Chitinases and Chitinase-Like Proteins as Therapeutic Targets in Inflammatory Diseases, with a Special Focus on Inflammatory Bowel Diseases
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Chitinases and Chitinase-Like Proteins as Therapeutic Targets in Inflammatory Diseases, with a Special Focus on Inflammatory Bowel Diseases
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 13, Pages 6966
Publisher
MDPI AG
Online
2021-06-28
DOI
10.3390/ijms22136966
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors
- (2020) Xi Jiang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase
- (2020) Gleb Andryianau et al. ACS Medicinal Chemistry Letters
- Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation
- (2020) Anu Mary Varghese et al. Journal of Neuroinflammation
- Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis
- (2020) Robert Koralewski et al. JOURNAL OF MEDICINAL CHEMISTRY
- Identification of Chitinase-3-like protein 1 as a novel neutrophil antigenic target in Crohn’s disease
- (2019) Claudia Deutschmann et al. Journal of Crohns & Colitis
- Development of Dual Chitinase Inhibitors as Potential New Treatment for Respiratory System Diseases
- (2019) Marzena Mazur et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of selective, orally bioavailable inhibitor of mouse chitotriosidase
- (2018) Marzena Mazur et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma
- (2018) Marzena Mazur et al. JOURNAL OF MEDICINAL CHEMISTRY
- Potential suppressive effects of theophylline on human rectal cancer SW480 cells in�vitro by inhibiting YKL-40 expression
- (2018) Hong Peng et al. Oncology Letters
- Chronic abdominal pain in irritable bowel syndrome – current and future therapies
- (2018) Anna Zielińska et al. Expert Review of Clinical Pharmacology
- A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40
- (2018) Nipaporn Ngernyuang et al. NEOPLASIA
- Tumor-associated macrophages in human breast cancer produce new monocyte attracting and pro-angiogenic factor YKL-39 indicative for increased metastasis after neoadjuvant chemotherapy
- (2018) Tengfei Liu et al. OncoImmunology
- Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression
- (2017) Petra Steinacker et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- CHI3L1 and CHI3L2 overexpression in motor cortex and spinal cord of sALS patients
- (2017) C. Sanfilippo et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Amyotrophic lateral sclerosis
- (2017) Orla Hardiman et al. Nature Reviews Disease Primers
- Increased chitotriosidase activity in plasma of patients with type 2 diabetes
- (2016) Ewa Żurawska-Płaksej et al. Archives of Medical Science
- Chitinases and immunity: Ancestral molecules with new functions
- (2016) Michelino Di Rosa et al. IMMUNOBIOLOGY
- Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs
- (2016) Kazuaki Okawa et al. MOLECULAR BIOLOGY AND EVOLUTION
- Acidic chitinase primes the protective immune response to gastrointestinal nematodes
- (2016) Kevin M Vannella et al. NATURE IMMUNOLOGY
- The Dual Role of Neutrophils in Inflammatory Bowel Diseases
- (2016) Odile Wéra et al. Journal of Clinical Medicine
- Increased Obesity-Associated Circulating Levels of the Extracellular Matrix Proteins Osteopontin, Chitinase-3 Like-1 and Tenascin C Are Associated with Colon Cancer
- (2016) Victoria Catalán et al. PLoS One
- Serum YKL-40 in Risk Assessment for Colorectal Cancer: A Prospective Study of 4,496 Subjects at Risk of Colorectal Cancer
- (2015) J. S. Johansen et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Chitin and Chitosan Preparation from Marine Sources. Structure, Properties and Applications
- (2015) Islem Younes et al. Marine Drugs
- New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM
- (2015) Firas Fadel et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Chitinase 3-like 1 Synergistically Activates IL6-mediated STAT3 Phosphorylation in Intestinal Epithelial Cells in Murine Models of Infectious Colitis
- (2014) Hoa T. Tran et al. INFLAMMATORY BOWEL DISEASES
- High-efficient synthesis and biological activities of allosamidins
- (2014) Gangliang Huang et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Chitinase 3-Like 1 Suppresses Injury and Promotes Fibroproliferative Responses in Mammalian Lung Fibrosis
- (2014) Y. Zhou et al. Science Translational Medicine
- Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease
- (2014) In-Ah Lee WORLD JOURNAL OF GASTROENTEROLOGY
- Novel Clinical and Diagnostic Aspects of Antineutrophil Cytoplasmic Antibodies
- (2014) Johannes Schulte-Pelkum et al. Journal of Immunology Research
- Human YKL39 (chitinase 3-like protein 2), an osteoarthritis-associated gene, enhances proliferation and type II collagen expression in ATDC5 cells
- (2013) Kazumasa Miyatake et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Chitotriosidase variants in patients with Gaucher disease. Implications for diagnosis and therapeutic monitoring
- (2013) P. Irún et al. CLINICAL BIOCHEMISTRY
- Potential Association Between TLR4 and Chitinase 3-Like 1 (CHI3L1/YKL-40) Signaling on Colonic Epithelial Cells in Inflammatory Bowel Disease and Colitis-Associated Cancer
- (2013) A. Kamba et al. CURRENT MOLECULAR MEDICINE
- Targeting AMCase reduces esophageal eosinophilic inflammation and remodeling in a mouse model of egg induced eosinophilic esophagitis
- (2013) Jae Youn Cho et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Oral caffeine administration ameliorates acute colitis by suppressing chitinase 3-like 1 expression in intestinal epithelial cells
- (2013) In-Ah Lee et al. JOURNAL OF GASTROENTEROLOGY
- Quantification of Chitinase mRNA Levels in Human and Mouse Tissues by Real-Time PCR: Species-Specific Expression of Acidic Mammalian Chitinase in Stomach Tissues
- (2013) Misa Ohno et al. PLoS One
- Chitin microparticles for the control of intestinal inflammation
- (2012) Katsuya Nagatani et al. INFLAMMATORY BOWEL DISEASES
- Human Chitotriosidase: a Sensitive Biomarker of Sarcoidosis
- (2012) Elena Bargagli et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Chitinase 1 Is a Biomarker for and Therapeutic Target in Scleroderma-Associated Interstitial Lung Disease That Augments TGF- 1 Signaling
- (2012) C. G. Lee et al. JOURNAL OF IMMUNOLOGY
- Faecal chitinase 3-like-1: a novel biomarker of disease activity in paediatric inflammatory bowel disease
- (2011) T. Aomatsu et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Chitinase 3-Like-1 Expression in Colonic Epithelial Cells as a Potentially Novel Marker for Colitis-Associated Neoplasia
- (2011) Chun-Chuan Chen et al. AMERICAN JOURNAL OF PATHOLOGY
- Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like Inhibitor
- (2011) Tara E. Sutherland et al. CHEMISTRY & BIOLOGY
- Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells
- (2011) Chun-Chuan Chen et al. CLINICAL IMMUNOLOGY
- The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the TNBS model of colitis
- (2011) Theresa C. Peterson et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Chitinase 3-like 1 promotes macrophage recruitment and angiogenesis in colorectal cancer
- (2011) M Kawada et al. ONCOGENE
- Identification and Characterization of Acidic Mammalian Chitinase Inhibitors
- (2010) Derek C. Cole et al. JOURNAL OF MEDICINAL CHEMISTRY
- Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms
- (2010) Tomoyasu HIROSE et al. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
- Lung Chitinolytic Activity and Chitotriosidase Are Elevated in Chronic Obstructive Pulmonary Disease and Contribute to Lung Inflammation
- (2009) Séverine Létuvé et al. AMERICAN JOURNAL OF PATHOLOGY
- CHIT1 and AMCase expression in human gastric mucosa: correlation with inflammation and Helicobacter pylori infection
- (2009) Elisa Cozzarini et al. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
- Inhibition of Acidic Mammalian Chitinase by RNA Interference Suppresses Ovalbumin-Sensitized Allergic Asthma
- (2009) Ching-Jen Yang et al. HUMAN GENE THERAPY
- Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13–induced tissue responses and apoptosis
- (2009) Chun Geun Lee et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Potential role of chitinase 3-like-1 in inflammationassociated carcinogenic changes of epithelial cells
- (2009) Katrin Eurich et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein
- (2008) Mayumi Kawada et al. LABORATORY INVESTIGATION
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More