capacity-Limited Dissolution Testing of Respirable Aerosol Drug Particles Generated from Inhaler Products

(2010) Deepika Arora et al.   PHARMACEUTICAL RESEARCH

Structure of pulmonary surfactant membranes and films: The role of proteins and lipid–protein interactions

(2008) Jesús Pérez-Gil   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES